Ryan E. Looper, PhD

Languages spoken:

Academic Information

Departments: Chemistry - Associate Professor

Academic Office Information

r.looper@utah.edu

  • Srinivas R. Paladugu, Chintelle K. James and Ryan E. Looper “A direct C11 alkylation strategy on the saxitoxin core; a synthesis of (+)-11-Saxitoxinethanoic acid” submitted, 2019
  • Catherine M. Serrano, Hariprasada R. Kanna Reddy, Daniel R. Eiler, Michael R. Koch, Louis R. Barrows, Ryan T. Vanderlinden, Charles A. Testa, Paul R. Sebahar and Ryan E. Looper* “Unifying aminohexopyranose nucleoside antibiotics; implications for antibiotic design” submitted, 2019
  • Dustin L. Williams, Scott R. Smith, R. Tyler Epperson, Brittany R. Peterson and Ryan E. Looper “Growth Substrate May Influence Biofilm Susceptibility to Antibiotics” PLOS One, 2019, in press.
  • Williams, Dustin L.; Epperson, Richard T.; Ashton, Nicholas N.; Taylor, Nicholas B.; Kawaguchi, Brooke; Olsen, Raymond E.; Haussener, Travis J.; Sebahar, Paul R.; Allyn, Gina; Looper, Ryan E. “In vivo analysis of a first-​in-​class tri-​alkyl norspermidine-​biaryl antibiotic in an active release coating to reduce the risk of implant-​related infection” Acta Biomaterialia, 2019 in press. PMID: 30710710
  • Williams, Dustin L.; Epperson, Richard T.; Ashton, Nicholas N.; Taylor, Nicholas B.; Kawaguchi, Brooke; Olsen, Raymond E.; Haussener, Travis J.; Sebahar, Paul R.; Allyn, Gina; Looper, Ryan E. “In Vitro Testing of a First-In-Class Tri-alkylnorspermidine-biaryl Antibiotic in an Anti-biofilm Silicone Coating” Acta Biomaterialia 2019 in press. PMID:30769135
  • Vaden, R. M.; Guillen, K. P.; Salvant, J. M.; Santiago, C. B.; Gibbons, J. B.; Pathi, S. S.; Arunachalam, S.; Sigman, M. S.; Looper, R. E.; Welm, B. E., A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A. ACS Chem. Biol. 2019, 14 (1), 106-117. PMID: 30571086
  • Laukka, T.; Myllykoski, M.; Looper, R. E.; Koivunen, P., Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. Journal of Molecular Biology 2018, 430 (18, Part B), 3081-3092;
  • Philip, B.; Yu, D. X.; Silvis, M. R.; Shin, C. H.; Robinson, J. P.; Robinson, G. L.; Welker, A. E.; Angel, S. N.; Tripp, S. R.; Sonnen, J. A.; VanBrocklin, M. W.; Gibbons, R. J.; Looper, R. E.; Colman, H.; Holmen, S. L., Mutant IDH1 Promotes Glioma Formation In Vivo. Cell Rep. 2018, 23 (5), 1553-1564;
  • Bharat, D.; Cavalcanti, R. R. M.; Petersen, C.; Begaye, N.; Cutler, B. R.; Costa, M. M. A.; Ramos, R. K. L. G.; Ferreira, M. R.; Li, Y.; Bharath, L. P.; Toolson, E.; Sebahar, P.; Looper, R. E.; Jalili, T.; Rajasekaran, N. S.; Jia, Z.; Symons, J. D.; Anandh Babu, P. V., Blueberry Metabolites Attenuate Lipotoxicity-Induced Endothelial Dysfunction. Nutr. Food Res. 2018, 62 (2), n/a;
  • McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell 2018, 175(1):101-116.e25. PMID: 30220459
  • Tuomas Laukka, Matti Myllykoski, Ryan E. Looper, Peppi Koivunen “Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases” Mol. Biol 2018, 430, 3081-3092.
  • Joseph B. Gibbons, Justin M. Salvant, Rachel M. Vaden, Bryan E. Welm and Ryan E. Looper “A synthesis of naamidine A and selective access to N2-acyl-2-aminoimidazoles.” Org. Chem. 2015, 80, 10076–10085.
  • Kaitlin J. Basham, Christopher J. Leonard, Collin Kieffer, Dawne N. Shelton, Vasudev R. Bhonde, Ryan E. Looper, and Bryan E. Welm “Dioxin Exposure Blocks Lactation Through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor”Sci. 2015, 143 (1), 36-45. PMCID: PMC4274378
  • Jing Fan, Xin Teng, Ling Liu, Ryan E. Looper and Joshua D. Rabinowitz “Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate” ACS Chemical Biology 2015, 10, 510-516. PMCID:PMC4340346

Selected Publications

  1. Looper Ryan E (07/06/2021). Small Molecular Weapons against Multi-Drug Resistance. Acc Chem Res, 54(13), 2785-2787.
  2. Nelli Matthew R (07/06/2021). Dissecting the Nucleoside Antibiotics as Universal Translation Inhibitors. Acc Chem Res, 54(13), 2798-2811.
  3. Banerjee Aishwaryadev (03/21/2021). Molecular bridge-mediated ultralow-power gas sensing. 7.
  4. Miller Mariel (10/19/2020). Examination of a first-in-class bis-dialkylnorspermidine-terphenyl antibiotic in topical formulation against mono and polymicrobial biofilms. PLoS One, 15.
  5. Willilams D L (07/27/2020). In vivo efficacy of a unique first-in-class antibiofilm antibiotic for biofilm-related wound infections caused by Acinetobacter baumannii. 2.
  6. Serrano Catherine M (04/27/2020). Unifying aminohexopyranose nucleoside antibiotics; implications for antibiotic design. Angew Chem Int Ed Engl, 59, 11330-11333.
  7. Paladugu Srinivas R (09/25/2019). A Direct C11 Alkylation Strategy on the Saxitoxin Core: A Synthesis of (+)-11-Saxitoxinethanoic Acid. 21, 7999–8002.
  8. Williams DL (07/15/2019). In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection. 93, 36-49.
  9. Ashton NN (07/15/2019). In vitro testing of a first-in-class tri-alkylnorspermidine-biaryl antibiotic in an anti-biofilm silicone coating. 93, 25-35.
  10. Banerjee Aishwaryadev (05/10/2019). Batch-Fabricated α-Si Assisted Nanogap Tunneling Junctions. 9, 727.
  11. Williams Dustin L (03/14/2019). Growth substrate may influence biofilm susceptibility to antibiotics. PLoS One.
  12. Vaden R M (12/2018). A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine .
  13. Tuomas Laukka (09/2018). “Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. J Mol Biol, 430.
  14. Laukka T (09/2018). Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. J Mol Biol.
  15. Philip B (09/2018). Mutant IDH1 Promotes Glioma Formation In Vivo. 430.
  16. McBrayer SK (08/2018). Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
  17. Philip B (05/2018). Mutant IDH1 Promotes Glioma Formation In Vivo.
  18. Divya Bharat (01/2018). Blueberry metabolites attenuate indices of lipotoxicity-induced endothelial dysfunction. PubMed.
  19. Samuel K McBrayer (10/2016).
  20. Justin M Salvant (08/2016).
  21. Ki-Hyeok Kwon (01/2016).
  22. RYAN E LOOPER (09/11/2015).
  23. RYAN E LOOPER (01/2015).
  24. RYAN E LOOPER (08/2014).
  25. RYAN E LOOPER (08/2014).
  26. RYAN E LOOPER (08/2014).
  27. RYAN E LOOPER (08/2014).
  28. RYAN E LOOPER (08/2014).
  29. RYAN E LOOPER (08/2014).
  30. RYAN E LOOPER (08/2014).

Global Impact

Awards & Honors

Description Country
Thieme Journals Award for Creative Research Germany