A man with dark hair wearing a grey suit and purple tie, smiling against a neutral background.

Siam Oottamasathien, MD

Languages spoken: English, Thai

Academic Information

Departments Adjunct - Surgery

Divisions: Urology

Siam Oottamasathien, MD, FAAP, FACS is a board-certified urologist with subspecialty certification in pediatric urology. He attended the University of Colorado at Boulder studying Molecular Biology and Biochemistry, then obtained his medical degree and completed his urologic residency at the University of Colorado Health Sciences Center. Dr. Oottamasathien pursued a fellowship in pediatric urology at Vanderbilt University, with a special focus on basic science research and inflammatory disorders that affect the bladder. Currently, Dr. Oottamasathien's practice is dedicated to pediatric urology but he also directs the basic science research efforts for the group. He is a member of multiple medical organizations, including the American Urological Association, Society for Basic Urologic Research, Society for Fetal Urology, and Society for Pediatric Urology. In addition, Dr. Oottamasathien is a Fellow of the American Academy of Pediatrics and Fellow of the American College of Surgeons.

Research Statement

Dr. Oottamasathien launched a pediatric urology basic science research program for the group in 2007. His initial work was in the Department of Human Molecular Biology and Genetics at the University of Utah, investigating the role of T-box proteins in genitourinary development. During that time, he gained invaluable research tools, developed elaborate experimental designs, including the use of germ-line and conditional mutagenesis experiments in mice, and further enhanced his background in genitourinary embryology, molecular biology, and developmental biology. In addition, he was awarded a three year NIH T32 training grant (5T32HL079874) under the auspices of Nobel Laureate Dr. Mario Capecchi and received NIH loan repayment program (LRP) funding for pediatric research. After spending a year and a half along this line of research, more clinical translational science was necessary and he partnered with the laboratory of Glenn Prestwich, PhD, a senior investigator and presidential professor of medicinal chemistry at the University of Utah.

Since establishing his collaboration with Dr. Prestwich, his projects have demonstrated great potential in making a significant impact towards treating pediatric urologic disease conditions. The scientific aspects build upon novel hyaluronic acid (HA)¿based biomaterials and have been used to investigate and treat bladder inflammatory and fibrotic conditions. Thus far, he has obtained grant funding from the National Kidney Foundation'Utah Chapter, Early Career Development Award from the Primary Children's Hospital Foundation, NIH K12 Career Development Award (UL1RR025764) University of Utah Center for Clinical and Translational Science, American Urological Association/Pfizer Award for Investigation in Benign Urologic Disease, Primary Children's Hospital Integrated Science Award, and an NIH Phase I SBIR Grant (R43DK093413) in conjunction with a small start up company GlycoMira Therapeutics that Dr. Oottamasathien is a part of. Recently, Dr. Oottamasathien received NIH R01 funding to further investigate the treatment of bladder pain by novel glycosaminoglycan derivatives (R01DK100868). Dr. Oottamasathien has also been a three-time recipient (2006, 2010, 2012) of the prestigious Basic Science Research Award presented by the American Academy of Pediatrics Section on Urology. He was also selected in 2013 by the Society of Pediatric Urology as their early career investigator representative and presented his group's work at the 2013 American Urologic Association Annual Meeting showcasing the best of the best early career investigators. At this forum, he was awarded 2nd place honors. His research efforts continue to represent significant, innovative, and high-impact science that continues to move the field of urology forward.

Education History

Undergraduate Illinois Institute of Technology
Undergraduate University of Colorado at Boulder
 BA
Professional Medical University of Colorado School of Medicine
 MD
Internship University of Colorado at Denver and Health Sciences Center
 Intern
Residency University of Colorado at Denver and Health Sciences Center
 Resident
Residency University of Colorado at Denver and Health Sciences Center
 Resident
Chief Resident University of Colorado at Denver and Health Sciences Center
 Chief Resident
Fellowship Vanderbilt University
 Fellow

Selected Publications

Journal Article

  1. Oottamasathien S, Williams K, Franco OE, Thomas JC, Saba K, Bhowmick NA, Staack A, Demarco RT, Brock JW 3rd, Hayward SW, Pope JC 4t (2006). Bladder tissue formation from cultured bladder urothelium. Developmental dynamics, 235(10), 2795-801.
  2. Oottamasathien S, Wang Y, Williams K, Franco OE, Wills ML, Thomas JC, Saba K, Sharif-Afshar AR, Makari JH, Bhowmick NA, DeMarco RT, Hipkens S, Magnuson M, Brock JW 3rd, Hayward SW, Pope JC 4th, Matusik R (2007). Directed differentiation of embryonic stem cells into bladder tissue. Developmental biology, 304(2), 556-66.
  3. Matusik RJ, Jin RJ, Sun Q, Wang Y, Yu X, Gupta A, Nandana S, Case TC, Paul M, Mirosevich J, Oottamasathien S, Thomas (2008). Prostate epithelial cell fate. Differentiation; research in biological diversity, 76(6), 682-98.
  4. Brant WO, Rajimwale A, Lovell MA, Travers SH, Furness PD 3rd, Sorensen M, Oottamasathien S, Koyle M (2006). Gonadoblastoma and Turner syndrome. The Journal of urology, 175(5), 1858-60.
  5. Oottamasathien S, Williams K, Franco OE, Wills ML, Thomas JC, Sharif-Afshar AR, DeMarco RT, Brock JW 3rd, Bhowmick NA, Hayward SW, Pope JC 4t (2007). Urothelial inhibition of transforming growth factor-beta in a bladder tissue recombination model. The Journal of urology, 178(4 Pt 2), 1643-9.
  6. Thomas JC, Oottamasathien S, Makari JH, Honea L, Sharif-Afshar AR, Wang Y, Adams C, Wills ML, Bhowmick NA, Adams MC, Brock JW 3rd, Hayward SW, Matusik RJ, Pope JC 4t (2008). Temporal-spatial protein expression in bladder tissue derived from embryonic stem cells. The Journal of urology, 180(4 Suppl), 1784-9.
  7. Wicher C, Hadley D, Ludlow D, Oottamasathien S, Wallis MC, Devries C, Snow BW, Cartwright P (2010). 250 consecutive unilateral extravesical ureteral reimplantations in an outpatient setting. The Journal of urology, 184(1), 311-4.
  8. Willis HL, Snow BW, Cartwright PC, Wallis MC, Oottamasathien S, deVries (2011). Parameatal urethral cysts in prepubertal males. The Journal of urology, 185(3), 1042-5.
  9. Oottamasathien S, Jia W, McCoard L, Slack S, Zhang J, Skardal A, Job K, Kennedy TP, Dull RO, Prestwich G (2011). A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides. The Journal of urology, 186(4 Suppl), 1684-92.
  10. Gabrielsen JS, Laciak RJ, Frank EL, McFadden M, Bates CS, Oottamasathien S, Hamilton BD, Wallis M (2012). Pediatric urinary stone composition in the United States. The Journal of urology, 187(6), 2182-7.
  11. Oottamasathien S, Thomas JC, Adams MC, Demarco RT, Brock JW 3rd, Pope JC 4t (2007). Testicular tumours in children: a single-institutional experience. BJU international,
  12. Oottamasathien S, Thomas JC, Adams MC, DeMarco RT, Brock JW 3rd, Pope JC 4t (2007). Testicular tumours in children: a single-institutional experience. BJU international, 99(5), 1123-6.
  13. Skardal A, Zhang J, McCoard L, Oottamasathien S, Prestwich G (2010). Dynamically crosslinked gold nanoparticle - hyaluronan hydrogels. Advanced materials (Deerfield Beach, Fla.), 22(42), 4736-40.
  14. Skardal A, Zhang J, McCoard L, Xu X, Oottamasathien S, Prestwich G (2010). Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting. Tissue engineering. Part A, 16(8), 2675-85.

Book Chapter

  1. Oottamasathien S, Furness PD, Mingin G, Brant WO, Koyle M (2006). Management of Undescended Testes. Progress in Paediatric Urology Volume 8.
  2. Oottamasathien S, Snow B (2011). Office Procedures for Pediatric Urology. v. 30,

Case Report

  1. Oottamasathien S, Wills ML, Brock JW 3rd, Pope JC 4t (2007). Primary extrarenal nephroblastomatosis. Urology, 69(1), 184.e3-4.

Letter

  1. Pohl JF, Comstock JM, Oottamasathien (2011). Metastatic Crohn's disease of the penis in a pediatric patient. Inflammatory bowel diseases, 17(4), 1056.

Abstract

  1. Foot LM, Bates CS, Steadman C, Laciak RJ, Oottamasathien (2008). Testis Tumors in Children - An Argument for Testis Sparing Surgery.
  2. Wicher C, Hadley DA, Cartwright PC, Oottamasathien (2008). Scrotoplasty in Scrotal Agenesis.
  3. Wicher CG, Hadley DA, Cartwright PC, Oottamasathien (2009). Scrotoplasty in Scrotal Agenesis.
  4. Jia WJ, McCoard L, Zhang J, Skardal A, Prestwich GD, Oottamasathien (2010). Abrogaton of LL-37 Mediated Bladder Inflammation and the Role of the Receptor for Advanced Glycation End-Products (RAGE) Pathway.
  5. Gabrielsen JS, Laciak RJ, Frank EL, McFadden M, Bates CS, Oottamasathien S, Hamilton BD, Wallis M (2010). Pediatric Urinary Stone Composition in the United States.
  6. Oottamasathien S, Jia W, Roundy LM, Zhang J, Wang L, Ye X, Hill AC, Savage J, Lee WY, Hannon A, Milner S, Prestwich G (2012). Physiologic Relevance of LL-37 Induced Bladder Inflammation and Mast Cells.