Tim Jenkins

Tim Jenkins, PhD

Languages spoken: English

Academic Information

Departments Adjunct - Surgery

Divisions:

Academic Office Information

Tim.Jenkins@hsc.utah.edu

Research Interests

  • Sperm Epigenetic Research
  • Effect of Age on the Sperm Epigenome
  • Germline Aging Calculator

Tim Jenkins received his B.S. in Physiology and Developmental Biology from Brigham Young University in 2008. He received his Ph.D. in Physiology from the University of Utah in 2013. Tim’s dissertation research evaluated the impact of age on male fertility and offspring health. Following completion of his Ph.D. he was offered a fellowship at the University of Utah and soon thereafter a faculty position with the Division of Urology. Tim’s research efforts as a faculty member at the University of Utah have been focussed on improving reproductive outcomes in patients with male factor infertility by optimizing clinical treatment options for couples seeking fertility care. One key project has been the improvement of sperm preparation procedures for intrauterine insemination with the use of microfluidic technology. This line of study is designed to improve the reliability of sperm preparation methods while decreasing exposures and stresses to sperm cells. As a result, the procedures being assessed have the capacity to increase success rates of commonly utilized assisted reproductive therapies. In his free time, he loves to spend time with his wife and three kids, fly fish, and mountain bike.

Education History

Postdoctoral Fellowship University of Utah School of Medicine
 Postdoctoral Fellow
Doctoral Training University of Utah
 PhD
Undergraduate Brigham Young University
 BS

Selected Publications

Journal Article

  1. James ER, Carrell DT, Aston KI, Jenkins TG, Yeste M, Salas-Huetos A (2020). The Role of the Epididymis and the Contribution of Epididymosomes to Mammalian Reproduction. Int J Mol Sci, 21(15).
  2. Salas-Huetos A, Maghsoumi-Norouzabad L, James ER, Carrell DT, Aston KI, Jenkins TG, Becerra-Toms N, Javid AZ, Abed R, Torres PJ, Luque EM, Ramrez ND, Martini AC, Salas-Salvad J (2020). Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta-analysis. Obes Rev, 22(1), e13082.
  3. Santana VP, James ER, Miranda-Furtado CL, Souza MF, Pompeu CP, Esteves SC, Carrell DT, Aston KI, Jenkins TG, Reis RMD (2020). Differential DNA methylation pattern and sperm quality in men with varicocele. Fertil Steril, 114(4), 770-778.
  4. Murphy PJ, Guo J, Jenkins TG, James ER, Hoidal JR, Huecksteadt T, Broberg DS, Hotaling JM, Alonso DF, Carrell DT, Cairns BR, Aston KI (2020). NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure. PLoS Genet, 16(6), e1008756.
  5. Samuel R, Son J, Jenkins TG, Jafek A, Feng H, Gale BK, Carrell DT, Hotaling JM (2020). Microfluidic System for Rapid Isolation of Sperm From Microdissection TESE Specimens. Urology, 140, 70-76.
  6. Samuel R, Son J, Jenkins TG, Jafek A, Feng H, Gale BK, Carrell DT, Hotaling JM (2019). AUTHOR REPLY. Urology, 140, 75-76.
  7. Patel DP, Jenkins TG, Aston KI, Guo J, Pastuszak AW, Hanson HA, Hotaling JM (2020). Harnessing the full potential of reproductive genetics and epigenetics for male infertility in the era of "big data". Fertil Steril, 113(3), 478-488.
  8. Mangum CL, Patel DP, Jafek AR, Samuel R, Jenkins TG, Aston KI, Gale BK, Hotaling JM (2020). Towards a better testicular sperm extraction: novel sperm sorting technologies for non-motile sperm extracted by microdissection TESE. Transl Androl Urol, 9(Suppl 2), S206-S214.
  9. Salas-Huetos A, James ER, Aston KI, Carrell DT, Jenkins TG, Yeste M (2019). The role of miRNAs in male human reproduction: a systematic review. Andrology, 8(1), 7-26.
  10. Jenkins TG, James ER, Aston KI, Salas-Huetos A, Pastuszak AW, Smith KR, Hanson HA, Hotaling JM, Carrell DT (2019). Age-associated sperm DNA methylation patterns do not directly persist trans-generationally. Epigenetics Chromatin, 12(1), 74.
  11. Salas-Huetos A, James ER, Aston KI, Jenkins TG, Carrell DT, Yeste M (2019). The Expression of miRNAs in Human Ovaries, Oocytes, Extracellular Vesicles, and Early Embryos: A Systematic Review. Cells, 8(12).
  12. Salas-Huetos A, James ER, Aston KI, Jenkins TG, Carrell DT (2019). Diet and sperm quality: Nutrients, foods and dietary patterns. Reprod Biol, 19(3), 219-224.
  13. Samuel R, Feng H, Jafek A, Despain D, Jenkins T, Gale B (2018). Microfluidic-based sperm sorting & analysis for treatment of male infertility. Transl Androl Urol, 7(Suppl 3), S336-S347.
  14. Keihani S, Craig JR, Zhang C, Presson AP, Myers JB, Brant WO, Aston KI, Emery BR, Jenkins TG, Carrell DT, Hotaling JM (2018). Proton-pump inhibitor use does not affect semen quality in subfertile men. Asian J Androl, 20(3), 290-293.
  15. Jenkins TG, Liu L, Aston KI, Carrell DT (2018). Pre-screening method for somatic cell contamination in human sperm epigenetic studies. Syst Biol Reprod Med, 64(2), 146-155.
  16. Jenkins TG, James ER, Alonso DF, Hoidal JR, Murphy PJ, Hotaling JM, Cairns BR, Carrell DT, Aston KI (2017). Cigarette smoking significantly alters sperm DNA methylation patterns. Andrology, 5(6), 1089-1099.
  17. Keihani S, Craig JR, Zhang C, Presson AP, Myers JB, Brant WO, Aston KI, Emery BR, Jenkins TG, Carrell DT, Hotaling JM (2017). Impacts of Abstinence Time on Semen Parameters in a Large Population-based Cohort of Subfertile Men. Urology, 108, 90-95.
  18. Jenkins TG, Aston KI, James ER, Carrell DT (2017). Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications. Syst Biol Reprod Med, 63(2), 69-76.
  19. Jenkins T, Shamsi MB, James E, Aston KI, Carrell DT (2017). Thermo stability of DNA methylation marks in human sperm. J Genet Genome Res, 4(1).
  20. Jenkins TG, Aston KI, Hotaling JM, Shamsi MB, Simon L, Carrell DT (2016). Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures. Andrology, 4(5), 843-9.
  21. Jenkins TG, Aston KI, Meyer TD, Hotaling JM, Shamsi MB, Johnstone EB, Cox KJ, Stanford JB, Porucznik CA, Carrell DT (2016). Decreased fecundity and sperm DNA methylation patterns. Fertil Steril, 105(1), 51-7.e1-3.
  22. Aston KI, Uren PJ, Jenkins TG, Horsager A, Cairns BR, Smith AD, Carrell DT (2015). Aberrant sperm DNA methylation predicts male fertility status and embryo quality. Fertil Steril, 104(6), 1388-97.e1-5.
  23. Hotaling JM, Jenkins TG (2015). MicroRNA: a step beyond bulk seminal parameters? Fertil Steril, 104(3), 554.
  24. Ge SQ, Grifin J, Liu LH, Aston KI, Simon L, Jenkins TG, Emery BR, Carrell DT (2015). Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia. Genet Mol Res, 14(3), 9053-61.
  25. Jenkins TG, Aston KI, Trost C, Farley J, Hotaling JM, Carrell DT (2015). Intra-sample heterogeneity of sperm DNA methylation. Mol Hum Reprod, 21(4), 313-9.
  26. Jenkins TG, Aston KI, Pflueger C, Cairns BR, Carrell DT (2014). Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genet, 10(7), e1004458.
  27. Jenkins TG, Aston KI, Cairns BR, Carrell DT (2013). Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels. Fertil Steril, 100(4), 945-51.
  28. Ge SQ, Jeanine G, Liu LH, Kenneth IA, Luke S, Timothy GJ, Benjamin RE, Douglas TC (2013). [Association of single nucleotide polymorphisms(SNPs) in Pygo2 coding gene with idiopathic oligospermia and azoospermia]. Yi Chuan, 35(5), 616-22.
  29. Jenkins TG, Carrell DT (2012). Dynamic alterations in the paternal epigenetic landscape following fertilization. Front Genet, 3, 143.
  30. Jenkins TG, Aston KI, Carrell DT (2011). Supplementation of cryomedium with ascorbic acid-2-glucoside (AA2G) improves human sperm post-thaw motility. Fertil Steril, 95(6), 2001-4.

Editorial

  1. Patel DP, Jenkins TG, Hotaling JM (2019). Microfluidics: a way to interrogate a single sperm? Fertil Steril, 112(5), 808.

Patent

  1. Carrell DT, Cairns BR, Jenkins TG, Aston KI (2019). Systems and Methods for Determining Impact of Age Related Changes in Sperm Epigenome on Offspring Phenotype.