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Robert A. Campbell, PhD

Languages spoken: English

Academic Information

Departments: Internal Medicine - Assistant Professor, Pathology - Adjunct Assistant Professor

Divisions: General Internal Medicine

Academic Office Information

rcampbell@u2m2.utah.edu

Research Interests

  • Platelets
  • Stroke
  • Inflammation
  • Neutrophils
  • Thrombosis
  • Infectious Disease

Research Statement

My research efforts focus on dissecting the mechanisms underpinning how cells alter coagulation under normal and disease situations, as well as determining how hemostasis and thrombosis, in turns, alters cellular response during inflammation. In particular, I have focused on understanding the regulation of transcription and translation in megakaryocyte and platelets under health and disease conditions. To accomplish these goals, I have developed in vitro and in vivo model systems to examine gene and protein expression in megakaryocytes and platelets. We have also elucidated novel mechanisms regulating megakaryocyte and platelet function and activation under normal homeostasis, including translational control mechanism regulated by microRNAs. We have also discovered that platelets and megakaryocytes possess novel intrinsic host defense mechanisms in addition to their ability to respond to inflammatory signals that induce robust changes in gene and protein expression. We have also demonstrated these changes in gene expression alter thrombo-inflammatory responses, which often occur in the setting of aging and in the context of stroke. We also have extensively studied platelet interactions with other cells including neutrophils and monocytes and how these interactions alter platelet and leukocyte responses, including neutrophil extracellular trap formation (NET).

In addition, my laboratory has significant experience dissecting molecular pathway in platelets and neutrophils, which regulate thrombosis using murine model systems. This includes in vivo models of thrombosis such as venous thrombosis, pulmonary embolism, and ischemic stroke. In these studies, we have used state-of-the-art technologies including RNA-seq to examine the transcriptional changes in platelets and megakaryocytes from mice to uncover novel genes critical for platelet responses during inflammation and thrombosis.

Education History

Postdoctoral Fellowship University of North Carolina at Chapel Hill
Pathology and Laboratory Medicine
Postdoctoral Fellow
Postdoctoral Fellowship University of Utah
Molecular Medicine
Postdoctoral Fellow
Doctoral Training University of North Carolina at Chapel Hill
Pathology and Laboratory Medicine
Ph.D.
Undergraduate Furman University
Biology
B.S.

Selected Publications

  1. Denorme F, Rustad JL, Portier I, Crandell JL, de Araujo CV, Cody MJ, Campbell RA, Yost CC (2022). Neutrophil extracellular trap inhibition improves survival in neonatal mouse infectious peritonitis. Pediatr Res.
  2. Schwertz H, Rowley JW, Portier I, Middleton EA, Tolley ND, Campbell RA, Eustes AS, Chen K, Rondina MT (2021). Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5. Autophagy (18(7), pp. 1534-1550). United States.
  3. Kim SJ, Yao Z, Marsh MC, Eckert DM, Kay MS, Lyakisheva A, Pasic M, Bansal A, Birnboim C, Jha P, Galipeau Y, Langlois MA, Delgado JC, Elgort MG, Campbell RA, Middleton EA, Stagljar I, Owen SC (2022). Homogeneous surrogate virus neutralization assay to rapidly assess neutralization activity of anti-SARS-CoV-2 antibodies. Nat Commun (13(1), p. 3716). England.
  4. Denorme F, Ajanel A, Campbell RA (2022). Shining a light on platelet activation in COVID-19. J Thromb Haemost (20(6), pp. 1286-1289). England.
  5. Denorme F, Portier I, Rustad JL, Cody MJ, de Araujo CV, Hoki C, Alexander MD, Grandhi R, Dyer MR, Neal MD, Majersik JJ, Yost CC, Campbell RA (2021). Neutrophil extracellular traps regulate ischemic stroke brain injury. J Clin Invest (132(10)). United States.
  6. Stoller ML, Basak I, Denorme F, Rowley JW, Alsobrooks J, Parsawar K, Nieman MT, Yost CC, Hamilton JR, Bray PF, Campbell RA (2021). Neutrophil cathepsin G proteolysis of protease-activated receptor 4 generates a novel, functional tethered ligand. Blood Adv (6(7), pp. 2303-2308). United States.
  7. Sommakia S, Almaw NH, Lee SH, Ramadurai DKA, Taleb I, Kyriakopoulos CP, Stubben CJ, Ling J, Campbell RA, Alharethi RA, Caine WT, Navankasattusas S, Hoareau GL, Abraham AE, Fang JC, Selzman CH, Drakos SG, Chaudhuri D (2021). FGF21 (Fibroblast Growth Factor 21) Defines a Potential Cardiohepatic Signaling Circuit in End-Stage Heart Failure. Circ Heart Fail (15(3), pp. e008910). United States.
  8. Bounajem MT, Campbell RA, Denorme F, Grandhi R (2021). Paradigms in chronic subdural hematoma pathophysiology: Current treatments and new directions. [Review]. J Trauma Acute Care Surg, 91(6), e134-e141.
  9. Bhatlekar S, Jacob S, Manne BK, Guo L, Denorme F, Tugolukova EA, Cody MJ, Kosaka Y, Rigoutsos I, Campbell RA, Rowley JW, OConnell RM, Bray PF (2021). Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet count without altering platelet function. Blood Cells Mol Dis (92, p. 102624). United States.
  10. Denorme F, Rustad JL, Campbell RA (2021). Brothers in arms: platelets and neutrophils in ischemic stroke. Curr Opin Hematol, 28(5), 301-307.
  11. Queisser KA, Mellema RA, Middleton EA, Portier I, Manne BK, Denorme F, Beswick EJ, Rondina MT, Campbell RA, Petrey AC (2021). COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction. JCI Insight, 6(17).
  12. Portier I, Campbell RA, Denorme F (2021). Mechanisms of immunothrombosis in COVID-19. Curr Opin Hematol, 28, 445-453.
  13. Campbell RA, Campbell HD, Bircher JS, de Araujo CV, Denorme F, Crandell JL, Rustad JL, Monts J, Cody MJ, Kosaka Y, Yost CC (2021). Placental HTRA1 cleaves alpha-1-antitrypsin to generate a NET-Inhibitory Peptide. Blood, 138, 977-988.
  14. Campbell RA, Hisada Y, Denorme F, Grover SP, Bouck EG, Middleton EA, Wolberg AS, Rondina MT, Mackman N (2021). Comparison of the coagulopathies associated with COVID-19 and sepsis. Res Pract Thromb Haemost, 5(4), e12525.
  15. Sumanth MS, Jacob SP, Abhilasha KV, Manne BK, Basrur V, Lehoux S, Campbell RA, Yost CC, McIntyre TM, Cummings RD, Weyrich AS, Rondina MT, Marathe GK (2020). Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils. J Leukoc Biol, 109(5), 915-930.
  16. Eustes AS, Campbell RA, Middleton EA, Tolley ND, Manne BK, Montenont E, Rowley JW, Krauel K, Blair A, Guo L, Kosaka Y, Medeiros-de-Moraes IM, Lacerda M, Hottz ED, Neto HCF, Zimmerman GA, Weyrich AS, Petrey A, Rondina MT (2021). Heparanase expression and activity are increased in platelets during clinical sepsis. J Thromb Haemost, 19(5), 1319-1330.
  17. Guo L, Shen S, Rowley JW, Tolley ND, Jia W, Manne BK, McComas KN, Bolingbroke B, Kosaka Y, Krauel K, Denorme F, Jacob SP, Eustes AS, Campbell RA, Middleton EA, He X, Brown SM, Morrell CN, Weyrich AS, Rondina MT (2021). Platelet MHC Class I Mediates CD8+ T Cell Suppression During Sepsis. Blood, 138(5), 401-416.
  18. Denorme F, Portier I, Kosaka Y, Campbell RA (2020). Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake. J Thromb Haemost, 19(2), 536-546.
  19. Griffiths TM, Page L, Weyrich AS, Rondina MT, Campbell RA (2020). Platelet electrical resistance for measuring platelet activation and adhesion in human health and disease. Thromb Res, 198, 204-209.
  20. Petrey AC, Qeadan F, Middleton EA, Pinchuk IV, Campbell RA, Beswick EJ (2020). Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex. J Leukoc Biol, 109(1), 55-66.
  21. Portier I, Campbell RA (2020). Role of Platelets in Detection and Regulation of Infection. Arterioscler Thromb Vasc Biol, 41(1), 70-78.
  22. Campbell RA, Boilard E, Rondina MT (2020). Is there a role for the ACE2 receptor in SARS-CoV-2 interactions with platelets? J Thromb Haemost, 19(1), 46-50.
  23. Bouck EG, Denorme F, Holle LA, Middelton EA, Blair AM, de Laat B, Schiffman JD, Yost CC, Rondina MT, Wolberg AS, Campbell RA (2020). COVID-19 and Sepsis Are Associated With Different Abnormalities in Plasma Procoagulant and Fibrinolytic Activity. Arterioscler Thromb Vasc Biol, 41(1), 401-414.
  24. Melki I, Allaeys I, Tessandier N, Mailhot B, Cloutier N, Campbell RA, Rowley JW, Salem D, Zufferey A, Laroche A, Lvesque T, Patey N, Rauch J, Lood C, Droit A, McKenzie SE, Machlus KR, Rondina MT, Lacroix S, Fortin PR, Boilard E (2020). FcγRIIA expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus. Blood, 136(25), 2933-2945.
  25. Campbell RA, Stoller ML, Denorme F, Manne BK, Bhatlekar S, Tugolukova EA, Bray PF (2020). Blockade of Human PAR4 in Novel Humanized Mouse Strains Supports PAR4 As a Potential Target in Stroke: Ex Vivo Demonstration of Platelet Hyperreactivity of the Thr120 Variant. . 62nd American Society of Hematology, Virtual Meeting.
  26. Trivedi S, Labuz D, Anderson CP, Araujo CV, Blair A, Middleton EA, Jensen O, Tran A, Mulvey MA, Campbell RA, Hale JS, Rondina MT, Leung DT (2020). Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis. Elife, 9.
  27. Denorme F, Manne BK, Portier I, Petrey AC, Middleton EA, Kile BT, Rondina MT, Campbell RA (2020). COVID-19 patients exhibit reduced procoagulant platelet responses. J Thromb Haemost, 18(11), 3067-3073.
  28. Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, OConnell RM, Rondina MT, Campbell RA, Bray PF (2020). miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin. Blood, 136(15), 1760-1772.
  29. Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA (2020). Platelet gene expression and function in patients with COVID-19. Blood, 136(11), 1317-1329.
  30. Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC (2020). Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 136(10), 1169-1179.
  31. Melki I, Allaeys I, Tessandier N, Mailhot B, Cloutier N, Campbell RA, Rowley JW, Salem D, Zufferey A, Laroche A, Lvesque T, Patey N, Rauch J, Lood C, Droit A, McKenzie SE, Machlus KR, Rondina MT, Lacroix S, Fortin P, Boilard E (2020). FcγRIIA expression aggravates nephritis and increases platelet activation in systemic lupus erythematosus in mice. Blood.
  32. de Azevedo-Quintanilha IG, Medeiros-de-Moraes IM, Ferreira AC, Reis PA, Vieira-de-Abreu A, Campbell RA, Weyrich AS, Bozza PT, Zimmerman GA, Castro-Faria-Neto HC (2020). Haem oxygenase protects against thrombocytopaenia and malaria-associated lung injury. Malar J, 19(1), 234.
  33. Rondina MT, Voora D, Simon LM, Schwertz H, Harper JF, Lee O, Bhatlekar SC, Li Q, Eustes AS, Montenont E, Campbell RA, Tolley ND, Kosaka Y, Weyrich AS, Bray PF, Rowley JW (2019). Longitudinal RNA-Seq Analysis of the Repeatability of Gene Expression and Splicing in Human Platelets Identifies a Platelet SELP Splice QTL. Circ Res, 126(4), 501-516.
  34. Denorme F, Manne BK, Portier I, Eustes AS, Kosaka Y, Kile BT, Rondina MT, Campbell RA (2019). Platelet necrosis mediates ischemic stroke outcome in mice. Blood, 135(6), 429-440.
  35. Azevedo-Quintanilha IG, Vieira-de-Abreu A, Ferreira AC, Reis PA, Silva TI, Nascimento DO, Campbell RA, Estato V, Weyrich AS, Bozza PT, Zimmerman GA, Castro-Faria-Neto HC (2019). Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria. PLoS One, 14(12), e0224610.
  36. Bhatlekar S, Basak I, Edelstein LC, Campbell RA, Lindsey CR, Italiano JE Jr, Weyrich AS, Rowley JW, Rondina MT, Sola-Visner M, Bray PF (2019). Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood. Haematologica, 104(10), 2075-2083.
  37. Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT (2019). Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood, 134(12), 911-923.
  38. Montenont E, Rondina MT, Campbell RA (2019). Altered functions of platelets during aging. Curr Opin Hematol, 26(5), 336-342.
  39. Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, DAlessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J (2019). TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood, 134(9), 727-740.
  40. Campbell RA, Arajuo C, Manne BK, Rowley JW, Tolley N, Rondina MT, Weyrich AS (2019).  The Mammalian Target of Rapamycin in Megakaryocytes and Platelets Regulates Mortality and Disease Severity in Sepsis. XXIX Congress of the International Society on Thrombosis and Haemostasis, Melbourne, Australia.
  41. Middleton E, Rowley J, Campbell RA, Grissom C, Beesely S, Brown S, Schwertz H, Kosaka Y, Krauel K, Manne BK, Tolley N, Eustes A, Guo L, Paine R, Harris E, Zimmerman G Weyrich AS, Rondina MT (2019). Platelet Transcription and Translation Is Altered in Sepsis and Associated with Mortality. XXIX Congress of the International Society on Thrombosis and Haemostasis, Melbourne, Australia.
  42. Guo L, Shen S, Rowley J, Jia W, Manne BK, Tolley N, McComas K, Su J, Jacob S, Campbell RA, Middleton E, Rondina MT, Weyrich AS (2019). Platelets Suppress Antigen Specific CD8+ T Cells in Sepsis Through MHC Class I. . XXIX Congress of the International Society on Thrombosis and Haemostasis, Melbourne, Australia.
  43. Campbell RA, Cody MJ, Manne BK, Zimmerman GA, Yost CC (2019). Interleukin 6 receptor alpha expression in PMNs isolated from prematurely born neonates: decreased expression is associated with differential mTOR signaling. Pediatr Res, 86(1), 55-62.
  44. Campbell RA, Schwertz H, Hottz ED, Rowley JW, Manne BK, Washington AV, Hunter-Mellado R, Tolley ND, Christensen M, Eustes AS, Montenont E, Bhatlekar S, Ventrone CH, Kirkpatrick BD, Pierce KK, Whitehead SS, Diehl SA, Bray PF, Zimmerman GA, Kosaka Y, Bozza PT, Bozza FA, Weyrich AS, Rondina MT (2019). Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3. Blood, 133(19), 2013-2026.
  45. Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel ED (2019). Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes. Diabetes, 68(5), 932-938.
  46. Campbell HD, Manne BK, Tolley N, Yost CC, Campbell RA (2019). Platelet IFITM3 contributes to thrombosis in preeclampsia. Society for Reproductive Investigation 66th Annual Scientific Meeting, Paris.
  47. Campbell RA, Denorme F, Manne BK, Arajuo C, Majersik J, Weyrich AS, Rondina MT (2019). The Mammalian Target of Rapamycin Regulates Platelet Integrin Activation, Aggregation, and Ischemic Stroke. International Stroke Conference, Honolulu.
  48. Mor-Cohen R, Zucker M, Grissom C, Brown SM, Seligsohn U, Campbell RA, Blair AM, Rondina MT (2019). The reduced form of coagulation factor XI is associated with illness severity and coagulopathy in critically-ill septic patients. J Thromb Thrombolysis, 47(2), 186-191.
  49. Campbell RA, Schwertz H, Tolley N, Diaz-Oritz R, Hunter-Mellado R, Bozza F, Washington V, Zimmerman GA, Weyrich AS (2019). Type I Interferons Upregulate IFITM3 in Human Platelets and Megakaryocytes to Control Viral Infectivity. Megakaryocytes and Platelet Gordon Research Conference, Galveston.
  50. Campbell RA, Schwertz H, Tolley N, Diaz-Oritz R, Hunter-Mellado R, Bozza F, Washington V, Zimmerman GA, Weyrich AS (2018). Type I Interferons Upregulate IFITM3 in Human Platelets and Megakaryocytes to Control Viral Infectivity. 68th Scientific Standardization Committee of the International Society of Thrombosis and Hemostasis, Dublin.
  51. Campbell RA, Manne BK, Saperstein S, Schwertz H, Rowley JW, Weyrich AS, and Rondina MT (2018). Interferon-induced Transmembrane 3 (IFITM3) on Megakaryocytes and Platelets Regulates Fibrinogen Endocytosis and Thrombosis During Inflammation. Vascular Discovery: From Genes to Medicine, San Francisco.
  52. Machin DR, Bloom SI, Campbell RA, Phuong TTT, Gates PE, Lesniewski LA, Rondina MT, Donato AJ (2018). Advanced age results in a diminished endothelial glycocalyx. Am J Physiol Heart Circ Physiol, 315(3), H531-H539.
  53. Campbell RA, Cody M, Kosaka Y, Campbell HD, Yost CC (2018). Placental HTRA1 Protease Cleaves Alpha-1-Antitrypsin and Generates Neonatal NET-Inhibitory Factor. American Society of Hematology, San Diego.
  54. Davizon-Castillo P, McMahon B, Aguila S, Jones KL, Trahan GD, Ashworth KJ, Bark D, Campbell RA, Higa K, Shih LC, Saunders N, DeGregori J, Rondina MT, DiPaola J (2018). TNF-α Driven Inflammation and Mitochondrial Dysfunction Characterize the Platelet Hyperreactivity of Aging and Myeloproliferative Neoplasms (MPN). American Society of Hematology, San Diego.
  55. Manne BK, Munzer P, Badolia R, Walker-Allgaier B, Campbell RA, Middleton E, Weyrich AS, Kunapuli SP, Borst O, Rondina MT (2018). PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway. J Thromb Haemost, 16(6), 1211-1225.
  56. Manne BK, Mnzer P, Badolia R, Walker-Allgaier B, Campbell RA, Middleton E, Weyrich AS, Kunapuli SP, Borst O, Rondina MT (2018). PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway. J Thromb Haemost, 16(6), 1211-1225.
  57. Schwertz H, Rowley JW, Schumann GG, Thorack U, Campbell RA, Manne BK, Zimmerman GA, Weyrich AS, Rondina MT (2018). Endogenous LINE-1 (Long Interspersed Nuclear Element-1) Reverse Transcriptase Activity in Platelets Controls Translational Events Through RNA-DNA Hybrids. Arterioscler Thromb Vasc Biol, 38(4), 801-815.
  58. Campbell RA, Franks Z, Bhatnagar A, Rowley JW, Manne BK, Supiano MA, Schwertz H, Weyrich AS, Rondina MT (2018). Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging. J Immunol, 200(1), 295-304.
  59. Davizon-Castillo P, Aguila, S, Higa K, Ashworth K, Hernandez G, Bark D, Campbell RA, Rondina MT, DeGregori J, Pietras E, Di Paola J (2017). TNF-α is an Important Factor for Platelet Hyperreactivity in Aging. XXVIII Congress of the International Society on Thrombosis and Haemostasis, Berlin.
  60. Campbell RA, Manne BK, Saperstein S, Schwertz H, Rowley JW, Weyrich AS, Rondina MT (2017). Interferon-induced Transmembrane 3 (IFITM3) on Megakaryocytes and Platelets Regulates Fibrinogen Endocytosis and Thrombosis During Inflammation. XXVIII Congress of the International Society on Thrombosis and Haemostasis, Berlin.
  61. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED (2017). Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep, 21(6), 1705.
  62. Campbell RA, Vieira-de-Abreu A, Rowley JW, Franks ZG, Manne BK, Rondina MT, Kraiss LW, Majersik JJ, Zimmerman GA, Weyrich AS (2017). Clots Are Potent Triggers of Inflammatory Cell Gene Expression: Indications for Timely Fibrinolysis. Arterioscler Thromb Vasc Biol, 37(10), 1819-1827.
  63. Tugolukova EM, Campbell RA, Hoerger KB, Schwertz H, Weyrich AS, Rowley JW (2017). Mitochondrial Fission Protein Drp1 Regulates Megakaryocyte and Platelet Mitochondrial Morphology, Platelet Numbers, and Platelet Function. 59th American Hematology Society Annual Meeting, Atlanta.
  64. Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED (2017). Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol, 37(9), 1628-1639.
  65. Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W (2017). Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood Adv, 1(18), 1398-1408.
  66. Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W (2017). Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood Adv, 1(18), 1398-1408.
  67. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED (2017). Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep, 20(4), 881-894.
  68. Campbell RA, Smith TL, Vieira-de-Abreu A, Franks Z, Rowley JW, Majersik JJ, Rondina MT, Kraiss LW, Zimmerman GA, Weyrich AS (2017). Timely Fibrinolysis Blunts Cytokines Synthesized by Monocytes Embedded within Clots. International Stroke Conference, Houston.
  69. Rowley JW, Campbell RA, Schwertz H, Weyrich AS, Tolly ND, Voora D, Rondina MT (2017). Transcript Expression, Intron Retention, and RNA Editing Are Conserved in Human Platelets over a 4 Year Period. 59th American Hematology Society Annual Meeting, Atlanta.
  70. Campbell RA, Bhatnagar A, Franks Z, Rowley JW, Manne BK, Supiano MA, Weyrich AS, Rondina MT (2017). Granzyme A in Human Platelets Regulates Pro-Inflammatory Gene Synthesis in Aging. XXVIII Congress of the International Society on Thrombosis and Haemostasis, Berlin.
  71. Campbell RA, Cody M, Yost CC (2017). Placental HTRA1 protease cleaves alpha-1-antitrypsin and generates neonatal NET-Inhibitory Factor. Pediatric American Society, San Francisco.
  72. Davizon-Castillo P, Jones KL, Aguila S, Bark D, Ashworth KJ, Higa K, Pietras EM, Campbell RA, Shi LC, Saunders N, DeGregori J, Rondina MT, DiPaola J (2017). Aging-Associated Inflammation Due to Elevated Levels of TNF-α Increases Activation of the Integrin αIIbβ3 and the Procoagulant Potential of Platelets. American Hematology Society Annual Meeting, Atlanta.
  73. Meidel ZM, Robinson R, Vieira-de-Abreu A, Gormley AJ, Ghandehari H, Grainger D, Campbell RA (2017). RGDfk-coated gold nanorods bind only to activated platelets. J Biomed Mater Res A, 105(1), 209-21.
  74. Nance D, Campbell RA, Rowley JW, Downie JM, Jorde LB, Kahr WH, Mereby SA, Tolley ND, Zimmerman GA, Weyrich AS, Rondina MT (2016). Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants. J Thromb Haemost, 14(11), 2230-2240.
  75. Nance D, Campbell RA, Rowley JW, Downie JM, Jorde LB, Kahr WH, Mereby SA, Tolley ND, Zimmerman GA, Weyrich AS, Rondina MT (2016). Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants. J Thromb Haemost, 14(11), 2230-2240.
  76. Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman GA (2016). Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. J Clin Invest, 126(10), 3783-3798.
  77. Manne BK, Badolia R, Campbell RA, Kunapuli SP, Weyrich AS, Rondina MT (2016). Inhibition of MAP Kinase-Interacting Kinase-1 (Mnk1) Regulates Platelet Functional and Protein Synthesis in Megakaryocytes. 58th Annual American Society for Hematology Meeting, San Diego.
  78. de Azevedo-Quintanilha IG, Vieira-de-Abreu A, Ferreira AC, Nascimento DO, Siqueira AM, Campbell RA, Teixeira Ferreira TP, Gutierrez TM, Ribeiro GM, E Silva PM, Carvalho AR, Bozza PT, Zimmerman GA, Castro-Faria-Neto HC (2016). Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS). Malar J, 15(1), 393.
  79. Rowley JW, Chappaz S, Corduan A, Chong MM, Campbell R, Khoury A, Manne BK, Wurtzel JG, Michael JV, Goldfinger LE, Mumaw MM, Nieman MT, Kile BT, Provost P, Weyrich AS (2016). Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood, 127(14), 1743-51.
  80. Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE Jr (2016). Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood, 127(11), 1468-80.
  81. Staddon JH, Smock KJ, Schiffman JD, Fluchel MN, Engel ME, Weyrich AS, Campbell RA (2015). Pegasparaginase treatment alters thrombin generation by modulating the protein C and S system in acute lymphoblastic leukaemia/lymphoma. Blood Coagul Fibrinolysis, 26(7), 840-3.
  82. Fidler TP, Middleton E, Rowley JW, Boudreau L, Campbell RA, Souvenir R, Funari T, Boilard E, Weyrich AS, Abel ED (2015). Platelet specific knockout of glucose transporter 3 leads to altered metabolism and decreased platelet activation. Arteriosclerosis, Thrombosis, and Vascular Biology, San Francisco.
  83. Stefanini L, Paul DS, Robledo RF, Chan ER, Getz TM, Campbell RA, Kechele DO, Casari C, Piatt R, Caron KM, Mackman N, Weyrich AS, Parrott MC, Boulaftali Y, Adams MD, Peters LL, Bergmeier W (2015). RASA3 is a critical inhibitor of RAP1-dependent platelet activation. J Clin Invest, 125(4), 1419-32.
  84. Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE Jr, Christensen H, Kahr WH, Li DY, Weyrich AS (2014). Proteasome function is required for platelet production. J Clin Invest, 124(9), 3757-66.
  85. Major HD, Campbell RA, Silver RM, Branch DW, Weyrich AS (2014). Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia. Am J Obstet Gynecol, 210(6), 547.e1-7.
  86. Fidler TP, Middleton E, Rowley JW, Boudreau L, Campbell RA, Souvenir R, Funari T, Boilard E, Weyrich AS, Abel ED (2014). Platelet specific knockout of glucose transporter 3 alters metabolism, reduces platelet activation in vitro and in vivo. Midwest Platelet Meeting, Chicago.
  87. Schmid DI, Schwertz H, Jiang H, Campbell RA, Weyrich AS, McIntyre TM, Zimmerman GA, Kraiss LW (2013). Translational control of JunB, an AP-1 transcription factor, in activated human endothelial cells. J Cell Biochem, 114(7), 1519-28.
  88. Franks Z, Campbell RA, Vieira de Abreu A, Holloway JT, Marvin JE, Kraemer BF, Zimmerman GA, Weyrich AS, Rondina MT (2013). Methicillin-resistant Staphylococcus aureus-induced thrombo-inflammatory response is reduced with timely antibiotic administration. Thromb Haemost, 109(4), 684-95.
  89. Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich AS (2012). Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood, 120(25), 5014-20.
  90. Jones CF, Campbell RA, Brooks AE, Assemi S, Tadjiki S, Thiagarajan G, Mulcock C, Weyrich AS, Brooks BD, Ghandehari H, Grainger DW (2012). Cationic PAMAM dendrimers aggressively initiate blood clot formation. ACS Nano, 6(11), 9900-10.
  91. Marchi R, Walton BL, McGary CS, Lin FC, Ma AD, Pawlinski R, Mackman N, Campbell RA, Di Paola J, Wolberg AS (2012). Dysregulated coagulation associated with hypofibrinogenaemia and plasma hypercoagulability: implications for identifying coagulopathic mechanisms in humans. Thromb Haemost, 108(3), 516-26.
  92. Jones CF, Campbell RA, Franks Z, Gibson CC, Thiagarajan G, Vieira-de-Abreu A, Sukavaneshvar S, Mohammad SF, Li DY, Ghandehari H, Weyrich AS, Brooks BD, Grainger DW (2012). Cationic PAMAM dendrimers disrupt key platelet functions. Mol Pharm, 9(6), 1599-611.
  93. Jones CF, Campbell RA, Franks Z, Gibson CC, Thiagarajan G, Vieira-de-Abreu A, Sukavaneshvar S, Mohammad SF, Li DY, Ghandehari H, Weyrich AS, Brooks BD, Grainger DW (2012). Cationic PAMAM dendrimers disrupt key platelet functions. Mol Pharm, 9(6), 1599-611.
  94. Schwertz H, Rowley JW, Tolley ND, Campbell RA, Weyrich AS (2012). Assessing protein synthesis by platelets. Methods Mol Biol, 788, 141-53.
  95. Schwertz H, Rowley JW, Tolley ND, Campbell RA, Weyrich AS (2012). Assessing protein synthesis by platelets. Methods Mol Biol, 788, 141-53.
  96. Vieira-de-Abreu A, Campbell RA, Weyrich AS, Zimmerman GA (2012). Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. [Review]. Semin Immunopathol, 34(1), 5-30.
  97. Gray LD, Hussey MA, Larson BM, Machlus KR, Campbell RA, Koch G, Ezban M, Hedner U, Wolberg AS (2011). Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma. Thromb Res, 128(6), 570-6.
  98. Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS (2011). Novel anti-bacterial activities of beta-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog, 7(11), e1002355.
  99. Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, Grissom CK, Weyrich AS, Zimmerman GA (2011). The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. J Thromb Haemost, 9(4), 748-58.
  100. Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, Grissom CK, Weyrich AS, Zimmerman GA (2011). The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. J Thromb Haemost, 9(4), 748-58.
  101. Campbell RA, Tolley ND, Schwertz H, Weyrich AS (2011). Platelet protein synthesis and translational control. Curr Proteomics, 8(3), 200-7.
  102. Franks ZG, Campbell RA, Zimmerman GA, Weyrich AS, Rondina MT (2011). Methicillin-resistant Staphylococcus aureus induces in vitro platelet activation and a procoagulant response. The American College of CHEST physicians, Honolulu.
  103. Campbell RA, Aleman M, Gray LD, Falvo MR, Wolberg AS (2010). Flow profoundly influences fibrin network structure: implications for fibrin formation and clot stability in haemostasis. [Letter to the editor]. Thromb Haemost, 104(6), 1281-4.
  104. Franks ZG, Campbell RA, Weyrich AS, Rondina MT (2010). Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke. [Review]. Ann N Y Acad Sci, 1207, 11-7.
  105. Carter JC, Campbell RA, Gibbons JA, Gramling MW, Wolberg AS, Church FC (2010). Enhanced cell-associated plasminogen activator pathway but not coagulation pathway activity contributes to motility in metastatic breast cancer cells. J Thromb Haemost, 8(6), 1323-32.
  106. Carter JC, Campbell RA, Gibbons JA, Gramling MW, Wolberg AS, Church FC (2010). Enhanced cell-associated plasminogen activator pathway but not coagulation pathway activity contributes to motility in metastatic breast cancer cells. J Thromb Haemost, 8(6), 1323-32.
  107. Campbell RA, Smith TL, Tolley NS, Weyrich AS (2010). Platelets Synthesize Functional Urokinase Plasminogen Activator Receptor. Gordon Research Seminar, Waterville Valley.
  108. Campbell RA, Machlus KR, Wolberg AS (2010). Smoking out the cause of thrombosis. Arterioscler Thromb Vasc Biol, 30(1), 7-8.
  109. Rowley JW, Weyrich AS, Campbell RA (2009). TGFBIp: more than meets the eye? Blood, 114(25), 5113-4.
  110. Campbell RA, Overmyer KA, Selzman CH, Sheridan BC, Wolberg AS (2009). Contributions of extravascular and intravascular cells to fibrin network formation, structure, and stability. Blood, 114(23), 4886-96.
  111. Campbell RA, Overmyer KA, Wolberg AS (2009). The Procoagulant Phenotype of the Cell Determines Fibrin Clot Structure. Arteriosclerosis, Thrombosis, and Vascular Biology, Washington, DC.
  112. Carter JC, Campbell RA, Gibbons JA, Wolberg AS, Church FC (2009). Enhanced Cell-Associated Fibrinolytic Pathway but Not Coagulation Pathway Activity Contributes to Motility in Metastatic Breast Cancer Cells. 49th Meeting of the American Society of Hematology, New Orleans.
  113. Campbell RA, Overmyer KA, Wolberg AS (2009). The Procoagulant Phenotype of the Cell Dictates Fibrin Clot Structure. XXII Congress of the International Society on Thrombosis and Haemostasis, Boston.
  114. Campbell RA, Overmyer KA, Bagnell CR, Wolberg AS (2008). Cellular procoagulant activity dictates clot structure and stability as a function of distance from the cell surface. Arterioscler Thromb Vasc Biol, 28(12), 2247-54.
  115. Wolberg AS, Campbell RA (2008). Thrombin generation, fibrin clot formation and hemostasis. [Review]. Transfus Apher Sci, 38(1), 15-23.
  116. Campbell RA, Fischer TH, Wolberg AS (2007). A novel approach to improving recombinant factor VIIa activity with a preserved platelet preparation. Br J Haematol, 138(1), 82-93.
  117. Allen GA, Persson E, Campbell RA, Ezban M, Hedner U, Wolberg AS (2007). A variant of recombinant factor VIIa with enhanced procoagulant and antifibrinolytic activities in an in vitro model of hemophilia. Arterioscler Thromb Vasc Biol, 27(3), 683-9.
  118. Campbell RA, Fischer TH, Wolberg AS (2006). A Novel Use of Rehydrated, Lyophilized Platelets Increases Recombinant Factor VIIa Procoagulant Activity in a Model of Hemophilia.Abstract #882, Poster presentation. 48th Meeting of the American Society of Hematology, Orlando, 108(11).
  119. Campbell RA, Fischer TH, Wolberg AS (2005). Reconstituted, Lyophilized Platelets Generate Thrombin in the Presence of Recombinant Factor VIIa. Abstract #4057, Poster Presentation. 47th Meeting of the American Society of Hematology Blood, Atlanta, 106(11).
  120. Campbell RA, Fischer TH, Wolberg AS (2005). Activity of Recombinant Factor FVIIa (rFVIIa) on Reconstituted, Lyophilized Platelets in an in-vitro Model of Hemophilia. 8th Novo Nordisk Symposium on Haemostasis Management, Copenhagen.