Adam Frost

Adam Frost, MD, PhD

Languages spoken: English

Academic Information

Departments Adjunct - Biochemistry

Lab

Adam Frost, MD, PhD, is an Assistant Professor in the Department of Biochemistry, and a member of the Cell Response and Regulation Program at the Huntsman Cancer Institute.

Frost studies the molecular and structural biology of membrane trafficking, with a special focus on the mechanisms that determine membrane shape and topology. His work with membrane-binding proteins has led him to focus recently on the mechanisms that govern the cell division cycle. Structural work in the Frost lab has led to direct, molecular scale views of the cell division machinery as it engages and reshapes cellular membranes. This approach has direct relevance to understanding many diseases, especially cancer. Several components of the cell division machinery have been implicated genetically in tumor formation, but until now there has been no direct method for studying their mechanisms of action.

Education History

Undergraduate Brigham Young University
 BS
Doctoral Training Yale University
 PhD
Professional Medical Yale University School of Medicine
 MD
Postdoctoral Fellowship University of California, San Francisco
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Mim C, Cui H, Gawronski-Salerno JA, Frost A, Lyman E, Voth GA, Unger V (2012). Structural basis of membrane bending by the N-BAR protein endophilin. Cell, 149(1), 137-45.
  2. Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman J (2012). Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell, 149(6), 1339-52.
  3. Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman J (2012). A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell, 151(5), 1042-54.
  4. Busath DD, Woodbury DJ, Frost (2012). Endosis and exosis: new names for fusion and budding. The Journal of membrane biology, 245(11), 759-60.
  5. Kalia R, Talledge N, Frost (2015). Structural and functional studies of membrane remodeling machines. Methods in cell biology, 128, 165-200.
  6. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw J (2013). Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proceedings of the National Academy of Sciences of the United States of America, 110(15), E1342-51.
  7. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost (2015). Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science (New York, N.Y.), 347(6217), 75-8.
  8. McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost (2015). Structure and membrane remodeling activity of ESCRT-III helical polymers. Science (New York, N.Y.), 350(6267), 1548-51.
  9. Frost (2011). Membrane trafficking: decoding vesicle identity with contrasting chemistries. Current biology, 21(19), R811-3.

Abstract

  1. Mim C, Gawronski-Salerno J, Unger VM, Frost (2012). Visualizing BAR-Dependent Membrane Remodeling. Microscopy and microanalysis, 18 Suppl 2, 44-5.