Kensaku Kawamoto

Kensaku Kawamoto, MD, PhD, MHS, FACMI, FAMIA

Languages spoken: English, Japanese

Academic Information

Departments Primary - Biomedical Informatics

Dr. Kensaku Kawamoto is the Dr. Helmuth F. Orthner Endowed Professor and Vice Chair of Clinical AI and Informatics for the University of Utah Department of Biomedical Informatics. He is also Associate Chief Medical Information Officer, Founding Director of the ReImagine EHR Initiative, and Co-Senior Director of the Digital Health Initiative for University of Utah Health. He is a Fellow of the American College of Medical Informatics and a Fellow of the American Medical Informatics Association. Dr. Kawamoto was recognized as a Top 25 Innovator in health care in 2019 by Modern Healthcare.

Dr. Kawamoto earned his B.A. in biochemical sciences from Harvard University, and he earned his M.D., Ph.D. in biomedical engineering with a focus on biomedical informatics, and M.H.S. in clinical research from Duke University. At the University of Utah, Dr. Kawamoto directs the University’s ReImagine EHR initiative, which is a multi-stakeholder enterprise initiative for improving health and health care through interoperable electronic health record (EHR) innovations (https://reimagineehr.utah.edu/). The ReImagine EHR initiative has developed a number of award-winning EHR add-on apps, including a neonatal bilirubin management app that won the 2019 American Medical Informatics Association (AMIA)/Health Level Seven International (HL7) FHIR Applications Showcase, a lung cancer screening shared decision making app that was a finalist in the 2020 AMIA/HL7 Showcase, and a Disease Manager application that won the 2021 AMIA/HL7 Showcase. The initiative has also helped to bring in over $60 million in external grants and contracts and leverages artificial intelligence (AI) to improve patient care at scale. Dr. Kawamoto is also the co-solution architect of the enterprise Value Driven Outcomes (VDO) framework for analyzing and improving care value

Beyond the University of Utah, Dr. Kawamoto was a 2-term member of the U.S. Health IT Advisory Committee (HITAC), which provides guidance to the U.S. Office of the National Coordinator for Health IT on policies, standards, implementation specifications, and certification criteria related to health information technology. In this capacity, he also co-chaired the federal Interoperability Standards Priorities Task Force, whose charge is to recommend priority uses of health IT and the associated standards and implementation specifications.
Dr. Kawamoto co-chairs the Clinical Decision Support Work Group of HL7, the primary standards development organization in health IT. He is also a past board member of HL7 and served as Initiative Coordinator for the U.S. Health eDecisions and Clinical Quality Framework initiatives for developing and validating interoperability standards for clinical decision support and clinical quality measurement. Dr. Kawamoto founded and directs OpenCDS (http://www.opencds.org), which is a multi-institutional initiative to enable advanced, standards-based, and open-source clinical decision support at scale. OpenCDS is used in all 50 states by over 40,000 healthcare facilities.

Dr. Kawamoto is a member of the Huntsman Cancer Institute Cancer Control and Population Science Program, and he is engaged in a number of projects aimed at cancer prevention. Dr. Kawamoto has been the PI or co-PI on various grants sponsored by the federal government and industry, including from the National Cancer Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Human Genome Research Institute, and the Agency for Healthcare Research and Quality. He is currently the Contact PI of the University of Utah node of the National Institutes of Health Genomics-Enabled Learning Health Systems Network (https://www.nih.gov/news-events/news-releases/nih-awards-27m-establish-new-network-genomics-enabled-learning-health-systems). Dr. Kawamoto is also the author or co-author of over 150 peer-reviewed journal articles and conference proceedings and 10 book chapters.

“I believe one of the greatest challenges facing our nation is how to provide high-quality health care at a cost affordable by society. It is truly gratifying to work with talented colleagues from across the University and beyond to address this grand challenge of our times, with clinical informatics serving as a core enabler for the types of fundamental changes required to realize the vision of high-quality, high-value health care.”

http://scholar.google.com/citations?user=pTliAH0AAAAJ

Education History

Undergraduate Harvard University
 BA
Professional Medical Duke University School of Medicine
 MD
Doctoral Training Duke University Graduate School
 PhD
Graduate Training Duke University Allied Health Graduate Program
 MHS

Selected Publications

Journal Article

  1. Kawamoto K, McDonald C (2020). Designing, Conducting, and Reporting Clinical Decision Support Studies: Recommendations and Call to Action. Annals of internal medicine, 172(11 Suppl), S101-S109.
  2. Zhang D, Sanchez-Fueyo A, Kawamoto K, Alexopoulos SP, Zhang W, Zheng X (2010). Th1 to Th2 immune deviation facilitates, but does not cause, islet allograft tolerance in mice. Cytokine, 51(3), 311-9.
  3. Stagg B, Mariottoni EB, Berchuck S, Jammal A, Elam AR, Hess R, Kawamoto K, Haaland B, Medeiros F (2021). Longitudinal visual field variability and the ability to detect glaucoma progression in black and white individuals. The British journal of ophthalmology, 106, 1115-1120.
  4. Edholm K, Lappé K, Kukhareva P, Hopkins C, Hatton ND, Gebhart B, Nyman H, Signor E, Davis M, Kawamoto K, Johnson S (2020). Reducing Diabetic Ketoacidosis Intensive Care Unit Admissions Through an Electronic Health Record-Driven, Standardized Care Pathway. Journal for healthcare quality, 42(5), e66-e74.
  5. Tarumi S, Takeuchi W, Chalkidis G, Rodriguez-Loya S, Kuwata J, Flynn M, Turner KM, Sakaguchi FH, Weir C, Kramer H, Shields DE, Warner PB, Kukhareva P, Ban H, Kawamoto (2021). Leveraging Artificial Intelligence to Improve Chronic Disease Care: Methods and Application to Pharmacotherapy Decision Support for Type-2 Diabetes Mellitus. Methods of information in medicine, 60(S 01), e32-e43.
  6. Stipelman CH, Smith ER, Diaz-Ochu M, Spackman J, Stoddard G, Kawamoto K, Shakib J (2019). Early-Onset Sepsis Risk Calculator Integration Into an Electronic Health Record in the Nursery. Pediatrics, 144(2),
  7. Metcalf RA, Goodfellow J, Cail K, Blaylock R, Kawamoto K, Enniss T, Galaviz C, Lim M, Reddy S, Sharma V, Wanner (2021). Electronic clinical decision support: Evidence that default settings influence end-user behavior. Transfusion, 61(3), 669-670.
  8. Drew RH, Kawamoto K, Adams M (2006). Information technology for optimizing the management of infectious diseases. American journal of health-system pharmacy, 63(10), 957-65.
  9. Ferranti JM, Musser RC, Kawamoto K, Hammond W (2006). The clinical document architecture and the continuity of care record: a critical analysis. Journal of the American Medical Informatics Association, 13(3), 245-52.
  10. Richesson RL, Staes CJ, Douthit BJ, Thoureen T, Hatch DJ, Kawamoto K, Del Fiol (2020). Measuring implementation feasibility of clinical decision support alerts for clinical practice recommendations. Journal of the American Medical Informatics Association, 27(4), 514-521.
  11. Curran RL, Kukhareva PV, Taft T, Weir CR, Reese TJ, Nanjo C, Rodriguez-Loya S, Martin DK, Warner PB, Shields DE, Flynn MC, Boltax JP, Kawamoto (2020). Integrated displays to improve chronic disease management in ambulatory care: A SMART on FHIR application informed by mixed-methods user testing. Journal of the American Medical Informatics Association, 27(8), 1225-1234.
  12. Reese TJ, Del Fiol G, Tonna JE, Kawamoto K, Segall N, Weir C, Macpherson BC, Kukhareva P, Wright M (2020). Impact of integrated graphical display on expert and novice diagnostic performance in critical care. Journal of the American Medical Informatics Association, 27(8), 1287-1292.
  13. Reese TJ, Segall N, Del Fiol G, Tonna JE, Kawamoto K, Weir C, Wright M (2020). Iterative heuristic design of temporal graphic displays with clinical domain experts. Journal of clinical monitoring and computing, 35(5), 1119-1131.
  14. Welch BM, Eilbeck K, Del Fiol G, Meyer LJ, Kawamoto (2014). Technical desiderata for the integration of genomic data with clinical decision support. Journal of biomedical informatics, 51, 3-7.
  15. Morid MA, Sheng ORL, Kawamoto K, Abdelrahman (2020). Learning hidden patterns from patient multivariate time series data using convolutional neural networks: A case study of healthcare cost prediction. Journal of biomedical informatics, 111, 103565.
  16. Karhade AV, Schwab JH, Del Fiol G, Kawamoto (2020). SMART on FHIR in spine: integrating clinical prediction models into electronic health records for precision medicine at the point of care. The spine journal, 21(10), 1649-1651.
  17. Fernandez ME, Schlechter CR, Del Fiol G, Gibson B, Kawamoto K, Siaperas T, Pruhs A, Greene T, Nahum-Shani I, Schulthies S, Nelson M, Bohner C, Kramer H, Borbolla D, Austin S, Weir C, Walker TW, Lam CY, Wetter D (2020). QuitSMART Utah: an implementation study protocol for a cluster-randomized, multi-level Sequential Multiple Assignment Randomized Trial to increase Reach and Impact of tobacco cessation treatment in Community Health Centers. Implementation science, 15(1), 9.
  18. Bahr TM, Shakib JH, Stipelman CH, Kawamoto K, Cail K, Lauer S, Christensen R (2020). Improving the Bilirubin Management Program in the Newborn Nursery: Background, Aims, and Protocol. Neonatology, 117(3), 358-364.
  19. Norton JM, Ali K, Jurkovitz CT, Kiryluk K, Park M, Kawamoto K, Shang N, Navaneethan SD, Narva AS, Drawz (2019). Development and Validation of a Pragmatic Electronic Phenotype for CKD. Clinical journal of the American Society of Nephrology, 14(9), 1306-1314.
  20. Oswald N, Lin T, Haaland B, Flynn M, Kawamoto K, Cooney KA, Lowrance W, Hanson HA, O'Neil (2020). Factors associated with appropriate and low-value PSA testing. Cancer epidemiology, 66, 101724.
  21. Stagg BC, Gupta D, Ehrlich JR, Newman-Casey PA, Stein JD, Kawamoto K, Hess (2020). Evaluation for Disparities in Experience With Internet-Based Health Care Among US Patients With Chronic Eye Diseases. JAMA ophthalmology, 138(10), 1097-1099.
  22. Welch BM, Loya SR, Eilbeck K, Kawamoto (2014). A proposed clinical decision support architecture capable of supporting whole genome sequence information. Journal of personalized medicine, 4(2), 176-99.
  23. Marcial LH, Richardson JE, Lasater B, Middleton B, Osheroff JA, Kawamoto K, Ancker JS, van Leeuwen D, Lomotan EA, Al-Showk S, Blumenfeld B (2018). The Imperative for Patient-Centered Clinical Decision Support. EGEMS (Washington, DC), 6(1), 12.
  24. Ciarkowski CE, Timbrook TT, Kukhareva PV, Edholm KM, Hatton ND, Hopkins CL, Thomas F, Sanford MN, Igumnova E, Benefield RJ, Kawamoto K, Spivak E (2020). A Pathway for Community-Acquired Pneumonia With Rapid Conversion to Oral Therapy Improves Health Care Value. Open forum infectious diseases, 7(11), ofaa497.
  25. Del Fiol G, Kohlmann W, Bradshaw RL, Weir CR, Flynn M, Hess R, Schiffman JD, Nanjo C, Kawamoto (2020). Standards-Based Clinical Decision Support Platform to Manage Patients Who Meet Guideline-Based Criteria for Genetic Evaluation of Familial Cancer. JCO clinical cancer informatics, 4, 1-9.
  26. Hanauer DA, Barnholtz-Sloan JS, Beno MF, Del Fiol G, Durbin EB, Gologorskaya O, Harris D, Harnett B, Kawamoto K, May B, Meeks E, Pfaff E, Weiss J, Zheng (2020). Electronic Medical Record Search Engine (EMERSE): An Information Retrieval Tool for Supporting Cancer Research. JCO clinical cancer informatics, 4, 454-463.
  27. Stagg B, Stein JD, Medeiros FA, Cummins M, Kawamoto K, Hess (2021). Interests and needs of eye care providers in clinical decision support for glaucoma. BMJ open ophthalmology, 6(1), e000639.
  28. Kawamoto K, Kukhareva P, Shakib JH, Kramer H, Rodriguez S, Warner PB, Shields D, Weir C, Del Fiol G, Taft T, Stipelman C (2019). Association of an Electronic Health Record Add-on App for Neonatal Bilirubin Management With Physician Efficiency and Care Quality. JAMA network open, 2(11), e1915343.
  29. Reese TJ, Schlechter CR, Potter LN, Kawamoto K, Del Fiol G, Lam CY, Wetter D (2021). Evaluation of Revised US Preventive Services Task Force Lung Cancer Screening Guideline Among Women and Racial/Ethnic Minority Populations. JAMA network open, 4(1), e2033769.
  30. Stagg BC, Gupta D, Ehrlich JR, Newman-Casey PA, Stein JD, Kawamoto K, Hess (2021). The Use of eHealth Practices by United States Patients with Self-Reported Glaucoma. Ophthalmology. Glaucoma, 4(1), 71-77.
  31. Horton DJ, Graves KK, Kukhareva PV, Johnson SA, Cedillo M, Sanford M, Dunson WA Jr, White M, Roach D, Arego JJ, Kawamoto (2020). Modified early warning score-based clinical decision support: cost impact and clinical outcomes in sepsis. JAMIA open, 3(2), 261-268.
  32. Willis C, Watanabe AH, Hughes J, Nolen K, O'Meara J, Schepart A, Bruno M, Biskupiak J, Kawamoto K, Shara N, Kannampallil (2022). Applying diagnosis support systems in electronic health records to identify wild-type transthyretin amyloid cardiomyopathy risk. Future cardiology, 18, 367-376.
  33. Tarumi S, Takeuchi W, Qi R, Ning X, Ruppert L, Ban H, Robertson DH, Schleyer TK, Kawamoto (2022). Predicting pharmacotherapeutic outcomes for type 2 diabetes: An evaluation of three approaches to leveraging electronic health record data from multiple sources. Journal of biomedical informatics, 129, 104001.
  34. Liu S, Kawamoto K, Del Fiol G, Weir C, Malone DC, Reese TJ, Morgan K, ElHalta D, Abdelrahman (2022). The potential for leveraging machine learning to filter medication alerts. Journal of the American Medical Informatics Association, 29, 891-899.
  35. Chavez-Yenter D, Kimball KE, Kohlmann W, Lorenz Chambers R, Bradshaw RL, Espinel WF, Flynn M, Gammon A, Goldberg E, Hagerty KJ, Hess R, Kessler C, Monahan R, Temares D, Tobik K, Mann DM, Kawamoto K, Del Fiol G, Buys SS, Ginsburg O, Kaphingst K (2021). Patient Interactions With an Automated Conversational Agent Delivering Pretest Genetics Education: Descriptive Study. Journal of medical Internet research, 23(11), e29447.
  36. Bahr TM, Shakib JH, Stipelman CH, Kawamoto K, Lauer S, Christensen R (2021). Improvement Initiative: End-Tidal Carbon Monoxide Measurement in Newborns Receiving Phototherapy. The Journal of pediatrics, 238, 168-173.e2.
  37. Reese TJ, Del Fiol G, Morgan K, Hurwitz JT, Kawamoto K, Gomez-Lumbreras A, Brown ML, Thiess H, Vazquez SR, Nelson SD, Boyce R, Malone (2021). A Shared Decision-making Tool for Drug Interactions Between Warfarin and Nonsteroidal Anti-inflammatory Drugs: Design and Usability Study. JMIR human factors, 8(4), e28618.
  38. Schlechter CR, Del Fiol G, Lam CY, Fernandez ME, Greene T, Yack M, Schulthies S, Nelson M, Bohner C, Pruhs A, Siaperas T, Kawamoto K, Gibson B, Nahum-Shani I, Walker TJ, Wetter D (2021). Application of community - engaged dissemination and implementation science to improve health equity. Preventive medicine reports, 24, 101620.
  39. Liu S, Reese TJ, Kawamoto K, Del Fiol G, Weir (2021). A theory-based meta-regression of factors influencing clinical decision support adoption and implementation. Journal of the American Medical Informatics Association, 28(11), 2514-2522.
  40. Hunt TC, Ambrose JP, Haaland B, Kawamoto K, Dechet CB, Lowrance WT, Hanson HA, O'Neil B (2021). Decision fatigue in low-value prostate cancer screening. Cancer, 127(18), 3343-3353.
  41. Reese TJ, Schlechter CR, Kramer H, Kukhareva P, Weir CR, Del Fiol G, Caverly T, Hess R, Flynn MC, Taft T, Kawamoto (2021). Implementing lung cancer screening in primary care: needs assessment and implementation strategy design. Translational behavioral medicine, 12, 187-197.
  42. Kawamoto K, Kukhareva PV, Weir C, Flynn MC, Nanjo CJ, Martin DK, Warner PB, Shields DE, Rodriguez-Loya S, Bradshaw RL, Cornia RC, Reese TJ, Kramer HS, Taft T, Curran RL, Morgan KL, Borbolla D, Hightower M, Turnbull WJ, Strong MB, Chapman WW, Gregory T, Stipelman CH, Shakib JH, Hess R, Boltax JP, Habboushe JP, Sakaguchi F, Turner KM, Narus SP, Tarumi S, Takeuchi W, Ban H, Wetter DW, Lam C, Caverly TJ, Fagerlin A, Norlin C, Malone DC, Kaphingst KA, Kohlmann WK, Brooke BS, Del Fiol (2021). Establishing a multidisciplinary initiative for interoperable electronic health record innovations at an academic medical center. JAMIA open, 4(3), ooab041.
  43. Kaphingst KA, Kohlmann W, Chambers RL, Goodman MS, Bradshaw R, Chan PA, Chavez-Yenter D, Colonna SV, Espinel WF, Everett JN, Gammon A, Goldberg ER, Gonzalez J, Hagerty KJ, Hess R, Kehoe K, Kessler C, Kimball KE, Loomis S, Martinez TR, Monahan R, Schiffman JD, Temares D, Tobik K, Wetter DW, Mann DM, Kawamoto K, Del Fiol G, Buys SS, Ginsburg O, BRIDGE research team (2021). Comparing models of delivery for cancer genetics services among patients receiving primary care who meet criteria for genetic evaluation in two healthcare systems: BRIDGE randomized controlled trial. BMC health services research, 21(1), 542.
  44. Taber P, Ghani P, Schiffman JD, Kohlmann W, Hess R, Chidambaram V, Kawamoto K, Waller RG, Borbolla D, Del Fiol G, Weir (2020). Physicians' strategies for using family history data: having the data is not the same as using the data. JAMIA open, 3(3), 378-385.
  45. Morgan KL, Kukhareva PV, Warner PB, Wilkof J, Snyder M, Horton D, Madsen T, Habboushe J, Kawamoto (2022). Using CDS Hooks to increase SMART on FHIR app utilization: a cluster-randomized trial. Journal of the American Medical Informatics Association, 29(9), 1461-1470.
  46. Stagg BC, Stein JD, Medeiros FA, Horns J, Hartnett ME, Kawamoto K, Hess (2022). The frequency of visual field testing in a US nationwide cohort of individuals with open angle glaucoma. Ophthalmology. Glaucoma, 5(6), 587-593.
  47. Wiley K, Findley L, Goldrich M, Rakhra-Burris TK, Stevens A, Williams P, Bult CJ, Chisholm R, Deverka P, Ginsburg GS, Green ED, Jarvik G, Mensah GA, Ramos E, Relling MV, Roden DM, Rowley R, Alterovitz G, Aronson S, Bastarache L, Cimino JJ, Crowgey EL, Del Fiol G, Freimuth RR, Hoffman MA, Jeff J, Johnson K, Kawamoto K, Madhavan S, Mendonca EA, Ohno-Machado L, Pratap S, Taylor CO, Ritchie MD, Walton N, Weng C, Zayas-Cabán T, Manolio TA, Williams M (2022). A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources. Journal of the American Medical Informatics Association, 29, 1342-1349.
  48. Bradshaw RL, Kawamoto K, Kaphingst KA, Kohlmann WK, Hess R, Flynn MC, Nanjo CJ, Warner PB, Shi J, Morgan K, Kimball K, Ranade-Kharkar P, Ginsburg O, Goodman M, Chambers R, Mann D, Narus SP, Gonzalez J, Loomis S, Chan P, Monahan R, Borsato EP, Shields DE, Martin DK, Kessler CM, Del Fiol (2022). GARDE: a standards-based clinical decision support platform for identifying population health management cohorts. Journal of the American Medical Informatics Association, 29(5), 928-936.
  49. Kukhareva PV, Caverly TJ, Li H, Katki HA, Cheung LC, Reese TJ, Del Fiol G, Hess R, Wetter DW, Zhang Y, Taft TY, Flynn MC, Kawamoto (2022). Inaccuracies in electronic health records smoking data and a potential approach to address resulting underestimation in determining lung cancer screening eligibility. Journal of the American Medical Informatics Association, 29(5), 779-788.
  50. Thiess H, Del Fiol G, Malone DC, Cornia R, Sibilla M, Rhodes B, Boyce RD, Kawamoto K, Reese (2022). Coordinated use of Health Level 7 standards to support clinical decision support: Case study with shared decision making and drug-drug interactions. International journal of medical informatics, 162, 104749.
  51. Kukhareva PV, Weir C, Del Fiol G, Aarons GA, Taft TY, Schlechter CR, Reese TJ, Curran RL, Nanjo C, Borbolla D, Staes CJ, Morgan KL, Kramer HS, Stipelman CH, Shakib JH, Flynn MC, Kawamoto (2022). Evaluation in Life Cycle of Information Technology (ELICIT) framework: Supporting the innovation life cycle from business case assessment to summative evaluation. Journal of biomedical informatics, 127, 104014.
  52. Reese T, Wright A, Liu S, Boyce R, Romero A, Del Fiol G, Kawamoto K, Malone (2022). Improving the specificity of drug-drug interaction alerts: Can it be done?. American journal of health-system pharmacy, 79, 1086-1095.
  53. Kukhareva P, Caverly T, Kawamoto (2022). Re: Inaccuracies in electronic health records smoking data and a potential approach to address resulting underestimation in determining lung cancer screening eligibility. Journal of the American Medical Informatics Association, 29(9), 1655.
  54. Lario R, Kawamoto K, Sottara D, Eilbeck K, Huff S, Del Fiol G, Soley R, Middleton (2022). A method for structuring complex clinical knowledge and its representational formalisms to support composite knowledge interoperability in healthcare. Journal of biomedical informatics, 137, 104251.
  55. Gomez Lumbreras A, Reese TJ, Del Fiol G, Tan MS, Butler JM, Hurwitz JT, Brown M, Kawamoto K, Thiess H, Wright M, Malone D (2022). Shared Decision-Making for Drug-Drug Interactions: Formative Evaluation of an Anticoagulant Drug Interaction. JMIR formative research, 6(10), e40018.
  56. Chavez-Yenter D, Goodman MS, Chen Y, Chu X, Bradshaw RL, Lorenz Chambers R, Chan PA, Daly BM, Flynn M, Gammon A, Hess R, Kessler C, Kohlmann WK, Mann DM, Monahan R, Peel S, Kawamoto K, Del Fiol G, Sigireddi M, Buys SS, Ginsburg O, Kaphingst K (2022). Association of Disparities in Family History and Family Cancer History in the Electronic Health Record With Sex, Race, Hispanic or Latino Ethnicity, and Language Preference in 2 Large US Health Care Systems. JAMA network open, 5(10), e2234574.
  57. Shi J, Morgan KL, Bradshaw RL, Jung SH, Kohlmann W, Kaphingst KA, Kawamoto K, Fiol G (2022). Identifying Patients Who Meet Criteria for Genetic Testing of Hereditary Cancers Based on Structured and Unstructured Family Health History Data in the Electronic Health Record: Natural Language Processing Approach. JMIR medical informatics, 10(8), e37842.
  58. Stagg BC, Tullis B, Asare A, Stein JD, Medeiros FA, Weir C, Borbolla D, Hess R, Kawamoto (2023). Systematic User-centered Design of a Prototype Clinical Decision Support System for Glaucoma. Ophthalmology science, 3(3), 100279.
  59. Liebermann E, Taber P, Vega AS, Daly BM, Goodman MS, Bradshaw R, Chan PA, Chavez-Yenter D, Hess R, Kessler C, Kohlmann W, Low S, Monahan R, Kawamoto K, Del Fiol G, Buys SS, Sigireddi M, Ginsburg O, Kaphingst K (2022). Barriers to family history collection among Spanish-speaking primary care patients: a BRIDGE qualitative study. PEC innovation, 1,
  60. Kukhareva PV, Li H, Caverly TJ, Del Fiol G, Fagerlin A, Butler JM, Hess R, Zhang Y, Taft T, Flynn MC, Reddy C, Martin DK, Warner IA, Rodriguez-Loya S, Warner PB, Kawamoto (2023). Implementation of Lung Cancer Screening in Primary Care and Pulmonary Clinics: Pragmatic Clinical Trial of Electronic Health Record-Integrated Everyday Shared Decision-Making Tool and Clinician-Facing Prompts. Chest, 164(5), 1325-1338.
  61. Schlechter CR, Reese TJ, Wirth J, Gibson B, Kawamoto K, Siaperas T, Pruhs A, Dinkins CP, Zhang Y, Friedrichs M, George S, Lam CY, Pierce JH, Borsato EP, Cornia RC, Stevens L, Martinez A, Bradshaw RL, Kaphingst KA, Hess R, Del Fiol G, Wetter D (2023). Rapid-cycle designs to adapt interventions for COVID-19 in safety-net healthcare systems. Translational behavioral medicine, 13(6), 389-399.
  62. Staes CJ, Beck AC, Chalkidis G, Scheese CH, Taft T, Guo JW, Newman MG, Kawamoto K, Sloss EA, McPherson J (2023). Design of an interface to communicate artificial intelligence-based prognosis for patients with advanced solid tumors: a user-centered approach. Journal of the American Medical Informatics Association, 31(1), 174-187.
  63. Bradshaw RL, Kawamoto K, Bather JR, Goodman MS, Kohlmann WK, Chavez-Yenter D, Volkmar M, Monahan R, Kaphingst KA, Del Fiol (2023). Enhanced family history-based algorithms increase the identification of individuals meeting criteria for genetic testing of hereditary cancer syndromes but would not reduce disparities on their own. Journal of biomedical informatics, 149, 104568.
  64. Stevens ER, Caverly T, Butler JM, Kukhareva P, Richardson S, Mann DM, Kawamoto (2023). Considerations for using predictive models that include race as an input variable: The case study of lung cancer screening. Journal of biomedical informatics, 147, 104525.
  65. Landy R, Gomez I, Caverly TJ, Kawamoto K, Rivera MP, Robbins HA, Young CD, Chaturvedi AK, Cheung LC, Katki H (2023). Methods for Using Race and Ethnicity in Prediction Models for Lung Cancer Screening Eligibility. JAMA network open, 6(9), e2331155.
  66. Johnson D, Del Fiol G, Kawamoto K, Romagnoli KM, Sanders N, Isaacson G, Jenkins E, Williams M (2024). Genetically guided precision medicine clinical decision support tools: a systematic review. Journal of the American Medical Informatics Association, 31(5), 1183-1194.
  67. Lario R, Soley R, White S, Butler J, Del Fiol G, Eilbeck K, Huff S, Kawamoto (2024). The Business Process Management for Healthcare (BPM+ Health) Consortium: motivation, methodology, and deliverables for enabling clinical knowledge interoperability (CKI). Journal of the American Medical Informatics Association, 31(4), 797-808.
  68. Conroy MB, Cedillo M, Jordanova K, Zepeda J, Kiraly B, Flynn M, Wu C, Kukhareva PV, Butler JM, Hess R, Greene T, Kawamoto (2024). Implementing weight maintenance with existing staff and electronic health record tools in a primary care setting: Baseline results from the MAINTAIN PRIME trial. Contemporary clinical trials, 141, 107520.
  69. Lukyanchikov N, Kawamoto (2024). Evaluation of Discrepancies Among National Library of Medicine (NLM) Value Set Authority Center (VSAC) ICD-10-CM Value Sets: Case Study for Diagnoses of Common Chronic Conditions, Implications, and Potential Solutions. AMIA ... Annual Symposium proceedings. AMIA Symposium, 2023, 1087-1095.
  70. Balbin CA, Kawamoto (2024). The SIMPLE Architectural Pattern for Integrating Patient-Facing Apps into Clinical Workflows: Desiderata and Application for Lung Cancer Screening. AMIA ... Annual Symposium proceedings. AMIA Symposium, 2023, 844-853.
  71. Cedillo M, Zepeda J, Kiraly B, Flynn M, Larios Elizalde P, Zheutlin E, Rudd EA, Kukhareva PV, Butler JM, Hess R, Kawamoto K, Estabrooks P, Conroy M (2024). Scalable and successful patient portal lifestyle coaching training for primary care clinical staff. Translational behavioral medicine, 14(11), 661-672.
  72. Kukhareva PV, Facelli JC, O'Brien MJ, Gouripeddi R, Kawamoto K, Zhang Y, Reddy D, Malone D (2024). Racial and Ethnic Disparities in Prescribing of GLP-1 Receptor Agonists in the United States: A Retrospective Cohort Analysis.
  73. Schlechter CR, Kuzmenko TV, Orleans B, Wirth J, Kaphingst KA, Gibson B, Kawamoto K, Siaperas T, Pruhs A, Dinkins CP, Greene T, Zhang Y, Chipman JJ, Friedrichs M, Lam CY, Pierce JH, Borsato EP, Cornia RC, Stevens L, Martinez A, Bradshaw RL, Hess R, Fiol GD, Wetter D (2024). Reach and Engagement With Population Health Management Interventions to Address COVID-19 Among Safety-Net Health Care Systems. American journal of public health, 114(11), 1207-1211.
  74. Kaphingst KA, Kohlmann WK, Lorenz Chambers R, Bather JR, Goodman MS, Bradshaw RL, Chavez-Yenter D, Colonna SV, Espinel WF, Everett JN, Flynn M, Gammon A, Harris A, Hess R, Kaiser-Jackson L, Lee S, Monahan R, Schiffman JD, Volkmar M, Wetter DW, Zhong L, Mann DM, Ginsburg O, Sigireddi M, Kawamoto K, Del Fiol G, Buys S (2024). Uptake of Cancer Genetic Services for Chatbot vs Standard-of-Care Delivery Models: The BRIDGE Randomized Clinical Trial. JAMA network open, 7(9), e2432143.
  75. Tiase VL, Richards G, Taft T, Stevens L, Balbin C, Kaphingst KA, Fagerlin A, Caverly T, Kukhareva P, Flynn M, Butler JM, Kawamoto (2024). Patient Perspectives on a Patient-Facing Tool for Lung Cancer Screening. Health expectations, 27(4), e14143.
  76. Kukhareva PV, Weir CR, Cedillo M, Taft T, Butler JM, Rudd EA, Zepeda J, Zheutlin E, Kiraly B, Flynn M, Conroy MB, Kawamoto (2024). Design and implementation of electronic health record-based tools to support a weight management program in primary care. JAMIA open, 7(2), ooae038.
  77. Kukhareva PV, Li H, Caverly TJ, Fagerlin A, Del Fiol G, Hess R, Zhang Y, Butler JM, Schlechter C, Flynn MC, Reddy C, Choi J, Balbin C, Warner IA, Warner PB, Nanjo C, Kawamoto (2024). Lung Cancer Screening Before and After a Multifaceted Electronic Health Record Intervention: A Nonrandomized Controlled Trial. JAMA network open, 7(6), e2415383.
  78. Finkelstein J, Cui W, Ferraro JP, Kawamoto (2024). Association of Diagnostic Discrepancy with Length of Stay and Mortality in Congestive Heart Failure Patients Admitted to the Emergency Department. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2024, 155-161.
  79. Harris A, Bather JR, Kawamoto K, Fiol GD, Bradshaw RL, Kaiser-Jackson L, Monahan R, Kohlmann W, Liu F, Ginsburg O, Goodman MS, Kaphingst K (2024). Determinants of Breast Cancer Screening Adherence During the COVID-19 Pandemic in a Cohort at Increased Inherited Cancer Risk in the United States. Cancer control, 31, 10732748241272727.
  80. Haaker TS, Choi JS, Nanjo CJ, Warner PB, Abu-Hanna A, Kawamoto (2025). Approaches for extracting daily dosage from free-text prescription signatures in heart failure with reduced ejection fraction: a comparative study. JAMIA open, 8(1), ooae153.
  81. Butler JM, Farrell TW, Puckett M, Nanjo C, Warner P, Shields D, Supiano MA, Kawamoto (2024). The Age-Friendly Learning Healthcare System: Replicating electronic health record based documentation metrics for 4Ms care. Journal of the American Geriatrics Society,
  82. Kukhareva PV, Li H, Balbin C, Stevens ER, Mann DM, Butler JM, Caverly TJ, Del Fiol G, Kaphingst KA, Schlechter CR, Tiase VL, Fagerlin A, Zhang Y, Hess R, Flynn MC, Reddy C, Martin D, Warner PB, Nanjo C, Choi J, Ngo-Metzger Q, Kawamoto (2025). Enhancement of Patient-Centered Lung Cancer Screening: The MyLungHealth Randomized Clinical Trial. JAMA oncology, 12(2), 167-176.
  83. Tiase VL, Fritz JM, Ferraro J, Bayles G, Alsaleem A, Del Fiol G, Kawamoto K, Brodke D, Martin B, Altizer (2025). Advancing Digital Access to Physical Therapy via Virtual and Extended Reality Technology: Prototype Development and Usability Evaluation. JMIR formative research, 9, e73783.
  84. Stagg BC, Brintz BJ, Stein JD, Hess R, Kawamoto K, Jammal AA, Medeiros F (2025). Time to Identify Glaucoma Progression Given Typical Visual Field Testing Frequencies in a US Nationwide Insured Population. Ophthalmology. Glaucoma,
  85. Harris A, Bather JR, Bradshaw RL, Kawamoto K, Del Fiol G, Kohlmann WK, Chavez-Yenter D, Monahan R, Chambers RL, Sigireddi M, Goodman MS, Kaphingst K (2025). Incomplete Family History and Meeting Algorithmic Criteria for Genetic Evaluation of Hereditary Cancer. JAMA network open, 8(10), e2539870.
  86. Kukhareva PV, O'Brien MJ, Malone DC, Kawamoto K, Gouripeddi R, Reddy D, Zhang M, Deshmukh VG, Danks D, Facelli J (2025). Documentation of social determinants of health for patients with type 2 diabetes in Epic Cosmos. JAMIA open, 8(5), ooaf095.
  87. Yi Y, Kaiser-Jackson L, Bather JR, Goodman MS, Chavez-Yenter D, Bradshaw RL, Chambers RL, Espinel WF, Hess R, Mann DM, Monahan R, Wetter DW, Ginsburg O, Sigireddi M, Kawamoto K, Del Fiol G, Buys SS, Kaphingst K (2025). Bridging Technology and Pretest Genetic Services: Quantitative Study of Chatbot Interaction Patterns, User Characteristics, and Genetic Testing Decisions. Journal of medical Internet research, 27, e73391.
  88. Wan YJ, Abdelrahman SE, Facelli JC, Madaras-Kelly K, Kawamoto K, Dishman D, Himes SR, Cato K, Rossetti SC, Del Fiol (2025). Conceptual framework for prediction models of patient deterioration based on nursing documentation patterns: reproducibility and generalizability with a large number of hospitals across the United States. Journal of biomedical informatics, 169, 104887.
  89. Stipelman CH, Ulibarri E, Wilson N, Olivas A, Sanders A, Trepman E, Kawamoto (2025). Electronic Health Record Clinical Decision Support to Close the Human Papillomavirus Vaccination Gender Disparity in Children Aged 9 and 10 Years. Clinical pediatrics, 64(8), 1160-1168.
  90. Del Fiol G, Kuzmenko TV, Orleans B, Chipman JJ, Greene T, Meads R, Kaphingst KA, Gibson B, Kawamoto K, King AJ, Siaperas T, Hughes S, Pruhs A, Dinkins CP, Lam CY, Pierce JH, Benson R, Borsato EP, Cornia RC, Stevens L, Bradshaw RL, Schlechter CR, Wetter D (2025). Population-Based Digital Health Interventions to Deliver at-Home COVID-19 Testing: SCALE-UP II Randomized Clinical Trial. Journal of medical Internet research, 27, e74145.
  91. Zhong L, Bather JR, Goodman MS, Kaiser-Jackson L, Volkmar M, Bradshaw RL, Lorenz Chambers R, Chavez-Yenter D, Colonna SV, Maxwell W, Flynn M, Gammon A, Hess R, Mann DM, Monahan R, Yi Y, Sigireddi M, Wetter DW, Kawamoto K, Del Fiol G, Buys SS, Kaphingst K (2025). Importance of Prior Patient Interactions With the Healthcare System to Engaging With Pretest Cancer Genetic Services via Digital Health Tools Among Unaffected Primary Care Patients: Findings From the BRIDGE Trial. Health services research, e14652.
  92. Colicchio TK, ElHalta D, Fiol GD, Kawamoto K, Strasberg HR, Cimino J (2025). Challenges to Reduce Alert Burden Using Current Decision Support Infrastructure in Two Commercial EHR Systems: Lessons Learned and Path Forward. Applied clinical informatics, 16(3), 575-582.
  93. Butler JM, Doubleday A, Sattar U, Nies M, Jeppesen A, Wright M, Reese T, Kawamoto K, Fiol GD, Madaras-Kelly (2025). "Be Really Careful about That": Clinicians' Perceptions of an Intelligence Augmentation Tool for In-Hospital Deterioration Detection. Applied clinical informatics, 16(2), 377-392.
  94. Pierce JH, Weir C, Taft T, Richards Ii W, McFarland MM, Kawamoto K, Del Fiol G, Butler J (2025). Shared Decision-Making Tools Implemented in the Electronic Health Record: Scoping Review. Journal of medical Internet research, 27, e59956.
  95. Bather JR, Goodman MS, Harris A, Del Fiol G, Hess R, Wetter DW, Chavez-Yenter D, Zhong L, Kaiser-Jackson L, Chambers R, Bradshaw R, Kohlmann W, Colonna S, Espinel W, Monahan R, Buys SS, Ginsburg O, Kawamoto K, Kaphingst KA, BRIDGE research tea (2025). Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility. BMC cancer, 25(1), 180.
  96. Kukhareva P, Balbin C, Stevens E, Mann D, Tiase V, Butler J, Del Fiol G, Caverly T, Kaphingst K, Schlechter CR, Fagerlin A, Li H, Zhang Y, Hess R, Flynn M, Reddy C, Warner P, Choi J, Martin D, Nanjo C, Metzger Q, Kawamoto (2024). The MyLungHealth study protocol: a pragmatic patient-randomised controlled trial to evaluate a patient-centred, electronic health record-integrated intervention to enhance lung cancer screening in primary care. BMJ open, 14(12), e087056.
  97. Del Fiol G, Orleans B, Kuzmenko TV, Chipman J, Greene T, Martinez A, Wirth J, Meads R, Kaphingst KK, Gibson B, Kawamoto K, King AJ, Siaperas T, Hughes S, Pruhs A, Pariera Dinkins C, Lam CY, Pierce JH, Benson R, Borsato EP, Cornia R, Stevens L, Bradshaw RL, Schlechter CR, Wetter D (2024). SCALE-UP II: protocol for a pragmatic randomised trial examining population health management interventions to increase the uptake of at-home COVID-19 testing in community health centres. BMJ open, 14(3), e081455.

Review

  1. Welch BM, Kawamoto (2013). Clinical decision support for genetically guided personalized medicine: a systematic review. Journal of the American Medical Informatics Association, 20(2), 388-400.
  2. Liu S, Reese TJ, Kawamoto K, Del Fiol G, Weir (2021). A systematic review of theoretical constructs in CDS literature. BMC medical informatics and decision making, 21(1), 102.
  3. Taber P, Radloff C, Del Fiol G, Staes C, Kawamoto (2021). New Standards for Clinical Decision Support: A Survey of The State of Implementation. Yearbook of medical informatics, 30(1), 159-171.
  4. Strasberg HR, Rhodes B, Del Fiol G, Jenders RA, Haug PJ, Kawamoto (2021). Contemporary clinical decision support standards using Health Level Seven International Fast Healthcare Interoperability Resources. Journal of the American Medical Informatics Association, 28(8), 1796-1806.
  5. Taber P, Armin JS, Orozco G, Del Fiol G, Erdrich J, Kawamoto K, Israni S (2023). Artificial Intelligence and Cancer Control: Toward Prioritizing Justice, Equity, Diversity, and Inclusion (JEDI) in Emerging Decision Support Technologies. Current oncology reports, 25(5), 387-424.
  6. Stipelman CH, Kukhareva PV, Trepman E, Nguyen QT, Valdez L, Kenost C, Hightower M, Kawamoto (2022). Electronic Health Record-Integrated Clinical Decision Support for Clinicians Serving Populations Facing Health Care Disparities: Literature Review. Yearbook of medical informatics, 31(1), 184-198.
  7. Shimbo D, Shah RU, Abdalla M, Agarwal R, Ahmad FS, Anaya G, Attia ZI, Bull S, Chang AR, Commodore-Mensah Y, Ferdinand K, Kawamoto K, Khera R, Leopold J, Luo J, Makhni S, Mortazavi BJ, Oh YS, Savage LC, Spatz ES, Stergiou G, Turakhia MP, Whelton PK, Yancy CW, Iturriaga (2024). Transforming Hypertension Diagnosis and Management in The Era of Artificial Intelligence: A 2023 National Heart, Lung, and Blood Institute (NHLBI) Workshop Report. Hypertension (Dallas, Tex.,
  8. Tawfik AG, Gomez-Lumbreras A, Del Fiol G, Kawamoto K, Trinkley KE, Reese T, Jones A, Malone D (2025). Nonsteroidal Anti-Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis. Clinical pharmacology and therapeutics,
  9. Rajagopal A, Ayanian S, Ryu AJ, Qian R, Legler SR, Peeler EA, Issa M, Coons TJ, Kawamoto (2024). Machine Learning Operations in Health Care: A Scoping Review. Mayo Clinic proceedings. Digital health, 2(3), 421-437.

Conference Proceedings

  1. Marcial LH, Blumenfeld B, Harle C, Jing X, Keller MS, Lee V, Lin Z, Dover A, Midboe AM, Al-Showk S, Bradley V, Breen J, Fadden M, Lomotan E, Marco-Ruiz L, Mohamed R, O'Connor P, Rosendale D, Solomon H, Kawamoto (2020). Barriers, Facilitators, and Potential Solutions to Advancing Interoperable Clinical Decision Support: Multi-Stakeholder Consensus Recommendations for the Opioid Use Case. AMIA ... Annual Symposium proceedings. AMIA Symposium, 2019, 637-646.

Commentary

  1. Stagg BC, Stein JD, Medeiros FA, Wirostko B, Crandall A, Hartnett ME, Cummins M, Morris A, Hess R, Kawamoto (2021). Special Commentary: Using Clinical Decision Support Systems to Bring Predictive Models to the Glaucoma Clinic. Ophthalmology. Glaucoma, 4(1), 5-9.

Editorial

  1. Kawamoto K, Finkelstein J, Del Fiol (2023). Implementing Machine Learning in the Electronic Health Record: Checklist of Essential Considerations. Mayo Clinic proceedings, 98(3), 366-369.
  2. Tiase VL, Kawamoto K, Sward K (2023). Supporting Nursing Efficiency by Understanding Workload: A Critical Need. Mayo Clinic proceedings. Digital health, 1(4), 629-631.

Letter

  1. Abedin Z, Hoerner R, Habboushe J, Lu Y, Kawamoto K, Warner PB, Shields DE, Shah R (2020). Implementation of a Fast Healthcare Interoperability Resources-Based Clinical Decision Support Tool for Calculating CHA2DS2-VASc Scores. Circulation. Cardiovascular quality and outcomes, 13(2), e006286.

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