Kensaku Kawamoto

Kensaku Kawamoto, MD, PhD, MHS, FACMI, FAMIA

Languages spoken: English, Japanese

Academic Information

Departments Primary - Biomedical Informatics

Research Interests

  • Clinical Decision Support Systems
  • Knowledge Management
  • Personalized Medicine
  • Standards and Scalability

Dr. Kensaku (Ken) Kawamoto serves as the Chief Health AI Transformation Officer for University of Utah Health, as well as the Dr. Helmuth F. Orthner Endowed Professor and Vice Chair of Clinical AI and Informatics for the University of Utah Department of Biomedical Informatics. Dr. Kawamoto also serves as the Founding Director of the University of Utah Health Innovation Lab, the Founding Director of the ReImagine EHR Initiative, and Co-Senior Director of the Digital Health Initiative. Dr. Kawamoto is a Fellow of the American College of Medical Informatics and a Fellow of the American Medical Informatics Association. Dr. Kawamoto was recognized as a Top 25 Innovator in health care by Modern Healthcare in 2019, and as a University of Utah Presidential Societal Impact Scholar in 2026. Dr. Kawamoto earned his B.A. in biochemical sciences from Harvard University, and he earned his M.D., Ph.D. in biomedical engineering with a focus on biomedical informatics, and M.H.S. in clinical research from Duke University.

At the University of Utah, Dr. Kawamoto leads efforts to advance AI across the health system, driving innovation that enhances patient care, operational performance, research, and education. He oversees University of Utah Health’s Innovation Lab, launched in January 2026 to accelerate the development and deployment of cutting-edge technologies across the system. Dr. Kawamoto also leads the University’s ReImagine EHR initiative, which is a multi-stakeholder enterprise initiative for improving health and health care through interoperable electronic health record (EHR) innovations. The ReImagine EHR initiative has developed a number of award-winning EHR add-on apps, has helped secure over $60 million in external grants and contracts, and leverages AI to improve patient care at scale. Dr. Kawamoto is also the co-solution architect of the enterprise Value Driven Outcomes (VDO) framework for analyzing and improving care value.

Beyond the University of Utah, Dr. Kawamoto served 2 terms on the U.S. Health IT Advisory Committee (HITAC), which provided guidance to the U.S. Office of the National Coordinator for Health IT on policies, standards, implementation specifications, and certification criteria related to health information technology. In this capacity, he also co-chaired the federal Interoperability Standards Priorities Task Force, which recommended priority uses of health IT and the associated standards and implementation specifications.

Dr. Kawamoto co-chairs the Clinical Decision Support Work Group of Health Level Seven International (HL7), the primary standards development organization in health IT. He is also a past board member of HL7 and served as Initiative Coordinator for the U.S. Health eDecisions and Clinical Quality Framework initiatives for developing and validating interoperability standards for clinical decision support and clinical quality measurement. Dr. Kawamoto founded and directs OpenCDS, which is a multi-institutional initiative to enable advanced, standards-based, and open-source clinical decision support at scale. OpenCDS is used in all 50 states and by tens of thousands of healthcare facilities.

Dr. Kawamoto is a member of the Huntsman Cancer Institute Cancer Control and Population Science Program, and he is engaged in a number of projects aimed at cancer prevention. Dr. Kawamoto has been the PI or co-PI on various grants sponsored by the federal government and industry, including from the National Cancer Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Human Genome Research Institute, and the Agency for Healthcare Research and Quality. He is currently the Contact PI of the University of Utah node of the National Institutes of Health Genomics-Enabled Learning Health Systems Network. Dr. Kawamoto is also the author or co-author of over 150 peer-reviewed journal articles and conference proceedings and 10 book chapters.

"I believe one of the greatest challenges facing our nation is how to provide high-quality health care at a cost affordable by society. It is truly gratifying to work with talented colleagues from across the University and beyond to address this grand challenge of our times, with clinical AI and informatics serving as core enablers for the transformational breakthroughs that can help us realize this vision of high-quality, high-value health care."

Education History

Graduate Training Duke University Allied Health Graduate Program
 MHS
Doctoral Training Duke University Graduate School
 PhD
Professional Medical Duke University School of Medicine
 MD
Undergraduate Harvard University
 BA

Selected Publications

Journal Article

  1. Kukhareva PV, Li H, Balbin C, Stevens ER, Mann DM, Butler JM, Caverly TJ, Del Fiol G, Kaphingst KA, Schlechter CR, Tiase VL, Fagerlin A, Zhang Y, Hess R, Flynn MC, Reddy C, Martin D, Warner PB, Nanjo C, Choi J, Ngo-Metzger Q, Kawamoto K (2025). Enhancement of Patient-Centered Lung Cancer Screening: The MyLungHealth Randomized Clinical Trial. JAMA Oncol, 12(2), 167-176.
  2. Tiase VL, Fritz JM, Ferraro J, Bayles G, Alsaleem A, Del Fiol G, Kawamoto K, Brodke D, Martin B, Altizer R (2025). Advancing Digital Access to Physical Therapy via Virtual and Extended Reality Technology: Prototype Development and Usability Evaluation. JMIR Form Res, 9, e73783.
  3. Stagg BC, Brintz BJ, Stein JD, Hess R, Kawamoto K, Jammal AA, Medeiros FA (2025). Time to Identify Glaucoma Progression Given Typical Visual Field Testing Frequencies in a US Nationwide Insured Population. Ophthalmol Glaucoma, 9(3), 250-256.
  4. Harris A, Bather JR, Bradshaw RL, Kawamoto K, Del Fiol G, Kohlmann WK, Chavez-Yenter D, Monahan R, Chambers RL, Sigireddi M, Goodman MS, Kaphingst KA (2025). Incomplete Family History and Meeting Algorithmic Criteria for Genetic Evaluation of Hereditary Cancer. JAMA Netw Open, 8(10), e2539870.
  5. Yi Y, Kaiser-Jackson L, Bather JR, Goodman MS, Chavez-Yenter D, Bradshaw RL, Chambers RL, Espinel WF, Hess R, Mann DM, Monahan R, Wetter DW, Ginsburg O, Sigireddi M, Kawamoto K, Del Fiol G, Buys SS, Kaphingst KA (2025). Bridging Technology and Pretest Genetic Services: Quantitative Study of Chatbot Interaction Patterns, User Characteristics, and Genetic Testing Decisions. J Med Internet Res, 27, e73391.
  6. Kukhareva PV, OBrien MJ, Malone DC, Kawamoto K, Gouripeddi R, Reddy D, Zhang M, Deshmukh VG, Danks D, Facelli JC (2025). Documentation of social determinants of health for patients with type 2 diabetes in Epic Cosmos. JAMIA Open, 8(5), ooaf095.
  7. Stipelman CH, Ulibarri E, Wilson N, Olivas A, Sanders A, Trepman E, Kawamoto K (2025). Electronic Health Record Clinical Decision Support to Close the Human Papillomavirus Vaccination Gender Disparity in Children Aged 9 and 10 Years. Clin Pediatr (Phila), 64(8), 1160-1168.
  8. Wan YJ, Abdelrahman SE, Facelli JC, Madaras-Kelly K, Kawamoto K, Dishman D, Himes SR, Cato K, Rossetti SC, Del Fiol G (2025). Conceptual framework for prediction models of patient deterioration based on nursing documentation patterns: reproducibility and generalizability with a large number of hospitals across the United States. J Biomed Inform, 169, 104887.
  9. Del Fiol G, Kuzmenko TV, Orleans B, Chipman JJ, Greene T, Meads R, Kaphingst KA, Gibson B, Kawamoto K, King AJ, Siaperas T, Hughes S, Pruhs A, Dinkins CP, Lam CY, Pierce JH, Benson R, Borsato EP, Cornia RC, Stevens L, Bradshaw RL, Schlechter CR, Wetter DW (2025). Population-Based Digital Health Interventions to Deliver at-Home COVID-19 Testing: SCALE-UP II Randomized Clinical Trial. J Med Internet Res, 27, e74145.
  10. Zhong L, Bather JR, Goodman MS, Kaiser-Jackson L, Volkmar M, Bradshaw RL, Lorenz Chambers R, Chavez-Yenter D, Colonna SV, Maxwell W, Flynn M, Gammon A, Hess R, Mann DM, Monahan R, Yi Y, Sigireddi M, Wetter DW, Kawamoto K, Del Fiol G, Buys SS, Kaphingst KA (2025). Importance of Prior Patient Interactions With the Healthcare System to Engaging With Pretest Cancer Genetic Services via Digital Health Tools Among Unaffected Primary Care Patients: Findings From the BRIDGE Trial. Health Serv Res, 61(2), e14652.
  11. Colicchio TK, ElHalta D, Fiol GD, Kawamoto K, Strasberg HR, Cimino JJ (2025). Challenges to Reduce Alert Burden Using Current Decision Support Infrastructure in Two Commercial EHR Systems: Lessons Learned and Path Forward. Appl Clin Inform, 16(3), 575-582.
  12. Butler JM, Doubleday A, Sattar U, Nies M, Jeppesen A, Wright M, Reese T, Kawamoto K, Fiol GD, Madaras-Kelly K (2025). "Be Really Careful about That": Clinicians' Perceptions of an Intelligence Augmentation Tool for In-Hospital Deterioration Detection. Appl Clin Inform, 16(2), 377-392.
  13. Pierce JH, Weir C, Taft T, Richards Ii W, McFarland MM, Kawamoto K, Del Fiol G, Butler JM (2025). Shared Decision-Making Tools Implemented in the Electronic Health Record: Scoping Review. J Med Internet Res, 27, e59956.
  14. Bather JR, Goodman MS, Harris A, Del Fiol G, Hess R, Wetter DW, Chavez-Yenter D, Zhong L, Kaiser-Jackson L, Chambers R, Bradshaw R, Kohlmann W, Colonna S, Espinel W, Monahan R, Buys SS, Ginsburg O, Kawamoto K, Kaphingst KA, BRIDGE research team (2025). Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility. BMC Cancer, 25(1), 180.
  15. Haaker TS, Choi JS, Nanjo CJ, Warner PB, Abu-Hanna A, Kawamoto K (2025). Approaches for extracting daily dosage from free-text prescription signatures in heart failure with reduced ejection fraction: a comparative study. JAMIA Open, 8(1), ooae153.
  16. Kukhareva P, Balbin C, Stevens E, Mann D, Tiase V, Butler J, Del Fiol G, Caverly T, Kaphingst K, Schlechter CR, Fagerlin A, Li H, Zhang Y, Hess R, Flynn M, Reddy C, Warner P, Choi J, Martin D, Nanjo C, Metzger Q, Kawamoto K (2024). The MyLungHealth study protocol: a pragmatic patient-randomised controlled trial to evaluate a patient-centred, electronic health record-integrated intervention to enhance lung cancer screening in primary care. BMJ Open, 14(12), e087056.
  17. Butler JM, Farrell TW, Puckett M, Nanjo C, Warner P, Shields D, Supiano MA, Kawamoto K (2024). The Age-Friendly Learning Healthcare System: Replicating electronic health record based documentation metrics for 4Ms care. J Am Geriatr Soc.
  18. Cedillo M, Zepeda J, Kiraly B, Flynn M, Larios Elizalde P, Zheutlin E, Rudd EA, Kukhareva PV, Butler JM, Hess R, Kawamoto K, Estabrooks P, Conroy MB (2024). Scalable and successful patient portal lifestyle coaching training for primary care clinical staff. Transl Behav Med, 14(11), 661-672.
  19. Schlechter CR, Kuzmenko TV, Orleans B, Wirth J, Kaphingst KA, Gibson B, Kawamoto K, Siaperas T, Pruhs A, Dinkins CP, Greene T, Zhang Y, Chipman JJ, Friedrichs M, Lam CY, Pierce JH, Borsato EP, Cornia RC, Stevens L, Martinez A, Bradshaw RL, Hess R, Fiol GD, Wetter DW (2024). Reach and Engagement With Population Health Management Interventions to Address COVID-19 Among Safety-Net Health Care Systems. Am J Public Health, 114(11), 1207-1211.
  20. Kukhareva PV, Facelli JC, OBrien MJ, Gouripeddi R, Kawamoto K, Zhang Y, Reddy D, Malone DC (2024). Racial and Ethnic Disparities in Prescribing of GLP-1 Receptor Agonists in the United States: A Retrospective Cohort Analysis.
  21. Kaphingst KA, Kohlmann WK, Lorenz Chambers R, Bather JR, Goodman MS, Bradshaw RL, Chavez-Yenter D, Colonna SV, Espinel WF, Everett JN, Flynn M, Gammon A, Harris A, Hess R, Kaiser-Jackson L, Lee S, Monahan R, Schiffman JD, Volkmar M, Wetter DW, Zhong L, Mann DM, Ginsburg O, Sigireddi M, Kawamoto K, Del Fiol G, Buys SS (2024). Uptake of Cancer Genetic Services for Chatbot vs Standard-of-Care Delivery Models: The BRIDGE Randomized Clinical Trial. JAMA Netw Open, 7(9), e2432143.
  22. Tiase VL, Richards G, Taft T, Stevens L, Balbin C, Kaphingst KA, Fagerlin A, Caverly T, Kukhareva P, Flynn M, Butler JM, Kawamoto K (2024). Patient Perspectives on a Patient-Facing Tool for Lung Cancer Screening. Health Expect, 27(4), e14143.
  23. Kukhareva PV, Li H, Caverly TJ, Fagerlin A, Del Fiol G, Hess R, Zhang Y, Butler JM, Schlechter C, Flynn MC, Reddy C, Choi J, Balbin C, Warner IA, Warner PB, Nanjo C, Kawamoto K (2024). Lung Cancer Screening Before and After a Multifaceted Electronic Health Record Intervention: A Nonrandomized Controlled Trial. JAMA Netw Open, 7(6), e2415383.
  24. Finkelstein J, Cui W, Ferraro JP, Kawamoto K (2024). Association of Diagnostic Discrepancy with Length of Stay and Mortality in Congestive Heart Failure Patients Admitted to the Emergency Department. AMIA Jt Summits Transl Sci Proc, 2024, 155-161.
  25. Kukhareva PV, Weir CR, Cedillo M, Taft T, Butler JM, Rudd EA, Zepeda J, Zheutlin E, Kiraly B, Flynn M, Conroy MB, Kawamoto K (2024). Design and implementation of electronic health record-based tools to support a weight management program in primary care. JAMIA Open, 7(2), ooae038.
  26. Johnson D, Del Fiol G, Kawamoto K, Romagnoli KM, Sanders N, Isaacson G, Jenkins E, Williams MS (2023). Genetically guided precision medicine clinical decision support tools: a systematic review. J Am Med Inform Assoc, 31(5), 1183-1194.
  27. Lario R, Soley R, White S, Butler J, Del Fiol G, Eilbeck K, Huff S, Kawamoto K (2023). The Business Process Management for Healthcare (BPM+ Health) Consortium: motivation, methodology, and deliverables for enabling clinical knowledge interoperability (CKI). J Am Med Inform Assoc, 31(4), 797-808.
  28. Conroy MB, Cedillo M, Jordanova K, Zepeda J, Kiraly B, Flynn M, Wu C, Kukhareva PV, Butler JM, Hess R, Greene T, Kawamoto K (2024). Implementing weight maintenance with existing staff and electronic health record tools in a primary care setting: Baseline results from the MAINTAIN PRIME trial. Contemp Clin Trials, 141, 107520.
  29. Del Fiol G, Orleans B, Kuzmenko TV, Chipman J, Greene T, Martinez A, Wirth J, Meads R, Kaphingst KK, Gibson B, Kawamoto K, King AJ, Siaperas T, Hughes S, Pruhs A, Pariera Dinkins C, Lam CY, Pierce JH, Benson R, Borsato EP, Cornia R, Stevens L, Bradshaw RL, Schlechter CR, Wetter DW (2024). SCALE-UP II: protocol for a pragmatic randomised trial examining population health management interventions to increase the uptake of at-home COVID-19 testing in community health centres. BMJ Open, 14(3), e081455.
  30. Balbin CA, Kawamoto K (2024). The SIMPLE Architectural Pattern for Integrating Patient-Facing Apps into Clinical Workflows: Desiderata and Application for Lung Cancer Screening. AMIA Annu Symp Proc, 2023, 844-853.
  31. Lukyanchikov N, Kawamoto K (2024). Evaluation of Discrepancies Among National Library of Medicine (NLM) Value Set Authority Center (VSAC) ICD-10-CM Value Sets: Case Study for Diagnoses of Common Chronic Conditions, Implications, and Potential Solutions. AMIA Annu Symp Proc, 2023, 1087-1095.
  32. Harris A, Bather JR, Kawamoto K, Fiol GD, Bradshaw RL, Kaiser-Jackson L, Monahan R, Kohlmann W, Liu F, Ginsburg O, Goodman MS, Kaphingst KA (2024). Determinants of Breast Cancer Screening Adherence During the COVID-19 Pandemic in a Cohort at Increased Inherited Cancer Risk in the United States. Cancer Control, 31, 10732748241272727.
  33. Staes CJ, Beck AC, Chalkidis G, Scheese CH, Taft T, Guo JW, Newman MG, Kawamoto K, Sloss EA, McPherson JP (2023). Design of an interface to communicate artificial intelligence-based prognosis for patients with advanced solid tumors: a user-centered approach. J Am Med Inform Assoc, 31(1), 174-187.
  34. Bradshaw RL, Kawamoto K, Bather JR, Goodman MS, Kohlmann WK, Chavez-Yenter D, Volkmar M, Monahan R, Kaphingst KA, Del Fiol G (2023). Enhanced family history-based algorithms increase the identification of individuals meeting criteria for genetic testing of hereditary cancer syndromes but would not reduce disparities on their own. J Biomed Inform, 149, 104568.
  35. Stevens ER, Caverly T, Butler JM, Kukhareva P, Richardson S, Mann DM, Kawamoto K (2023). Considerations for using predictive models that include race as an input variable: The case study of lung cancer screening. J Biomed Inform, 147, 104525.
  36. Landy R, Gomez I, Caverly TJ, Kawamoto K, Rivera MP, Robbins HA, Young CD, Chaturvedi AK, Cheung LC, Katki HA (2023). Methods for Using Race and Ethnicity in Prediction Models for Lung Cancer Screening Eligibility. JAMA Netw Open, 6(9), e2331155.
  37. Schlechter CR, Reese TJ, Wirth J, Gibson B, Kawamoto K, Siaperas T, Pruhs A, Dinkins CP, Zhang Y, Friedrichs M, George S, Lam CY, Pierce JH, Borsato EP, Cornia RC, Stevens L, Martinez A, Bradshaw RL, Kaphingst KA, Hess R, Del Fiol G, Wetter DW (2024). Rapid-cycle designs to adapt interventions for COVID-19 in safety-net healthcare systems. Transl Behav Med, 13(6), 389-399.
  38. Kukhareva PV, Li H, Caverly TJ, Del Fiol G, Fagerlin A, Butler JM, Hess R, Zhang Y, Taft T, Flynn MC, Reddy C, Martin DK, Warner IA, Rodriguez-Loya S, Warner PB, Kawamoto K (2023). Implementation of Lung Cancer Screening in Primary Care and Pulmonary Clinics: Pragmatic Clinical Trial of Electronic Health Record-Integrated Everyday Shared Decision-Making Tool and Clinician-Facing Prompts. Chest, 164(5), 1325-1338.
  39. Stagg BC, Tullis B, Asare A, Stein JD, Medeiros FA, Weir C, Borbolla D, Hess R, Kawamoto K (2023). Systematic User-centered Design of a Prototype Clinical Decision Support System for Glaucoma. Ophthalmol Sci, 3(3), 100279.
  40. Liebermann E, Taber P, Vega AS, Daly BM, Goodman MS, Bradshaw R, Chan PA, Chavez-Yenter D, Hess R, Kessler C, Kohlmann W, Low S, Monahan R, Kawamoto K, Del Fiol G, Buys SS, Sigireddi M, Ginsburg O, Kaphingst KA (2022). Barriers to family history collection among Spanish-speaking primary care patients: a BRIDGE qualitative study. PEC Innov, 1.
  41. Lario R, Kawamoto K, Sottara D, Eilbeck K, Huff S, Del Fiol G, Soley R, Middleton B (2022). A method for structuring complex clinical knowledge and its representational formalisms to support composite knowledge interoperability in healthcare. J Biomed Inform, 137, 104251.
  42. Gomez Lumbreras A, Reese TJ, Del Fiol G, Tan MS, Butler JM, Hurwitz JT, Brown M, Kawamoto K, Thiess H, Wright M, Malone DC (2022). Shared Decision-Making for Drug-Drug Interactions: Formative Evaluation of an Anticoagulant Drug Interaction. JMIR Form Res, 6(10), e40018.
  43. Chavez-Yenter D, Goodman MS, Chen Y, Chu X, Bradshaw RL, Lorenz Chambers R, Chan PA, Daly BM, Flynn M, Gammon A, Hess R, Kessler C, Kohlmann WK, Mann DM, Monahan R, Peel S, Kawamoto K, Del Fiol G, Sigireddi M, Buys SS, Ginsburg O, Kaphingst KA (2022). Association of Disparities in Family History and Family Cancer History in the Electronic Health Record With Sex, Race, Hispanic or Latino Ethnicity, and Language Preference in 2 Large US Health Care Systems. JAMA Netw Open, 5(10), e2234574.
  44. Shi J, Morgan KL, Bradshaw RL, Jung SH, Kohlmann W, Kaphingst KA, Kawamoto K, Fiol GD (2022). Identifying Patients Who Meet Criteria for Genetic Testing of Hereditary Cancers Based on Structured and Unstructured Family Health History Data in the Electronic Health Record: Natural Language Processing Approach. JMIR Med Inform, 10(8), e37842.
  45. Kukhareva P, Caverly T, Kawamoto K (2022). Re: Inaccuracies in electronic health records smoking data and a potential approach to address resulting underestimation in determining lung cancer screening eligibility. J Am Med Inform Assoc, 29(9), 1655.
  46. Morgan KL, Kukhareva PV, Warner PB, Wilkof J, Snyder M, Horton D, Madsen T, Habboushe J, Kawamoto K (2022). Using CDS Hooks to increase SMART on FHIR app utilization: a cluster-randomized trial. J Am Med Inform Assoc, 29(9), 1461-1470.
  47. Stagg BC, Stein JD, Medeiros FA, Horns J, Hartnett ME, Kawamoto K, Hess R (2022). The frequency of visual field testing in a US nationwide cohort of individuals with open angle glaucoma. Ophthalmol Glaucoma, 5(6), 587-593.
  48. Wiley K, Findley L, Goldrich M, Rakhra-Burris TK, Stevens A, Williams P, Bult CJ, Chisholm R, Deverka P, Ginsburg GS, Green ED, Jarvik G, Mensah GA, Ramos E, Relling MV, Roden DM, Rowley R, Alterovitz G, Aronson S, Bastarache L, Cimino JJ, Crowgey EL, Del Fiol G, Freimuth RR, Hoffman MA, Jeff J, Johnson K, Kawamoto K, Madhavan S, Mendonca EA, Ohno-Machado L, Pratap S, Taylor CO, Ritchie MD, Walton N, Weng C, Zayas-Cabn T, Manolio TA, Williams MS (2022). A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources. J Am Med Inform Assoc, 29, 1342-1349.
  49. Kukhareva PV, Caverly TJ, Li H, Katki HA, Cheung LC, Reese TJ, Del Fiol G, Hess R, Wetter DW, Zhang Y, Taft TY, Flynn MC, Kawamoto K (2021). Inaccuracies in electronic health records smoking data and a potential approach to address resulting underestimation in determining lung cancer screening eligibility. J Am Med Inform Assoc, 29(5), 779-788.
  50. Bradshaw RL, Kawamoto K, Kaphingst KA, Kohlmann WK, Hess R, Flynn MC, Nanjo CJ, Warner PB, Shi J, Morgan K, Kimball K, Ranade-Kharkar P, Ginsburg O, Goodman M, Chambers R, Mann D, Narus SP, Gonzalez J, Loomis S, Chan P, Monahan R, Borsato EP, Shields DE, Martin DK, Kessler CM, Del Fiol G (2021). GARDE: a standards-based clinical decision support platform for identifying population health management cohorts. J Am Med Inform Assoc, 29(5), 928-936.
  51. Thiess H, Del Fiol G, Malone DC, Cornia R, Sibilla M, Rhodes B, Boyce RD, Kawamoto K, Reese T (2022). Coordinated use of Health Level 7 standards to support clinical decision support: Case study with shared decision making and drug-drug interactions. Int J Med Inform, 162, 104749.
  52. Kukhareva PV, Weir C, Del Fiol G, Aarons GA, Taft TY, Schlechter CR, Reese TJ, Curran RL, Nanjo C, Borbolla D, Staes CJ, Morgan KL, Kramer HS, Stipelman CH, Shakib JH, Flynn MC, Kawamoto K (2022). Evaluation in Life Cycle of Information Technology (ELICIT) framework: Supporting the innovation life cycle from business case assessment to summative evaluation. J Biomed Inform, 127, 104014.
  53. Reese T, Wright A, Liu S, Boyce R, Romero A, Del Fiol G, Kawamoto K, Malone D (2022). Improving the specificity of drug-drug interaction alerts: Can it be done? Am J Health Syst Pharm, 79, 1086-1095.
  54. Willis C, Watanabe AH, Hughes J, Nolen K, OMeara J, Schepart A, Bruno M, Biskupiak J, Kawamoto K, Shara N, Kannampallil T (2022). Applying diagnosis support systems in electronic health records to identify wild-type transthyretin amyloid cardiomyopathy risk. Future Cardiol, 18, 367-376.
  55. Tarumi S, Takeuchi W, Qi R, Ning X, Ruppert L, Ban H, Robertson DH, Schleyer TK, Kawamoto K (2022). Predicting pharmacotherapeutic outcomes for type 2 diabetes: An evaluation of three approaches to leveraging electronic health record data from multiple sources. J Biomed Inform, 129, 104001.
  56. Liu S, Kawamoto K, Del Fiol G, Weir C, Malone DC, Reese TJ, Morgan K, ElHalta D, Abdelrahman S (2022). The potential for leveraging machine learning to filter medication alerts. J Am Med Inform Assoc, 29, 891-899.
  57. Chavez-Yenter D, Kimball KE, Kohlmann W, Lorenz Chambers R, Bradshaw RL, Espinel WF, Flynn M, Gammon A, Goldberg E, Hagerty KJ, Hess R, Kessler C, Monahan R, Temares D, Tobik K, Mann DM, Kawamoto K, Del Fiol G, Buys SS, Ginsburg O, Kaphingst KA (2021). Patient Interactions With an Automated Conversational Agent Delivering Pretest Genetics Education: Descriptive Study. J Med Internet Res, 23(11), e29447.
  58. Bahr TM, Shakib JH, Stipelman CH, Kawamoto K, Lauer S, Christensen RD (2021). Improvement Initiative: End-Tidal Carbon Monoxide Measurement in Newborns Receiving Phototherapy. J Pediatr, 238, 168-173.e2.
  59. Reese TJ, Del Fiol G, Morgan K, Hurwitz JT, Kawamoto K, Gomez-Lumbreras A, Brown ML, Thiess H, Vazquez SR, Nelson SD, Boyce R, Malone D (2021). A Shared Decision-making Tool for Drug Interactions Between Warfarin and Nonsteroidal Anti-inflammatory Drugs: Design and Usability Study. JMIR Hum Factors, 8(4), e28618.
  60. Schlechter CR, Del Fiol G, Lam CY, Fernandez ME, Greene T, Yack M, Schulthies S, Nelson M, Bohner C, Pruhs A, Siaperas T, Kawamoto K, Gibson B, Nahum-Shani I, Walker TJ, Wetter DW (2021). Application of community - engaged dissemination and implementation science to improve health equity. Prev Med Rep, 24, 101620.
  61. Liu S, Reese TJ, Kawamoto K, Del Fiol G, Weir C (2021). A theory-based meta-regression of factors influencing clinical decision support adoption and implementation. J Am Med Inform Assoc, 28(11), 2514-2522.
  62. Hunt TC, Ambrose JP, Haaland B, Kawamoto K, Dechet CB, Lowrance WT, Hanson HA, ONeil BB (2021). Decision fatigue in low-value prostate cancer screening. Cancer, 127(18), 3343-3353.
  63. Reese TJ, Schlechter CR, Kramer H, Kukhareva P, Weir CR, Del Fiol G, Caverly T, Hess R, Flynn MC, Taft T, Kawamoto K (2021). Implementing lung cancer screening in primary care: needs assessment and implementation strategy design. Transl Behav Med, 12, 187-197.
  64. Kawamoto K, Kukhareva PV, Weir C, Flynn MC, Nanjo CJ, Martin DK, Warner PB, Shields DE, Rodriguez-Loya S, Bradshaw RL, Cornia RC, Reese TJ, Kramer HS, Taft T, Curran RL, Morgan KL, Borbolla D, Hightower M, Turnbull WJ, Strong MB, Chapman WW, Gregory T, Stipelman CH, Shakib JH, Hess R, Boltax JP, Habboushe JP, Sakaguchi F, Turner KM, Narus SP, Tarumi S, Takeuchi W, Ban H, Wetter DW, Lam C, Caverly TJ, Fagerlin A, Norlin C, Malone DC, Kaphingst KA, Kohlmann WK, Brooke BS, Del Fiol G (2021). Establishing a multidisciplinary initiative for interoperable electronic health record innovations at an academic medical center. JAMIA Open, 4(3), ooab041.
  65. Kaphingst KA, Kohlmann W, Chambers RL, Goodman MS, Bradshaw R, Chan PA, Chavez-Yenter D, Colonna SV, Espinel WF, Everett JN, Gammon A, Goldberg ER, Gonzalez J, Hagerty KJ, Hess R, Kehoe K, Kessler C, Kimball KE, Loomis S, Martinez TR, Monahan R, Schiffman JD, Temares D, Tobik K, Wetter DW, Mann DM, Kawamoto K, Del Fiol G, Buys SS, Ginsburg O, BRIDGE research team (2021). Comparing models of delivery for cancer genetics services among patients receiving primary care who meet criteria for genetic evaluation in two healthcare systems: BRIDGE randomized controlled trial. BMC Health Serv Res, 21(1), 542.
  66. Stagg B, Mariottoni EB, Berchuck S, Jammal A, Elam AR, Hess R, Kawamoto K, Haaland B, Medeiros FA (2021). Longitudinal visual field variability and the ability to detect glaucoma progression in black and white individuals. Br J Ophthalmol, 106, 1115-1120.
  67. Tarumi S, Takeuchi W, Chalkidis G, Rodriguez-Loya S, Kuwata J, Flynn M, Turner KM, Sakaguchi FH, Weir C, Kramer H, Shields DE, Warner PB, Kukhareva P, Ban H, Kawamoto K (2021). Leveraging Artificial Intelligence to Improve Chronic Disease Care: Methods and Application to Pharmacotherapy Decision Support for Type-2 Diabetes Mellitus. Methods Inf Med, 60(S 01), e32-e43.
  68. Metcalf RA, Goodfellow J, Cail K, Blaylock R, Kawamoto K, Enniss T, Galaviz C, Lim M, Reddy S, Sharma V, Wanner N (2021). Electronic clinical decision support: Evidence that default settings influence end-user behavior. Transfusion, 61(3), 669-670.
  69. Stagg B, Stein JD, Medeiros FA, Cummins M, Kawamoto K, Hess R (2021). Interests and needs of eye care providers in clinical decision support for glaucoma. BMJ Open Ophthalmol, 6(1), e000639.
  70. Reese TJ, Schlechter CR, Potter LN, Kawamoto K, Del Fiol G, Lam CY, Wetter DW (2021). Evaluation of Revised US Preventive Services Task Force Lung Cancer Screening Guideline Among Women and Racial/Ethnic Minority Populations. JAMA Netw Open, 4(1), e2033769.
  71. Stagg BC, Gupta D, Ehrlich JR, Newman-Casey PA, Stein JD, Kawamoto K, Hess R (2020). The Use of eHealth Practices by United States Patients with Self-Reported Glaucoma. Ophthalmol Glaucoma, 4(1), 71-77.
  72. Morid MA, Sheng ORL, Kawamoto K, Abdelrahman S (2020). Learning hidden patterns from patient multivariate time series data using convolutional neural networks: A case study of healthcare cost prediction. J Biomed Inform, 111, 103565.
  73. Ciarkowski CE, Timbrook TT, Kukhareva PV, Edholm KM, Hatton ND, Hopkins CL, Thomas F, Sanford MN, Igumnova E, Benefield RJ, Kawamoto K, Spivak ES (2020). A Pathway for Community-Acquired Pneumonia With Rapid Conversion to Oral Therapy Improves Health Care Value. Open Forum Infect Dis, 7(11), ofaa497.
  74. Taber P, Ghani P, Schiffman JD, Kohlmann W, Hess R, Chidambaram V, Kawamoto K, Waller RG, Borbolla D, Del Fiol G, Weir C (2020). Physicians' strategies for using family history data: having the data is not the same as using the data. JAMIA Open, 3(3), 378-385.
  75. Stagg BC, Gupta D, Ehrlich JR, Newman-Casey PA, Stein JD, Kawamoto K, Hess R (2021). Evaluation for Disparities in Experience With Internet-Based Health Care Among US Patients With Chronic Eye Diseases. JAMA Ophthalmol, 138(10), 1097-1099.
  76. Edholm K, Lapp K, Kukhareva P, Hopkins C, Hatton ND, Gebhart B, Nyman H, Signor E, Davis M, Kawamoto K, Johnson SA (2020). Reducing Diabetic Ketoacidosis Intensive Care Unit Admissions Through an Electronic Health Record-Driven, Standardized Care Pathway. J Healthc Qual, 42(5), e66-e74.
  77. Reese TJ, Segall N, Del Fiol G, Tonna JE, Kawamoto K, Weir C, Wright MC (2020). Iterative heuristic design of temporal graphic displays with clinical domain experts. J Clin Monit Comput, 35(5), 1119-1131.
  78. Reese TJ, Del Fiol G, Tonna JE, Kawamoto K, Segall N, Weir C, Macpherson BC, Kukhareva P, Wright MC (2020). Impact of integrated graphical display on expert and novice diagnostic performance in critical care. J Am Med Inform Assoc, 27(8), 1287-1292.
  79. Curran RL, Kukhareva PV, Taft T, Weir CR, Reese TJ, Nanjo C, Rodriguez-Loya S, Martin DK, Warner PB, Shields DE, Flynn MC, Boltax JP, Kawamoto K (2020). Integrated displays to improve chronic disease management in ambulatory care: A SMART on FHIR application informed by mixed-methods user testing. J Am Med Inform Assoc, 27(8), 1225-1234.
  80. Karhade AV, Schwab JH, Del Fiol G, Kawamoto K (2020). SMART on FHIR in spine: integrating clinical prediction models into electronic health records for precision medicine at the point of care. Spine J, 21(10), 1649-1651.
  81. Kawamoto K, McDonald CJ (2020). Designing, Conducting, and Reporting Clinical Decision Support Studies: Recommendations and Call to Action. Ann Intern Med, 172(11 Suppl), S101-S109.
  82. Oswald N, Lin T, Haaland B, Flynn M, Kawamoto K, Cooney KA, Lowrance W, Hanson HA, ONeil B (2020). Factors associated with appropriate and low-value PSA testing. Cancer Epidemiol, 66, 101724.
  83. Hanauer DA, Barnholtz-Sloan JS, Beno MF, Del Fiol G, Durbin EB, Gologorskaya O, Harris D, Harnett B, Kawamoto K, May B, Meeks E, Pfaff E, Weiss J, Zheng K (2020). Electronic Medical Record Search Engine (EMERSE): An Information Retrieval Tool for Supporting Cancer Research. JCO Clin Cancer Inform, 4, 454-463.
  84. Horton DJ, Graves KK, Kukhareva PV, Johnson SA, Cedillo M, Sanford M, Dunson WA Jr, White M, Roach D, Arego JJ, Kawamoto K (2020). Modified early warning score-based clinical decision support: cost impact and clinical outcomes in sepsis. JAMIA Open, 3(2), 261-268.
  85. Richesson RL, Staes CJ, Douthit BJ, Thoureen T, Hatch DJ, Kawamoto K, Del Fiol G (2019). Measuring implementation feasibility of clinical decision support alerts for clinical practice recommendations. J Am Med Inform Assoc, 27(4), 514-521.
  86. Fernandez ME, Schlechter CR, Del Fiol G, Gibson B, Kawamoto K, Siaperas T, Pruhs A, Greene T, Nahum-Shani I, Schulthies S, Nelson M, Bohner C, Kramer H, Borbolla D, Austin S, Weir C, Walker TW, Lam CY, Wetter DW (2020). QuitSMART Utah: an implementation study protocol for a cluster-randomized, multi-level Sequential Multiple Assignment Randomized Trial to increase Reach and Impact of tobacco cessation treatment in Community Health Centers. Implement Sci, 15(1), 9.
  87. Del Fiol G, Kohlmann W, Bradshaw RL, Weir CR, Flynn M, Hess R, Schiffman JD, Nanjo C, Kawamoto K (2020). Standards-Based Clinical Decision Support Platform to Manage Patients Who Meet Guideline-Based Criteria for Genetic Evaluation of Familial Cancer. JCO Clin Cancer Inform, 4, 1-9.
  88. Bahr TM, Shakib JH, Stipelman CH, Kawamoto K, Cail K, Lauer S, Christensen RD (2020). Improving the Bilirubin Management Program in the Newborn Nursery: Background, Aims, and Protocol. Neonatology, 117(3), 358-364.
  89. Kawamoto K, Kukhareva P, Shakib JH, Kramer H, Rodriguez S, Warner PB, Shields D, Weir C, Del Fiol G, Taft T, Stipelman CH (2019). Association of an Electronic Health Record Add-on App for Neonatal Bilirubin Management With Physician Efficiency and Care Quality. JAMA Netw Open, 2(11), e1915343.
  90. Norton JM, Ali K, Jurkovitz CT, Kiryluk K, Park M, Kawamoto K, Shang N, Navaneethan SD, Narva AS, Drawz P (2019). Development and Validation of a Pragmatic Electronic Phenotype for CKD. Clin J Am Soc Nephrol, 14(9), 1306-1314.
  91. Stipelman CH, Smith ER, Diaz-Ochu M, Spackman J, Stoddard G, Kawamoto K, Shakib JH (2019). Early-Onset Sepsis Risk Calculator Integration Into an Electronic Health Record in the Nursery. Pediatrics, 144(2).
  92. Marcial LH, Richardson JE, Lasater B, Middleton B, Osheroff JA, Kawamoto K, Ancker JS, van Leeuwen D, Lomotan EA, Al-Showk S, Blumenfeld BH (2018). The Imperative for Patient-Centered Clinical Decision Support. EGEMS (Wash DC), 6(1), 12.
  93. Welch BM, Eilbeck K, Del Fiol G, Meyer LJ, Kawamoto K (2014). Technical desiderata for the integration of genomic data with clinical decision support. J Biomed Inform, 51, 3-7.
  94. Welch BM, Loya SR, Eilbeck K, Kawamoto K (2014). A proposed clinical decision support architecture capable of supporting whole genome sequence information. J Pers Med, 4(2), 176-99.
  95. Zhang D, Sanchez-Fueyo A, Kawamoto K, Alexopoulos SP, Zhang W, Zheng XX (2010). Th1 to Th2 immune deviation facilitates, but does not cause, islet allograft tolerance in mice. Cytokine, 51(3), 311-9.
  96. Drew RH, Kawamoto K, Adams MB (2006). Information technology for optimizing the management of infectious diseases. Am J Health Syst Pharm, 63(10), 957-65.
  97. Ferranti JM, Musser RC, Kawamoto K, Hammond WE (2006). The clinical document architecture and the continuity of care record: a critical analysis. J Am Med Inform Assoc, 13(3), 245-52.

Review

  1. Tawfik AG, Gomez-Lumbreras A, Del Fiol G, Kawamoto K, Trinkley KE, Reese T, Jones A, Malone DC (2025). Nonsteroidal Anti-Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis. [Review]. Clin Pharmacol Ther.
  2. Shimbo D, Shah RU, Abdalla M, Agarwal R, Ahmad FS, Anaya G, Attia ZI, Bull S, Chang AR, Commodore-Mensah Y, Ferdinand K, Kawamoto K, Khera R, Leopold J, Luo J, Makhni S, Mortazavi BJ, Oh YS, Savage LC, Spatz ES, Stergiou G, Turakhia MP, Whelton PK, Yancy CW, Iturriaga E (2024). Transforming Hypertension Diagnosis and Management in The Era of Artificial Intelligence: A 2023 National Heart, Lung, and Blood Institute (NHLBI) Workshop Report. [Review]. Hypertension, 82(1), 36-45.
  3. Rajagopal A, Ayanian S, Ryu AJ, Qian R, Legler SR, Peeler EA, Issa M, Coons TJ, Kawamoto K (2024). Machine Learning Operations in Health Care: A Scoping Review. [Review]. Mayo Clin Proc Digit Health, 2(3), 421-437.
  4. Taber P, Armin JS, Orozco G, Del Fiol G, Erdrich J, Kawamoto K, Israni ST (2023). Artificial Intelligence and Cancer Control: Toward Prioritizing Justice, Equity, Diversity, and Inclusion (JEDI) in Emerging Decision Support Technologies. [Review]. Curr Oncol Rep, 25(5), 387-424.
  5. Stipelman CH, Kukhareva PV, Trepman E, Nguyen QT, Valdez L, Kenost C, Hightower M, Kawamoto K (2022). Electronic Health Record-Integrated Clinical Decision Support for Clinicians Serving Populations Facing Health Care Disparities: Literature Review. [Review]. Yearb Med Inform, 31(1), 184-198.
  6. Taber P, Radloff C, Del Fiol G, Staes C, Kawamoto K (2021). New Standards for Clinical Decision Support: A Survey of The State of Implementation. [Review]. Yearb Med Inform, 30(1), 159-171.
  7. Strasberg HR, Rhodes B, Del Fiol G, Jenders RA, Haug PJ, Kawamoto K (2021). Contemporary clinical decision support standards using Health Level Seven International Fast Healthcare Interoperability Resources. [Review]. J Am Med Inform Assoc, 28(8), 1796-1806.
  8. Liu S, Reese TJ, Kawamoto K, Del Fiol G, Weir C (2021). A systematic review of theoretical constructs in CDS literature. [Review]. BMC Med Inform Decis Mak, 21(1), 102.
  9. Welch BM, Kawamoto K (2012). Clinical decision support for genetically guided personalized medicine: a systematic review. [Review]. J Am Med Inform Assoc, 20(2), 388-400.

Conference Proceedings

  1. Marcial LH, Blumenfeld B, Harle C, Jing X, Keller MS, Lee V, Lin Z, Dover A, Midboe AM, Al-Showk S, Bradley V, Breen J, Fadden M, Lomotan E, Marco-Ruiz L, Mohamed R, OConnor P, Rosendale D, Solomon H, Kawamoto K (2020). Barriers, Facilitators, and Potential Solutions to Advancing Interoperable Clinical Decision Support: Multi-Stakeholder Consensus Recommendations for the Opioid Use Case. AMIA Annu Symp Proc, United States, 2019, 637-646.

Commentary

  1. Stagg BC, Stein JD, Medeiros FA, Wirostko B, Crandall A, Hartnett ME, Cummins M, Morris A, Hess R, Kawamoto K (2020). Special Commentary: Using Clinical Decision Support Systems to Bring Predictive Models to the Glaucoma Clinic. Ophthalmol Glaucoma, 4(1), 5-9.

Editorial

  1. Tiase VL, Kawamoto K, Sward KA (2023). Supporting Nursing Efficiency by Understanding Workload: A Critical Need. Mayo Clin Proc Digit Health, 1(4), 629-631.
  2. Kawamoto K, Finkelstein J, Del Fiol G (2023). Implementing Machine Learning in the Electronic Health Record: Checklist of Essential Considerations. Mayo Clin Proc, 98(3), 366-369.

Letter

  1. Abedin Z, Hoerner R, Habboushe J, Lu Y, Kawamoto K, Warner PB, Shields DE, Shah RU (2020). Implementation of a Fast Healthcare Interoperability Resources-Based Clinical Decision Support Tool for Calculating CHA2DS2-VASc Scores. [Letter to the editor]. Circ Cardiovasc Qual Outcomes, 13(2), e006286.

News & Podcasts

Huntsman Cancer Institute News