Research Statement
Education History
Postdoctoral Fellowship |
University of California, San Diego |
Postdoctoral Fellow |
---|---|---|
Doctoral Training |
University of California, Santa Cruz Molecular, Cellular, and Developmental Biology |
Ph.D. |
Undergraduate |
Juniata College Biology, magna cum laude |
B.S. |
Selected Publications
- William N, Reissner C, Sargent R, Darlington TM, DiBlasi E, Li QS, Keeshin B, Callor WB, Ferris E, Jerominski L, Smith KR, Christensen ED, Gray DM, Camp NJ, Missler M, Williams ME, Coon H (2021). Neurexin 1 variants as risk factors for suicide death. Mol Psychiatry, 26, 7436-7445.
- Taylor MR, Martin EA, Sinnen B, Trilokekar R, Ranza E, Antonarakis SE, Williams ME (2020). Kirrel3-mediated synapse formation is attenuated by disease-associated missense variants. J Neurosci.
- Das SC, Chen D, Callor WB, Christensen E, Coon H, Williams ME (2019). DiI-mediated analysis of presynaptic and postsynaptic structures in human postmortem brain tissue. J Comp Neurol, 527(18), 3087-3098.
- Coon H, Darlington TM, DiBlasi E, Callor WB, Ferris E, Fraser A, Yu Z, William N, Das SC, Crowell SE, Chen D, Anderson JS, Klein M, Jerominski L, Cannon D, Shabalin A, Docherty A, Williams M, Smith KR, Keeshin B, Bakian AV, Christensen E, Li QS, Camp NJ, Gray D (2018). Genome-wide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide. Mol Psychiatry, 25(11), 3077-3090.
- Basu R, Duan X, Taylor MR, Martin EA, Muralidhar S, Wang Y, Gangi-Wellman L, Das SC, Yamagata M, West PJ, Sanes JR, Williams ME (2017). Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus. Neuron, 96(1), 160-176.e8.
- Rawson RL, Martin EA, Williams ME (2017). Mechanisms of input and output synaptic specificity: finding partners, building synapses, and fine-tuning communication. [Review]. Curr Opin Neurobiol, 45, 39-44.
- Martin EA, Woodruff D, Rawson RL, Williams ME (2017). Examining Hippocampal Mossy Fiber Synapses by 3D Electron Microscopy in Wildtype and Kirrel3 Knockout Mice. eNeuro, 4(3).
- Martin EA, Muralidhar S, Wang Z, Cervantes DC, Basu R, Taylor MR, Hunter J, Cutforth T, Wilke SA, Ghosh A, Williams ME (2015). The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus. Elife, 4, e09395.
- Viswanathan S, Williams ME, Bloss EB, Stasevich TJ, Speer CM, Nern A, Pfeiffer BD, Hooks BM, Li WP, English BP, Tian T, Henry GL, Macklin JJ, Patel R, Gerfen CR, Zhuang X, Wang Y, Rubin GM, Looger LL (2015). High-performance probes for light and electron microscopy. Nat Methods, 12(6), 568-76.
- Basu R, Taylor MR, Williams ME (2015). The classic cadherins in synaptic specificity. [Review]. Cell Adh Migr, 9(3), 193-201.
- Wilke SA, Hall BJ, Antonios JK, Denardo LA, Otto S, Yuan B, Chen F, Robbins EM, Tiglio K, Williams ME, Qiu Z, Biederer T, Ghosh A (2012). NeuroD2 regulates the development of hippocampal mossy fiber synapses. Neural Dev, 7, 9.
- Williams ME, Wilke SA, Daggett A, Davis E, Otto S, Ravi D, Ripley B, Bushong EA, Ellisman MH, Klein G, Ghosh A (2011). Cadherin-9 regulates synapse-specific differentiation in the developing hippocampus. Neuron, 71(4), 640-55.
- Ripley B, Otto S, Tiglio K, Williams ME, Ghosh A (2011). Regulation of synaptic stability by AMPA receptor reverse signaling. Proc Natl Acad Sci U S A, 108(1), 367-72.
- Williams ME, de Wit J, Ghosh A (2010). Molecular mechanisms of synaptic specificity in developing neural circuits. [Review]. Neuron, 68(1), 9-18.
- Loomis WF, Behrens MM, Williams ME, Anjard C (2010). Pregnenolone sulfate and cortisol induce secretion of acyl-CoA-binding protein and its conversion into endozepines from astrocytes. J Biol Chem, 285(28), 21359-65.
- Stebbins JL, Zhang Z, Chen J, Wu B, Emdadi A, Williams ME, Cashman J, Pellecchia M (2007). Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors. J Med Chem, 50(26), 6607-17.
- Williams ME, Lu X, McKenna WL, Washington R, Boyette A, Strickland P, Dillon A, Kaprielian Z, Tessier-Lavigne M, Hinck L (2006). UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1. Nat Neurosci, 9(8), 996-8.
- Williams ME, Wu SC, McKenna WL, Hinck L (2003). Surface expression of the netrin receptor UNC5H1 is regulated through a protein kinase C-interacting protein/protein kinase-dependent mechanism. J Neurosci, 23(36), 11279-88.
- Williams ME, Strickland P, Watanabe K, Hinck L (2003). UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE. J Biol Chem, 278(19), 17483-90.