Demián Cazalla

Demián Cazalla, PhD

Languages spoken: English, Spanish

Academic Information

Departments Primary - Biochemistry

Lab

Education History

Graduate Training University of Buenos Aires
 MSc
Doctoral Training Medical Research Council, Human Genetics Unit and Open University
 PhD
Postdoctoral Training Yale University
 Postdoctoral Training

Selected Publications

Journal Article

  1. Cazalla (2021). Learning noncoding RNA biology from viruses. Mammalian genome, 33, 412-420.
  2. Gorbea C, Mosbruger T, Cazalla (2017). A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis. Nature, 550(7675), 275-279.
  3. Maurin T, Cazalla D, Yang S Jr, Bortolamiol-Becet D, Lai E (2012). RNase III-independent microRNA biogenesis in mammalian cells. RNA (New York, N.Y.), 18(12), 2166-73.
  4. Cazalla D, Xie M, Steitz J (2011). A primate herpesvirus uses the integrator complex to generate viral microRNAs. Molecular cell, 43(6), 982-92.
  5. DePaula-Silva AB, Gorbea C, Doty DJ, Libbey JE, Sanchez JMS, Hanak TJ, Cazalla D, Fujinami R (2019). Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation. Journal of neuroinflammation, 16(1), 152.
  6. Cazalla (2018). Novel roles for Sm-class RNAs in the regulation of gene expression. RNA biology, Jul 9:1-7.
  7. Giusti SA, Vogl AM, Brockmann MM, Vercelli CA, Rein ML, Trümbach D, Wurst W, Cazalla D, Stein V, Deussing JM, Refojo (2014). MicroRNA-9 controls dendritic development by targeting REST. eLife, 3,
  8. Gorbea C, Mosbruger T, Nix DA, Cazalla (2019). Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing. eLife, 8,
  9. Gorbea C, Elhakiem A, Cazalla (2022). Allosteric regulation of noncoding RNA function by microRNAs. Nucleic acids research, 50(11), 6511-6520.

Review

  1. Steitz J, Borah S, Cazalla D, Fok V, Lytle R, Mitton-Fry R, Riley K, Samji (2011). Noncoding RNPs of viral origin.LID - 10.1101/cshperspect.a005165 [doi]LID - a005165 [pii]. Cold Spring Harbor perspectives in biology, 3(3),
  2. Gorbea C, Elhakiem A, Cazalla (2023). Shaping the host cell environment with viral noncoding RNAs. Seminars in cell & developmental biology, 146, 20-30.