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Anandh Velayutham, PhD, MS, MPhil

Languages spoken: Tamil

Academic Office Information

anandh.velayutham@utah.edu

Anandh Babu Pon Velayutham, PhD is an Associate Professor in the Department of Nutrition & Integrative Physiology. He received his Ph.D. in Biochemistry from the University of Madras and subsequently completed postdoctoral training at Virginia Polytechnic Institute and State University. Dr. Velayutham joined the faculty at the University of Utah in 2012.

Research Statement

Diabetes greatly increases the risk of cardiovascular diseases, which accounts for the largest number of deaths among American diabetic patients. Dr. Velayutham’s research aims to determine potential non-pharmacological, lifestyle-oriented strategies to reduce the cardiovascular complications in diabetes. His current research investigates the vascular effects of blueberries and strawberries with special emphasis on the microbial metabolites of berry anthocyanins and the molecular signaling mechanisms involved. These studies will provide key insights toward understanding the causal association between dietary berries, gut microbiome and vascular health.

Selected Publications

Journal Article

  1. Pon Velayutham Anandh Babu (06/2006). P.V.Anandh Babu, K.E.Sabitha, C.S.Shyamaladevi. Green tea extract impedes dyslipidemia and development of cardiac dysfunction in streptozotocin diabetic rats. Clinical & Experimental Pharmacology and Physiology, 33: 1184-9 (2006). PMID: 17184499
  2. D.Bharat (12/2017). Blueberry metabolites attenuate lipotoxicity-induced endothelial dysfunction.
  3. Pon Velayutham Anandh Babu (04/2006). P.V.A. Babu, K.E.Sabitha, C.S.Shyamaladevi. Therapeutic effect of Green tea extract on advanced glycation and cross-linking of collagen in the aorta of streptozotocin diabetic rats. Clinical & Experimental Pharmacology and Physiology, 33: 351-7 (2006). PMID: 16620300
  4. Zhenquan Jia (02/2013). Z. Jia, W. Zhen, P.V.A. Babu, D. Liu. Phytoestrogen genistein protects against endothelial barrier dysfunction in vascular endothelial cells through PKA-mediated suppression of RhoA signaling. Endocrinology, 154: 727-737 (2013). PMC3548180
  5. Y.L (2016).
  6. Hongwei S (2011).
  7. Zhenquan Ji (2013).
  8. P. Nallasam (2014).
  9. X. L (2014).
  10. Pon Velayutham Anandh Bab (2012).
  11. Pon Velayutham Anandh Bab (2008).
  12. Pon Velayutham Anandh Bab (2006).
  13. Pon Velayutham Anandh Bab (2007).
  14. Y.Qia (2017). Metabolites of flavonoid compounds preserve indices of endothelial cell nitric oxide bioavailability under glucotoxic conditions. Nature,
  15. Pon Velayutham Anandh Bab (2006).
  16. Ramalingam Sivakuma (2009).
  17. C. Peterse (2019). Dietary supplementation of strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice.
  18. Brett R Cutle (2018). Blueberry metabolites reduce cell surface glycosaminoglycans and improve endothelial dysfunction in diabetic human aortic endothelial cells. International journal of cardiology,
  19. Ramalingam Sivakuma (2008).
  20. Kalit (2020). Visualizing antithrombin-binding 3-O-sulfated heparan sulfate motifs on cell surfaces.
  21. Chrissa Peterse (2018). Circulating metabolites of strawberry mediate reductions in vascular inflammation and endothelial dysfunction in db/db mice.
  22. L. P. Bharat (2015).
  23. Pon Velayutham Anandh Bab (2012).
  24. Pon Velayutham Anandh Bab (2007).
  25. Periasamy Srinivasa (2008).
  26. Wei Che (2015). Natural Products for the Prevention of Oxidative Stress-Related Diseases: Mechanisms and Strategies.
  27. L. Bharat (2017). Endothelial cell autophagy maintains shear-stress-induced nitric oxide generation via glycolysis-dependent purinergic signaling to eNOS.
  28. L. Panneerseelan-Bharat (2014).

Review

  1. Pari Mokhtari (2021). Impact of Type 1 Diabetes on the Composition and Functional Potential of Gut Microbiome in Children and Adolescents: Possible Mechanisms, Current Knowledge and Challenges. [Review]. Gut Microbes.
  2. Pon Velayutham Anandh Bab (2008).
  3. B.Cutle (2016). Mechanistic insights in the vascular effects of blueberries: Evidence from recent studies.
  4. Pon Velayutham Anandh Bab (2013).

Book Chapter

  1. Jae Min Cho (03/15/2021). Procedures to Evaluate the Role of Heparan Sulfate in the Reactivity of Resistance and Conductance Arteries Ex Vivo. Springer.
  2. P.V.A.Bab (2009). Flavonoids and cardiovascular health.
  3. Brett Cutle (2021). Methods to Analyze the Effect of Diet-Derived Metabolites on Endothelial Inflammation and Cell Surface Glycosaminoglycans.
  4. P.V.A. Bab (2016). Sulforaphane and atherosclerosis.

Other

  1. Z. Jia (01/2018). Natural Products Targeting on Oxidative Stress and Inflammation: Mechanisms, Therapies, and Safety Assessment. Hindawi.