No profile photo available

Bijina Balakrishnan, PhD, MS

Languages spoken: English

Academic Information

Departments Primary - Pediatrics

Divisions: Medical Genetics

Education History

Postdoctoral Training University of Utah
 Postdoctoral Training
Postdoctoral Training Nanyang Technological University
 Postdoctoral Training
Doctoral Training Cochin University of Science and Technology
 PhD
Graduate Training Cochin University of Science and Technology
 MS
Undergraduate University of Calicut
 BS

Selected Publications

Journal Article

  1. Zhong M, Balakrishnan B, Guo AJ, Lai K (2023). AAV9-based PMM2 gene replacement augments PMM2 expression and improves glycosylation in primary fibroblasts of patients with phosphomannomutase 2 deficiency (PMM2-CDG). Mol Genet Metab Rep, 38, 101035.
  2. Balakrishnan B, Altassan R, Budhraja R, Liou W, Lupo A, Bryant S, Mankouski A, Radenkovic S, Preston GJ, Pandey A, Boudina S, Kozicz T, Morava E, Lai K (2023). AAV-based gene therapy prevents and halts the progression of dilated cardiomyopathy in a mouse model of phosphoglucomutase 1 deficiency (PGM1-CDG). Transl Res, 257, 1-14.
  3. Liu L, Tang M, Pragani R, Whitby FG, Zhang YQ, Balakrishnan B, Fang Y, Karavadhi S, Tao D, LeClair CA, Hall MD, Marugan JJ, Boxer M, Shen M, Hill CP, Lai K, Patnaik S (2021). Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J Med Chem, 64(18), 13551-13571.
  4. Balakrishnan B, An D, Nguyen V, DeAntonis C, Martini PGV, Lai K (2019). Novel mRNA-Based Therapy Reduces Toxic Galactose Metabolites and Overcomes Galactose Sensitivity in a Mouse Model of Classic Galactosemia. Mol Ther, 28(1), 304-312.
  5. Balakrishnan B, Siddiqi A, Mella J, Lupo A, Li E, Hollien J, Johnson J, Lai K (2019). Salubrinal enhances eIF2α phosphorylation and improves fertility in a mouse model of Classic Galactosemia. Biochim Biophys Acta Mol Basis Dis, 1865(11), 165516.
  6. Balakrishnan B, Verheijen J, Lupo A, Raymond K, Turgeon C, Yang Y, Carter KL, Whitehead KJ, Kozicz T, Morava E, Lai K (2019). A novel phosphoglucomutase-deficient mouse model reveals aberrant glycosylation and early embryonic lethality. J Inherit Metab Dis, 42(5), 998-1007.
  7. Yuzyuk T, Balakrishnan B, Schwarz EL, De Biase I, Hobert J, Longo N, Mao R, Lai K, Pasquali M (2018). Effect of genotype on galactose-1-phosphate in classic galactosemia patients. Mol Genet Metab, 125(3), 258-265.
  8. Frigeni M, Balakrishnan B, Yin X, Calderon FRO, Mao R, Pasquali M, Longo N (2017). Functional and molecular studies in primary carnitine deficiency. Hum Mutat, 38(12), 1684-1699.
  9. Balakrishnan B, Nicholas C, Siddiqi A, Chen W, Bales E, Feng M, Johnson J, Lai K (2017). Reversal of aberrant PI3K/Akt signaling by Salubrinal in a GalT-deficient mouse model. Biochim Biophys Acta Mol Basis Dis, 1863(12), 3286-3293.
  10. Chen W, Caston R, Balakrishnan B, Siddiqi A, Parmar K, Tang M, Feng M, Lai K (2016). Assessment of ataxia phenotype in a new mouse model of galactose-1 phosphate uridylyltransferase (GALT) deficiency. J Inherit Metab Dis, 40(1), 131-137.
  11. Balakrishnan B, Chen W, Tang M, Huang X, Cakici DD, Siddiqi A, Berry G, Lai K (2016). Galactose-1 phosphate uridylyltransferase (GalT) gene: A novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts. Biochem Biophys Res Commun, 470(1), 205-212.
  12. Balakrishnan B, Chellappan S, Krishna JG, Basheer SM, Elyas KK, Bahkali AH, Chandrasekaran M (2011). Protease inhibitor from Moringa oleifera with potential for use as therapeutic drug and as seafood preservative. Saudi J Biol Sci, 18(3), 273-81.

Conference Proceedings

  1. Zhong M, Balakrishnan B, Guo AJ, Lai K (2023). AAV9-based PMM2 gene replacement augments PMM2 expression and improves glycosylation in primary fibroblasts of patients with phosphomannomutase 2 deficiency (PMM2-CDG). Glycobiology - Oxford Academic.