Education History
Postdoctoral Fellowship |
University of California, San Francisco |
Postdoctoral Fellow |
---|---|---|
Doctoral Training |
Massachusetts Institute of Technology Biology |
Ph.D. |
Undergraduate |
Pomona College Molecular Biology |
B.A. |
Selected Publications
- Denham ST, Brown JCS (2018). Mechanisms of pulmonary escape and dissemination by Cryptococcus neoformans. [Review]. J Fungi (Basel), 4(1), 25.
- Denham ST, Verma S, Reynolds RC, Worne CL, Daugherty JM, Lane TE, Brown JCS (2018). Regulated release of cryptococcal polysaccharide drives virulence and suppresses immune cell infiltration into the central nervous system. Infect Immun, 86(3), e00662-17.
- Wambaugh MA, Shakya VPS, Lewis AJ, Mulvey MA, Brown JCS (2017). High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance. PLoS Biol, 15(6), e2001644.
- Chiaro TR, Soto R, Stephens WZ, Kubinak JL, Petersen C, Gogokhia L, Bell R, Delgado JC, Cox J, Voth W, Brown J, Stillman DJ, OConnell RM, Tebo AE, and Round JL (2017). A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice. Sci Transl Med, 9(380), eaaf9044.
- Brown JC, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD (2014). Unraveling the biology of a fungal meningitis pathogen using chemical genetics. Cell, 159(5), 1168-87.
- Jarosz DF, Lancaster AK, Brown JC, Lindquist S (2014). An evolutionarily conserved prion-like element converts wild fungi from metabolic specialists to generalists. Cell, 158(5), 1072-82.
- Jarosz D, Brown JC, Walker GA, Datta MS, Ung WL, Lancaster AK, Rotem A, Chang A, Newby GA, Weitz DA, Bisson LF, Lindquist S (2014). Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism. Cell, 158(5), 1083-93.
- Butts A, Koselny K, Chabrier-Rosello Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE Jr, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ (2014). Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. mBio, 5(1), e00765-13.
- Brown JC, Madhani HD (2012). Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling. PLoS Genet, 8(12), e1003168.
- Chun CD, Brown JC, Madhani HD (2011). A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell Host Microbe, 9(3), 243-51.
- Brown JC, Lindquist S (2009). A heritable switch in carbon source utilization driven by an unusual yeast prion. Genes Dev, 23(19), 2320-32.
- Edwards S, Li CM, Levy DL, Brown J, Snow PM, Campbell JL (2003). Saccharomyces cerevisiae DNA polymerase epsilon and polymerase sigma interact physically and functionally, suggesting a role for polymerase epsilon in sister chromatid cohesion. Mol Cell Biol, 23(8), 2733-48.
- Grossmann KF, Brown JC, Moses RE (1999). Cisplatin DNA cross-links do not inhibit S-phase and cause only a G2/M arrest in Saccharomyces cerevisiae. Mutat Res, 434(1), 29-39.