Ryan M. Broxterman

Ryan M. Broxterman, PhD

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine

Divisions: Geriatrics

Academic Office Information

ryan.broxterman@hsc.utah.edu

Research Interests

  • Endothelial Function
  • Bioenergetics
  • Exercise Physiology
  • Breast Cancer
  • Blood Gas Analysis
  • Blood Pressure
  • Cardiovascular Diseases
  • Cardiovascular Physiology
  • Mitochondria, Muscle
  • Magnetic Resonance Spectroscopy
  • Oxygen Consumption
  • Exercise
  • Exercise Tolerance
  • Oxidative Stress
  • Muscle Fatigue
  • Cardiopulmonary Physiology
  • Blood Flow
  • Hypertension Management and Cardiovascular Disease Risk Reduction
  • Vascular Biology

Dr. Ryan M. Broxterman, Ph.D., is an Assistant Professor of Internal Medicine in the Division of Geriatrics and an Adjunct Assistant Professor in the Department of Nutrition & Integrative Physiology at the University of Utah, and a Research Health Scientist at the Salt Lake City Veterans Affairs Geriatric Research, Education, and Clinical Center. Dr. Broxterman is a member of the Utah Vascular Research Laboratory (UVRL) and maintains an extramurally-funded research program. His research broadly focuses on the integration of vascular, metabolic, and neuromuscular function as determinants of health and physical function. This includes assessing vascular function, oxygen transport and utilization, exercise tolerance, and skeletal muscle bioenergetics in health and disease. Dr. Broxterman has published over 65 peer-reviewed papers in journals such as European Respiratory Journal, Hypertension, Journal of Physiology, and Journal of Applied Physiology.

Education History

Fellowship University of Utah School of Medicine
 Fellow
Veterans Affairs Medical Center
 Fellow
Professional Medical Kansas State University
 PhD
Kansas State University
 MS
Undergraduate Washburn University
 BA

Selected Publications

Journal Article

  1. Broxterman RM, Wagner PD, Richardson RS (2023). Endurance exercise training changes the limitation on muscle V̇O2max in normoxia from the capacity to utilize O(2) to the capacity to transport O(2). J Physiol, 602(3), 445-459. (Read full article)
  2. Ratchford SM, Broxterman RM, La Salle DT, Kwon OS, Hopkins PN, Richardson RS, Trinity JD (2023). Obesity does not alter vascular function and handgrip exercise hemodynamics in middle-aged patients with hypertension. Am J Physiol Regul Integr Comp Physiol, 326(1), R1-R9. (Read full article)
  3. Shields KL, Jarrett CL, Bisconti AV, Park SH, Craig JC, Broxterman RM, Richardson RS (2023). Preserved endothelium-independent vascular function with aging in men and women: evidence from the peripheral and cerebral vasculature. J Appl Physiol (1985), 135(3), 559-571. (Read full article)
  4. Fermoyle CC, La Salle DT, Alpenglow JK, Craig JC, Jarrett CL, Broxterman RM, McKenzie AI, Morgan DE, Birgenheier NM, Wray DW, Richardson RS, Trinity JD (2023). Pharmacological modulation of adrenergic tone alters the vasodilatory response to passive leg movement in young but not in old adults. J Appl Physiol (1985), 134(5), 1124-1134. (Read full article)
  5. Abdalla LHP, Broxterman RM, Barstow TJ, Greco CC, Denadai BS (2022). Does creatine supplementation affect recovery speed of impulse above critical torque? Eur J Sport Sci, 1-12. (Read full article)
  6. Broxterman RM, La Salle DT, Zhao J, Reese VR, Kwon OS, Richardson RS, Trinity JD (2022). Dietary nitrate supplementation and small muscle mass exercise hemodynamics in patients with essential hypertension. J Appl Physiol (1985), 133(2), 506-516. (Read full article)
  7. Hureau TJ, Broxterman RM Co-First Author, Weavil JC, Lewis MT, Layec G, Amann M (2022). On the role of skeletal muscle acidosis and inorganic phosphates as determinants of central and peripheral fatigue: A 31 P-MRS study. J Physiol, 600(13), 3069-3081. (Read full article)
  8. Fermoyle CC, Broxterman RM, La Salle DT, Ratchford SM, Hopkins PN, Richardson RS, Trinity JD (2023). Persistent vascular dysfunction following an acute nonpharmacological reduction in blood pressure in hypertensive patients. J Hypertens, 40(6), 1115-1125. (Read full article)
  9. Groot HJ, Broxterman RM, Gifford JR, Garten RS, Rossman MJ, Jarrett CL, Kwon OS, Hydren JR, Richardson RS (2022). Reliability of the passive leg movement assessment of vascular function in men. Exp Physiol, 107(5), 541-552. (Read full article)
  10. Bisconti AV, Garten RS, Broxterman RM, Jarrett CL, Park SH, Shields KL, Clifton HL, Ratchford SM, Reese VR, Zhao J, Wray DW, Richardson RS (2022). No effect of acute tetrahydrobiopterin (BH4) supplementation on vascular dysfunction in the old. J Appl Physiol (1985), 132(3), 773-784. (Read full article)
  11. Shields KL, Broxterman RM, Jarrett CL, Bisconti AV, Park SH, Richardson RS (2021). The passive leg movement technique for assessing vascular function: the impact of baseline blood flow. Exp Physiol, 106(10), 2133-2147. (Read full article)
  12. Abdalla LHP, Broxterman RM, Barstow TJ, Greco CC, Denadai BS (2021). W' reconstitution rate at different intensities above critical torque: the role of muscle size and maximal strength. Exp Physiol, 106(9), 1909-1921. (Read full article)
  13. Broxterman RM, Wagner PD, Richardson RS (2021). Exercise training in COPD: muscle O2 transport plasticity. Eur Respir J, 58(2). (Read full article)
  14. Craig JC, Broxterman RM, Cerbie JF, La Salle DT, Roundy CS, Jarrett CL, Richardson RS, Trinity JD (2021). The dynamic adjustment of mean arterial pressure during exercise: a potential tool for discerning cardiovascular health status. J Appl Physiol (1985), 130(5), 1544-1554. (Read full article)
  15. Hydren JR, Gifford JR, Jarrett CL, Park SH, Shields KL, Broxterman RM, Kithas AC, Bisconti AV, Thurston TS, Ratchford SM, Wray DW, Stehlik J, Selzman CH, Drakos SG, Richardson RS (2021). Vascular function in continuous-flow left ventricular assist device recipients: effect of a single pulsatility treatment session. Am J Physiol Regul Integr Comp Physiol, 320(4), R425-R437. (Read full article)
  16. Trinity JD, Kwon OS, Broxterman RM, Gifford JR, Kithas AC, Hydren JR, Jarrett CL, Shields KL, Bisconti AV, Park SH, Craig JC, Nelson AD, Morgan DE, Jessop JE, Bledsoe AD, Richardson RS (2020). The role of the endothelium in the hyperemic response to passive leg movement: looking beyond nitric oxide. Am J Physiol Heart Circ Physiol, 320(2), H668-H678. (Read full article)
  17. Weavil JC, Thurston TS, Hureau TJ, Gifford JR, Kithas PA, Broxterman RM, Bledsoe AD, Nativi JN, Richardson RS, Amann M (2020). Heart failure with preserved ejection fraction diminishes peripheral hemodynamics and accelerates exercise-induced neuromuscular fatigue. Am J Physiol Heart Circ Physiol, 320(1), H338-H351. (Read full article)
  18. Ratchford SM, Clifton HL, La Salle DT, Broxterman RM, Lee JF, Ryan JJ, Hopkins PN, Wright JB, Trinity JD, Richardson RS, Wray DW (2020). Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction. J Appl Physiol (1985), 129(6), 1267-1276. (Read full article)
  19. Abdalla LHP, Broxterman RM, Greco CC, Denadai BS (2020). Creatine supplementation attenuates the rate of fatigue development during intermittent isometric exercise performed above end-test torque. Exp Physiol, 105(12), 2073-2085. (Read full article)
  20. Kithas AC, Broxterman RM, Trinity JD, Gifford JR, Kwon OS, Hydren JR, Nelson AD, Jessop JE, Bledsoe AD, Morgan DE, Richardson RS (2020). Nitric oxide synthase inhibition with N(G)-monomethyl-l-arginine: Determining the window of effect in the human vasculature. Nitric Oxide, 104-105, 51-60. (Read full article)
  21. Jarrett CL, Shields KL, Broxterman RM, Hydren JR, Park SH, Gifford JR, Richardson RS (2020). Imaging transcranial Doppler ultrasound to measure middle cerebral artery blood flow: the importance of measuring vessel diameter. Am J Physiol Regul Integr Comp Physiol, 319(1), R33-R42. (Read full article)
  22. Broxterman RM, Hoff J, Wagner PD, Richardson RS (2020). Determinants of the diminished exercise capacity in patients with chronic obstructive pulmonary disease: looking beyond the lungs. J Physiol, 598(3), 599-610. (Read full article)
  23. Craig JC, Broxterman RM, La Salle DT, Cerbie J, Ratchford SM, Gifford JR, Bunsawat K, Nelson AD, Bledsoe AD, Morgan DE, Wray DW, Richardson RS, Trinity JD (2019). The role of endothelin A receptors in peripheral vascular control at rest and during exercise in patients with hypertension. J Physiol, 598(1), 71-84. (Read full article)
  24. Ratchford SM, Broxterman RM, La Salle DT, Kwon OS, Park SY, Hopkins PN, Richardson RS, Trinity JD (2019). Salt restriction lowers blood pressure at rest and during exercise without altering peripheral hemodynamics in hypertensive individuals. Am J Physiol Heart Circ Physiol, 317(6), H1194-H1202. (Read full article)
  25. Shields KL, Broxterman RM, Jarrett CL, Bisconti AV, Park SH, Richardson RS (2019). The passive leg movement technique for assessing vascular function: defining the distribution of blood flow and the impact of occluding the lower leg. Exp Physiol, 104(10), 1575-1584. (Read full article)
  26. Broxterman RM, La Salle DT, Zhao J, Reese VR, Richardson RS, Trinity JD (2019). Influence of dietary inorganic nitrate on blood pressure and vascular function in hypertension: prospective implications for adjunctive treatment. J Appl Physiol (1985), 127(4), 1085-1094. (Read full article)
  27. Broxterman RM, Witman MA, Trinity JD, Groot HJ, Rossman MJ, Park SY, Malenfant S, Gifford JR, Kwon OS, Park SH, Jarrett CL, Shields KL, Hydren JR, Bisconti AV, Owan T, Abraham A, Tandar A, Lui CY, Smith BR, Richardson RS (2019). Strong Relationship Between Vascular Function in the Coronary and Brachial Arteries. Hypertension, 74(1), 208-215. (Read full article)
  28. Hydren JR, Broxterman RM, Trinity JD, Gifford JR, Kwon OS, Kithas AC, Richardson RS (2019). Delineating the age-related attenuation of vascular function: Evidence supporting the efficacy of the single passive leg movement as a screening tool. J Appl Physiol (1985), 126(6), 1525-1532. (Read full article)
  29. Alexander AM, Didier KD, Hammer SM, Dzewaltowski AC, Kriss KN, Lovoy GM, Hammer JL, Smith JR, Ade CJ, Broxterman RM, Barstow TJ (2019). Exercise tolerance through severe and extreme intensity domains. Physiol Rep, 7(5), e14014. (Read full article)
  30. Broxterman RM, Craig JC, Richardson RS (2018). The Respiratory Compensation Point and the Deoxygenation Break Point Are Not Valid Surrogates for Critical Power and Maximum Lactate Steady State. Med Sci Sports Exerc, 50(11), 2379-2382. (Read full article)
  31. Craig JC, Broxterman RM, Smith JR, Allen JD, Barstow TJ (2018). Effect of dietary nitrate supplementation on conduit artery blood flow, muscle oxygenation, and metabolic rate during handgrip exercise. J Appl Physiol (1985), 125(2), 254-262. (Read full article)
  32. Broxterman RM, Hureau TJ, Layec G, Morgan DE, Bledsoe AD, Jessop JE, Amann M, Richardson RS (2018). Influence of group III/IV muscle afferents on small muscle mass exercise performance: a bioenergetics perspective. J Physiol, 596(12), 2301-2314. (Read full article)
  33. Hureau TJ, Weavil JC, Thurston TS, Broxterman RM, Nelson AD, Bledsoe AD, Jessop JE, Richardson RS, Wray DW, Amann M (2018). Identifying the role of group III/IV muscle afferents in the carotid baroreflex control of mean arterial pressure and heart rate during exercise. J Physiol, 596(8), 1373-1384. (Read full article)
  34. Broxterman RM, Layec G, Hureau TJ, Morgan DE, Bledsoe AD, Jessop JE, Amann M, Richardson RS (2017). Bioenergetics and ATP Synthesis during Exercise: Role of Group III/IV Muscle Afferents. Med Sci Sports Exerc, 49(12), 2404-2413. (Read full article)
  35. Broxterman RM, Trinity JD, Gifford JR, Kwon OS, Kithas AC, Hydren JR, Nelson AD, Morgan DE, Jessop JE, Bledsoe AD, Richardson RS (2017). Single passive leg movement assessment of vascular function: contribution of nitric oxide. J Appl Physiol (1985), 123(6), 1468-1476. (Read full article)
  36. Craig JC, Broxterman RM, Wilcox SL, Chen C, Barstow TJ (2017). Effect of adipose tissue thickness, muscle site, and sex on near-infrared spectroscopy derived total-[hemoglobin + myoglobin]. J Appl Physiol (1985), 123(6), 1571-1578. (Read full article)
  37. Ade CJ, Broxterman RM, Charvat JM, Barstow TJ (2017). Incidence Rate of Cardiovascular Disease End Points in the National Aeronautics and Space Administration Astronaut Corps. J Am Heart Assoc, 6(8). (Read full article)
  38. Layec G, Hart CR, Trinity JD, Kwon OS, Rossman MJ, Broxterman RM, Le Fur Y, Jeong EK, Richardson RS (2017). Oxygen delivery and the restoration of the muscle energetic balance following exercise: implications for delayed muscle recovery in patients with COPD. Am J Physiol Endocrinol Metab, 313(1), E94-E104. (Read full article)
  39. Broxterman RM, Layec G, Hureau TJ, Amann M, Richardson RS (2017). Skeletal muscle bioenergetics during all-out exercise: mechanistic insight into the oxygen uptake slow component and neuromuscular fatigue. J Appl Physiol (1985), 122(5), 1208-1217. (Read full article)
  40. Smith JR, Alexander AM, Hammer SM, Didier KD, Kurti SP, Broxterman RM, Barstow TJ, Harms CA (2017). Cardiovascular consequences of the inspiratory muscle metaboreflex: effects of age and sex. Am J Physiol Heart Circ Physiol, 312(5), H1013-H1020. (Read full article)
  41. Ade CJ, Broxterman RM, Moore AD, Barstow TJ (2017). Decreases in maximal oxygen uptake following long-duration spaceflight: Role of convective and diffusive O2 transport mechanisms. J Appl Physiol (1985), 122(4), 968-975. (Read full article)
  42. Venturelli M, Layec G, Trinity J, Hart CR, Broxterman RM, Richardson RS (2016). Single passive leg movement-induced hyperemia: a simple vascular function assessment without a chronotropic response. J Appl Physiol (1985), 122(1), 28-37. (Read full article)
  43. Broxterman RM, Skiba PF, Craig JC, Wilcox SL, Ade CJ, Barstow TJ (2016). W' expenditure and reconstitution during severe intensity constant power exercise: mechanistic insight into the determinants of W'. Physiol Rep, 4(19). (Read full article)
  44. Smith JR, Broxterman RM, Hammer SM, Alexander AM, Didier KD, Kurti SP, Barstow TJ, Harms CA (2016). Sex differences in the cardiovascular consequences of the inspiratory muscle metaboreflex. Am J Physiol Regul Integr Comp Physiol, 311(3), R574-81. (Read full article)
  45. Noel JA, Broxterman RM, McCoy GM, Craig JC, Phelps KJ, Burnett DD, Vaughn MA, Barstow TJ, OQuinn TG, Woodworth JC, DeRouchey JM, Rozell TG, Gonzalez JM (2016). Use of electromyography to detect muscle exhaustion in finishing barrows fed ractopamine HCl. J Anim Sci, 94(6), 2344-56. (Read full article)
  46. Ade CJ, Broxterman RM, Craig JC, Schlup SJ, Wilcox SL, Warren S, Kuehl P, Gude D, Jia C, Barstow TJ (2016). Prediction of Lunar- and Martian-Based Intra- and Site-to-Site Task Performance. Aerosp Med Hum Perform, 87(4), 367-74. (Read full article)
  47. Smith JR, Broxterman RM, Ade CJ, Evans KK, Kurti SP, Hammer SM, Barstow TJ, Harms CA (2016). Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise. Physiol Rep, 4(7). (Read full article)
  48. Wilcox SL, Broxterman RM, Barstow TJ (2015). Constructing quasi-linear V̇O2 responses from nonlinear parameters. J Appl Physiol (1985), 120(2), 121-9. (Read full article)
  49. Schlup SJ, Ade CJ, Broxterman RM, Barstow TJ (2015). Discrepancy between femoral and capillary blood flow kinetics during knee extension exercise. Respir Physiol Neurobiol, 219, 69-77. (Read full article)
  50. Ade CJ, Broxterman RM, Craig JC, Schlup SJ, Wilcox SL, Barstow TJ (2015). Standardized Exercise Tests and Simulated Terrestrial Mission Task Performance. Aerosp Med Hum Perform, 86(11), 982-9. (Read full article)
  51. Broxterman RM, Craig JC, Ade CJ, Wilcox SL, Barstow TJ (2015). The effect of resting blood flow occlusion on exercise tolerance and W'. Am J Physiol Regul Integr Comp Physiol, 309(6), R684-91. (Read full article)
  52. Broxterman RM, Craig JC, Smith JR, Wilcox SL, Jia C, Warren S, Barstow TJ (2015). Influence of blood flow occlusion on the development of peripheral and central fatigue during small muscle mass handgrip exercise. J Physiol, 593(17), 4043-54. (Read full article)
  53. Ade CJ, Broxterman RM, Barstow TJ (2014). VO(2max) and Microgravity Exposure: Convective versus Diffusive O(2) Transport. Med Sci Sports Exerc, 47(7), 1351-61. (Read full article)
  54. Ade CJ, Broxterman RM, Craig JC, Schlup SJ, Wilcox SL, Barstow TJ (2015). Upper Body Aerobic Exercise as a Possible Predictor of Lower Body Performance. Aerosp Med Hum Perform, 86(7), 599-605. (Read full article)
  55. Broxterman RM, Ade CJ, Craig JC, Wilcox SL, Schlup SJ, Barstow TJ (2015). Influence of blood flow occlusion on muscle oxygenation characteristics and the parameters of the power-duration relationship. J Appl Physiol (1985), 118(7), 880-9. (Read full article)
  56. Broxterman RM, Ade CJ, Barker T, Barstow TJ (2014). Influence of pedal cadence on the respiratory compensation point and its relation to critical power. Respir Physiol Neurobiol, 208, 1-7. (Read full article)
  57. Broxterman RM, Ade CJ, Craig JC, Wilcox SL, Schlup SJ, Barstow TJ (2014). The relationship between critical speed and the respiratory compensation point: Coincidence or equivalence. Eur J Sport Sci, 15(7), 631-9. (Read full article)
  58. Ade CJ, Broxterman RM, Craig JC, Schlup SJ, Wilcox SL, Barstow TJ (2014). Relationship between simulated extravehicular activity tasks and measurements of physical performance. Respir Physiol Neurobiol, 203, 19-27. (Read full article)
  59. Smith JR, Ade CJ, Broxterman RM, Skutnik BC, Barstow TJ, Wong BJ, Harms CA (2014). Influence of exercise intensity on respiratory muscle fatigue and brachial artery blood flow during cycling exercise. Eur J Appl Physiol, 114(8), 1767-77. (Read full article)
  60. Broxterman RM, Ade CJ, Wilcox SL, Schlup SJ, Craig JC, Barstow TJ (2013). Influence of duty cycle on the power-duration relationship: observations and potential mechanisms. Respir Physiol Neurobiol, 192, 102-11. (Read full article)
  61. Kuehl P, Chen Jia, Gude D, Broxterman R, Barstow T, Warren S (2015). Real-time processing of electromyograms in an automated hand-forearm ergometer data collection and analysis system. Annu Int Conf IEEE Eng Med Biol Soc, 2014, 5756-9. (Read full article)
  62. Ade CJ, Broxterman RM, Barstow TJ (2013). Effects of body posture and exercise training on cardiorespiratory responses to exercise. Respir Physiol Neurobiol, 188(1), 39-48. (Read full article)
  63. Broxterman RM, Ade CJ, Poole DC, Harms CA, Barstow TJ (2012). A single test for the determination of parameters of the speed-time relationship for running. Respir Physiol Neurobiol, 185(2), 380-5. (Read full article)
  64. Ade CJ, Broxterman RM, Wong BJ, Barstow TJ (2012). Anterograde and retrograde blood velocity profiles in the intact human cardiovascular system. Exp Physiol, 97(7), 849-60. (Read full article)
  65. Song W, Ade C, Broxterman R, Barstow T, Nelson T, Warren S (2013). Activity recognition in planetary navigation field tests using classification algorithms applied to accelerometer data. Annu Int Conf IEEE Eng Med Biol Soc, 2012, 1586-9. (Read full article)
  66. Gude D, Broxterman R, Ade C, Barstow T, Nelson T, Song W, Warren S (2013). Automated hand-forearm ergometer data collection system. Annu Int Conf IEEE Eng Med Biol Soc, 2012, 2379-82. (Read full article)

Review

  1. Trinity JD, Broxterman RM, Richardson RS (2016). Regulation of exercise blood flow: Role of free radicals. [Review]. Free Radic Biol Med, 98, 90-102.

Editorial

  1. Ade CJ, Broxterman R, Hundley WG (2022). Exercise Testing in Those Treated for Breast Cancer: Can One Forecast Peak Oxygen Consumption? JACC CardioOncol, 4(2), 220-222. (Read full article)

Letter

  1. Broxterman RM, Craig JC, Kirby BS (2022). Critical Power: Over 95 years of evidence and evolution. [Letter to the editor]. Scand J Med Sci Sports, 32(5), 933-934. (Read full article)
  2. Broxterman RM, Craig JC, Weavil JC, Hureau TJ (2019). The relationship between W' and peripheral fatigue considered. [Letter to the editor]. Exp Physiol, 105(1), 211-212. (Read full article)
  3. Broxterman RM, Layec G, Hureau TJ, Morgan DE, Bledsoe AD, Jessop JE, Amann M, Richardson RS (2018). Response. [Letter to the editor]. Med Sci Sports Exerc, 50(8), 1719. (Read full article)
  4. Angius L, Crisafulli A, Hureau TJ, Broxterman RM, Amann M, Incognito AV, Burr JF, Millar PJ, Jones H, Thijssen DJ, Patterson SD, Jeffries O, Waldron M, Silva BM, Lopes TR, Vianna LC, Smith JR, Copp SW, Van Guilder GP, Zuo L, Chuang CC (2017). Commentaries on Viewpoint: Could small-diameter muscle afferents be responsible for the ergogenic effect of limb ischemic preconditioning? [Letter to the editor]. J Appl Physiol (1985), 122(3), 721-725.
  5. Hureau TJ, Broxterman RM, Weavil JC (2016). The mechanistic basis of the power-time relationship: potential role of the group III/IV muscle afferents. [Letter to the editor]. J Physiol, 594(24), 7165-7166.
  6. Broxterman RM, Richardson RS, Amann M (2015). Less peripheral fatigue after prior exercise is not evidence against the regulation of the critical peripheral fatigue threshold. [Letter to the editor]. J Appl Physiol (1985), 119(12), 1520. (Read full article)
  7. Craig JC, Broxterman RM, Barstow TJ (2015). Considerations for Identifying the Boundaries of Sustainable Performance. [Letter to the editor]. Med Sci Sports Exerc, 47(9), 1997. (Read full article)
  8. Ade CJ, Broxterman RM, Barstow TJ (2011). Critical velocity and maximal lactate steady state: better determinants of 2-hour marathon. [Letter to the editor]. J Appl Physiol (1985), 110(1), 287-8; discussion 294. (Read full article)