Clement Y. Chow

Clement Y. Chow, PhD

Languages spoken: English

Academic Information

Departments Primary - Human Genetics

Research Interests

  • Genetic Variation
  • Rare Diseases
  • Genetic Modifiers
  • ER Stress
  • Drosophila
  • Human and Mouse Genetics

Education History

Postdoctoral Fellowship Cornell University
 Postdoctoral Fellow
University of Michigan
 PhD
Undergraduate Cornell University
 BA

Selected Publications

Journal Article

  1. Thorpe HJ, Partha R, Little J, Clark NL, Chow CY (2024). Evolutionary rate covariation is pervasive between glycosylation pathways and points to potential disease modifiers. bioRxiv.
  2. Thorpe HJ, Owings KG, Aziz MC, Haller M, Coelho E, Chow CY (2023). Drosophila models of phosphatidylinositol glycan biosynthesis class A congenital disorder of glycosylation (PIGA-CDG) mirror patient phenotypes. G3 (Bethesda), 14(3). (Read full article)
  3. Owings KG, Chow CY (2023). A Drosophila screen identifies a role for histone methylation in ER stress preconditioning. G3 (Bethesda), 14(2). (Read full article)
  4. Russell ND, Jorde LB, Chow CY (2023). Characterizing genetic variation in the regulation of the ER stress response through computational and cis-eQTL analyses. G3 (Bethesda), 13(12). (Read full article)
  5. Johnstone EB, Gorsi B, Coelho E, Moore B, Farr AM, Cooper AR, Mardis ER, Rajkovic A, Chow CY, Yandell M, Welt CK (2022). DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis. J Clin Endocrinol Metab, 108(9), 2330-2335. (Read full article)
  6. Dalton HM, Viswanatha R, Brathwaite R Jr, Zuno JS, Berman AR, Rushforth R, Mohr SE, Perrimon N, Chow CY (2022). A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. PLoS Genet, 18(9), e1010430. (Read full article)
  7. Hope KA, Berman AR, Peterson RT, Chow CY (2022). An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency. PLoS Genet, 18(6), e1010228. (Read full article)
  8. Russell ND, Chow CY (2022). The dynamic effect of genetic variation on the in vivo ER stress transcriptional response in different tissues. G3 (Bethesda), 12(6). (Read full article)
  9. Gorsi B, Hernandez E, Moore MB, Moriwaki M, Chow CY, Coelho E, Taylor E, Lu C, Walker A, Touraine P, Nelson LM, Cooper AR, Mardis ER, Rajkovic A, Yandell M, Welt CK (2021). Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency. J Clin Endocrinol Metab, 107(3), 685-714. (Read full article)
  10. Talsness DM, Owings KG, Coelho E, Mercenne G, Pleinis JM, Partha R, Hope KA, Zuberi AR, Clark NL, Lutz CM, Rodan AR, Chow CY (2020). A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency. Elife, 9. (Read full article)
  11. Palu RAS, Dalton HM, Chow CY (2020). Decoupling of Apoptosis from Activation of the ER Stress Response by the Drosophila Metallopeptidase superdeath. Genetics, 214(4), 913-925. (Read full article)
  12. Palu RAS, Ong E, Stevens K, Chung S, Owings KG, Goodman AG, Chow CY (2019). Natural Genetic Variation Screen in Drosophila Identifies Wnt Signaling, Mitochondrial Metabolism, and Redox Homeostasis Genes as Modifiers of Apoptosis. G3 (Bethesda), 9(12), 3995-4005. (Read full article)
  13. Ahlers LRH, Trammell CE, Carrell GF, Mackinnon S, Torrevillas BK, Chow CY, Luckhart S, Goodman AG (2019). Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors. Cell Rep, 29(7), 1946-1960.e5. (Read full article)
  14. Palu RAS, Chow CY (2018). Baldspot/ELOVL6 is a conserved modifier of disease and the ER stress response. PLoS Genet, 14(8), e1007557. (Read full article)
  15. Lavoy S, Chittoor-Vinod VG, Chow CY, Martin I (2018). Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease. Genetics, 209(4), 1345-1356. (Read full article)
  16. Owings KG, Lowry JB, Bi Y, Might M, Chow CY (2018). Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches. Hum Mol Genet, 27(6), 1055-1066. (Read full article)
  17. Delbare SYN, Chow CY, Wolfner MF, Clark AG (2017). Roles of Female and Male Genotype in Post-Mating Responses in Drosophila melanogaster. J Hered, 108(7), 740-753. (Read full article)
  18. Chow CY, Kelsey KJ, Wolfner MF, Clark AG (2016). Candidate genetic modifiers of retinitis pigmentosa identified by exploiting natural variation in Drosophila. Hum Mol Genet, 25(4), 651-9. (Read full article)
  19. Chow CY (2016). Bringing genetic background into focus. Nat Rev Genet, 17(2), 63-4. (Read full article)
  20. Chow CY, Avila FW, Clark AG, Wolfner MF (2015). Induction of excessive endoplasmic reticulum stress in the Drosophila male accessory gland results in infertility. PLoS One, 10(3), e0119386. (Read full article)
  21. Chow CY, Wang X, Riccardi D, Wolfner MF, Clark AG (2015). The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse. PLoS Genet, 11(2), e1004924. (Read full article)
  22. Chow CY, Wolfner MF, Clark AG (2013). Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes. Proc Natl Acad Sci U S A, 110(22), 9013-8. (Read full article)
  23. Chow CY, Wolfner MF, Clark AG (2013). Large neurological component to genetic differences underlying biased sperm use in Drosophila. Genetics, 193(1), 177-85. (Read full article)
  24. Im KM, Kirchhoff T, Wang X, Green T, Chow CY, Vijai J, Korn J, Gaudet MM, Fredericksen Z, Shane Pankratz V, Guiducci C, Crenshaw A, McGuffog L, Kartsonaki C, Morrison J, Healey S, Sinilnikova OM, Mai PL, Greene MH, Piedmonte M, Rubinstein WS, Hogervorst FB, Rookus MA, Collee JM, Hoogerbrugge N, van Asperen CJ, Meijers-Heijboer HE, Van Roozendaal CE, Caldes T, Perez-Segura P, Jakubowska A, Lubinski J, Huzarski T, Blecharz P, Nevanlinna H, Aittomaki K, Lazaro C, Blanco I, Barkardottir RB, Montagna M, DAndrea E, Devilee P, Olopade OI, Neuhausen SL, Peissel B, Bonanni B, Peterlongo P, Singer CF, Rennert G, Lejbkowicz F, Andrulis IL, Glendon G, Ozcelik H, Toland AE, Caligo MA, Beattie MS, Chan S, Domchek SM, Nathanson KL, Rebbeck TR, Phelan C, Narod S, John EM, Hopper JL, Buys SS, Daly MB, Southey MC, Terry MB, Tung N, Hansen TV, Osorio A, Benitez J, Duran M, Weitzel JN, Garber J, Hamann U, Peock S, Cook M, Oliver CT, Frost D, Platte R, Evans DG, Eeles R, Izatt L, Paterson J, Brewer C, Hodgson S, Morrison PJ, Porteous M, Walker L, Rogers MT, Side LE, Godwin AK, Schmutzler RK, Wappenschmidt B, Laitman Y, Meindl A, Deissler H, Varon-Mateeva R, Preisler-Adams S, Kast K, Venat-Bouvet L, Stoppa-Lyonnet D, Chenevix-Trench G, Easton DF, Klein RJ, Daly MJ, Friedman E, Dean M, Clark AG, Altshuler DM, Antoniou AC, Couch FJ, Offit K, Gold B (2011). Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers. Hum Genet, 130(5), 685-99. (Read full article)
  25. Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM, Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler MH (2011). Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J. PLoS Genet, 7(6), e1002104. (Read full article)
  26. Chow CY, Wolfner MF, Clark AG (2010). The genetic basis for male x female interactions underlying variation in reproductive phenotypes of Drosophila. Genetics, 186(4), 1355-65. (Read full article)
  27. Sirot LK, LaFlamme BA, Sitnik JL, Rubinstein CD, Avila FW, Chow CY, Wolfner MF (2009). Molecular social interactions: Drosophila melanogaster seminal fluid proteins as a case study. Adv Genet, 68, 23-56. (Read full article)
  28. Chow CY, Landers JE, Bergren SK, Sapp PC, Grant AE, Jones JM, Everett L, Lenk GM, McKenna-Yasek DM, Weisman LS, Figlewicz D, Brown RH, Meisler MH (2009). Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. Am J Hum Genet, 84(1), 85-8. (Read full article)
  29. Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS (2008). VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J, 27(24), 3221-34. (Read full article)
  30. Zhang X, Chow CY, Sahenk Z, Shy ME, Meisler MH, Li J (2008). Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration. Brain, 131(Pt 8), 1990-2001. (Read full article)
  31. McKinney BC, Chow CY, Meisler MH, Murphy GG (2008). Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6). Genes Brain Behav, 7(6), 629-38. (Read full article)
  32. Zhang Y, Zolov SN, Chow CY, Slutsky SG, Richardson SC, Piper RC, Yang B, Nau JJ, Westrick RJ, Morrison SJ, Meisler MH, Weisman LS (2007). Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A, 104(44), 17518-23. (Read full article)
  33. Chow CY, Zhang Y, Dowling JJ, Jin N, Adamska M, Shiga K, Szigeti K, Shy ME, Li J, Zhang X, Lupski JR, Weisman LS, Meisler MH (2007). Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature, 448(7149), 68-72. (Read full article)

Review

  1. Chow CY, Reiter LT (2017). Etiology of Human Genetic Disease on the Fly. [Review]. Trends Genet, 33(6), 391-398. (Read full article)