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Candice D. Fike

Candice D. Fike, MD

Languages spoken: English

Academic Information

Departments Primary - Pediatrics

Divisions: Neonatology

Board Certification

  • National Board of Medical Examiners
  • American Board of Pediatrics (Pediatrics)
  • American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine)

Dr. Fike received her medical degree from the University of Colorado Health Sciences Center in Denver, Colorado and completed her Pediatric residency at the University of Arizona Health Sciences Center in Tucson, Arizona. She then completed a Neonatology fellowship at Baylor College of Medicine in Houston, TX followed by a research fellowship at the Cardiovascular Research Institute at the University of California, San Francisco. She has been on the faculty in the Dept. of Pediatrics at Baylor College of Medicine, the University of Utah School of Medicine, the Medical College of Wisconsin, Wake Forest University Medical School, and Vanderbilt University School of Medicine. Dr. Fike’s clinical interests include improving the care of infants with chronic lung diseases and chronic forms of pulmonary hypertension. She is particularly interested in applying knowledge gained from pre-clinical development studies performed in her laboratory to improve the outcome for infants with pulmonary hypertension associated with chronic cardiopulmonary conditions. She is also interested in improving the continuity of clinical care for newborns with complex chronic conditions, including those with chronic lung and pulmonary vascular diseases.

Education History

Undergraduate Rice University
BA
Professional Medical University of Colorado School of Medicine
MD
Internship University of Arizona Health Sciences Center
Intern
Residency University of Arizona Health Sciences Center
Resident
Postdoctoral Fellowship Baylor College of Medicine
Postdoctoral Fellow
Research Fellow Cardiovascular Research Institute, University of California, San Francisco School of Medicine
Postdoctoral Research Fellow

Selected Publications

Journal Article

  1. Dikalova A, Aschner JL, Kaplowitz MR, Cunningham G, Summar M, Fike C (2020). Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs. American journal of physiology. Lung cellular and molecular physiology, 318(4), L762-L772.
  2. McClellan EB, Wang Z, Albertine KH, Kaplowitz MR, Zhang Y, Fike C (2020). l-Citrulline treatment alters the structure of the pulmonary circulation in hypoxic newborn pigs. Pediatric pulmonology, 55(10), 2762-2772.
  3. Douglass MS, Zhang Y, Kaplowitz MR, Fike C (2021). L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells. Pulmonary circulation, 11(2), 20458940211006289.
  4. Douglass M, Dikalova A, Kaplowitz MR, Zhang Y, Cunningham G, Summar M, Fike C (2021). Folic acid, either solely or combined with L-citrulline, improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs. Physiological reports, 9(21), e15096.
  5. Fike CD, Avachat C, Birnbaum AK, Aschner JL, Sherwin C (2023). Pharmacokinetics of L-Citrulline in Neonates at Risk of Developing Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension. Paediatric drugs, 25(1), 87-96.
  6. Douglass MS, Kaplowitz MR, Zhang Y, Fike C (2023). Impact of l-citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells. Pulmonary circulation, 13(2), e12221.
  7. Fike CD, Aschner JL, Avachat C, Birnbaum AK, Sherwin CM (2024). Multi-dose enteral L-citrulline administration in premature infants at risk of developing pulmonary hypertension associated with bronchopulmonary dysplasia. Journal of perinatology, 44(2), 280-287.

Review

  1. Fike CD, Aschner J (2023). Pharmacotherapy for Pulmonary Hypertension in Infants with Bronchopulmonary Dysplasia: Past, Present, and Future. Pharmaceuticals (Basel, Switzerland), 16(4),
  2. Rashid J, Kumar SS, Job KM, Liu X, Fike CD, Sherwin CM (2020). Therapeutic Potential of Citrulline as an Arginine Supplement: A Clinical Pharmacology Review. Paediatric drugs, 22(3), 279-293.