Education History
| Undergraduate |
Rice University |
BA |
|---|---|---|
| Professional Medical |
University of Colorado School of Medicine |
MD |
| Internship |
University of Arizona Health Sciences Center |
Intern |
| Residency |
University of Arizona Health Sciences Center |
Resident |
| Postdoctoral Fellowship |
Baylor College of Medicine |
Postdoctoral Fellow |
| Research Fellow |
Cardiovascular Research Institute, University of California, San Francisco School of Medicine |
Postdoctoral Research Fellow |
Selected Publications
Journal Article
- Dikalova A, Aschner JL, Kaplowitz MR, Cunningham G, Summar M, Fike C (2020). Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs. American journal of physiology. Lung cellular and molecular physiology, 318(4), L762-L772.
- McClellan EB, Wang Z, Albertine KH, Kaplowitz MR, Zhang Y, Fike C (2020). l-Citrulline treatment alters the structure of the pulmonary circulation in hypoxic newborn pigs. Pediatric pulmonology, 55(10), 2762-2772.
- Douglass MS, Zhang Y, Kaplowitz MR, Fike C (2021). L-citrulline increases arginase II protein levels and arginase activity in hypoxic piglet pulmonary artery endothelial cells. Pulmonary circulation, 11(2), 20458940211006289.
- Douglass M, Dikalova A, Kaplowitz MR, Zhang Y, Cunningham G, Summar M, Fike C (2021). Folic acid, either solely or combined with L-citrulline, improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs. Physiological reports, 9(21), e15096.
- Fike CD, Avachat C, Birnbaum AK, Aschner JL, Sherwin C (2023). Pharmacokinetics of L-Citrulline in Neonates at Risk of Developing Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension. Paediatric drugs, 25(1), 87-96.
- Douglass MS, Kaplowitz MR, Zhang Y, Fike C (2023). Impact of l-citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells. Pulmonary circulation, 13(2), e12221.
- Fike CD, Aschner JL, Avachat C, Birnbaum AK, Sherwin CM (2024). Multi-dose enteral L-citrulline administration in premature infants at risk of developing pulmonary hypertension associated with bronchopulmonary dysplasia. Journal of perinatology, 44(2), 280-287.
Review
- Fike CD, Aschner J (2023). Pharmacotherapy for Pulmonary Hypertension in Infants with Bronchopulmonary Dysplasia: Past, Present, and Future. Pharmaceuticals (Basel, Switzerland), 16(4),
- Rashid J, Kumar SS, Job KM, Liu X, Fike CD, Sherwin CM (2020). Therapeutic Potential of Citrulline as an Arginine Supplement: A Clinical Pharmacology Review. Paediatric drugs, 22(3), 279-293.