Brian D. Evavold

Brian D. Evavold, PhD

Languages spoken: English

Academic Information

Departments Primary - Pathology

Academic Office Information

brian.evavold@path.utah.edu

Lab

Research Statement

My research centers on how antigen recognition by T cells determines cell phenotype, fate, and outcome of the adaptive immune response. Understanding the mechanisms driving T cell activation provides novel insight into the basis of autoimmune disease and effective response to infections.

Education History

Postdoctoral Fellowship Washington University
 Postdoctoral Fellow
Doctoral Training University of Chicago
 PhD
Undergraduate St. Olaf College
 BA

Selected Publications

Journal Article

  1. Reed JS, Nayan R, Deckers M, Evavold BD, Lamb TJ (2024). Influenza-induced alveolar macrophages protect against death by malaria-associated acute lung injury. bioRxiv. (Read full article)
  2. Eggert J, Zinzow-Kramer WM, Hu Y, Kolawole EM, Tsai YL, Weiss A, Evavold BD, Salaita K, Scharer CD, Au-Yeung BB (2024). Cbl-b mitigates the responsiveness of naive CD8(+) T cells that experience extensive tonic T cell receptor signaling. Sci Signal, 17(822), eadh0439. (Read full article)
  3. Evavold BD (2023). Force in Immunology: There Is Often a Catch. J Immunol, 211(3), 307. (Read full article)
  4. Nguyen NX, Richens AW, Sircy LM, Allard DE, Kolawole EM, Evavold BD, Bettini M, Hale JS (2022). Immunogen-Specific Strengths and Limitations of the Activation-Induced Marker Assay for Assessing Murine Antigen-Specific CD4+ T Cell Responses. J Immunol, 210(7), 916-925. (Read full article)
  5. Lo WL, Kuhlmann M, Rizzuto G, Ekiz HA, Kolawole EM, Revelo MP, Andargachew R, Li Z, Tsai YL, Marson A, Evavold BD, Zehn D, Weiss A (2023). A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function. Nat Immunol, 24(4), 676-689. (Read full article)
  6. Jing Y, Kong Y, Allard D, Liu B, Kolawole E, Sprouse M, Evavold B, Bettini M, Bettini M (2023). Increased TCR signaling in regulatory T cells is disengaged from TCR affinity. bioRxiv. (Read full article)
  7. Beskid NM, Kolawole EM, Coronel MM, Nguyen B, Evavold B, Garca AJ, Babensee JE (2022). IL-10-Functionalized Hydrogels Support Immunosuppressive Dendritic Cell Phenotype and Function. ACS Biomater Sci Eng, 8(10), 4341-4353. (Read full article)
  8. Zinzow-Kramer WM, Kolawole EM, Eggert J, Evavold BD, Scharer CD, Au-Yeung BB (2022). Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4(+) T Cells. Immunohorizons, 6(9), 671-683. (Read full article)
  9. Zhao X, Kolawole EM, Chan W, Feng Y, Yang X, Gee MH, Jude KM, Sibener LV, Fordyce PM, Germain RN, Evavold BD, Garcia KC (2022). Tuning T cell receptor sensitivity through catch bond engineering. Science, 376(6589), eabl5282. (Read full article)
  10. Ma VP, Hu Y, Kellner AV, Brockman JM, Velusamy A, Blanchard AT, Evavold BD, Alon R, Salaita K (2022). The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation. Sci Adv, 8(8), eabg4485. (Read full article)
  11. Kim H, Perovanovic J, Shakya A, Shen Z, German CN, Ibarra A, Jafek JL, Lin NP, Evavold BD, Chou DH, Jensen PE, He X, Tantin D (2020). Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes. J Exp Med, 218(3). (Read full article)
  12. Singh NK, Alonso JA, Harris DT, Anderson SD, Ma J, Hellman LM, Rosenberg AM, Kolawole EM, Evavold BD, Kranz DM, Baker BM (2020). An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes. Biochemistry, 59(43), 4163-4175. (Read full article)
  13. Kolawole EM, Lamb TJ, Evavold BD (2020). Relationship of 2D Affinity to T Cell Functional Outcomes. Int J Mol Sci, 21(21). (Read full article)
  14. Thomas AM, Beskid NM, Blanchfield JL, Rosado AM, Garca AJ, Evavold BD, Babensee JE (2020). Localized hydrogel delivery of dendritic cells for attenuation of multiple sclerosis in a murine model. J Biomed Mater Res A, e37118. (Read full article)
  15. Ren HM, Kolawole EM, Ren M, Jin G, Netherby-Winslow CS, Wade Q, Shwetank, Rahman ZSM, Evavold BD, Lukacher AE (2020). IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection. Sci Immunol, 5(51). (Read full article)
  16. Liu B, Hood JD, Kolawole EM, Woodruff DM, Vignali DA, Bettini M, Evavold BD (2019). A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery. Diabetes, 69(3), 381-391. (Read full article)
  17. Bettini M, Scavuzzo MA, Liu B, Kolawole E, Guo L, Evavold BD, Borowiak M, Bettini ML (2019). A Critical Insulin TCR Contact Residue Selects High-Affinity and Pathogenic Insulin-Specific T Cells. Diabetes, 69(3), 392-400. (Read full article)
  18. Krummey SM, Morris AB, Jacobs JR, McGuire DJ, Ando S, Tong KP, Zhang W, Robertson J, Guasch SA, Araki K, Larsen CP, Evavold BD, Kissick HT, Ford ML (2019). CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence. Cell Rep, 30(5), 1282-1291.e5. (Read full article)
  19. Spear TT, Evavold BD, Baker BM, Nishimura MI (2019). Understanding TCR affinity, antigen specificity, and cross-reactivity to improve TCR gene-modified T cells for cancer immunotherapy. Cancer Immunol Immunother, 68(11), 1881-1889. (Read full article)
  20. Chow IT, Gates TJ, Papadopoulos GK, Moustakas AK, Kolawole EM, Notturno RJ, McGinty JW, Torres-Chinn N, James EA, Greenbaum C, Nepom GT, Evavold BD, Kwok WW (2019). Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes. Sci Adv, 5(8), eaaw9336. (Read full article)
  21. Shwetank, Frost EL, Mockus TE, Ren HM, Toprak M, Lauver MD, Netherby-Winslow CS, Jin G, Cosby JM, Evavold BD, Lukacher AE (2019). PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis. Front Immunol, 10, 783. (Read full article)
  22. Wu P, Zhang T, Liu B, Fei P, Cui L, Qin R, Zhu H, Yao D, Martinez RJ, Hu W, An C, Zhang Y, Liu J, Shi J, Fan J, Yin W, Sun J, Zhou C, Zeng X, Xu C, Wang J, Evavold BD, Zhu C, Chen W, Lou J (2019). Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition. Mol Cell, 73(5), 1015-1027.e7. (Read full article)
  23. Hong J, Ge C, Jothikumar P, Yuan Z, Liu B, Bai K, Li K, Rittase W, Shinzawa M, Zhang Y, Palin A, Love P, Yu X, Salaita K, Evavold BD, Singer A, Zhu C (2018). A TCR mechanotransduction signaling loop induces negative selection in the thymus. Nat Immunol, 19(12), 1379-1390. (Read full article)
  24. Kolawole EM, Andargachew R, Liu B, Jacobs JR, Evavold BD (2018). 2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes. Front Immunol, 9, 2348. (Read full article)
  25. DiToro D, Winstead CJ, Pham D, Witte S, Andargachew R, Singer JR, Wilson CG, Zindl CL, Luther RJ, Silberger DJ, Weaver BT, Kolawole EM, Martinez RJ, Turner H, Hatton RD, Moon JJ, Way SS, Evavold BD, Weaver CT (2017). Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science, 361(6407). (Read full article)

Review

  1. Faust MA, Ras VJ, Lamb TJ, Evavold BD (2023). What's the Catch? The Significance of Catch Bonds in T Cell Activation. [Review]. J Immunol, 211(3), 333-342. (Read full article)

Letter

  1. Guo L, Jacob S, Manne BK, Kolawole EM, Guo S, Wang X, Murray D, Tugolukova EA, Portier I, Kosaka Y, Barba C, Rondina MT, Evavold B, Morley C, Bhatlekar S, Bray PF (2024). Actin-bundling protein L-plastin promotes megakaryocyte rigidity and dampens proplatelet formation. [Letter to the editor]. Haematologica, 109(1), 331-336. (Read full article)

Patent

  1. Allen PM, Sloan-Lancaster J, Evavold BD (1994). Anergy of T cells using partial agonist peptides.