Elizabeth Kolawole

Elizabeth Kolawole, PhD

Academic Information

Departments Primary - Pathology

Divisions:

Academic Office Information

emkolawole@path.utah.edu

My major interests lie in dissecting how TCR interacts with antigen as it occurs in 2D at the cell surface. As the cell membrane environment affects these protein interactions, my projects focus on the role that dietary fatty acids play in altering T cell affinity, force and cell flexibility for both infection and autoimmune disease.

Education History

Postdoctoral Training University of Utah School of Medicine
 Postdoctoral Researcher
Emory University
 Postdoctoral Research Fellow
Doctoral Training Virginia Commonwealth University
 PhD
University of the West of England, Bristol
 BSc (Hons)

Selected Publications

Journal Article

  1. Kiwanuka KN, Motunrayo Kolawole E, Mcleod JJA, Baker B, Paez PA, Zellner MP, Haque TT, Paranjape A, Jackson K, Kee SA, Dailey J, Martin RK, Ryan JJ (2021). Stat5B is required for IgE-Mediated mast cell function in vitro and in vivo. . Cell Immunol.
  2. Dileepan T, Malhotra D, Kotov DI, Kolawole EM, Krueger PD, Evavold BD, Jenkins MK (2021).  MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells. . Nat Biotechnol.
  3. Singh NK, Alonso JA, Harris DT, Anderson SD, Ma J, Hellman LM, Rosenberg AM, Kolawole EM, Evavold BD, Kranz DM, Baker BM (2020).  An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes. . Biochemistry, 59(43), 4163-4175.
  4. Ren HM, Kolawole EM, Ren M, Jin G, Netherby-Winslow CS, Wade Q, Shwetank, Rahman ZSM, Evavold BD, Lukacher AE (2020). IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection. . Sci Immunol, 5(51), eabb5590..
  5. Paez PA, Kolawole M, Taruselli MT, Ajith S, Dailey JM, Kee SA, Haque TT, Barnstein BO, McLeod JJA, Caslin HL, Kiwanuka KN, Fukuoka Y, Le QT, Schwartz LB, Straus DB, Gewirtz DA, Martin RK, Ryan JJ (2020). Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells. . J Pharmacol Exp Ther, 374(1), 104-112.
  6. Liu B, Hood JD, Kolawole EM, Woodruff DM, Vignali DA, Bettini M, Evavold BD (2020).  A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery. Diabetes, 69(3), 381-391.
  7. Bettini M, Scavuzzo MA, Liu B, Kolawole E, Guo L, Evavold BD, Borowiak M, Bettini ML (2020). A Critical Insulin TCR Contact Residue Selects High-Affinity and Pathogenic Insulin-Specific T Cells. . Diabetes, 69(3), 392-400.
  8. Chow IT, Gates TJ, Papadopoulos GK, Moustakas AK, Kolawole EM, Notturno RJ, McGinty JW, Torres-Chinn N, James EA, Greenbaum C, Nepom GT, Evavold BD, Kwok WW (2019). Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes. Sci Adv, 5(8), eaaw9336.
  9. Abebayehu D, Spence AJ, Caslin H, Taruselli M, Haque TT, Kiwanuka KN, Kolawole EM, Chumanevich AP, Sell SA, Oskeritzian CA, Ryan J, Kee SA (2019). Lactic acid suppresses IgE-mediated mast cell function in vitro and in vivo. Cell Immunol, 341, 103918.
  10. Kolawole EM, Andargachew R, Liu B, Jacobs JR, Evavold BD (2018). 2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes. Front Immunol, 9, 2348.
  11. DiToro D, Winstead CJ, Pham D, Witte S, Andargachew R, Singer JR, Wilson CG, Zindl CL, Luther RJ, Silberger DJ, Weaver BT, Kolawole EM, Martinez RJ, Turner H, Hatton RD, Moon JJ, Way SS, Evavold BD, Weaver CT (2017). Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science, 361(6407).
  12. Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA 3rd, Heath JR, Evavold BD, Vale RD, Garcia KC (2017). Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 174(3), 672-687.e27.
  13. Andargachew R, Martinez RJ, Kolawole EM, Evavold BD (2018). CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection. J Immunol, 201(1), 19-30.
  14. Sanecka A, Yoshida N, Kolawole EM, Patel H, Evavold BD, Frickel EM (2018). T Cell Receptor-Major Histocompatibility Complex Interaction Strength Defines Trafficking and CD103+ Memory Status of CD8 T Cells in the Brain. Front Immunol, 9, 1290.
  15. Moore T, Wagner CR, Scurti GM, Hutchens KA, Godellas C, Clark AL, Kolawole EM, Hellman LM, Singh NK, Huyke FA, Wang SY, Calabrese KM, Embree HD, Orentas R, Shirai K, Dellacecca E, Garrett-Mayer E, Li M, Eby JM, Stiff PJ, Evavold BD, Baker BM, Le Poole IC, Dropulic B, Clark JI, Nishimura MI (2017). Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells. Cancer Immunol Immunother, 67(2), 311-325.
  16. McLeod JJA, Caslin HL, Spence AJ, Kolawole EM, Qayum AA, Paranjape A, Taruselli M, Haque TT, Kiwanuka KN, Elford HL, Ryan JJ (2017). Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription. Cell Immunol, 322, 41-48.
  17. Caslin HL, McLeod JJA, Spence AJ, Qayum AA, Kolawole EM, Taruselli MT, Paranjape A, Elford HL, Ryan JJ (2017). Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IL-33-induced cytokine production in primary mouse mast cells. Cell Immunol, 319, 10-16.
  18. Ndaw VS, Abebayehu D, Spence AJ, Paez PA, Kolawole EM, Taruselli MT, Caslin HL, Chumanevich AP, Paranjape A, Baker B, Barnstein BO, Haque TT, Kiwanuka KN, Oskeritzian CA, Ryan JJ (2017). TGF-β1 Suppresses IL-33-Induced Mast Cell Function. J Immunol, 199(3), 866-873.
  19. Abebayehu D, Spence AJ, Qayum AA, Taruselli MT, McLeod JJ, Caslin HL, Chumanevich AP, Kolawole EM, Paranjape A, Baker B, Ndaw VS, Barnstein BO, Oskeritzian CA, Sell SA, Ryan JJ (2016). Lactic Acid Suppresses IL-33-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1α-Dependent miR-155 Suppression. J Immunol, 197(7), 2909-17.
  20. Qayum AA, Paranjape A, Abebayehu D, Kolawole EM, Haque TT, McLeod JJ, Spence AJ, Caslin HL, Taruselli MT, Chumanevich AP, Baker B, Oskeritzian CA, Ryan JJ (2016). IL-10-Induced miR-155 Targets SOCS1 To Enhance IgE-Mediated Mast Cell Function. J Immunol, 196(11), 4457-67.
  21. Kolawole EM, McLeod JJ, Ndaw V, Abebayehu D, Barnstein BO, Faber T, Spence AJ, Taruselli M, Paranjape A, Haque TT, Qayum AA, Kazmi QA, Wijesinghe DS, Sturgill JL, Chalfant CE, Straus DB, Oskeritzian CA, Ryan JJ (2016). Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. J Immunol, 196(4), 1461-70.
  22. Oskeritzian CA, Hait NC, Wedman P, Chumanevich A, Kolawole EM, Price MM, Falanga YT, Harikumar KB, Ryan JJ, Milstien S, Sabbadini R, Spiegel S (2014). The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses. J Allergy Clin Immunol, 135(4), 1008-18.e1.
  23. Faber TW, Pullen NA, Fernando JF, Kolawole EM, McLeod JJ, Taruselli M, Williams KL, Rivera KO, Barnstein BO, Conrad DH, Ryan JJ (2014). ADAM10 is required for SCF-induced mast cell migration. Cell Immunol, 290(1), 80-8.
  24. Morales JK, Saleem SJ, Martin RK, Saunders BL, Barnstein BO, Faber TW, Pullen NA, Kolawole EM, Brooks KB, Norton SK, Sturgill J, Graham L, Bear HD, Urban JF Jr, Lantz CS, Conrad DH, Ryan JJ (2013). Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses. J Leukoc Biol, 95(4), 643-50.
  25. Fernando J, Faber TW, Pullen NA, Falanga YT, Kolawole EM, Oskeritzian CA, Barnstein BO, Bandara G, Li G, Schwartz LB, Spiegel S, Straus DB, Conrad DH, Bunting KD, Ryan JJ (2013). Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway. J Immunol, 191(9), 4505-13.
  26. Falanga YT, Chaimowitz NS, Charles N, Finkelman FD, Pullen NA, Barbour S, Dholaria K, Faber T, Kolawole M, Huang B, Odom S, Rivera J, Carlyon J, Conrad DH, Spiegel S, Oskeritzian CA, Ryan JJ (2012). Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. J Immunol, 188(9), 4360-8.
  27. Speiran K, Bailey DP, Fernando J, Macey M, Barnstein B, Kolawole M, Curley D, Watowich SS, Murray PJ, Oskeritzian C, Ryan JJ (2009). Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol, 85(5), 826-36.

Review

  1. Kolawole EM, Lamb TJ, Evavold BD (2020).  Relationship of 2D Affinity to T Cell Functional Outcomes. . [Review]. Int J Mol Sci, 21(21).