Jincheng Shen

Jincheng Shen, PhD

Languages spoken: English

Academic Information

Departments Primary - Population Health Sciences , Adjunct - Family & Preventive Medicine , Adjunct - Internal Medicine

Divisions: Epidemiology , Public Health

Research Interests

  • Causal Inference
  • Machine Learning
  • High Dimensional Data Analysis
  • Statistical Genetics
  • Mediation Analysis
  • Personalized Treatment Regime

Jincheng Shen is an Assistant Professor in the Department of Population Health Sciences, and holds adjunct appointments with the Department of Internal Medicine and Department of Family & Preventive Medicine, at the University of Utah. He obtained his Ph.D. in Biostatistics from the University of Michigan, Ann Arbor. Prior to coming to Utah, he completed his postdoctoral training in the Department of Biostatistics at Harvard T.H. Chan School of Public Health. Jincheng joined the University of Utah in 2017.

Research Statement

Dr. Jincheng Shen is interested in statistical methodology development and its application for various health related questions, especially implementation of causal inference tools in cancer studies and statistical genetics and genomics research. His primary methodology research interests include: i) comparative effectiveness analysis in clinical trials and observational study with longitudinal data; ii) Heterogeneous treatment effect estimation and individual treatment rules identification in complex disease setting; iii) statistical analysis of high throughput genetics and epigenetics studies, including genome-wide association studies and mediation analysis. He is actively engaged in a wide spectrum of collaborations with clinicians, biologists and epidemiologists.

Education History

Doctoral Training University of Michigan
 PhD
Graduate Training Tsinghua University
 MS
Undergraduate Tsinghua University
 BS

Selected Publications

Journal Article

  1. Sideris K, Zhang M, Wohlfahrt P, Siu AF, Shen J, Carter S, Kyriakopoulos CP, Taleb I, Wever-Pinzon O, Shah K, Selzman CH, Rodriguez-Correa C, Kapelios C, Brinker L, Alharethi R, Hess R, Drakos SG, Steinberg BA, Fang JC, Kfoury AG, Melenovsky V, Greene T, Spertus JA, Stehlik J (2024). Integration of Patient Reported Quality-of-life Data into Risk Assessment in Heart Failure. J Card Fail. (Read full article)
  2. Magel JS, Beneciuk JM, Siantz E, Fritz J, Garland EL, Hanley A, Shen J, Blosser P, Matev T, Gordon AJ (2024). PT-IN-MIND: study protocol for a multisite randomised feasibility trial investigating physical therapy with integrated mindfulness (PT-IN-MIND) for patients with chronic musculoskeletal pain and long-term opioid treatment who attend outpatient physical therapy. BMJ Open, 14(7), e082611. (Read full article)
  3. Cooperman NA, Shen J, Gordon AJ, Garland EL (2024). Commentary With Study Protocol: Implementation and Effectiveness of Mindfulness-Oriented Recovery Enhancement (MORE) as an Adjunct to Methadone Treatment for Opioid Use Disorder (IMPOWR-MORE). Subst Use Addctn J, 29767342241261890. (Read full article)
  4. Bansal S, Boucher R, Shen J, Wei G, Chertow GM, Whelton PK, Cushman WC, Cheung AK, Beddhu S, on behalf of SPRINT (2024). Role of Diuretics in Cardiovascular Events and Mortality in Systolic Blood Pressure Intervention Trial: A Post Hoc Analysis. Clin J Am Soc Nephrol, 19(5), 620-627. (Read full article)
  5. Wu YP, Stump TK, Hay JL, Buller DB, Jensen JD, Grossman D, Shen J, Haaland BA, Jones J, Tercyak KP (2024). Protocol for a cluster-randomized trial of a school-based skin cancer preventive intervention for adolescents. Contemp Clin Trials, 140, 107494. (Read full article)
  6. Wang X, Lee H, Haaland B, Kerrigan K, Puri S, Akerley W, Shen J (2024). A matching-based machine learning approach to estimating optimal dynamic treatment regimes with time-to-event outcomes. Stat Methods Med Res, 33(5), 794-806. (Read full article)
  7. Xu M, Feng R, Liu Z, Zhou X, Chen Y, Cao Y, Valeri L, Li Z, Liu Z, Cao SM, Liu Q, Xie SH, Chang ET, Jia WH, Shen J, Yao Y, Cai YL, Zheng Y, Zhang Z, Huang G, Ernberg I, Tang M, Ye W, Adami HO, Zeng YX, Lin X (2024). Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation. Cell Genom, 4(2), 100474. (Read full article)
  8. Hashibe M, Wei M, Lee CJ, Tao R, Koric A, Wang J, Daud A, Tay D, Shen J, Lee YA, Chang CE (2023). Incident Cardiovascular Disease Risk among Older Asian, Native Hawaiian and Pacific Islander Breast Cancer Survivors. Cancer Epidemiol Biomarkers Prev, 33(1), 126-135. (Read full article)
  9. Tjilos M, Drainoni ML, Burrowes SAB, Butler JM, Damschroder LJ, Bidwell Goetz M, Madaras-Kelly K, Reardon CM, Samore MH, Shen J, Stenehjem EA, Zhang Y, Barlam TF (2023). A qualitative evaluation of frontline clinician perspectives toward antibiotic stewardship programs. Infect Control Hosp Epidemiol, 44(12), 1995-2001. (Read full article)
  10. Derington CG, Bress AP, Berchie RO, Herrick JS, Shen J, Ying J, Greene T, Tajeu GS, Sakhuja S, Ruiz-Negrn N, Zhang Y, Howard G, Levitan EB, Muntner P, Safford MM, Whelton PK, Weintraub WS, Moran AE, Bellows BK (2023). Estimated Population Health Benefits of Intensive Systolic Blood Pressure Treatment Among SPRINT-Eligible US Adults. Am J Hypertens, 36(9), 498-508. (Read full article)
  11. Ghazi L, Shen J, Ying J, Derington CG, Cohen JB, Marcum ZA, Herrick JS, King JB, Cheung AK, Williamson JD, Pajewski NM, Bryan N, Supiano M, Sonnen J, Weintraub WS, Greene TH, Bress AP (2023). Identifying Patients for Intensive Blood Pressure Treatment Based on Cognitive Benefit: A Secondary Analysis of the SPRINT Randomized Clinical Trial. JAMA Netw Open, 6(5), e2314443. (Read full article)
  12. Nevala-Plagemann C, Sama S, Ying J, Shen J, Haaland B, Florou V, Garrido-Laguna I (2022). A Real-World Comparison of Regorafenib and Trifluridine/Tipiracil in Refractory Metastatic Colorectal Cancer in the United States. J Natl Compr Canc Netw, 21(3), 257-264. (Read full article)
  13. Sisco-Taylor BL, Magel JS, McFadden M, Greene T, Shen J, Fritz JM (2021). Changes in Pain Catastrophizing and Fear-Avoidance Beliefs as Mediators of Early Physical Therapy on Disability and Pain in Acute Low-Back Pain: A Secondary Analysis of a Clinical Trial. Pain Med, 23(6), 1127-1137. (Read full article)
  14. Cochran G, Shen J, Cox N, Field C, Carlston K, Sengpraseut B, White A, Okifuji A, Jackman C, Haaland B, Ragsdale R, Gordon AJ, Tarter R (2022). Addressing opioid medication misuse at point of service in community pharmacy: A study protocol for an interdisciplinary behavioral health trial. Contemp Clin Trials, 116, 106759. (Read full article)
  15. Xu Y, Greene TH, Bress AP, Sauer BC, Bellows BK, Zhang Y, Weintraub WS, Moran AE, Shen J (2020). Estimating the optimal individualized treatment rule from a cost-effectiveness perspective. Biometrics, 78(1), 337-351. (Read full article)
  16. Wang X, Kerrigan K, Puri S, Shen J, Akerley W, Haaland B (2022). Dynamic Prediction of Near-Term Overall Survival in Patients with Advanced NSCLC Based on Real-World Data. Cancers (Basel), 14(3). (Read full article)
  17. Liu Z, Shen J, Barfield R, Schwartz J, Baccarelli AA, Lin X (2021). Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies. J Am Stat Assoc, 117(537), 67-81. (Read full article)
  18. Burrowes SAB, Drainoni ML, Tjilos M, Butler JM, Damschroder LJ, Goetz MB, Madaras-Kelly K, Reardon CM, Samore MH, Shen J, Stenehjem E, Zhang Y, Barlam TF (2021). Survey of physician and pharmacist steward perceptions of their antibiotic stewardship programs. Antimicrob Steward Healthc Epidemiol, 1(1), e48. (Read full article)
  19. Sauer BC, Chen W, Shen J, Accortt NA, Collier DH, Cannon GW (2021). Potential for Major Therapeutic Changes to Produce Significant Clinical Response Across a Broad Range of Disease Activity: An Observational Study of US Veterans With Rheumatoid Arthritis. Arthritis Care Res (Hoboken), 73(7), 964-974. (Read full article)
  20. Jones BE, Ying J, Nevers M, Alba PR, He T, Patterson OV, Jones MM, Stevens V, Shen J, Humpherys J, Peterson KS, Rutter ED, Gundlapalli AV, Weir CR, Dean NC, Fine MJ, Samore MC, Greene TH (2021). Computerized Mortality Prediction for Community-acquired Pneumonia at 117 Veterans Affairs Medical Centers. Ann Am Thorac Soc, 18(7), 1175-1184. (Read full article)
  21. Jhun MA, Mendelson M, Wilson R, Gondalia R, Joehanes R, Salfati E, Zhao X, Braun KVE, Do AN, Hedman K, Zhang T, Carnero-Montoro E, Shen J, Bartz TM, Brody JA, Montasser ME, OConnell JR, Yao C, Xia R, Boerwinkle E, Grove M, Guan W, Liliane P, Singmann P, Mller-Nurasyid M, Meitinger T, Gieger C, Peters A, Zhao W, Ware EB, Smith JA, Dhana K, van Meurs J, Uitterlinden A, Ikram MA, Ghanbari M, Zhi D, Gustafsson S, Lind L, Li S, Sun D, Spector TD, Chen YI, Damcott C, Shuldiner AR, Absher DM, Horvath S, Tsao PS, Kardia S, Psaty BM, Sotoodehnia N, Bell JT, Ingelsson E, Chen W, Dehghan A, Arnett DK, Waldenberger M, Hou L, Whitsel EA, Baccarelli A, Levy D, Fornage M, Irvin MR, Assimes TL (2021). A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids. Nat Commun, 12(1), 3987. (Read full article)
  22. Matas-Garca PR, Ward-Caviness CK, Raffield LM, Gao X, Zhang Y, Wilson R, Go X, Nano J, Bostom A, Colicino E, Correa A, Coull B, Eaton C, Hou L, Just AC, Kunze S, Lange L, Lange E, Lin X, Liu S, Nwanaji-Enwerem JC, Reiner A, Shen J, Schttker B, Vokonas P, Zheng Y, Young B, Schwartz J, Horvath S, Lu A, Whitsel EA, Koenig W, Adamski J, Winkelmann J, Brenner H, Baccarelli AA, Gieger C, Peters A, Franceschini N, Waldenberger M (2021). DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function. Clin Epigenetics, 13(1), 121. (Read full article)
  23. Bress AP, Greene T, Derington CG, Shen J, Xu Y, Zhang Y, Ying J, Bellows BK, Cushman WC, Whelton PK, Pajewski NM, Reboussin D, Beddu S, Hess R, Herrick JS, Zhang Z, Kolm P, Yeh RW, Basu S, Weintraub WS, Moran AE, SPRINT Research Group (2021). Patient Selection for Intensive Blood Pressure Management Based on Benefit and Adverse Events. J Am Coll Cardiol, 77(16), 1977-1990. (Read full article)
  24. Sauer BC, Chen W, Xu Y, Shen J, Accortt NA, Collier DH, Cannon GW (2020). Empirical evidence of disease activity thresholds used to indicate need for major therapeutic change in US veterans with rheumatoid arthritis. Arthritis Res Ther, 22(1), 253. (Read full article)
  25. Breen M, Nwanaji-Enwerem JC, Karrasch S, Flexeder C, Schulz H, Waldenberger M, Kunze S, Ollert M, Weidinger S, Colicino E, Gao X, Wang C, Shen J, Just AC, Vokonas P, Sparrow D, Hou L, Schwartz JD, Baccarelli AA, Peters A, Ward-Caviness CK (2020). Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies. Aging (Albany NY), 12(16), 16539-16554. (Read full article)
  26. Barlam TF, Childs E, Zieminski SA, Meshesha TM, Jones KE, Butler JM, Damschroder LJ, Goetz MB, Madaras-Kelly K, Reardon CM, Samore MH, Shen J, Stenehjem E, Zhang Y, Drainoni ML (2020). Perspectives of Physician and Pharmacist Stewards on Successful Antibiotic Stewardship Program Implementation: A Qualitative Study. Open Forum Infect Dis, 7(7), ofaa229. (Read full article)
  27. Gao X, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Wang C, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA (2019). Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males. Int J Epidemiol, 48(6), 1958-1971. (Read full article)
  28. Beddhu S, Shen J, Cheung AK, Kimmel PL, Chertow GM, Wei G, Boucher RE, Chonchol M, Arman F, Campbell RC, Contreras G, Dwyer JP, Freedman BI, Ix JH, Kirchner K, Papademetriou V, Pisoni R, Rocco MV, Whelton PK, Greene T (2019). Implications of Early Decline in eGFR due to Intensive BP Control for Cardiovascular Outcomes in SPRINT. J Am Soc Nephrol, 30(8), 1523-1533. (Read full article)
  29. Gao X, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA (2019). Correction for: Accelerated DNA methylation age and the use of antihypertensive medication among older adults. Aging (Albany NY), 11(9), 2911. (Read full article)
  30. Li Z, Li X, Liu Y, Shen J, Chen H, Zhou H, Morrison AC, Boerwinkle E, Lin X (2019). Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies. Am J Hum Genet, 104(5), 802-814. (Read full article)
  31. Gao X, Colicino E, Shen J, Kioumourtzoglou MA, Just AC, Nwanaji-Enwerem JC, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA (2019). Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective. Environ Int, 126, 395-405. (Read full article)
  32. Gao X, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Wang C, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA (2018). Accelerated DNA methylation age and the use of antihypertensive medication among older adults. Aging (Albany NY), 10(11), 3210-3228. (Read full article)
  33. Joyce BT, Zheng Y, Nannini D, Zhang Z, Liu L, Gao T, Kocherginsky M, Murphy R, Yang H, Achenbach CJ, Roberts LR, Hoxha M, Shen J, Vokonas P, Schwartz J, Baccarelli A, Hou L (2018). DNA Methylation of Telomere-Related Genes and Cancer Risk. Cancer Prev Res (Phila), 11(8), 511-522. (Read full article)
  34. Kresovich JK, Joyce BT, Gao T, Zheng Y, Zhang Z, Achenbach CJ, Murphy RL, Just AC, Shen J, Yang H, Vokonas P, Schwartz J, Baccarelli AA, Hou L (2018). Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort. Epigenomics, 10(6), 733-743. (Read full article)
  35. Joyce BT, Zheng Y, Zhang Z, Liu L, Kocherginsky M, Murphy R, Achenbach CJ, Musa J, Wehbe F, Just A, Shen J, Vokonas P, Schwartz J, Baccarelli AA, Hou L (2018). miRNA-Processing Gene Methylation and Cancer Risk. Cancer Epidemiol Biomarkers Prev, 27(5), 550-557. (Read full article)
  36. Shen J, Wang L, Daignault S, Spratt DE, Morgan TM, Taylor JMG (2017). Estimating the Optimal Personalized Treatment Strategy Based on Selected Variables to Prolong Survival via Random Survival Forest with Weighted Bootstrap. J Biopharm Stat, 28(2), 362-381. (Read full article)
  37. Richard MA, Huan T, Ligthart S, Gondalia R, Jhun MA, Brody JA, Irvin MR, Marioni R, Shen J, Tsai PC, Montasser ME, Jia Y, Syme C, Salfati EL, Boerwinkle E, Guan W, Mosley TH Jr, Bressler J, Morrison AC, Liu C, Mendelson MM, Uitterlinden AG, van Meurs JB, BIOS Consortium, Franco OH, Zhang G, Li Y, Stewart JD, Bis JC, Psaty BM, Chen YI, Kardia SLR, Zhao W, Turner ST, Absher D, Aslibekyan S, Starr JM, McRae AF, Hou L, Just AC, Schwartz JD, Vokonas PS, Menni C, Spector TD, Shuldiner A, Damcott CM, Rotter JI, Palmas W, Liu Y, Paus T, Horvath S, OConnell JR, Guo X, Pausova Z, Assimes TL, Sotoodehnia N, Smith JA, Arnett DK, Deary IJ, Baccarelli AA, Bell JT, Whitsel E, Dehghan A, Levy D, Fornage M (2017). DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. Am J Hum Genet, 101(6), 888-902. (Read full article)

Letter

  1. King JB, Sakhuja S, Derington CG, Kolm P, Herrick JS, Berchie RO, Shen J, Greene T, Tajeu GS, Howard G, Levitan EB, Muntner P, Safford MM, Ying J, Weintraub WS, Moran AE, Bress AP, Bellows BK (2024). Annual Cost of Implementing Intensive Systolic Blood Pressure Goals in the United States. [Letter to the editor]. J Am Heart Assoc, 13(18), e034515. (Read full article)

Other

  1. Jhun MA, Mendelson M, Wilson R, Gondalia R, Joehanes R, Salfati E, Zhao X, Braun KVE, Do AN, Hedman K, Zhang T, Carnero-Montoro E, Shen J, Bartz TM, Brody JA, Montasser ME, OConnell JR, Yao C, Xia R, Boerwinkle E, Grove M, Guan W, Liliane P, Singmann P, Mller-Nurasyid M, Meitinger T, Gieger C, Peters A, Zhao W, Ware EB, Smith JA, Dhana K, van Meurs J, Uitterlinden A, Ikram MA, Ghanbari M, Zhi D, Gustafsson S, Lind L, Li S, Sun D, Spector TD, Chen YI, Damcott C, Shuldiner AR, Absher DM, Horvath S, Tsao PS, Kardia S, Psaty BM, Sotoodehnia N, Bell JT, Ingelsson E, Chen W, Dehghan A, Arnett DK, Waldenberger M, Hou L, Whitsel EA, Baccarelli A, Levy D, Fornage M, Irvin MR, Assimes TL (2021). Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids. Nat Commun (12(1), p. 4256). England. (Read full article)