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Joseph L. Wilkerson, PhD

Languages spoken: English

Academic Information

Departments Primary - Neurology

Education History

Undergraduate University of Oklahoma
 BS
Doctoral Training University of Oklahoma Health Science Center
 PhD

Selected Publications

Journal Article

  1. Velasco-Silva JN, Wilkerson JL, Ramos D, Low HK, Bowman F, Evason KJ, Boudina S, Holland WL, Ducker GS (2025). Loss of hepatic autophagy induces ¿-cell proliferation through impaired glutamine-dependent gluconeogenesis. Physiol Rep, 13(10), e70381.
  2. Norris MK, Tippetts TS, Wilkerson JL, Nicholson RJ, Maschek JA, Levade T, Medin JA, Summers SA, Holland WL (2024). Adiponectin overexpression improves metabolic abnormalities caused by acid ceramidase deficiency but does not prolong lifespan in a mouse model of Farber Disease. Mol Genet Metab Rep, 39, 101077.
  3. Li Y, Chaurasia B, Rahman MM, Kaddai V, Maschek JA, Berg JA, Wilkerson JL, Mahmassani ZS, Cox J, Wei P, Meikle PJ, Atkinson D, Wang L, Poss AM, Playdon MC, Tippetts TS, Mousa EM, Nittayaboon K, Anandh Babu PV, Drummond MJ, Clevers H, Shayman JA, Hirabayashi Y, Holland WL, Rutter J, Edgar BA, Summers SA (2023). Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk. Gastroenterology, 165(5), 1136-1150.
  4. Wilkerson JL, Basu SK, Mandal NA (2023). Angiogenesis Model of Cornea to Understand the Role of Sphingosine 1-Phosphate. Methods Mol Biol, 2625, 231-240.
  5. Hopiavuori BR, Masser DR, Wilkerson JL, Brush RS, Mandal NA, Anderson RE, Freeman WM (2023). Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation. Methods Mol Biol, 2625, 7-15.
  6. Wilkerson JL, Basu SK, Stiles MA, Prislovsky A, Grambergs RC, Nicholas SE, Karamichos D, Allegood JC, Proia RL, Mandal N (2022). Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model. Cells, 11(18).
  7. Simeone CA, Wilkerson JL, Poss AM, Banks JA, Varre JV, Guevara JL, Hernandez EJ, Gorsi B, Atkinson DL, Turapov T, Frodsham SG, Morales JCF, O'Neil K, Moore B, Yandell M, Summers SA, Krolewski AS, Holland WL, Pezzolesi MG (2022). A dominant negative ADIPOQ mutation in a diabetic family with renal disease, hypoadiponectinemia, and hyperceramidemia. NPJ Genom Med, 7(1), 43.
  8. Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA (2019). Targeting a ceramide double bond improves insulin resistance and hepatic steatosis. Science, 365(6451), 386-392.
  9. Wilkerson JL, Stiles MA, Gurley JM, Grambergs RC, Gu X, Elliott MH, Proia RL, Mandal NA (2019). Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina. Mol Neurobiol, 56(10), 7188-7207.
  10. Hopiavuori BR, Deák F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP (2018). Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency. Mol Neurobiol, 55(2), 1795-1813.
  11. Wilkerson JL, Mandal NA (2017). Angiogenesis Model of Cornea to Understand the Role of Sphingosine 1-Phosphate. Methods Mol Biol, 1609, 267-276.
  12. Hopiavuori BR, Masser DR, Wilkerson JL, Brush RS, Mandal NA, Anderson RE, Freeman WM (2017). Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation. Methods Mol Biol, 1609, 33-41.
  13. Mandal NA, Tran JT, Zheng L, Wilkerson JL, Brush RS, McRae J, Agbaga MP, Zhang K, Petrukhin K, Ayyagari R, Anderson RE (2014). In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4. Invest Ophthalmol Vis Sci, 55(4), 2705-13.
  14. Guiraldelli MF, Eyster C, Wilkerson JL, Dresser ME, Pezza RJ (2013). Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. PLoS Genet, 9(3), e1003383.
  15. Conrad MN, Lee CY, Wilkerson JL, Dresser ME (2007). MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 104(21), 8863-8.

Review

  1. Wilkerson JL, Tatum SM, Holland WL, Summers SA (2024). Ceramides are fuel gauges on the drive to cardiometabolic disease. [Review]. Physiol Rev, 104, (3), 1061-1119.

Letter

  1. Wilkerson JL, Summers SA, Holland WL (2019). Listen to your heart when ceramide's calling for higher glucose. [Letter to the editor]. EBioMedicine, 41, 3-4.