Frederik Denorme

Frederik Denorme, PhD

Languages spoken: English

Academic Information

Departments Primary - Neurology

Academic Office Information

frederik.denorme@utah.edu

Education History

Fellowship University of Utah
 Postdoctoral Fellow
KU Leuven Campus Kulak
 Postdoctoral Fellow
Doctoral Training KU Leuven Campus Kulak
 PhD
KU Leuven
 MS
Undergraduate KU Leuven
 BS

Selected Publications

Journal Article

  1. Denorme F, Rustad JL, Portier I, Crandell JL, de Araujo CV, Cody MJ, Campbell RA, Yost CC (2022). Neutrophil extracellular trap inhibition improves survival in neonatal mouse infectious peritonitis. Pediatr Res, 93(4), 862-869.
  2. de Araujo CV, Denorme F, Stephens WZ, Li Q, Cody MJ, Crandell JL, Petrey AC, Queisser KA, Rustad JL, Fulcher JM, Evangelista JL, Kay MS, Schiffman JD, Campbell RA, Yost CC (2023). Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps. Front Immunol, 13, 1046574.
  3. Manne BK, Campbell RA, Bhatlekar S, Ajanel A, Denorme F, Portier I, Middleton EA, Tolley ND, Kosaka Y, Montenont E, Guo L, Rowley JW, Bray PF, Jacob S, Fukanaga R, Proud C, Weyrich AS, Rondina MT (2022). MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis. Blood, 140(23), 2477-2489.
  4. Campbell RA, Manne BK, Banerjee M, Middleton EA, Ajanel A, Schwertz H, Denorme F, Stubben C, Montenont E, Saperstein S, Page L, Tolley ND, Lim DL, Brown SM, Grissom CK, Sborov DW, Krishnan A, Rondina MT (2022). IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis. J Clin Invest, 132(23).
  5. Bounajem MT, Denorme F, Rustad JL, Campbell RA, Grandhi R (2022). Investigation of Neutrophil Extracellular Traps as Potential Mediators in the Pathogenesis of Non-Acute Subdural Hematomas: A Pilot Study. Diagnostics (Basel), 12(12).
  6. Denorme F, Campbell RA (2022). Procoagulant platelets: novel players in thromboinflammation. Am J Physiol Cell Physiol, 323(4), C951-C958.
  7. Denorme F, Ajanel A, Campbell RA (2022). Shining a light on platelet activation in COVID-19. J Thromb Haemost, 20(6), 1286-1289.
  8. Denorme F, Portier I, Rustad JL, Cody MJ, de Araujo CV, Hoki C, Alexander MD, Grandhi R, Dyer MR, Neal MD, Majersik JJ, Yost CC, Campbell RA (2021). Neutrophil extracellular traps regulate ischemic stroke brain injury. J Clin Invest, 132(10).
  9. M Ravindra V, Denorme F, D Alexander M, A Campbell R, Grandhi R (2022). Endovascular mechanical thrombectomy in a child with COVID-19: Clot analysis reveals a novel pathway in the neuroinflammatory cascade resulting in large-vessel occlusion. Interv Neuroradiol, 15910199221094758.
  10. Stoller ML, Basak I, Denorme F, Rowley JW, Alsobrooks J, Parsawar K, Nieman MT, Yost CC, Hamilton JR, Bray PF, Campbell RA (2021). Neutrophil cathepsin G proteolysis of protease-activated receptor 4 generates a novel, functional tethered ligand. Blood Adv, 6(7), 2303-2308.
  11. Bounajem MT, Campbell RA, Denorme F, Grandhi R (2021). Paradigms in chronic subdural hematoma pathophysiology: Current treatments and new directions. J Trauma Acute Care Surg, 91(6), e134-e141.
  12. Bhatlekar S, Jacob S, Manne BK, Guo L, Denorme F, Tugolukova EA, Cody MJ, Kosaka Y, Rigoutsos I, Campbell RA, Rowley JW, OConnell RM, Bray PF (2021). Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet count without altering platelet function. Blood Cells Mol Dis, 92, 102624.
  13. Portier I, Campbell RA, Denorme F (2021). Mechanisms of immunothrombosis in COVID-19. Curr Opin Hematol, 28(6), 445-453.
  14. Campbell RA, Campbell HD, Bircher JS, de Araujo CV, Denorme F, Crandell JL, Rustad JL, Monts J, Cody MJ, Kosaka Y, Yost CC (2020). Placental HTRA1 cleaves α1-antitrypsin to generate a NET-inhibitory peptide. Blood, 138(11), 977-988.
  15. Queisser KA, Mellema RA, Middleton EA, Portier I, Manne BK, Denorme F, Beswick EJ, Rondina MT, Campbell RA, Petrey AC (2021). COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction. JCI Insight, 6(17).
  16. Denorme F, Rustad JL, Campbell RA (2021). Brothers in arms: platelets and neutrophils in ischemic stroke. Curr Opin Hematol, 28(5), 301-307.
  17. Guo L, Shen S, Rowley JW, Tolley ND, Jia W, Manne BK, McComas KN, Bolingbroke B, Kosaka Y, Krauel K, Denorme F, Jacob SP, Eustes AS, Campbell RA, Middleton EA, He X, Brown SM, Morrell CN, Weyrich AS, Rondina MT (2020). Platelet MHC class I mediates CD8+ T-cell suppression during sepsis. Blood, 138(5), 401-416.
  18. Campbell RA, Hisada Y, Denorme F, Grover SP, Bouck EG, Middleton EA, Wolberg AS, Rondina MT, Mackman N (2021). Comparison of the coagulopathies associated with COVID-19 and sepsis. Res Pract Thromb Haemost, 5(4), e12525.
  19. Othman M, Cormier M, Barnes GD, Comer SP, Connors JM, Denorme F, Khorana AA, Las Casas PH, Morla S, Muia J, N inle F, Taylor KA, van der Wal DE, Weyand AC, Lavin M, ISTH Registration Marketing teams (2021). Harnessing Twitter to empower scientific engagement and communication: The ISTH 2020 virtual congress experience. Res Pract Thromb Haemost, 5(2), 253-260.
  20. Denorme F, Martinod K, Vandenbulcke A, Denis CV, Lenting PJ, Deckmyn H, Vanhoorelbeke K, De Meyer SF (2021). The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice. Haematologica, 106(3), 819-828.
  21. Denorme F, Portier I, Kosaka Y, Campbell RA (2020). Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake. J Thromb Haemost, 19(2), 536-546.
  22. Bouck EG, Denorme F, Holle LA, Middelton EA, Blair AM, de Laat B, Schiffman JD, Yost CC, Rondina MT, Wolberg AS, Campbell RA (2020). COVID-19 and Sepsis Are Associated With Different Abnormalities in Plasma Procoagulant and Fibrinolytic Activity. Arterioscler Thromb Vasc Biol, 41(1), 401-414.
  23. Denorme F, Manne BK, Portier I, Petrey AC, Middleton EA, Kile BT, Rondina MT, Campbell RA (2020). COVID-19 patients exhibit reduced procoagulant platelet responses. J Thromb Haemost, 18(11), 3067-3073.
  24. Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA (2020). Platelet gene expression and function in patients with COVID-19. Blood, 136(11), 1317-1329.
  25. Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC (2020). Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 136(10), 1169-1179.
  26. Staessens S, Fitzgerald S, Andersson T, Clarenon F, Denorme F, Gounis MJ, Hacke W, Liebeskind DS, Szikora I, van Es A, Brinjikji W, Doyle KM, De Meyer SF (2019). Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations. Int J Stroke, 15(5), 467-476.
  27. Denorme F, Manne BK, Portier I, Eustes AS, Kosaka Y, Kile BT, Rondina MT, Campbell RA (2019). Platelet necrosis mediates ischemic stroke outcome in mice. Blood, 135(6), 429-440.
  28. Staessens S, Denorme F, Francois O, Desender L, Dewaele T, Vanacker P, Deckmyn H, Vanhoorelbeke K, Andersson T, De Meyer SF (2020). Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance. Haematologica, 105(2), 498-507.
  29. Denorme F, Vanhoorelbeke K, De Meyer SF (2019). von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke. Front Immunol, 10, 2884.
  30. Denorme F, Rondina MT (2019). Targeting Glycoprotein VI for Thromboembolic Disorders. Arterioscler Thromb Vasc Biol, 39(5), 839-840.
  31. South K, Denorme F, Salles-Crawley II, De Meyer SF, Lane DA (2018). Enhanced activity of an ADAMTS-13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischemic stroke. J Thromb Haemost, 16(11), 2289-2299.
  32. Laridan E, Denorme F, Desender L, Franois O, Andersson T, Deckmyn H, Vanhoorelbeke K, De Meyer SF (2017). Neutrophil extracellular traps in ischemic stroke thrombi. Ann Neurol, 82(2), 223-232.
  33. Denorme F, Kraft P, Pareyn I, Drechsler C, Deckmyn H, Vanhoorelbeke K, Kleinschnitz C, De Meyer SF (2017). Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease. PLoS One, 12(6), e0179258.
  34. Denorme F, De Meyer SF (2016). The VWF-GPIb axis in ischaemic stroke: lessons from animal models. Thromb Haemost, 116(4), 597-604.
  35. Denorme F, Wyseure T, Peeters M, Vandeputte N, Gils A, Deckmyn H, Vanhoorelbeke K, Declerck PJ, De Meyer SF (2016). Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice. Stroke, 47(9), 2419-22.
  36. Denorme F, Langhauser F, Desender L, Vandenbulcke A, Rottensteiner H, Plaimauer B, Franois O, Andersson T, Deckmyn H, Scheiflinger F, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF (2016). ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice. Blood, 127(19), 2337-45.
  37. De Meyer SF, Denorme F, Langhauser F, Geuss E, Fluri F, Kleinschnitz C (2016). Thromboinflammation in Stroke Brain Damage. Stroke, 47(4), 1165-72.
  38. Verhenne S, Denorme F, Libbrecht S, Vandenbulcke A, Pareyn I, Deckmyn H, Lambrecht A, Nieswandt B, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF (2015). Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice. Blood, 126(14), 1715-22.
  39. Wyseure T, Rubio M, Denorme F, Martinez de Lizarrondo S, Peeters M, Gils A, De Meyer SF, Vivien D, Declerck PJ (2014). Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke. Blood, 125(8), 1325-32.

Patent

  1. Plaimauer B, Rottensteiner H, Scheiflinger F, De Meyer SF, Denorme F (2016). Compositions comprising adamts13 for use in methods for the recanalization of occluded blood vessels in an infarction. U.S. Patent No. WO2016191565 A1. Washington, D.C.:U.S. Patent and Trademark Office.