Xiaoyang Zhang

Xiaoyang Zhang, PhD

Academic Information

Departments Primary - Oncological Sciences

Selected Publications

Journal Article

  1. Llabata P, Mitsuishi Y, Choi PS, Cai D, Francis JM, Torres-Diz M, Udeshi ND, Golomb L, Wu Z, Zhou J, Svinkina T, Aguilera-Jimenez E, Liu Y, Carr SA, Sanchez-Cespedes M, Meyerson M, Zhang (2020). Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma. Molecular cancer research, 18(4), 574-584. (Read full article)
  2. Abewe H, Richey A, Vahrenkamp JM, Ginley-Hidinger M, Rush CM, Kitchen N, Zhang X, Gertz (2025). Estrogen-induced chromatin looping changes identify a subset of functional regulatory elements. Genome research, 35(3), 393-403. (Read full article)
  3. Gillis K, Orellana WA, Wilson E, Parnell TJ, Fort G, Fang P, Essel Dadzie H, Murphy BM, Zhang X, Snyder E (2025). FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma. Developmental cell, 60(3), 472-489.e8. (Read full article)
  4. Mortenson KL, Dawes C, Wilson ER, Patchen NE, Johnson HE, Gertz J, Bailey SD, Liu Y, Varley KE, Zhang (2024). 3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression. Nature communications, 15(1), 6130. (Read full article)
  5. Gnanapragasam A, Kirbizakis E, Li A, White KH, Mortenson KL, Cavalcante de Moura J, Jawhar W, Yan Y, Falter R, Russett C, Giannias B, Camilleri-Broët S, Bertos N, Cools-Lartigue J, Garzia L, Sangwan V, Ferri L, Zhang X, Bailey S (2024). HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer. Cancer research, 84(14), 2377-2389. (Read full article)
  6. Ginley-Hidinger M, Abewe H, Osborne K, Richey A, Kitchen N, Mortenson KL, Wissink EM, Lis J, Zhang X, Gertz (2024). Cis-regulatory control of transcriptional timing and noise in response to estrogen. Cell genomics, 4(5), 100542. (Read full article)
  7. Liu Y, Wu Z, Zhou J, Ramadurai DKA, Mortenson KL, Aguilera-Jimenez E, Yan Y, Yang X, Taylor AM, Varley KE, Gertz J, Choi PS, Cherniack AD, Chen X, Bass AJ, Bailey SD, Zhang (2021). A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer. Nature communications, 12(1), 7139. (Read full article)
  8. Llabata P, Torres-Diz M, Gomez A, Tomas-Daza L, Romero OA, Grego-Bessa J, Llinas-Arias P, Valencia A, Esteller M, Javierre BM, Zhang X, Sanchez-Cespedes (2021). MAX mutant small-cell lung cancers exhibit impaired activities of MGA-dependent noncanonical polycomb repressive complex. Proceedings of the National Academy of Sciences of the United States of America, 118(37), (Read full article)
  9. Liu Y, Guo B, Aguilera-Jimenez E, Chu VS, Zhou J, Wu Z, Francis JM, Yang X, Choi PS, Bailey SD, Zhang (2020). Chromatin Looping Shapes KLF5-Dependent Transcriptional Programs in Human Epithelial Cancers. Cancer research, 80(24), 5464-5477. (Read full article)

Review

  1. Wilson ER, Zhang (2025). Enhancers, silencers, and attenuators: A dynamic and reversible regulatory code. Developmental cell, 60(18), 2381-2382. (Read full article)
  2. Zhang X, Meyerson (2020). Illuminating the noncoding genome in cancer. Nature cancer, 1(9), 864-872. (Read full article)