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Alexander W. Pastuszak, MD, PhD

Languages spoken: English, Spanish, Polish

Academic Information

Departments: Surgery - Assistant Professor, Pathology - Adjunct Assistant Professor

Divisions: Microbiology and Immunology, Urology

Academic Office Information

Alexander.Pastuszak@utah.edu

Board Certification

  • American Board of Urology

Research Interests

  • Peyronie's Disease
  • Dupuytren's Contracture
  • Ledderhose Disease
  • Fibrosis
  • Inflammation
  • Fibroblasts
  • TGF-β
  • Male Infertility
  • Transforming Growth Factor beta

Alexander W. Pastuszak, MD, PhD, is Assistant Professor of Surgery - Urology in the Department of Surgery at The University of Utah School of Medicine in Salt Lake City, Utah. Dr. Pastuszak earned his undergraduate degree at Yale University and completed his MD and PhD at the University of California, San Francisco. He completed his urology residency at Baylor College of Medicine and a fellowship in male reproductive medicine and surgery with Drs. Larry I. Lipshultz and Dolores J. Lamb, also at Baylor College of Medicine.

Dr. Pastuszak specializes in the treatment of male infertility, as well as both male and female sexual dysfunction. His clinical and basic science research focuses on men’s health, with his laboratory investigating the genetic factors that cause male infertility and Peyronie’s disease.

In 2011 Dr. Pastuszak was awarded the Urology Care Foundation’s Russell Scott, Jr., MD, Resident Research Award for his work on male infertility. In 2017, he received the Urology Care Foundation Research Scholar Award, and in 2018 he received the Urology Care Foundation Rising Stars in Urology Award for his work on Peyronie’s Disease. In 2018, he also received NIH funding supporting his Peyronie’s disease research. He has received numerous other awards for his work, has authored over 80 peer-reviewed articles and numerous book chapters on men’s reproductive and sexual health, and he is editor of the textbook entitled Management of Sexual Dysfunction in Men and Women: An Interdisciplinary Approach.

Dr. Pastuszak is an active member of the Sexual Medicine Society of North America, the American Society of Andrology, the American Society of Reproductive Medicine, the Society for Reproductive Endocrinology and Infertility, and the American Urological Association. Since 2014, he has been Section Editor for the journals Sexual Medicine and Current Sexual Health Reports, and is Associate Editor of Sexual Medicine Reviews, the Journal of Sexual Medicine, and Fertility and Sterility.

Dr. Pastuszak regularly shares his time and knowledge with the general public, conducting regular media interviews. He is also an entrepreneur, having founded a medical communications company, Woven Health, which focuses on optimizing patient care team collaboration and efficiency using mobile technologies.

Education History

Fellowship Baylor College of Medicine
Male Reproductive Medicine and Surgery
Fellow
Residency Baylor College of Medicine
Urology
Resident
Internship Baylor College of Medicine
General Surgery
Intern
Doctoral Training University of California, San Francisco
Ph.D.
Professional Medical University of California, San Francisco
Medicine
M.D.
Undergraduate Yale University
Molecular, Cellular, and Developmental Biology
B.S.

Selected Publications

  1. Allen-Brady KL, Christensen MB, Sandberg AD, Pastuszak AW (2022). Significant familial clustering of Peyronie's disease in close and distant relatives. Andrology.
  2. Patel DP, Cheng PJ, Hanson HA, Smith KR, Aston KI, Pastuszak AW, Hotaling JM (2022). Seasonal variation in semen quality is not associated with fecundity in the Utah Population Database. Andrologia, e14515.
  3. Patel DP, Horns JJ, Pastuszak AW, Hsieh TC, Yafi FA, Hotaling JM (2022). Hypogonadism associated with higher rate of penile prosthesis infection: An Analysis of United States claims data. Urology.
  4. Hebert KJ, Matta R, Horns JJ, Paudel N, Das R, Kohler TS, Pastuszak AW, McCormick BJ, Hotaling JM, Myers JB (2022). Risk of Post-operative Thromboembolism in Men Undergoing Urologic Prosthetic Surgery: An Assessment of 21,413 Men. J Urol, 101097JU0000000000002801.
  5. Adam JA, Pastuszak AW, Christensen MB, Spencer R, Sandberg A, Hotaling JM, Lipshultz LI (2022). Occurrence of pulmonary oil microembolism (POME) with intramuscular testosterone undecanoate injection: literature review. [Review]. Int J Impot Res.
  6. Shindel AW, Althof SE, Carrier S, Chou R, McMahon CG, Mulhall JP, Paduch DA, Pastuszak AW, Rowland D, Tapscott AH, Sharlip ID (2021). Disorders of Ejaculation: An AUA/SMSNA Guideline. J Urol, 207(3), 504-512.
  7. Pastuszak AW, Gittelman M, Tursi JP, Jaffe JS, Schofield D, Miner MM (2021). Pharmacokinetics of testosterone therapies in relation to diurnal variation of serum testosterone levels as men age. [Review]. Andrology, 10(2), 209-222.
  8. Patel DP, Meeks HT, Pastuszak AW, Hanson HA, Smith KR, Letourneau JM, Hotaling JM (2021). Lower female partner live birth rate in male cancer survivors: An age-matched cohort analysis of the Utah Population Database. Andrologia, 54(1), e14293.
  9. Pastuszak AW, Patel DP, Jenkins LC, Hsieh TC, Yafi FA, Mumford SL, Mulhall JP, Hotaling JM (2021). A Call for Quality: Substandard Research in Male Sexual and Reproductive Medicine During the COVID-19 Pandemic. J Sex Med, 19(1), 1-4.
  10. Pastuszak AW, Bush M, Curd L, Vijayan S, Priestley T, Xiang Q, Hu Y (2021). Population Pharmacokinetic Modeling and Simulations to Evaluate a Potential Dose Regimen of Testosterone Undecanoate in Hypogonadal Males. J Clin Pharmacol (61(12), pp. 1618-1625). England.
  11. Jrgensen N, Lamb DJ, Levine H, Pastuszak AW, Sigalos JT, Swan SH, Eisenberg ML (2021). Are worldwide sperm counts declining? Fertil Steril, 116(6), 1457-1463.
  12. Auerbach JM, Moghalu OI, Das R, Horns J, Campbell A, Hotaling J, Pastuszak AW (2021). Evaluating incidence, prevalence, and treatment trends in adult men with hypogonadism in the United States. Int J Impot Res.
  13. Wright LN, Hotaling J, Pastuszak AW (2021). Response to the Letter-to-the-Editor: "Erectile Dysfunction and Treatment: An Analysis of Associated Chronic Health Conditions". [Letter to the editor]. Urology, 160, 231.
  14. Wright LN, Moghalu OI, Das R, Horns J, Campbell A, Hotaling J, Pastuszak AW (2021). Erectile Dysfunction and Treatment: An Analysis of Associated Chronic Health Conditions. Urology, 157, 148-154.
  15. Lo SP, Hsieh TC, Pastuszak AW, Hotaling JM, Patel DP (2021). Effects of SARS CoV-2, COVID-19, and its vaccines on male sexual health and reproduction: where do we stand? [Review]. Int J Impot Res, 34, 138-144.
  16. Keihani S, Verrilli LE, Zhang C, Presson AP, Hanson HA, Pastuszak AW, Johnstone EB, Hotaling JM (2021). Semen parameter thresholds and time-to-conception in subfertile couples: how high is high enough? Hum Reprod, 36(8), 2121-2133.
  17. Patel DP, Meeks HT, Hanson HA, Pastuszak AW, Hotaling JM, Smith KR (2021). Lower total motile count is associated with smaller historic intergenerational family size: a pedigree analysis from the Utah Population Database. J Assist Reprod Genet, 38(5), 1207-1213.
  18. Moghalu OI, Das R, Horns J, Campbell A, Hotaling JM, Pastuszak AW (2021). Trends in treatment of Peyronie's disease in adult men in the United States from 2008 to 2017-results from an encounter and claims database. Int J Impot Res, 34, 280-288.
  19. Cheng PJ, Kim J, Craig JR, Alukal J, Pastuszak AW, Walsh TJ, Hotaling JM (2021). "The Back-up Vasectomy Reversal." Simultaneous Sperm Retrieval and Vasectomy Reversal in the Couple With Advanced Maternal Age: A Cost-Effectiveness Analysis. Urology, 153, 175-180.
  20. Payne K, Lipshultz LI, Hotaling JM, Pastuszak AW (2020). Obstructive Sleep Apnea and Testosterone Therapy. Sex Med Rev, 9(2), 296-303.
  21. Hanson BM, Kohn TP, Pastuszak AW, Scott RT Jr, Cheng PJ, Hotaling JM (2021). Round spermatid injection into human oocytes: a systematic review and meta-analysis. Asian J Androl, 23, 363-369.
  22. Dupree JM, Coward RM, Hsieh TC, Tanrikut C, Shin P, Mehta A, Hotaling JM, Pastuszak AW, Williams D, Alukal J, Lipshultz LI, Schlegel P, Walsh TJ, Eisenberg ML, Shin D, Honig S, Nagler HM, Samplaski M, Nangia AK, Sandlow J, Smith JF, Society for the Study of Male Reproduction SSMR and Society for Male Reproduction and Urology SMRU (2021). The Impact of Physician Productivity Models on Access to Subspecialty Care: A White Paper From the Society for the Study of Male Reproduction and the Society for Male Reproduction and Urology. Urology, 153, 28-34.
  23. Twitchell DK, Pastuszak AW, Khera M (2020). Controversies in Testosterone Therapy. Sex Med Rev, 9(1), 149-159.
  24. Khera M, Miner M, Jaffe J, Pastuszak AW (2020). Testosterone Therapy and Cardiovascular Risk: A Critical Analysis of Studies Reporting Increased Risk. J Sex Med, 18(1), 83-98.
  25. Patel DP, Pastuszak AW, Hotaling JM (2020). Genetics and erectile dysfunction: leveraging early foundations for new discoveries. Int J Impot Res, 34, 252-259.
  26. Thirumavalavan N, Scovell JM, Lo E, Gondokusomo J, Khera M, Pastuszak AW, Lipshultz LI (2020). Is treatment of hypogonadism safe for men after a solid organ transplant? Results from a retrospective controlled cohort study. Int J Impot Res, 34, 50-54.
  27. Moghalu OI, Das R, Horns J, Campbell A, Hotaling JM, Pastuszak AW (2020). Regional variation in the incidence and prevalence of Peyronie's disease in the United States-results from an encounters and claims database. Int J Impot Res, 34, 64-70.
  28. Keihani S, Alder NJ, Cheng PJ, Stoddard GJ, Pastuszak AW, Hotaling JM (2020). Obesity and Baseline Estradiol Levels Are Independent Predictors for Initiation of Anastrozole in Hypogonadal Men on Clomiphene Citrate. World J Mens Health, 38(4), 582-590.
  29. Rodriguez KM, Kohn TP, Kohn JR, Sigalos JT, Kirby EW, Pickett SM, Pastuszak AW, Lipshultz LI (2020). Shift Work Sleep Disorder and Night Shift Work Significantly Impair Erectile Function. J Sex Med, 17(9), 1687-1693.
  30. Gondokusumo JC, Butaney M, Balasubramanian A, Beilan JA, Tatem AJ, Thirumavalavan N, Pastuszak AW, Lipshultz LI (2020). The use of scrotal ultrasound in the evaluation of varicoceles: A survey study of reproductive specialists. Can Urol Assoc J, 14(8), E358-E362.
  31. Keihani S, Wright LN, Alder NJ, Jiang J, Cheng PJ, Stoddard GJ, Pastuszak AW, Deibert CM, Hotaling JM (2020). Baseline Gonadotropin Levels and Testosterone Response in Hypogonadal Men Treated With Clomiphene Citrate. Urology, 142, 119-124.
  32. Srivatsav A, Balasubramanian A, Pathak UI, Rivera-Mirabal J, Thirumavalavan N, Hotaling JM, Lipshultz LI, Pastuszak AW (2020). Efficacy and Safety of Common Ingredients in Aphrodisiacs Used for Erectile Dysfunction: A Review. Sex Med Rev, 8(3), 431-442.
  33. Ku S, Balasubramanian A, Yu J, Srivatsav A, Gondokusumo J, Tatem AJ, Beilan JA, Hasan A, Hotaling JM, Lipshultz LI, Pastuszak AW (2020). A systematic evaluation of youtube as an information source for male infertility. Int J Impot Res, 33(6), 611-615.
  34. Pastuszak AW, Hu Y, Freid JD (2020). Occurrence of Pulmonary Oil Microembolism After Testosterone Undecanoate Injection: A Postmarketing Safety Analysis. Sex Med, 8(2), 237-242.
  35. Patel DP, Christensen MB, Hotaling JM, Pastuszak AW (2019). Erectile Dysfunction and Peyronie's Disease: Genetic Diseases? Eur Urol Focus, 6(3), 572-574.
  36. Lo EM, Balasubramanian A, Pastuszak AW, Khera M (2020). Bipolar Androgen Therapy in Prostate Cancer (Update). J Sex Med, 17(5), 831-834.
  37. Butaney M, Thirumavalavan N, Balasubramanian A, McBride JA, Gondokusumo J, Pastuszak AW, Lipshultz LI (2020). Treatment of Estrogen Levels in the Management of Hypogonadism: An Anonymous Survey of ISSM Members. Urology, 139, 104-109.
  38. Basilius JR, Hotaling JM, Pastuszak AW (2020). Unwinding Fibrosis in Peyronie's Disease. J Sex Med, 17(5), 835-837.
  39. McGriff SC, Lo EM, Hotaling JM, Pastuszak AW (2020). Optimal Endocrine Evaluation and Treatment of Male Infertility. Urol Clin North Am, 47(2), 139-146.
  40. Balasubramanian A, Kohn TP, Santiago JE, Sigalos JT, Kirby EW, Hockenberry MS, Pickett SM, Pastuszak AW, Lipshultz LI (2020). Increased Risk of Hypogonadal Symptoms in Shift Workers With Shift Work Sleep Disorder. Urology, 138, 52-59.
  41. Balasubramanian A, Kohn TP, Santiago JE, Sigalos JT, Kirby EW, Hockenberry MS, Pickett SM, Pastuszak AW, Lipshultz LI (2019). AUTHOR REPLY. Urology, 138, 58-59.
  42. Towe M, El-Khatib F, Osman M, Huynh L, Carrion R, Ward S, Reisman Y, Serefoglu EC, Pastuszak A, Yafi FA (2020). "Doc, if it were you, what would you do?": a survey of Men's Health specialists' personal preferences regarding treatment modalities. Int J Impot Res.
  43. Patel DP, Jenkins TG, Aston KI, Guo J, Pastuszak AW, Hanson HA, Hotaling JM (2020). Harnessing the full potential of reproductive genetics and epigenetics for male infertility in the era of "big data". Fertil Steril, 113(3), 478-488.
  44. Lipshultz LI, Pastuszak AW (2020). Men's health: a rapidly changing landscape of healthcare delivery and treatment. Transl Androl Urol, 9(Suppl 2), S114-S115.
  45. Balasubramanian A, Yu J, Srivatsav A, Spitz A, Eisenberg ML, Thirumavalavan N, McBride JA, Lipshultz LI, Pastuszak AW (2020). A review of the evolving landscape between the consumer Internet and men's health. Transl Androl Urol, 9(Suppl 2), S123-S134.
  46. Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW (2020). Selective androgen receptor modulators: the future of androgen therapy? Transl Androl Urol, 9(Suppl 2), S135-S148.
  47. Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI (2020). Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol, 9(Suppl 2), S149-S159.
  48. Kohn TP, Kohn JR, Haney NM, Pastuszak AW, Lipshultz LI (2020). The effect of sleep on men's health. Transl Androl Urol, 9(Suppl 2), S178-S185.
  49. Patel DP, Christensen MB, Hotaling JM, Pastuszak AW (2019). A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie's disease. World J Urol, 38(2), 253-261.
  50. Twitchell DK, Pastuszak AW (2019). Editorial Comment. J Urol, 203(2), 403-404.
  51. Jenkins TG, James ER, Aston KI, Salas-Huetos A, Pastuszak AW, Smith KR, Hanson HA, Hotaling JM, Carrell DT (2019). Age-associated sperm DNA methylation patterns do not directly persist trans-generationally. Epigenetics Chromatin, 12(1), 74.
  52. Pastuszak AW, Thirumavalavan N, Kohn TP, Lipshultz LI, Eisenberg ML (2019). Increased Risk of Cancer in Men With Peyronie's Disease: A Cohort Study Using a Large United States Insurance Claims Database. Sex Med, 7(4), 403-408.
  53. Masterson TA, Galante A, Butaney M, Pastuszak A, Sadeghi-Nejad H, Ramasamy R (2019). Variation in collagenase Clostridium histolyticum practice patterns: a Survey of ISSM Members. Int J Impot Res, 31(6), 439-443.
  54. Keihani S, Pastuszak AW, Hotaling JM (2019). Re: Are WHO Recommendations to Perform 2 Consecutive Semen Analyses for Reliable Diagnosis of Male Infertility Still Valid? [Letter to the editor]. J Urol, 202(5), 1057-1058.
  55. Balasubramanian A, Thirumavalavan N, Pastuszak AW (2019). Evolving insights into the relationship between miR-23a/b-3p and target genes in subfertile patients. Fertil Steril, 112(2), 241-242.
  56. Krieger JR, Rizk PJ, Kohn TP, Pastuszak A (2019). Shockwave Therapy in the Treatment of Peyronie's Disease. Sex Med Rev, 7(3), 499-507.
  57. Balasubramanian A, Thirumavalavan N, Pastuszak AW (2019). DNA methylation profiling of peripheral blood samples is a promising new approach to screen for male infertility. Fertil Steril, 112(1), 32-33.
  58. Kohn GE, Rodriguez KM, Hotaling J, Pastuszak AW (2019). The History of Estrogen Therapy. Sex Med Rev, 7(3), 416-421.
  59. Srivatsav A, Balasubramanian A, Butaney M, Thirumavalavan N, McBride JA, Gondokusumo J, Pastuszak AW, Lipshultz L (2019). Patient Attitudes Toward Testicular Prosthesis Placement After Orchiectomy. Am J Mens Health, 13(4), 1557988319861019.
  60. Patel DP, Pastuszak AW, Hotaling JM (2019). Emerging Treatments for Erectile Dysfunction: a Review of Novel, Non-surgical Options. Curr Urol Rep, 20(8), 44.
  61. Cheng PJ, Pastuszak AW, Myers JB, Goodwin IA, Hotaling JM (2019). Fertility concerns of the transgender patient. Transl Androl Urol, 8(3), 209-218.
  62. Pastuszak AW (2019). Systems and Methods of Improving Communications Amongst Healthcare Professionals. U.S. Patent No. CTLK001USP2. Washington, D.C.:U.S. Patent and Trademark Office.
  63. Bates JN, Pastuszak AW, Khera M (2019). Effect of Body Weight on Sexual Function in Men and Women. Curr Sex Health Rep, 11(1), 52-59.
  64. Gul A, Pastuszak A, Kabasakal L, Bates J, Altinay S, Celik DS, Semercioz A, Serefoglu EC (2019). Tadalafil Preserves Penile Nitric Oxide Synthase from Detrimental Effect of Paroxetine in Rats. Eurasian J Med, 51(1), 60-63.
  65. Culha MG, Pastuszak A, Serefoglu EC (2015). Re: Effect of Tadalafil Once Daily on Penile Length Loss and Morning Erections in Patients After Bilateral Nerve-sparing Radical Prostatectomy: Results From a Randomized Controlled Trial (Urology 2015;85:1090-1096). [Letter to the editor]. Urology, 86(6), 1242-3.