Guillaume L. Hoareau

Guillaume L. Hoareau, PhD, DVM

Languages spoken: English, French, Spanish

Academic Information

Departments Primary - Emergency Medicine

Academic Office Information

Guillaume.Hoareau@utah.edu

Board Certification

  • American College of Veterinary Emergency Critical Care
  • European College of Veterinary Emergency and Critical Care

Research Interests

  • Mitochondria
  • Translational Research
  • Acute Trauma Resuscitation

Dr. Hoareau is a veterinarian with board certification in Emergency and Critical Care and a Ph.D. in Integrative Pathobiology. His research focuses on acute care translational research with an interest in military resuscitation. Specifically, he studies novel therapeutic approaches to mitigate ischemia-reperfusion injury in hemorrhagic shock. He works toward preserving mitochondrial function, the essential cell machinery for energy production. He seeks to accelerate the transition of new therapies to clinical practice. Dr. Hoareau mentors trainees around all aspects of translational acute care research with a strong interest and commitment to diversity, equity, and inclusion. He is part of several pipelines for trainees from underrepresented minorities.

Education History

Research Fellow Travis Air Force Base/Oak Ridge Institute for Science and Education
 Postdoctoral Research Fellow
Postdoctoral Fellowship Travis Air Force Base/Henry M. Jackson Foundation for the Advancement of Military Medicine
 Postdoctoral Fellow
Doctoral Training University of California, Davis
 PhD
Residency University of California, Davis/William R. Pritchard Veterinary Medical Teaching Hospital
 Resident
Internship University of Pennsylvania School of Veterinary Medicine/Matthew J. Ryan Hospital
 Intern
Professional Other National Veterinary School of Toulouse
 DVM
Undergraduate Levavasseur
 BSc (Hons)

Selected Publications

Journal Article

  1. Kelly C, Palatinus H, Johnson R, Hunt-Smith T, Ewer N, Saint-Pierre L, Hoareau GL, Johnson MA, Youngquist ST (2025). Nebulized Nitroglycerin Improves Carotid Blood Flow During Cardiopulmonary Resuscitation in a Swine Model of Cardiac Arrest. Prehosp Emerg Care, 1-10.
  2. Silverton NA, Hoareau GL, Kuck K (2025). Cardiopulmonary Bypass and the Kidney: New Evidence for Old Foes. Anesthesiology, 142(6), 985-988.
  3. Edwards T, Gonzalez JM, Hernandez-Torres S, Venn E, Ford R, Ewer N, Hoareau GL, Holland L, Convertino VA, Snider E (2024). Predicting blood loss volume in a canine model of hemorrhagic shock using arterial waveform machine learning analysis. Am J Vet Res, 1-10.
  4. Li J, Balmaceda P, Ha T, Visker JR, Maalouf N, Kwan E, Hoareau GL, Accad M, Ranjan R, Selzman CH, Drakos SG, Shaw RM, Hong T (2024). Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs. NPJ Regen Med, 9(1), 36.
  5. Ryan MA, Ford R, Ewer N, Hall KE, Guillaumin J, Edwards TH, Venn EC, Grantham LE, Hoareau GL (2024). Sidestream dark field video microscopy demonstrates shelf-stable blood products preserve the endothelial glycocalyx in a canine hemorrhagic shock model. Am J Vet Res, 1-7.
  6. Weaver AJ Jr, Venn EC, Ford R, Ewer N, Hildreth KE, Williams CE, Duncan CE, Calhoun CL, Grantham LE, Hoareau GL, Edwards TH (2024). Comparing the effects of various fluid resuscitative strategies on Glycocalyx damage in a canine hemorrhage model. Vet J, 307, 106221.
  7. Brant-Zawadzki G, Hoareau GL, Stoecklein HH, Levin N, Selzman CH, Ciullo A, Tonna J, Kelly C, Jones J, Youngquist ST, Johnson MA (2024). Successful Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) deployment by emergency medicine physicians for refractory non-traumatic cardiac arrest. Resusc Plus, 20, 100784.
  8. Gonzalez JM, Edwards TH, Hoareau GL, Snider EJ (2024). Refinement of machine learning arterial waveform models for predicting blood loss in canines. Front Artif Intell, 7, 1408029.
  9. Palatinus HN, Johnson MA, Wang HE, Hoareau GL, Youngquist ST (2024). Early intramuscular adrenaline administration is associated with improved survival from out-of-hospital cardiac arrest. Resuscitation, 201, 110266.
  10. Edwards TH, Venn EC, Le TD, Grantham LE 2nd, Hogen T, Ford R, Ewer N, Gunville R, Carroll C, Taylor A, Hoareau GL (2024). Comparison of Shelf-stable and Conventional Resuscitation Products in a Canine Model of Hemorrhagic Shock. J Trauma Acute Care Surg.
  11. Huther A, Edwards TH, Jaramillo EL, Giles JT 3rd, Israel SK, Mison M, Ambrosius L, Kaiser T, Hoareau GL (2024). The use of a kaolin-based hemostatic dressing to attenuate bleeding in dogs: A series of 4 cases. J Vet Emerg Crit Care (San Antonio).
  12. Silverton NA, Lofgren LR, Kuck K, Stoddard GJ, Johnson R, Ramezani A, Hoareau GL (2024). Near-infrared spectroscopy for kidney oxygen monitoring in a porcine model of hemorrhagic shock, hemodilution, and REBOA. Sci Rep, 14(1), 2646.
  13. Haugland H, Gamberini L, Hoareau GL, Haenggi M, Greif R, Brede JR, REBOA OHCA expert panel and other Collaborators (2023). Resuscitative endovascular balloon occlusion of the aorta in out-of-hospital cardiac arrest - A Delphi consensus study for uniform data collection. Resusc Plus, 16, 100485.
  14. Hirahara AM, Khan MS, Ishidoya Y, Smego D, Roman O, Ranjan R, Krueger L, Hoareau G, Selzman CH, Dosdall DJ (2023). Canine Model of Ischemia-Induced Ventricular Tachycardia. J Surg Res, 293, 196-203.
  15. Krulewitz N, Levin NM, Youngquist S, Kelly C, Hoareau G, Johnson MA, Ockerse P (2023). Evaluation of esophageal injuries after defibrillation with transesophageal ultrasound probe in the mid-esophagus in pigs. Am J Emerg Med, 74, 14-16.
  16. Hilgart DR, Iversen MM, Peters AY, Zabriskie MS, Hoareau GL, Vapniarsky N, Clark GA, Shah LM, Rieke V (2023). Non-invasive central nervous system assessment of a porcine model of neuropathic pain demonstrates increased latency of somatosensory-evoked potentials. J Neurosci Methods, 396, 109934.
  17. Khan MS, Smego D, Ishidoya Y, Hirahara AM, Offei E, Ruiz Castillo MS, Gharbia O, Li H, Palatinus JA, Krueger L, Hong T, Hoareau GL, Ranjan R, Selzman CH, Shaw RM, Dosdall DJ (2023). A canine model of chronic ischemic heart failure. Am J Physiol Heart Circ Physiol, 324(6), H751-H761.
  18. Patel N, Johnson MA, Vapniarsky N, Van Brocklin MW, Williams TK, Youngquist ST, Ford R, Ewer N, Neff LP, Hoareau GL (2023). Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock. Sci Rep, 13(1), 4496.
  19. Alexander MD, Hoareau G, Zabriskie MS, Palatinus H, Chakravarthula NR, Wang C, Johnson MA (2023). Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke. J Vis Exp, (192).
  20. Patel NTP, Gaffley M, Leblanc MJR, Lane MR, Hoareau GL, Johnson MA, Jordan JE, Neff LP, Williams TK (2022). Endovascular Perfusion Augmentation After Resuscitative Endovascular Balloon Occlusion of the Aorta Improves Renal Perfusion and Decreases Vasopressors. J Surg Res, 279, 712-721.
  21. Lofgren LR, Hoareau GL, Kuck K, Silverton NA (2022). Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock. J Vis Exp, (188).
  22. Wheeler LR, Edwards TH, Heinz JA, Scott LLF, Grantham LE 2nd, Keesee JD, Henderson AF, Gerardo AC, Hoareau G, Bynum JA (2022). Comparison of assessment of coagulation in healthy dogs by the TEG 6s and TEG 5000 viscoelastic analyzers. J Vet Diagn Invest, 34(5), 780-788.
  23. Hoareau GL, Beyer CA, Caples CM, Spruce MW, Gilbert Z, Grayson JK, Neff LP, Williams TK, Johnson MA (2020). Esmolol reduces myocardial injury induced by resuscitative endovascular balloon occlusion of the aorta (REBOA) in a porcine model of hemorrhagic shock. Injury, 51(10), 2165-2171.
  24. Abid M, Neff LP, Russo RM, Hoareau G, Williams TK, Grayson JK, DuBose JJ, Lendrum R, Johnson MA (2020). Reperfusion repercussions: A review of the metabolic derangements following resuscitative endovascular balloon occlusion of the aorta. J Trauma Acute Care Surg, 89(2S Suppl 2), S39-S44.
  25. Beyer CA, Burmeister DM, Gmez BI, Tercero J, Babcock E, Walker LE, Hoareau G, Sosnov J, Chung KK, Stewart IJ (2019). Point-of-Care Urinary Biomarker Testing for Risk Prediction in Critically Injured Combat Casualties. J Am Coll Surg, 229(5), 508-515.e1.
  26. Tibbits EM, Hoareau GL, Simon MA, Davidson AJ, DeSoucy ES, Faulconer ER, DuBose JJ, Neff LP, Grayson JK, Williams TK, Johnson MA (2018 Jul). Location is everything: The hemodynamic effects of REBOA in Zone 1 versus Zone 3 of the aorta. J Trauma Acute Care Surg, 85(1), 101-107.

Review

  1. Nwaduru C, Ovalle LA, Hoareau GL, Baker E, Buff M, Selim M, Baker TB, Zimmerman MA (2024). Ectonucleotidases in Ischemia Reperfusion Injury: Unravelling the Interplay With Mitochondrial Dysfunction in Liver Transplantation. [Review]. Transplant Proc, 56(7), 1598-1606.
  2. Hall KE, Tucker C, Dunn JA, Webb T, Watts SA, Kirkman E, Guillaumin J, Hoareau GL, Pidcoke HF (2024). Breaking barriers in trauma research: A narrative review of opportunities to leverage veterinary trauma for accelerated translation to clinical solutions for pets and people. [Review]. J Clin Transl Sci, 8(1), e74.
  3. Youngquist ST, Tonna JE, Bartos JA, Johnson MA, Hoareau GL, Hutin A, Lamhaut L (2020). Current Work in Extracorporeal Cardiopulmonary Resuscitation. [Review]. Crit Care Clin, 36(4), 723-735.

Letter

  1. Johnson MA, Hoareau G, Williams TK, Neff LP (2020). Letter to the editor: Response to letter from Dr. Martin et al: Not ready for prime time: Intermittent versus partial REBOA for prolonged hemorrhage control in a highly lethal porcine injury model. [Letter to the editor]. J Trauma Acute Care Surg, 88(6), e150-e151.

Other

  1. Hoareau GL, Beyer CA, Kashtan HW, Walker LE, Wilson C, Wishy A, Grayson JK, Stewart IJ (2020). Improvised Field Expedient Method for Renal Replacement Therapy in a Porcine Model of Acute Kidney Injury. Disaster Med Public Health Prep (15(6), pp. 741-749). United States.
  2. Hoareau GL, Beyer CA, Caples CA, Spruce MW, Kevin Grayson J, Neff LP, Williams TK, Johnson MA (2020). Automated Partial Versus Complete Resuscitative Endovascular Balloon Occlusion of the Aorta for the Management of Hemorrhagic Shock in a Pig Model of Polytrauma: a Randomized Controlled Pilot Study. Mil Med (185(11-12), pp. e1923-e1930). England.
  3. Beyer CA, Hoareau GL, Kashtan HW, Wishy AM, Caples C, Spruce M, Grayson JK, Neff LP, Williams TK, Johnson MA (2019). Resuscitative endovascular balloon occlusion of the aorta (REBOA) in a swine model of hemorrhagic shock and blunt thoracic injury. Eur J Trauma Emerg Surg (46(6), pp. 1357-1366). Germany.