Brandi M. Wynne

Brandi M. Wynne, MS, PhD, FAHA

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine

Divisions: Nephrology & Hypertension

Education History

Undergraduate East Carolina University
 BS
Graduate Training East Carolina University
 MS
Doctoral Training Medical College of Georgia
 PhD
Postdoctoral Fellowship Emory University School of Medicine
 Postdoctoral Fellow
Postdoctoral Fellowship Emory University School of Medicine
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Mistry AC, Wynne BM, Yu L, Tomilin V, Yue Q, Zhou Y, Al-Khalili O, Mallick R, Cai H, Alli AA, Ko B, Mattheyses A, Bao HF, Pochynyuk O, Theilig F, Eaton DC, Hoover RS (2016). The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate. Biochem J, 473(19), 3237-52.
  2. Nunes KP, Wynne BM, Cordeiro MN, Borges MH, Richardson M, Leite R, DeLima ME, Webb RC (2012). Increased cavernosal relaxation by Phoneutria nigriventer toxin, PnTx2-6, via activation at NO/cGMP signaling. Int J Impot Res, 24(2), 69-76.
  3. Wynne BM, Labazi H, Lima VV, Carneiro FS, Webb RC, Tostes RC, Giachini FR (2018). Mesenteric arteries from stroke-prone spontaneously hypertensive rats exhibit an increase in nitric-oxide-dependent vasorelaxation. Can J Physiol Pharmacol, 96(8), 719-727.
  4. Wynne BM, Labazi H, Carneiro ZN, Tostes RC, Webb RC (2017). Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta. Eur J Pharmacol, 814, 294-301.
  5. Wynne BM, McCarthy CG, Szasz T, Molina PA, Chapman AB, Webb RC, Klein JD, Hoover RS (2018). Protein kinase Calpha deletion causes hypotension and decreased vascular contractility. J Hypertens, 36(3), 510-519.
  6. Wynne BM, Labazi H, Tostes RC, Webb RC (2012). Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses. Pharmacol Res, 65(1), 41-7.
  7. Lazo-Fernandez Y, Aguilera G, Pham TD, Park AY, Beierwaltes WH, Sutliff RL, Verlander JW, Pacak K, Osunkoya AO, Ellis CL, Kim YH, Shipley GL, Wynne BM, Hoover RS, Sen SK, Plotsky PM, Wall SM (2015). Pendrin localizes to the adrenal medulla and modulates catecholamine release. Am J Physiol Endocrinol Metab, 309(6), E534-45.
  8. Ko B, Mistry AC, Hanson L, Mallick R, Wynne BM, Thai TL, Bailey JL, Klein JD, Hoover RS (2013). Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway. Am J Physiol Renal Physiol, 305(5), F645-52.
  9. Williams CR, Wynne BM, Walker M, Hoover RS, Gooch JL (2014). Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent. J Cell Mol Med, 18(12), 2361-6.
  10. Wynne BM, Labazi H, Tostes RC, Webb RC (2017). Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice. Curr Vasc Pharmacol, 16(1), 93-101.
  11. Carneiro FS, Sturgis LC, Giachini FR, Carneiro ZN, Lima VV, Wynne BM, San Martin S, Brands MW, Tostes RC, Webb RC (2009). TNF-alpha knockout mice have increased corpora cavernosa relaxation. J Sex Med, 6(1), 115-25.
  12. Labazi H, Wynne BM, Tostes R, Webb RC (2013). Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. J Sex Med, 10(9), 2154-64.
  13. Wynne BM, Chiao CW, Webb RC (2009). Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction to Angiotensin II and Endothelin-1. J Am Soc Hypertens, 3(2), 84-95.
  14. Wynne BM, Mistry AC, Al-Khalili O, Mallick R, Theilig F, Eaton DC, Hoover RS (2017). Aldosterone Modulates the Association between NCC and ENaC. Sci Rep, 7(1), 4149.
  15. Wynne BM, Itani HA (2019). Highlights From the American Heart Association's Joint Hypertension 2018 Scientific Sessions. J Am Heart Assoc, 8(5), e011176.
  16. Park AY, Plotsky PM, Pham TD, Pacak K, Wynne BM, Wall SM, Lazo-Fernandez Y (2018). Blood collection in unstressed, conscious, and freely moving mice through implantation of catheters in the jugular vein: a new simplified protocol. Physiol Rep, 6(21), e13904.
  17. Yue Q, Al-Khalili O, Moseley A, Yoshigi M, Wynne BM, Ma H, Eaton D (2022). PIP(2) Interacts Electrostatically with MARCKS-like Protein-1 and ENaC in Renal Epithelial Cells. Biology, 11(12),
  18. Schutte AE, Jafar TH, Poulter NR, Damasceno A, Khan NA, Nilsson PM, Alsaid J, Neupane D, Kario K, Beheiry H, Brouwers S, Burger D, Charchar FJ, Cho MC, Guzik TJ, Haji Al-Saedi GF, Ishaq M, Itoh H, Jones ESW, Khan T, Kokubo Y, Kotruchin P, Muxfeldt E, Odili A, Patil M, Ralapanawa U, Romero CA, Schlaich MP, Shehab A, Mooi CS, Steckelings UM, Stergiou G, Touyz RM, Unger T, Wainford RD, Wang JG, Williams B, Wynne BM, Tomaszewski (2023). Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension. Cardiovascular research, 119(2), 381-409.
  19. Wynne BM, Samson TK, Moyer HC, van Elst HJ, Moseley AS, Hecht G, Paul O, Al-Khalili O, Gomez-Sanchez C, Ko B, Eaton DC, Hoover R (2022). Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron. American journal of physiology. Cell physiology, 323(5), C1512-C1523.
  20. Song C, Yue Q, Moseley A, Al-Khalili O, Wynne BM, Ma H, Wang L, Eaton D (2020). Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells. American journal of physiology. Cell physiology, 319(3), C589-C604.
  21. Kruger R, Brunström M, Burger D, Charchar F, Climie R, Mirabito Colafella KM, Kempny P, Korostovtseva L, Marques FZ, Picone D, Romero C, Steckelings UM, Velkoska E, Wainford R, Wynne BM, Zanuzzi M (2020). Highlights from the International Society of Hypertension's New Investigators Network during 2019. Journal of hypertension, 38(5), 968-973.
  22. Frame AA, Farquhar WB, Latulippe ME, McDonough AA, Wainford RD, Wynne B (2019). Moving the Needle on Hypertension: What Knowledge Is Needed?. Nutrition today, 54(6), 248-256.
  23. Agarwal A, Beddhu S, Boucher R, Rao V, Ramkumar N, Rodan AR, Fang J, Wynne BM, Drakos SG, Hanff T, Cheung AK, Fang J (2024). Evaluation of renal sodium handling in heart failure with preserved ejection fraction: A pilot study. Physiological reports, 12(9), e16033.
  24. Romero CA, Lim J, Wang H, Wynne BM, Ma P, Jing Y, Liotta DC, D'Erasmo M, Traynelis SF, Eaton DC, Wall S (2023). Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation. bioRxiv,

Review

  1. Wynne BM, Zou L, Linck V, Hoover RS, Ma HP, Eaton DC (2017). Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines. [Review]. Front Immunol, 8, 766.
  2. Nishimoto M, Griffin KA, Wynne BM, Fujita (2024). Salt-Sensitive Hypertension and the Kidney. Hypertension (Dallas, Tex., 81(6), 1206-1217.

Editorial

  1. Carlini NA, Culver MN, Wynne BM, Hyndman KA, Bunsawat (2024). Diving deep toward the bottlenose dolphins' antiarterial aging secret: insight for the circulating milieu as a novel mechanism to preserve endothelial health. American journal of physiology. Heart and circulatory physiology, 327(3), H639-H641.

Abstract

  1. Williams CR, Wynne BM, Gooch J (2013). Calcineurin Is Involved in Pathological but Not Adaptive Hypertrophy of the Kidney [Abstract]. J Am Soc Nephrol, 24, 412A.
  2. Wynne BM, Mattheyses AL, Abinash M, Mallick R, Hoover RS (2013). Co-localization and Fluorescence Resonance Energy Transfer (FRET) Demonstrate Interaction between the Sodium Chloride Cotransporter (NCC) and the Epithelial Sodium Channel (ENaC) [Abstract]. J Am Soc Nephrol, 24, 532A.
  3. Hoover RS, Bao HF, Wynne BM, Mallick R, Eaton DC, Mistry AC (2013). The Sodium Chloride Cotransporter and Epithelial Sodium Channel Associate in a Complex in the Distal Convoluted Tubule [Abstract]. J Am Soc Nephrol, 24, 532A.
  4. Wynne BM, Moyer HC, Hecht GG, Krishnamurthy A, Ko B, Hoover RS (2018). Interleukin-6 Activates the Sodium Chloride Cotransporter via the Janus Kinase (Jak)/Signal Transducer and Activator of Signaling (STAT) [Abstract]. Exp Biol.
  5. Hecht GG, Moyer HC, Krishnamurthy A, van Elst HJ, Hoover RS, Wynne BM (2018). Interleukin 6 plus High Salt Increases Systolic Blood Pressure [Abstract]. Exp Biol.
  6. Moyer HC, Krishnamurthy A, Mallick R, Hoover RS, Wynne BM (2018). IL-6 Activates the Mineralocorticoid Receptor via the JAK2/STAT3 Pathway [Abstract]. Exp Biol.
  7. Wynne BM, Molina P, Klein J, Hoover RS (2014). The role of PKC-alpha in NCC-mediated hypertension [Abstract]. Hypertension, 64, A318.
  8. Labazi H, Wynne BM, Webb RC (2011). Endothelium-dependent relaxation in pudendal arteries is partially dependent upon nitroxyl anion [Abstract]. Hypertension, 58, 2011.
  9. Labazi H, Wynne BM, Webb RC (2010). Cystathionine beta-synthase (CBS) inhibition decreased acetylcholine mediated relaxation in murine resistance arteries; a potential role for hydrogen sulfide in endothelium mediated relaxation [Abstract]. Hypertension, 56.
  10. Wynne BM, McCarthy CG, Szasz T, Klein JD, Webb RC, Hoover RS (2017). Protein Kinase C¿ (PKC¿) Deletion Causes Hypotension due to Decreased Vascular Contractility [Abstract]. Hypertension, 70, AP49.
  11. Labazi H, Wynne BM, Webb RC (2011). Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction [Abstract]. J Sex Med, 10(9), 2154-64.
  12. Cozzi E, Wynne BM, Stallings H, VanScott M (2005). P190RhoGEF Protein Expression in the Airway Mucosa.
  13. Wynne BM, Molina P, Klein J, Hoover R (2016). Loss of Protein Kinase C Alpha Disrupts Mean Arterial Pressure and Diurnal Rhythm. 30(Supple 1), 1233.3.
  14. Kronk TA, Theilig F, Al-Khalili O, Mallick R, Eaton DC, Hoover RS, Wynne B (2016). Interleukin-6 Receptor Alpha Exhibits Differential Cellular Localization Within the Nephron. 30(Supple 1), 966.6.
  15. Wynne BM, Al-Khalili O, Eaton DC, Hoover R (2015). Interaction Between NCC and ENaC ¿, ¿ Subunits are Differentially Regulated- Role of SGK1. 29(Supple 1), 969.2.
  16. Liu MY, Al-Khalili O, Eaton DC, Wynne BM, Hoover R (2015). Regulation of the Interaction of NCC and ENaCß by SGK1. 29(Supple 969), 1.
  17. Wynne BM, Labazi H, Tostes RC, Webb R (2011). Angeli's Salt, a nitroxyl anion donor, reduces endothelin-1 induced vascular contractility via decreased reactive oxygen species.
  18. Labazi H, Wynne BM, Webb R (2011). Inhibition of Cystathionine Beta-Synthase (CBS) Decreases Acetylcholine Mediated Relaxation in Murine Aorta and Mesenteric Arteries. (Supple 25), 643.26.
  19. Wynne BM, Labazi H, Tostes RC, Webb R (2010). Nitroxyl anion mediates vasorelaxation in salt-loaded AngII hypertensive mesenteric arteries. (Supple 24), 984.20.
  20. Labazi H, Wynne BM, Webb R (2010). Metformin treatment of Angiotensin II rats decreased electric field stimulation-mediated contraction in corpus cavernosum. (Supple 24), 986.11.
  21. Wynne BM, Labazi H, Webb R (2009). Differential mechanisms of nitroxyl anion mediated vasorelaxation in the aorta and mesenteric artery during angiotensin II hypertension.
  22. Labazi H, Wynne BM, Webb R (2009). Activation of AMP-activated protein kinase (AMPK) increases phenylephrine-mediated contraction in murine corpus cavernosum. (Supple 23), 781.1.
  23. Wynne BM, Giachini F, Santos JES, Tostes RC, Webb R (2008). A Role for Arginase in the Relaxation Response to Acetylcholine in Murine Small Resistance Vessels of the Mesentery.
  24. Wynne BM, Brands M (2007). The Effect of IL-6 on the Acute Hypertensive Responses to Psychosocial Stress Depends on Angiotensin II. 21, LB124.
  25. Wynne BM, Hecht G, Kronk TA, van Elst H, Malu Tansey DCE, Hoover R (2017). Renal-Specific Dendritic Cell Depletion Reduces Urinary Interleukin 6 Levels Following Angiotensin II-Mediated Hypertension and Dietary High Salt. 131(Supple 1),