Brandi M. Wynne

Brandi M. Wynne, MS, PhD, FAHA

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine

Divisions: Nephrology & Hypertension

Academic Office Information

Brandi.Wynne@hsc.utah.edu

Education History

Undergraduate East Carolina University
 BS
Graduate Training East Carolina University
 MS
Doctoral Training Medical College of Georgia
 PhD
Postdoctoral Fellowship Emory University School of Medicine
 Postdoctoral Fellow
Postdoctoral Fellowship Emory University School of Medicine
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Zanuzzi MG, Hiremath S, Romero CA, Wynne B (2026). Arterial hypertension-attributable mortality in Europe: implications for the Americas. Journal of hypertension, 44(1), 60-61.
  2. Ibrahim A, Kolachalama VB, Abuelsamen T, Mekki O, Takayama S, Wynne BM, Chemaly E, Alsaleem A, Revelo M, Sauer L, Vitale A, Thomas A, Pasaye M, Schmitz-Valckenberg S, Gregory M, Bernstein PS, Al-Rabadi (2026). Noninvasive optical coherence tomography biomarker for Alport syndrome, COL4-related focal segmental glomerulosclerosis, and COL4 variant interpretation. Kidney international,
  3. Agarwal A, Beddhu S, Boucher R, Rao V, Ramkumar N, Rodan AR, Fang J, Wynne BM, Drakos SG, Hanff T, Cheung AK, Fang J (2024). Evaluation of renal sodium handling in heart failure with preserved ejection fraction: A pilot study. Physiological reports, 12(9), e16033.
  4. Schutte AE, Jafar TH, Poulter NR, Damasceno A, Khan NA, Nilsson PM, Alsaid J, Neupane D, Kario K, Beheiry H, Brouwers S, Burger D, Charchar FJ, Cho MC, Guzik TJ, Haji Al-Saedi GF, Ishaq M, Itoh H, Jones ESW, Khan T, Kokubo Y, Kotruchin P, Muxfeldt E, Odili A, Patil M, Ralapanawa U, Romero CA, Schlaich MP, Shehab A, Mooi CS, Steckelings UM, Stergiou G, Touyz RM, Unger T, Wainford RD, Wang JG, Williams B, Wynne BM, Tomaszewski (2023). Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension. Cardiovascular research, 119(2), 381-409.
  5. Romero CA, Lim J, Wang H, Wynne BM, Ma P, Jing Y, Liotta DC, D'Erasmo M, Traynelis SF, Eaton DC, Wall S (2023). Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation. bioRxiv,
  6. Yue Q, Al-Khalili O, Moseley A, Yoshigi M, Wynne BM, Ma H, Eaton D (2022). PIP(2) Interacts Electrostatically with MARCKS-like Protein-1 and ENaC in Renal Epithelial Cells. Biology, 11(12),
  7. Wynne BM, Samson TK, Moyer HC, van Elst HJ, Moseley AS, Hecht G, Paul O, Al-Khalili O, Gomez-Sanchez C, Ko B, Eaton DC, Hoover R (2022). Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron. American journal of physiology. Cell physiology, 323(5), C1512-C1523.
  8. Song C, Yue Q, Moseley A, Al-Khalili O, Wynne BM, Ma H, Wang L, Eaton D (2020). Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells. American journal of physiology. Cell physiology, 319(3), C589-C604.
  9. Kruger R, Brunström M, Burger D, Charchar F, Climie R, Mirabito Colafella KM, Kempny P, Korostovtseva L, Marques FZ, Picone D, Romero C, Steckelings UM, Velkoska E, Wainford R, Wynne BM, Zanuzzi M (2020). Highlights from the International Society of Hypertension's New Investigators Network during 2019. Journal of hypertension, 38(5), 968-973.
  10. Wynne BM, Itani H (2019). Highlights From the American Heart Association's Joint Hypertension 2018 Scientific Sessions. Journal of the American Heart Association, 8(5), e011176.
  11. Frame AA, Farquhar WB, Latulippe ME, McDonough AA, Wainford RD, Wynne B (2019). Moving the Needle on Hypertension: What Knowledge Is Needed?. Nutrition today, 54(6), 248-256.
  12. Wynne BM, Labazi H, Lima VV, Carneiro FS, Webb RC, Tostes RC, Giachini FR (2018). Mesenteric arteries from stroke-prone spontaneously hypertensive rats exhibit an increase in nitric-oxide-dependent vasorelaxation. Can J Physiol Pharmacol, 96(8), 719-727.
  13. Wynne BM, McCarthy CG, Szasz T, Molina PA, Chapman AB, Webb RC, Klein JD, Hoover R (2018). Protein kinase Calpha deletion causes hypotension and decreased vascular contractility. Journal of hypertension, 36(3), 510-519.
  14. Park AY, Plotsky PM, Pham TD, Pacak K, Wynne BM, Wall SM, Lazo-Fernandez (2018). Blood collection in unstressed, conscious, and freely moving mice through implantation of catheters in the jugular vein: a new simplified protocol. Physiological reports, 6(21), e13904.
  15. Wynne BM, Labazi H, Carneiro ZN, Tostes RC, Webb R (2017). Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta. European journal of pharmacology, 814, 294-301.
  16. Wynne BM, Labazi H, Tostes RC, Webb R (2017). Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice. Current vascular pharmacology, 16(1), 93-101.
  17. Wynne BM, Mistry AC, Al-Khalili O, Mallick R, Theilig F, Eaton DC, Hoover R (2017). Aldosterone Modulates the Association between NCC and ENaC. Scientific reports, 7(1), 4149.
  18. Mistry AC, Wynne BM, Yu L, Tomilin V, Yue Q, Zhou Y, Al-Khalili O, Mallick R, Cai H, Alli AA, Ko B, Mattheyses A, Bao HF, Pochynyuk O, Theilig F, Eaton DC, Hoover RS (2016). The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate. Biochem J, 473(19), 3237-52.
  19. Lazo-Fernandez Y, Aguilera G, Pham TD, Park AY, Beierwaltes WH, Sutliff RL, Verlander JW, Pacak K, Osunkoya AO, Ellis CL, Kim YH, Shipley GL, Wynne BM, Hoover RS, Sen SK, Plotsky PM, Wall S (2015). Pendrin localizes to the adrenal medulla and modulates catecholamine release. American journal of physiology. Endocrinology and metabolism, 309(6), E534-45.
  20. Williams CR, Wynne BM, Walker M, Hoover RS, Gooch J (2014). Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent. Journal of cellular and molecular medicine, 18(12), 2361-6.
  21. Ko B, Mistry AC, Hanson L, Mallick R, Wynne BM, Thai TL, Bailey JL, Klein JD, Hoover R (2013). Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway. American journal of physiology. Renal physiology, 305(5), F645-52.
  22. Labazi H, Wynne BM, Tostes R, Webb R (2013). Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. The journal of sexual medicine, 10(9), 2154-64.
  23. Nunes KP, Wynne BM, Cordeiro MN, Borges MH, Richardson M, Leite R, DeLima ME, Webb RC (2012). Increased cavernosal relaxation by Phoneutria nigriventer toxin, PnTx2-6, via activation at NO/cGMP signaling. Int J Impot Res, 24(2), 69-76.
  24. Wynne BM, Labazi H, Tostes RC, Webb R (2012). Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses. Pharmacological research, 65(1), 41-7.
  25. Carneiro FS, Sturgis LC, Giachini FR, Carneiro ZN, Lima VV, Wynne BM, San Martin S, Brands MW, Tostes RC, Webb R (2009). TNF-alpha knockout mice have increased corpora cavernosa relaxation. The journal of sexual medicine, 6(1), 115-25.
  26. Wynne BM, Chiao CW, Webb R (2009). Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction to Angiotensin II and Endothelin-1. Journal of the American Society of Hypertension, 3(2), 84-95.

Review

  1. Nishimoto M, Griffin KA, Wynne BM, Fujita (2024). Salt-Sensitive Hypertension and the Kidney. Hypertension (Dallas, Tex., 81(6), 1206-1217.
  2. Wynne BM, Zou L, Linck V, Hoover RS, Ma HP, Eaton D (2017). Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines. Frontiers in immunology, 8, 766.

Editorial

  1. Carlini NA, Culver MN, Wynne BM, Hyndman KA, Bunsawat (2024). Diving deep toward the bottlenose dolphins' antiarterial aging secret: insight for the circulating milieu as a novel mechanism to preserve endothelial health. American journal of physiology. Heart and circulatory physiology, 327(3), H639-H641.

Abstract

  1. Wynne BM, Moyer HC, Hecht GG, Krishnamurthy A, Ko B, Hoover R (2018). Interleukin-6 Activates the Sodium Chloride Cotransporter via the Janus Kinase (Jak)/Signal Transducer and Activator of Signaling (STAT). Experimental biology,
  2. Hecht GG, Moyer HC, Krishnamurthy A, van Elst HJ, Hoover RS, Wynne B (2018). Interleukin 6 plus High Salt Increases Systolic Blood Pressure. Experimental biology,
  3. Moyer HC, Krishnamurthy A, Mallick R, Hoover RS, Wynne B (2018). IL-6 Activates the Mineralocorticoid Receptor via the JAK2/STAT3 Pathway. Experimental biology,
  4. Wynne BM, McCarthy CG, Szasz T, Klein JD, Webb RC, Hoover R (2017). Protein Kinase C¿ (PKC¿) Deletion Causes Hypotension due to Decreased Vascular Contractility. Hypertension (Dallas, Tex., 70, AP49.
  5. Wynne BM, Hecht G, Kronk TA, van Elst H, Malu Tansey DCE, Hoover R (2017). Renal-Specific Dendritic Cell Depletion Reduces Urinary Interleukin 6 Levels Following Angiotensin II-Mediated Hypertension and Dietary High Salt. 131(Supple 1),
  6. Wynne BM, Molina P, Klein J, Hoover R (2016). Loss of Protein Kinase C Alpha Disrupts Mean Arterial Pressure and Diurnal Rhythm. 30(Supple 1), 1233.3.
  7. Kronk TA, Theilig F, Al-Khalili O, Mallick R, Eaton DC, Hoover RS, Wynne B (2016). Interleukin-6 Receptor Alpha Exhibits Differential Cellular Localization Within the Nephron. 30(Supple 1), 966.6.
  8. Wynne BM, Al-Khalili O, Eaton DC, Hoover R (2015). Interaction Between NCC and ENaC ¿, ¿ Subunits are Differentially Regulated- Role of SGK1. 29(Supple 1), 969.2.
  9. Liu MY, Al-Khalili O, Eaton DC, Wynne BM, Hoover R (2015). Regulation of the Interaction of NCC and ENaCß by SGK1. 29(Supple 969), 1.
  10. Wynne BM, Molina P, Klein J, Hoover R (2014). The role of PKC-alpha in NCC-mediated hypertension. Hypertension (Dallas, Tex., 64, A318.
  11. Williams CR, Wynne BM, Gooch J (2013). Calcineurin Is Involved in Pathological but Not Adaptive Hypertrophy of the Kidney [Abstract]. J Am Soc Nephrol, 24, 412A.
  12. Wynne BM, Mattheyses AL, Abinash M, Mallick R, Hoover RS (2013). Co-localization and Fluorescence Resonance Energy Transfer (FRET) Demonstrate Interaction between the Sodium Chloride Cotransporter (NCC) and the Epithelial Sodium Channel (ENaC) [Abstract]. J Am Soc Nephrol, 24, 532A.
  13. Hoover RS, Bao HF, Wynne BM, Mallick R, Eaton DC, Mistry AC (2013). The Sodium Chloride Cotransporter and Epithelial Sodium Channel Associate in a Complex in the Distal Convoluted Tubule [Abstract]. J Am Soc Nephrol, 24, 532A.
  14. Labazi H, Wynne BM, Webb R (2011). Endothelium-dependent relaxation in pudendal arteries is partially dependent upon nitroxyl anion. Hypertension (Dallas, Tex., 58, 2011.
  15. Labazi H, Wynne BM, Webb R (2011). Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. The journal of sexual medicine, 10(9), 2154-64.
  16. Wynne BM, Labazi H, Tostes RC, Webb R (2011). Angeli's Salt, a nitroxyl anion donor, reduces endothelin-1 induced vascular contractility via decreased reactive oxygen species.
  17. Labazi H, Wynne BM, Webb R (2011). Inhibition of Cystathionine Beta-Synthase (CBS) Decreases Acetylcholine Mediated Relaxation in Murine Aorta and Mesenteric Arteries. (Supple 25), 643.26.
  18. Labazi H, Wynne BM, Webb R (2010). Cystathionine beta-synthase (CBS) inhibition decreased acetylcholine mediated relaxation in murine resistance arteries; a potential role for hydrogen sulfide in endothelium mediated relaxation. Hypertension (Dallas, Tex., 56,
  19. Wynne BM, Labazi H, Tostes RC, Webb R (2010). Nitroxyl anion mediates vasorelaxation in salt-loaded AngII hypertensive mesenteric arteries. (Supple 24), 984.20.
  20. Labazi H, Wynne BM, Webb R (2010). Metformin treatment of Angiotensin II rats decreased electric field stimulation-mediated contraction in corpus cavernosum. (Supple 24), 986.11.
  21. Wynne BM, Labazi H, Webb R (2009). Differential mechanisms of nitroxyl anion mediated vasorelaxation in the aorta and mesenteric artery during angiotensin II hypertension.
  22. Labazi H, Wynne BM, Webb R (2009). Activation of AMP-activated protein kinase (AMPK) increases phenylephrine-mediated contraction in murine corpus cavernosum. (Supple 23), 781.1.
  23. Wynne BM, Giachini F, Santos JES, Tostes RC, Webb R (2008). A Role for Arginase in the Relaxation Response to Acetylcholine in Murine Small Resistance Vessels of the Mesentery.
  24. Wynne BM, Brands M (2007). The Effect of IL-6 on the Acute Hypertensive Responses to Psychosocial Stress Depends on Angiotensin II. 21, LB124.
  25. Cozzi E, Wynne BM, Stallings H, VanScott M (2005). P190RhoGEF Protein Expression in the Airway Mucosa.