Brandi M. Wynne, MS, PhD, FAHA

Languages spoken: English

Academic Information

Departments: Internal Medicine - Assistant Professor

Divisions: Nephrology

Academic Office Information

Brandi.Wynne@hsc.utah.edu

Education History

Postdoctoral Fellowship Emory University School of Medicine
Epithelial Transport Physiology, Sodium Transporter 		Postdoctoral Fellow
Postdoctoral Fellowship Emory University School of Medicine
Vascular Physiology, Angiogenesis, Hypertension 		Postdoctoral Fellow
Doctoral Training Medical College of Georgia
Biomedical Sciences/Physiology 		Ph.D.
Graduate Training East Carolina University
Biology, Concentration: Anatomy and Cell Biology 		M.S.
Undergraduate East Carolina University
Major: Biology, Anatomy and Cell; Minor: Spanish 		B.S.

Selected Publications

  1. Schutte AE, Jafar TH, Poulter NR, Damasceno A, Khan NA, Nilsson PM, Alsaid J, Neupane D, Kario K, Beheiry H, Brouwers S, Burger D, Charchar FJ, Cho MC, Guzik TJ, Haji Al-Saedi GF, Ishaq M, Itoh H, Jones ESW, Khan T, Kokubo Y, Kotruchin P, Muxfeldt E, Odili A, Patil M, Ralapanawa U, Romero CA, Schlaich MP, Shehab A, Mooi CS, Steckelings UM, Stergiou G, Touyz RM, Unger T, Wainford RD, Wang JG, Williams B, Wynne BM, Tomaszewski M (2022). Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension. Cardiovasc Res, 119(2), 381-409.
  2. Yue Q, Al-Khalili O, Moseley A, Yoshigi M, Wynne BM, Ma H, Eaton DC (2022). PIP(2) Interacts Electrostatically with MARCKS-like Protein-1 and ENaC in Renal Epithelial Cells. Biology (Basel), 11(12).
  3. Wynne BM, Samson TK, Moyer HC, van Elst HJ, Moseley AS, Hecht G, Paul O, Al-Khalili O, Gomez-Sanchez C, Ko B, Eaton DC, Hoover RS (2022). Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron. Am J Physiol Cell Physiol, 323(5), C1512-C1523.
  4. Song C, Yue Q, Moseley A, Al-Khalili O, Wynne BM, Ma H, Wang L, Eaton DC (2020). Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells. Am J Physiol Cell Physiol, 319(3), C589-C604.
  5. Kruger R, Brunstrm M, Burger D, Charchar F, Climie R, Mirabito Colafella KM, Kempny P, Korostovtseva L, Marques FZ, Picone D, Romero C, Steckelings UM, Velkoska E, Wainford R, Wynne BM, Zanuzzi MG (2020). Highlights from the International Society of Hypertension's New Investigators Network during 2019. J Hypertens, 38(5), 968-973.
  6. Frame AA, Farquhar WB, Latulippe ME, McDonough AA, Wainford RD, Wynne BM (2021). Moving the Needle on Hypertension: What Knowledge Is Needed? Nutr Today, 54(6), 248-256.
  7. Wynne BM, Itani HA (2019). Highlights From the American Heart Association's Joint Hypertension 2018 Scientific Sessions. J Am Heart Assoc, 8(5), e011176.
  8. Park AY, Plotsky PM, Pham TD, Pacak K, Wynne BM, Wall SM, Lazo-Fernandez Y (2018). Blood collection in unstressed, conscious, and freely moving mice through implantation of catheters in the jugular vein: a new simplified protocol. Physiol Rep, 6(21), e13904.
  9. Wynne BM, Labazi H, Lima VV, Carneiro FS, Webb RC, Tostes RC, Giachini FR (2018). Mesenteric arteries from stroke-prone spontaneously hypertensive rats exhibit an increase in nitric-oxide-dependent vasorelaxation. Can J Physiol Pharmacol, 96(8), 719-727.
  10. Wynne BM, McCarthy CG, Szasz T, Molina PA, Chapman AB, Webb RC, Klein JD, Hoover RS (2018). Protein kinase Calpha deletion causes hypotension and decreased vascular contractility. J Hypertens, 36(3), 510-519.
  11. Hecht GG, Moyer HC, Krishnamurthy A, van Elst HJ, Hoover RS, Wynne BM (2018). Interleukin 6 plus High Salt Increases Systolic Blood Pressure [Abstract]. Experimental Biology.
  12. Moyer HC, Krishnamurthy A, Mallick R, Hoover RS, Wynne BM (2018). IL-6 Activates the Mineralocorticoid Receptor via the JAK2/STAT3 Pathway [Abstract]. Experimental Biology.
  13. Wynne BM, Moyer HC, Hecht GG, Krishnamurthy A, Ko B, Hoover RS (2018). Interleukin-6 Activates the Sodium Chloride Cotransporter via the Janus Kinase (Jak)/Signal Transducer and Activator of Signaling (STAT) [Abstract]. Experimental Biology.
  14. Wynne BM, Labazi H, Carneiro ZN, Tostes RC, Webb RC (2017). Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta. Eur J Pharmacol, 814, 294-301.
  15. Wynne BM, McCarthy CG, Szasz T, Klein JD, Webb RC, Hoover RS (2017). Protein Kinase Cα (PKCα) Deletion Causes Hypotension due to Decreased Vascular Contractility [Abstract]. Hypertension, 70, AP49.
  16. Wynne BM, Mistry AC, Al-Khalili O, Mallick R, Theilig F, Eaton DC, Hoover RS (2017). Aldosterone Modulates the Association between NCC and ENaC. Sci Rep, 7(1), 4149.
  17. Wynne BM, Hecht G, Kronk TA, van Elst H, Malu Tansey DCE, Hoover RS (2017). Renal-Specific Dendritic Cell Depletion Reduces Urinary Interleukin 6 Levels Following Angiotensin II-Mediated Hypertension and Dietary High Salt [Abstract]. Federation of American Societies for Experimental Biology Journal, 131(Supple 1).
  18. Wynne BM, Labazi H, Tostes RC, Webb RC (2017). Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice. Curr Vasc Pharmacol, 16(1), 93-101.
  19. Wynne BM, Zou L, Linck V, Hoover RS, Ma HP, Eaton DC (2017). Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines. [Review]. Front Immunol, 8, 766.
  20. Mistry AC, Wynne BM, Yu L, Tomilin V, Yue Q, Zhou Y, Al-Khalili O, Mallick R, Cai H, Alli AA, Ko B, Mattheyses A, Bao HF, Pochynyuk O, Theilig F, Eaton DC, Hoover RS (2016). The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate. Biochem J, 473(19), 3237-52.
  21. Kronk TA, Theilig F, Al-Khalili O, Mallick R, Eaton DC, Hoover RS, Wynne BM (2016). Interleukin-6 Receptor Alpha Exhibits Differential Cellular Localization Within the Nephron [Abstract]. Federation of American Societies for Experimental Biology Journal, 30(Supple 1), 966.6.
  22. Wynne BM, Molina P, Klein J, Hoover RS (2016). Loss of Protein Kinase C Alpha Disrupts Mean Arterial Pressure and Diurnal Rhythm [Abstract]. The Federation of American Societies for Experimental Biology Journal, 30(Supple 1), 1233.3.
  23. Lazo-Fernandez Y, Aguilera G, Pham TD, Park AY, Beierwaltes WH, Sutliff RL, Verlander JW, Pacak K, Osunkoya AO, Ellis CL, Kim YH, Shipley GL, Wynne BM, Hoover RS, Sen SK, Plotsky PM, Wall SM (2015). Pendrin localizes to the adrenal medulla and modulates catecholamine release. Am J Physiol Endocrinol Metab, 309(6), E534-45.
  24. Wynne BM, Al-Khalili O, Eaton DC, Hoover RS (2015). Interaction Between NCC and ENaC α, γ Subunits are Differentially Regulated- Role of SGK1 [Abstract]. The Federation of American Societies for Experimental Biology Journal, 29(Supple 1), 969.2.
  25. Liu MY, Al-Khalili O, Eaton DC, Wynne BM, Hoover RS (2015). Regulation of the Interaction of NCC and ENaCβ by SGK1 [Abstract]. The Federation of American Societies for Experimental Biology Journal, 29(Supple 969), 1.
  26. Williams CR, Wynne BM, Walker M, Hoover RS, Gooch JL (2014). Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent. J Cell Mol Med, 18(12), 2361-6.
  27. Wynne BM, Molina P, Klein J, Hoover RS (2014). The role of PKC-alpha in NCC-mediated hypertension [Abstract]. Hypertension, 64, A318.
  28. Ko B, Mistry AC, Hanson L, Mallick R, Wynne BM, Thai TL, Bailey JL, Klein JD, Hoover RS (2013). Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway. Am J Physiol Renal Physiol, 305(5), F645-52.
  29. Labazi H, Wynne BM, Tostes R, Webb RC (2013). Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction. J Sex Med, 10(9), 2154-64.
  30. Williams CR, Wynne BM, Gooch J (2013). Calcineurin Is Involved in Pathological but Not Adaptive Hypertrophy of the Kidney [Abstract]. Journal of the American Society of Nephrology, 24, 412A.
  31. Wynne BM, Mattheyses AL, Abinash M, Mallick R, Hoover RS (2013). Co-localization and Fluorescence Resonance Energy Transfer (FRET) Demonstrate Interaction between the Sodium Chloride Cotransporter (NCC) and the Epithelial Sodium Channel (ENaC) [Abstract]. Journal of the American Society of Nephrology, 24, 532A.
  32. Hoover RS, Bao HF, Wynne BM, Mallick R, Eaton DC, Mistry AC (2013). The Sodium Chloride Cotransporter and Epithelial Sodium Channel Associate in a Complex in the Distal Convoluted Tubule [Abstract]. Journal of the American Society of Nephrology, 24, 532A.
  33. Nunes KP, Wynne BM, Cordeiro MN, Borges MH, Richardson M, Leite R, DeLima ME, Webb RC (2012). Increased cavernosal relaxation by Phoneutria nigriventer toxin, PnTx2-6, via activation at NO/cGMP signaling. Int J Impot Res, 24(2), 69-76.
  34. Wynne BM, Labazi H, Tostes RC, Webb RC (2012). Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses. Pharmacol Res, 65(1), 41-7.
  35. Labazi H, Wynne BM, Webb RC (2011). Endothelium-dependent relaxation in pudendal arteries is partially dependent upon nitroxyl anion [Abstract]. Hypertension, 58, 2011.
  36. Labazi H, Wynne BM, Webb RC (2011). Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction [Abstract]. Journal of Sexual Medicine, 10(9), 2154-64.
  37. Wynne BM, Labazi H, Tostes RC, Webb RC (2011). Angeli’s Salt, a nitroxyl anion donor, reduces endothelin-1 induced vascular contractility via decreased reactive oxygen species [Abstract]. Federation of American Societies for Experimental Biology.
  38. Labazi H, Wynne BM, Webb RC (2011). Inhibition of Cystathionine Beta-Synthase (CBS) Decreases Acetylcholine Mediated Relaxation in Murine Aorta and Mesenteric Arteries [Abstract]. Federation of American Societies for Experimental Biology, (Supple 25), 643.26.
  39. Labazi H, Wynne BM, Webb RC (2010). Cystathionine beta-synthase (CBS) inhibition decreased acetylcholine mediated relaxation in murine resistance arteries; a potential role for hydrogen sulfide in endothelium mediated relaxation [Abstract]. Hypertension, 56.
  40. Wynne BM, Labazi H, Tostes RC, Webb RC (2010). Nitroxyl anion mediates vasorelaxation in salt-loaded AngII hypertensive mesenteric arteries [Abstract]. Federation of American Societies for Experimental Biology, (Supple 24), 984.20.
  41. Labazi H, Wynne BM, Webb RC (2010). Metformin treatment of Angiotensin II rats decreased electric field stimulation-mediated contraction in corpus cavernosum [Abstract]. Federation of American Societies for Experimental Biology, (Supple 24), 986.11.
  42. Wynne BM, Chiao CW, Webb RC (2009). Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction to Angiotensin II and Endothelin-1. J Am Soc Hypertens, 3(2), 84-95.
  43. Carneiro FS, Sturgis LC, Giachini FR, Carneiro ZN, Lima VV, Wynne BM, San Martin S, Brands MW, Tostes RC, Webb RC (2009). TNF-alpha knockout mice have increased corpora cavernosa relaxation. J Sex Med, 6(1), 115-25.
  44. Wynne BM, Labazi H, Webb RC (2009). Differential mechanisms of nitroxyl anion mediated vasorelaxation in the aorta and mesenteric artery during angiotensin II hypertension [Abstract]. Federation of American Societies for Experimental Biology.
  45. Labazi H, Wynne BM, Webb RC (2009). Activation of AMP-activated protein kinase (AMPK) increases phenylephrine-mediated contraction in murine corpus cavernosum [Abstract]. Federation of American Societies for Experimental Biology, (Supple 23), 781.1.
  46. Wynne BM, Giachini F, Santos JES, Tostes RC, Webb RC (2008). A Role for Arginase in the Relaxation Response to Acetylcholine in Murine Small Resistance Vessels of the Mesentery [Abstract]. Federation of American Societies for Experimental Biology.
  47. Wynne BM, Brands MW (2007). The Effect of IL-6 on the Acute Hypertensive Responses to Psychosocial Stress Depends on Angiotensin II [Abstract]. Federation of American Societies for Experimental Biology, 21, LB124.
  48. Cozzi E, Wynne BM, Stallings H, VanScott MR (2005). P190RhoGEF Protein Expression in the Airway Mucosa [Abstract]. Federation of American Societies for Experimental Biology.

Global Impact

Education History

Type School Degree
Doctoral Training Medical College of Georgia
Biomedical Sciences/Physiology		 Ph.D.