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Maria Bettini, Ph.D.

Languages spoken: English

Academic Information

Departments: Pathology - Associate Professor

Divisions: Microbiology and Immunology

Academic Office Information

(801) 585-6421

Emma Eccles Jones Medical Research Building

15 N Medical Dr E, Room:
Salt Lake City, UT


Dr. Maria Bettini’s work has focused on understanding immunotolerance pathways and their dysregulation in autoimmunity. Dr. Bettini utilizes cutting edge genetic approaches to create systems that advance our knowledge of tissue targeted autoimmunity. Her work has uncovered several pathways that are important in suppression of autoimmune responses, which have therapeutic potential. More recently, Dr. Bettini has made significant advancement in our understanding of regulatory T cell function in autoimmunity and the signaling pathways that modulate Treg functional profile. Her current work is aimed at harnessing this knowledge to improve current cell based therapies for treatment of autoimmune disorders.

Research Statement

The focus of my research is mechanisms of tolerance and their failure in autoimmunity, with primary interest in type 1 diabetes. Our approach is built upon a combination of innovative mouse models of T cell biology and autoimmunity, including mouse and human single T cell receptor retrogenic mice.

Current projects investigate the role of T cell receptor antigen specificity and affinity in function of pathogenic and regulatory T cells in autoimmunity.

Education History

Post Graduate Training St. Jude Children’s Research Hospital
Postdoctoral Fellow
Post Graduate Training Emory University
Postdoctoral Associate
Doctoral Training Emory University
Immunology and Molecular Pathogenesis
Undergraduate East Tennessee State University
Biology, concentration Biochemistry