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Oliver J. Harrison, PhD

Languages spoken:

Academic Information

Departments: Biochemistry - Research Assistant Professor

Academic Office Information

(801) 213-0783

Emma Eccles Jones Medical Research Building

15 N Medical Dr E, Room:
Salt Lake City, UT

Education History

Doctoral Training Cambridge University/Babraham Institute
Undergraduate Durham University
Molecular Biology and Biochemistry
B.Sc. (Hons)

Selected Publications

  1. Chen Y, Brasch J, Harrison OJ, Bidone TC (2021). Computational model of E-cadherin clustering under force. Biophysical Journal, 120(22), 4944-4954.
  2. Harrison OJ, Brasch J, Katsamba PS, Ahlsen G, Noble AJ, Dan H, Sampogna RV, Potte CS, Carragher B, Honig B, Shapiro LS (2020). Family-wide structural and biophysical analysis of binding interactions among non-clustered delta-protocadherins. Cell reports, 30(8), 2655-2671.
  3. Generous AR, Harrison OJ, Troyanovsky RB, Mateo M, Navaratnarajah CK, Donohue RC, Pfaller CK, Alekhina O, Sergeeva AP, Indra I, Thornburg T, Kochetkova I, Billadeau DD, Taylor MP, Troyanovsky SM, Honig B, Shapiro LS, Cattaneo R (2019). Trans-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells. J Cell Sci, 132(16).
  4. Brasch J, Katsamba PS, Harrison OJ, Ahlsn G, Troyanovsky RB, Indra I, Kaczynska A, Kaeser B, Troyanovsky S, Honig B, Shapiro L (2017). Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior. Cell Rep, 23(6), 1840-1852.
  5. Evangelista F, Roth AJ, Prisayanh P, Temple BR, Li N, Qian Y, Culton DA, Liu Z, Harrison OJ, Brasch J, Honig B, Shapiro L, Diaz LA (2018). Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. J Autoimmun, 89, 171-185.
  6. Larsen ISB, Narimatsu Y, Joshi HJ, Siukstaite L, Harrison OJ, Brasch J, Goodman KM, Hansen L, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A (2017). Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. Proc Natl Acad Sci U S A, 114(42), 11163-11168.
  7. Larsen ISB, Narimatsu Y, Joshi HJ, Yang Z, Harrison OJ, Brasch J, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A (2017). Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2. J Biol Chem, 292(27), 11586-11598.
  8. Harrison OJ, Brasch J, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L (2016). Structural basis of adhesive binding by desmocollins and desmogleins. Proc Natl Acad Sci U S A, 113(26), 7160-5.
  9. Biswas KH, Hartman KL, Yu CH, Harrison OJ, Song H, Smith AW, Huang WY, Lin WC, Guo Z, Padmanabhan A, Troyanovsky SM, Dustin ML, Shapiro L, Honig B, Zaidel-Bar R, Groves JT (2015). E-cadherin junction formation involves an active kinetic nucleation process. Proc Natl Acad Sci U S A, 112(35), 10932-7.
  10. Vendome J, Felsovalyi K, Song H, Yang Z, Jin X, Brasch J, Harrison OJ, Ahlsen G, Bahna F, Kaczynska A, Katsamba PS, Edmond D, Hubbell WL, Shapiro L, Honig B (2014). Structural and energetic determinants of adhesive binding specificity in type I cadherins. Proc Natl Acad Sci U S A, 111(40), E4175-84.
  11. Harrison OJ, Vendome J, Brasch J, Jin X, Hong S, Katsamba PS, Ahlsen G, Troyanovsky RB, Troyanovsky SM, Honig B, Shapiro L (2012). Nectin ectodomain structures reveal a canonical adhesive interface. Nat Struct Mol Biol, 19(9), 906-15.
  12. Brasch J, Harrison OJ, Honig B, Shapiro L (2012). Thinking outside the cell: how cadherins drive adhesion. Trends Cell Biol, 22(6), 299-310.
  13. Brasch J, Harrison OJ, Ahlsen G, Liu Q, Shapiro L (2011). Crystal structure of the ligand binding domain of netrin G2. J Mol Biol, 414(5), 723-34.
  14. Brasch J, Harrison OJ, Ahlsen G, Carnally SM, Henderson RM, Honig B, Shapiro L (2011). Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin. J Mol Biol, 408(1), 57-73.
  15. Harrison OJ, Jin X, Hong S, Bahna F, Ahlsen G, Brasch J, Wu Y, Vendome J, Felsovalyi K, Hampton CM, Troyanovsky RB, Ben-Shaul A, Frank J, Troyanovsky SM, Shapiro L, Honig B (2010). The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure, 19(2), 244-56.
  16. Wu Y, Jin X, Harrison O, Shapiro L, Honig BH, Ben-Shaul A (2010). Cooperativity between trans and cis interactions in cadherin-mediated junction formation. Proc Natl Acad Sci U S A, 107(41), 17592-7.
  17. Harrison OJ, Bahna F, Katsamba PS, Jin X, Brasch J, Vendome J, Ahlsen G, Carroll KJ, Price SR, Honig B, Shapiro L (2010). Two-step adhesive binding by classical cadherins. Nat Struct Mol Biol, 17(3), 348-57.
  18. Ciatto C, Bahna F, Zampieri N, VanSteenhouse HC, Katsamba PS, Ahlsen G, Harrison OJ, Brasch J, Jin X, Posy S, Vendome J, Ranscht B, Jessell TM, Honig B, Shapiro L (2010). T-cadherin structures reveal a novel adhesive binding mechanism. Nat Struct Mol Biol, 17(3), 339-47.
  19. Harrison OJ, Corps EM, Kilshaw PJ (2005). Cadherin adhesion depends on a salt bridge at the N-terminus. J Cell Sci, 118(Pt 18), 4123-30.
  20. Harrison OJ, Corps EM, Berge T, Kilshaw PJ (2005). The mechanism of cell adhesion by classical cadherins: the role of domain 1. J Cell Sci, 118(Pt 4), 711-21.