Anna E. Beaudin

Anna E. Beaudin, PhD

Languages spoken: English

Academic Information

Departments Adjunct - Pathology , Adjunct - Human Genetics , Primary - Internal Medicine

Divisions: Hematology & Hematologic Malignancies

Lab

Dr. Anna E. Beaudin is a Tenured Professor and Associate Chief of Basic Research in the Division of Hematology and Hematologic Malignancies, Department of Internal Medicine at the University of Utah School of Medicine. She holds adjunct appointments in the Department of Human Genetics and the Division of Microbiology and Immunology in the Department of Pathology and is a member of the Molecular Medicine Program and the Cell Response and Regulation Program at the Huntsman Cancer Institute.
The overarching goal of Dr. Beaudin's research is to define the contribution of fetal hematopoiesis, or blood production, to immune development, immune function, and disease susceptibility across the lifespan. Hematopoietic stem cells (HSCs) are responsible for sustaining production of all blood and immune cells across the lifespan. Dr. Beaudin's research focuses on fetal HSCs and the process of fetal hematopoiesis, in which transient HSCs produce a series of distinct blood and immune cells that function to meet the discrete immunological needs of the fetus across development. Fetal-derived immune cells are fundamentally distinct from immune cells produced in adulthood -- they defy conventional phenotypic and functional definitions, and seed developing organs where they persist across the lifespan of the animal to support tissue homeostasis. The Beaudin lab utilizes single-cell analysis, fate-mapping, and in vivo analysis in mouse models to investigate how these specialized cells are made during fetal hematopoiesis in order to gain insight into the role of these cells in tissue development, regeneration, and disease pathogenesis across the lifespan. We also investigate how perturbation of fetal hematopoiesis by extrinsic stimuli during development (infection, nutrition) shapes susceptibility to immune dysfunction by disrupting immune system establishment and reshaping the trajectory of adult hematopoiesis.
Dr. Beaudin's training is highly interdisciplinary, spanning nutritional sciences, biochemistry, and developmental and stem cell biology, thereby allowing her to make unique contributions to research at the intersection of development, hematopoiesis, and immunology. Originally from Los Angeles, California, Dr. Beaudin completed a B.A. in Psychology and Ph.D. in Nutritional sciences at Cornell University in Ithaca, New York. She continued her postdoctoral work at UC Santa Cruz, where she used a fate-mapping approach to discover a novel, transient hematopoietic progenitor that serves as a cell of origin for fetal-restricted innate-like lymphocytes (Beaudin et al, Cell Stem Cell, 2016; Beaudin & Forsberg, Blood, 2016). Since opening her lab in 2016, Dr. Beaudin's work has been funded by several NIH-funded awards, the Hellman Foundation, and she is a recipient of the Pew Biomedical Scholars Award. Dr. Beaudin is an active member of the International Society of Experimental Hematology, the American Society of Hematology, and the American Association of Immunologists. She was also elected as a council member for the Midwinter Conference of Immunologists. Dr. Beaudin is an active reviewer for journals including Science, Nature, Cell Stem Cell, Stem Cell Reports, Blood, and Nature Communications, and her work has been published in high-profile journals such as Cell Stem Cell, Cell Reports, EMBO Journal, and Development.

Education History

Undergraduate Cornell University
 BA
Graduate Training Brown University
 MS
Doctoral Training Cornell University
 PhD

Selected Publications

Journal Article

  1. Lopez DA, Griffin A, Aguilar LM, Deering-Rice C, Myers EJ, Warren KJ, Welner RS, Beaudin A (2024). Prenatal inflammation remodels lung immunity and function by programming ILC2 hyperactivation. Cell reports, 43(7), 114365.
  2. Poscablo DM, Worthington AK, Smith-Berdan S, Rommel MGE, Manso BA, Adili R, Mok L, Reggiardo RE, Cool T, Mogharrab R, Myers J, Dahmen S, Medina P, Beaudin AE, Boyer SW, Holinstat M, Jonsson VD, Forsberg E (2024). An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis. Cell, 187(12), 3090-3107.e21.
  3. Lopez DA, Otsuka KS, Apostol AC, Posada J, Sánchez-Arcila JC, Jensen KD, Beaudin A (2023). Both maternal IFNγ exposure and acute prenatal infection with Toxoplasma gondii activate fetal hematopoietic stem cells. The EMBO journal, 42(14), e112693.
  4. Smith FL, Savage HP, Luo Z, Tipton CM, Lee FE, Apostol AC, Beaudin AE, Lopez DA, Jensen I, Keller S, Baumgarth (2023). B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM. The Journal of experimental medicine, 220(4),
  5. Lopez DA, Apostol AC, Lebish EJ, Valencia CH, Romero-Mulero MC, Pavlovich PV, Hernandez GE, Forsberg EC, Cabezas-Wallscheid N, Beaudin A (2022). Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity. Cell reports, 41(8), 111677.
  6. Worthington AK, Cool T, Poscablo DM, Hussaini A, Beaudin AE, Forsberg E (2022). IL7R¿, but not Flk2, is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells. Development (Cambridge, England), 149(8),
  7. Hernandez GE, Ma F, Martinez G, Firozabadi NB, Salvador J, Juang LJ, Leung J, Zhao P, Lopez DA, Ardehali R, Beaudin AE, Kastrup CJ, Pellegrini M, Flick MJ, Iruela-Arispe M (2022). Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state. Nature cardiovascular research, 1(1), 67-84.
  8. Lopez DA, Beaudin A (2023). Isolation and Characterization of Fetal Liver Hematopoietic Stem Cells. Methods in molecular biology (Clifton, N.J.), 2567, 99-112.
  9. Beaudin A (2021). Takes one to B1a: Dismantling the origin of mantle cell lymphoma. Journal of Experimental Medicine,
  10. Lopez DA, Beaudin A (2021). Layered immunity of the developing thymus. Blood,
  11. Apostol AC, Lopez DA, Beaudin A (2020). A "Switch" in time through genes aligned: Unraveling the genomic landscape of HSC development. Cell Stem Cell,
  12. Apostol AC, Jensen KDC, Beaudin A (2020). Training the fetal immune system through maternal inflammation: A layered hygiene hypothesis. Frontiers in Immunology,
  13. Leung GA, Cool T, Valencia CH, Worthington A, Beaudin AE, Forsberg E (2019). The lymphoid-associated interleukin-7 receptor (IL-7R) regulates tissue resident macrophage development. Development,
  14. Boyer SW, Rajendiran S, Beaudin AE, Perez-Cunningham J, Smith-Berdan S, Martin EW, Muthuswamy PK, Cheung C, Tsang H, Landon M, Forsberg E (2019). Clonal and quantitative in vivo assessment of hematopoietic stem and progenitor cell differentiation. Stem Cell Reports,
  15. Valentine KM, Davini D, Lawrence TJ, Mullins GN, Mansala M, Al-Kuhlani M, Pinney JM, Davis JK, Beaudin AE, Sindi SS, Gravano DM, Hoyer K (2018). CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease. J Immunol,
  16. Apostol AC, Beaudin A (2018). Reversing time: EZH1 deficiency hastens definitive hematopoiesis. Cell Stem Cell,
  17. Cole CK, Byrne A, Beaudin AE, Forsberg EC, Vollmers (2018). Tn5Prime, a Tn5 based 5’ Capture Method for Single Cell RNA-seq. Nucleic Acids Research,
  18. Byrne A, Beaudin AE, Olsen HE, Jain M, Cole C, Palmer T, DuBois RM, Forsberg EC, Akeson M, Vollmers (2017). Nanopore Long-Read RNAseq Reveals Widespread Transcriptional Variation Among the Surface Receptors of Individual B cells. Nature Communications,
  19. Beaudin AE, Forsberg E (2016). To B1a or not to B1a: do hematopoietic stem cells contribute to tissue-resident immune cells?. Blood,
  20. Beaudin AE, Boyer SW, Perez-Cunningham J, Hernandez GE, Derderian SC, Jujuvarapu C, Aaserude E, MacKenzie T, Forsberg E (2016). A transient development hematopoietic stem cell gives rise to innate-like B- and T-cells. Cell Stem Cell,
  21. Hoeffel G, Chen J, Lavin Y, Low D, Almeida A, See P, Beaudin AE, Lum J, Low I, Forsberg EC, Poidinger M, Zolezzi F, Larbi A, Ng LG, Chan JKY, Greter M, Becher B, Samokhvalov IM, Merad M, Ginhoux (2015). C-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity,
  22. Beaudin AE, Boyer SW, Forsberg E (2013). Flk2/Flt3 promotes both myeloid and lymphoid development by expanding non-self-renewing multipotent hematopoietic progenitor cells. Experimental Hematology,
  23. Epelman S, Lavine KJ, Beaudin AE, Sojka D, Brija T, Schwendener R, Forsberg EC, Yokoyama W, Murphy KM, Colonna M, Randolph GJ, Mann D (2014). Novel cardiac macrophage populations during steady-state and inflammation. Immunity,
  24. Hill JH, Bell R, Barrios L, Baird H, Ost K, Greenewood M, Monts JK, Tracy E, Meili CH, Chiaro TR, Weis AM, Guillemin K, Beaudin AE, Murtaugh LC, Stephens WZ, Round J (2025). Neonatal fungi promote lifelong metabolic health through macrophage-dependent ß cell development. Science (New York, N.Y.), 387(6738), eadn0953.

Review

  1. Otsuka KS, Nielson C, Firpo MA, Park AH, Beaudin A (2021). Early Life Inflammation and the Developing Hematopoietic and Immune Systems: The Cochlea as a Sensitive Indicator of Disruption. Cells, 10(12),
  2. Tseng NA, Beaudin A (2023). The impact of prenatal inflammation on hematopoietic development. Current opinion in hematology, 30(4), 130-136.

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