Keren Hilgendorf, PhD, is an Assistant Professor in the Department of Biochemistry at the University of Utah. She is also a member of the Cell Response and Regulation Program at Huntsman Cancer Institute.
Dr. Hilgendorf received a bachelor's degree from the University of Texas at Austin and a PhD from the Massachusetts Institute of Technology. She received her postdoctoral training at Stanford University School of Medicine and was a Damon Runyon Cancer Research Foundation Postdoctoral Fellow.
Research Statement
The Hilgendorf Lab studies the molecular mechanisms regulating adult stems cell expansion and differentiation to ensure proper tissue homeostasis, expansion, and regeneration. A major focus of the lab is to study the molecular mechanisms regulating fat tissue. We use a combination of animal models and cell culture techniques. We are particularly interested in how the primary cilium, an antenna-like signaling organelle, senses and organizes signal transduction pathways to regulate stem cell fate.
Education History
| Fellowship |
Stanford University |
Postdoctoral Fellow |
|---|---|---|
|
Massachusetts Institute of Technology |
PhD | |
| Undergraduate |
University of Texas at Austin |
BS |
Selected Publications
Journal Article
- Verma S, Giagnocavo SD, Curtin MC, Arumugam M, Osburn-Staker SM, Wang G, Atkinson A, Nix DA, Lum DH, Cox JE, Hilgendorf KI (2024). Zinc-alpha-2-glycoprotein Secreted by Triple-Negative Breast Cancer Promotes Peritumoral Fibrosis. Cancer Res Commun, 4(7), 1655-1666. (Read full article)
- Garritson JD, Zhang J, Achenbach A, Ferhat M, Eich E, Stubben CJ, Martinez PL, Ibele AR, Hilgendorf KI, Boudina S (2023). BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis. Commun Biol, 6(1), 638. (Read full article)
- Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf KI, Frsard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM (2022). Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration. Cell Stem Cell, 29(12), 1653-1668.e8. (Read full article)
- Hilgendorf KI, Johnson CT, Mezger A, Rice SL, Norris AM, Demeter J, Greenleaf WJ, Reiter JF, Kopinke D, Jackson PK (2019). Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell, 179(6), 1289-1305.e21. (Read full article)
- Maynard MA, Ferretti R, Hilgendorf KI, Perret C, Whyte P, Lees JA (2013). Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer. Oncogene, 33(28), 3742-7. (Read full article)
- Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA (2013). The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes Dev, 27(9), 1003-15. (Read full article)
Review
- Hilgendorf KI, Myers BR, Reiter JF (2024). Emerging mechanistic understanding of cilia function in cellular signalling. [Review]. Nat Rev Mol Cell Biol, 25(7), 555-573. (Read full article)
- Scamfer SR, Lee MD, Hilgendorf KI (2022). Ciliary control of adipocyte progenitor cell fate regulates energy storage. [Review]. Front Cell Dev Biol, 10, 1083372. (Read full article)
- Hilgendorf KI (2021). Primary Cilia Are Critical Regulators of White Adipose Tissue Expansion. [Review]. Front Physiol, 12, 769367. (Read full article)