Wan-Lin Lo

Wan-Lin Lo, PhD

Languages spoken: English

Academic Information

Departments Primary - Pathology

Lab

Education History

Fellowship University of California, San Francisco
 Postdoctoral Fellow
Professional Medical Washington University School of Medicine in St. Louis
 PhD
Fellowship Genomic Research Center, Academia Sinica
 Postbaccalaureate Research Fellow
Undergraduate National Taiwan University School of Medicine
 BPharm
Undergraduate National Taiwan University School of Medicine
 BS

Selected Publications

Journal Article

  1. Wan-Lin Lo, Miriam Kuhlmann, Gabrielle Rizzuto, Atakan Ekiz, Elizabeth M Kolawole, Monica P Revelo, Rakieb Andargachew, Zhongmei Li, Yuan-Li Tsai, Alexander Marson, Brian D Evavold, Dietmar Zehn, Arthur Weiss (2023). A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function. Nat Immunol, 24(4), 676-689.
  2. Enas Hallumi, Rose Shalah, Wan-Lin Lo, Jasmin Corso, Ilana Oz, Dvora Beach, Samuel Wittman, Amy Isenberg, Meirav Sela, Henning Urlaub, Arthur Weiss, Deborah Yablonski (2021). Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads. J Immunol, 206(10), 2322-2337.
  3. Raman S Ganti, Wan-Lin Lo, Darren B McAffee, Jay T Groves, Arthur Weiss, and Arup K Chakraborty (2020). How the T cell signaling network processes information to discriminate between self and agonist ligands. Proceedings of the National Academy of Sciences of the United States of America, 177(42), 26020-26030.
  4. Adam H Courtney, Alexey A Shvets, Wen Lu, Gloria Griffante, Marianne Mollenauer, Veronika Horkova, Wan-Lin Lo, Steven Yu, Ondrej Stepanek, Arup K Chakraborty, and Arthur Weiss (2019). CD45 functions as a signaling gatekeeper in T cells. Sci Signal, 12(604). (Read full article)
  5. Wan-Lin Lo, Neel H Shah, Sara A Rubin, Weiguo Zhang, Veronika Horkova, Ian R Fallahee, Ondrej Stepanek, Leonard I Zon, John Kuriyan, and Arthur Weiss (2019). Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nat Immunol, 20(11), 1481-1493. (Read full article)
  6. Wan-Lin Lo, Neel H Shah, Nagib Ahsan, Veronika Horkova, Ondrej Stepanek, Arthur R Salomon, John Kuriyan, and Arthur Weiss (2018). Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nat Immunol, 19(7), 733-741. (Read full article)
  7. Joseph L Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L Donermeyer, Paul M Allen, and Jeanne M Nerbonne (2017). Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance. Cell Rep, 20(6), 532-544. (Read full article)
  8. Stephen P Persaud, Chelsea R Parker, Wan-Lin Lo, K Scott Weber, and Paul M Allen (2014). Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol, 15(3), 266-74. (Read full article)
  9. Wan-Lin Lo, Benjamin D Solomon, David L Donermeyer, Chyi-Song Hsieh, and Paul M Allen (2014). T cell immunodominance is dictated by the positively selecting self-peptide. Elife, 3, e01457. (Read full article)
  10. Wan-Lin Lo, David L Donermeyer, and Paul M Allen (2012). A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells. Nat Immunol, 13(9), 880-887. (Read full article)
  11. Chun-Hao Huang, Ming-Hong Chuang, Wan-Lin Lo, Ming-Shiang Wu, Yuan-Heng Wu, Deng-Chyang Wu, and Shyh-Horng Chiou (2011). Alkylhydroperoxide reductase of Helicobacter pylori as a biomarker for gastric patients with different pathological manifestations. Biochimie, 93(7), 1115-1123. (Read full article)
  12. Sharon Celeste Morley, Chen Wang, Wan-Lin Lo, Chan-Wang J Lio, Bernd H Zinselmeyer, Mark J Miller, Eric J Brown, and Paul M Allen (2010). The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility. J Immunol, 184(7), 3628-3638. (Read full article)
  13. Wan-Lin Lo, Nathan J Felix, James J Walters, Henry Rohrs, Michael L Gross, and Paul M Allen (2009). An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells. Nat Immunol, 10(11), 1155-1161. (Read full article)
  14. You-Chin Lin, Ming-Wei Kuo, John Yu, Huan-Hsien Kuo, Ruey-Jen Lin, Wan-Lin Lo, and Alice L Yu (2008). c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development. Mol Biol Evol, 25(10), 2189-2198. (Read full article)
  15. You-Chin Lin, Li-Ching Hsieh, Ming-Wei Kuo, John Yu, Huan-Hsien Kuo, Wan-Lin Lo, Ruey-Jen Lin, Alice L Yu (2007). Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. Mol Biol Evol, 24(11), 2525-2534. (Read full article)
  16. Ming-Hong Chuang, Ming-Shiang Wu, Wan-Lin Lo, Jaw-Town Lin, Chi-Huey Wong, and Shyh-Horng Chiou (2006). The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function. Proc Natl Acad Sci U S A, 103(8), 2552-2557. (Read full article)

Review

  1. Judith F Ashouri, Wan-Lin Lo, Trang T T Nguyen, Lin Shen, Arthur Weiss (2022). ZAP70, too little, too much can lead to autoimmunity. [Review]. Immunol Rev, 307(1), 145-160.
  2. Francesca Alfei, Ping-Chih Ho, Wan-Lin Lo (2021). DCision-making in tumors orchestrates T cell anti-tumor immunity. [Review]. Oncogene, 40(34), 5253-5261.
  3. Wan-Lin Lo and Arthur Weiss (2021). Adapting T cell ligand discrimination via LAT. [Review]. Front Immunol, 12, 673196.
  4. Adam H Courtney, Wan-Lin Lo, and Arthur Weiss (2017). TCR Signaling: Mechanisms of Initiation and Propagation. [Review]. Trends Biochem Sci, 43(2), 108-123. (Read full article)
  5. Wan-Lin Lo and Paul M Allen (2013). Self-peptides in TCR repertoire selection and peripheral T cell function. [Review]. Curr Top Microbiol Immunol, 373, 49-67. (Read full article)
  6. Wan-Lin Lo and Paul M Allen (2012). Self-awareness: how self-peptide/MHC complexes are essential in the development of T cells. [Review]. Mol Immunol, 55(2), 186-189. (Read full article)

Commentary

  1. Preston Humphries Wan-Lin Lo (2022). Two CTLA-4 ligands, separate pHates. Nat Immunol, 23(9), 1297.