Gianna E. Hammer, PhD

Languages spoken:

Academic Information

Departments: Pathology - Associate Professor

Divisions: Microbiology and Immunology

Academic Office Information

Gianna.Hammer@path.utah.edu

Education History

Fellowship University of California, Berkeley
Immunology 		Postdoctoral Fellow
Fellowship University of California, San Francisco
Immunology 		Postdoctoral Fellow
Professional Medical University of California, Berkeley
Molecular and Cell Biology 		Ph.D.
Undergraduate Eastern Washington University
Microbiology 		B.S.

Selected Publications

  1. Huang HI, Jewell ML, Youssef N, Huang MN, Hauser ER, Fee BE, Rudemiller NP, Privratsky JR, Zhang JJ, Reyes EY, Wang D, Taylor GA, Gunn MD, Ko DC, Cook DN, Chandramohan V, Crowley SD, Hammer GE (2021). Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes. Front Immunol, 12, 661290.
  2. Swan G, Geng J, Park E, Ding Q, Zhou J, Walcott C, Zhang JJ, Huang HI, Hammer GE, Wang D (2021). A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis. Front Immunol, 12, 641188.
  3. Liang J, Zhang JJ, Huang HI, Kanayama M, Youssef N, Jin YJ, Reyes EY, Abram CL, Yang S, Lowell CA, Wang D, Shao L, Shinohara ML, Zhang JY, Hammer GE (2020). The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection. Infect Immun, 88(9).
  4. Taylor GA, Huang HI, Fee BE, Youssef N, Jewell ML, Cantillana V, Schoenborn AA, Rogala AR, Buckley AF, Feng CG, Vallance BA, Gulati AS, Hammer GE (2020). Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium. PLoS Pathog, 16(5), e1008553.
  5. Wen Y, Rudemiller NP, Zhang J, Lu X, Ren J, Privratsky JR, Griffiths R, Zhang JJ, Hammer GE, Crowley SD (2020). C-C Motif Chemokine Receptor 7 Exacerbates Hypertension Through Effects on T Lymphocyte Trafficking. Hypertension, 75(3), 869-876.
  6. Lu X, Rudemiller NP, Wen Y, Ren J, Hammer GE, Griffiths R, Privratsky JR, Yang B, Sparks MA, Crowley SD (2019). A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation. Circ Res, 125(12), 1055-1066.
  7. Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, Heaton NS, Wang D (2019). Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv, 5(5), eaav7999.
  8. Barth BB, Huang HI, Hammer GE, Shen X (2018). Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals. [Review]. Micromachines (Basel), 9(9).
  9. Jaslow SL, Gibbs KD, Fricke WF, Wang L, Pittman KJ, Mammel MK, Thaden JT, Fowler VG Jr, Hammer GE, Elfenbein JR, Ko DC (2017). Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10. Cell Rep, 23(12), 3525-3536.
  10. Liang J, Huang HI, Benzatti FP, Karlsson AB, Zhang JJ, Youssef N, Ma A, Hale LP, Hammer GE (2016). Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88. Cell Rep, 17(5), 1330-1343.
  11. Kanayama M, Inoue M, Danzaki K, Hammer G, He YW, Shinohara ML (2015). Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nat Commun, 6, 5779.
  12. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A (2013). Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol, 191(2), 535-9.
  13. Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A (2013). Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity, 38(5), 896-905.
  14. Hammer GE, Ma A (2013). Molecular control of steady-state dendritic cell maturation and immune homeostasis. [Review]. Annu Rev Immunol, 31, 743-91.
  15. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A (2011). Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol, 12(12), 1184-93.
  16. Hammer GE, Shastri N (2007). Construction and destruction of MHC class I in the peptide-loading complex. Nat Immunol, 8(8), 793-4.
  17. Hammer GE, Kanaseki T, Shastri N (2007). The final touches make perfect the peptide-MHC class I repertoire. [Review]. Immunity, 26(4), 397-406.
  18. Hammer GE, Gonzalez F, James E, Nolla H, Shastri N (2006). In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. Nat Immunol, 8(1), 101-8.
  19. Kanaseki T, Blanchard N, Hammer GE, Gonzalez F, Shastri N (2006). ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. Immunity, 25(5), 795-806.
  20. Hammer GE, Gonzalez F, Champsaur M, Cado D, Shastri N (2005). The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. Nat Immunol, 7(1), 103-12.
  21. McMahon CW, Zajac AJ, Jamieson AM, Corral L, Hammer GE, Ahmed R, Raulet DH (2002). Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. J Immunol, 169(3), 1444-52.