Sixiang Shi

Sixiang Shi, PhD

Languages spoken: English

Academic Information

Departments Primary - Radiology & Imaging Sciences , Primary - Radiology & Imaging Sciences

Academic Office Information

sixiang.shi@utah.edu

Research Interests

  • Biology
  • Biomedical Engineering
  • Molecular Imaging

Education History

Postdoctoral Fellowship University of Texas MD Anderson Cancer Center
 Postdoctoral Fellow
University of Texas MD Anderson Cancer Center
 Postdoctoral Fellow
Graduate Training University of Wisconsin–Madison
 PhD
Xi’an Jiaotong University
 BS

Selected Publications

Journal Article

  1. Luo H, Yang C, Kuang D, Shi S, Chan AW (2022). Visualizing dynamic changes in PD-L1 expression in non-small cell lung carcinoma with radiolabeled recombinant human PD-1. Eur J Nucl Med Mol Imaging. (Read full article)
  2. Zhao J, Wen X, Li T, Shi S, Xiong C, Wang YA, Li C (2020). Concurrent Injection of Unlabeled Antibodies Allows Positron Emission Tomography Imaging of Programmed Cell Death Ligand 1 Expression in an Orthotopic Pancreatic Tumor Model. ACS Omega, 5(15), 8474-8482. (Read full article)
  3. Cao Q, Wang W, Zhou M, Huang Q, Wen X, Zhao J, Shi S, Geng K, Li F, Hatakeyama H, Xu C, Piwnica-Worms D, Peng W, Zhou D, Sood AK, Li C (2020). Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition. Nanomedicine, 25, 102169. (Read full article)
  4. Shi S, Li T, Wen X, Wu SY, Xiong C, Zhao J, Lincha VR, Chow DS, Liu Y, Sood AK, Li C (2019). Copper-64 Labeled PEGylated Exosomes for In Vivo Positron Emission Tomography and Enhanced Tumor Retention. Bioconjug Chem, 30(10), 2675-2683. (Read full article)
  5. Shi S, Wen X, Li T, Wen X, Cao Q, Liu X, Liu Y, Pagel MD, Li C (2019). Thermosensitive Biodegradable Copper Sulfide Nanoparticles for Real-Time Multispectral Optoacoustic Tomography. ACS Appl Bio Mater, 2(8), 3203-3211. (Read full article)
  6. Miyake M, Furuya H, Onishi S, Hokutan K, Anai S, Chan O, Shi S, Fujimoto K, Goodison S, Cai W, Rosser CJ (2019). Monoclonal Antibody against CXCL1 (HL2401) as a Novel Agent in Suppressing IL6 Expression and Tumoral Growth. Theranostics, 9(3), 853-867. (Read full article)
  7. Cui L, Xiong C, Zhou M, Shi S, Chow DS, Li C (2018). Integrin αvβ3-Targeted [64Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation Therapy. Bioconjug Chem, 29(12), 4062-4071. (Read full article)
  8. Wang D, Shi R, Zhou J, Shi S, Wu H, Xu P, Wang H, Xia G, Barnhart TE, Cai W, Guo Z, Chen Q (2018). Photo-Enhanced Singlet Oxygen Generation of Prussian Blue-Based Nanocatalyst for Augmented Photodynamic Therapy. iScience, 9, 14-26. (Read full article)
  9. Chen F, Goel S, Shi S, Barnhart TE, Lan X, Cai W (2018). General synthesis of silica-based yolk/shell hybrid nanomaterials and in vivo tumor vasculature targeting. Nano Res, 11(9), 4890-4904. (Read full article)
  10. Liu B, Jones M, Kong L, Noel T, Jeng EK, Shi S, England CG, Alter S, Miller JS, Cai W, Rhode PR, Wong HC (2018). Evaluation of the biological activities of the IL-15 superagonist complex, ALT-803, following intravenous versus subcutaneous administration in murine models. Cytokine, 107, 105-112. (Read full article)
  11. Zhan Y, Ehlerding EB, Shi S, Graves SA, Goel S, Engle JW, Liang J, Cai W (2018). Intrinsically Zirconium-89-Labeled Manganese Oxide Nanoparticles for In Vivo Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging. J Biomed Nanotechnol, 14(5), 900-909. (Read full article)
  12. Shi S, Chen F, Goel S, Graves SA, Luo H, Theuer CP, Engle JW, Cai W (2018). In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem. Nanomicro Lett, 10(4), 65. (Read full article)
  13. Zhan Y, Shi S, Ehlerding EB, Graves SA, Goel S, Engle JW, Liang J, Tian J, Cai W (2017). Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging. ACS Appl Mater Interfaces, 9(44), 38304-38312. (Read full article)
  14. Shi S, Xu C, Yang K, Goel S, Valdovinos HF, Luo H, Ehlerding EB, England CG, Cheng L, Chen F, Nickles RJ, Liu Z, Cai W (2017). Chelator-Free Radiolabeling of Nanographene: Breaking the Stereotype of Chelation. Angew Chem Int Ed Engl, 56(11), 2889-2892. (Read full article)
  15. Liu B, Kong L, Han K, Hong H, Marcus WD, Chen X, Jeng EK, Alter S, Zhu X, Rubinstein MP, Shi S, Rhode PR, Cai W, Wong HC (2016). A Novel Fusion of ALT-803 (Interleukin (IL)-15 Superagonist) with an Antibody Demonstrates Antigen-specific Antitumor Responses. J Biol Chem, 291(46), 23869-23881. (Read full article)
  16. Luo H, England CG, Shi S, Graves SA, Hernandez R, Liu B, Theuer CP, Wong HC, Nickles RJ, Cai W (2016). Dual Targeting of Tissue Factor and CD105 for Preclinical PET Imaging of Pancreatic Cancer. Clin Cancer Res, 22(15), 3821-30. (Read full article)
  17. Xu C, Shi S, Feng L, Chen F, Graves SA, Ehlerding EB, Goel S, Sun H, England CG, Nickles RJ, Liu Z, Wang T, Cai W (2016). Long circulating reduced graphene oxide-iron oxide nanoparticles for efficient tumor targeting and multimodality imaging. Nanoscale, 8(25), 12683-92. (Read full article)
  18. Goel S, Chen F, Luan S, Valdovinos HF, Shi S, Graves SA, Ai F, Barnhart TE, Theuer CP, Cai W (2016). Engineering Intrinsically Zirconium-89 Radiolabeled Self-Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies. Adv Sci (Weinh), 3(11), 1600122. (Read full article)
  19. Chen F, Goel S, Hernandez R, Graves SA, Shi S, Nickles RJ, Cai W (2016). Dynamic Positron Emission Tomography Imaging of Renal Clearable Gold Nanoparticles. Small, 12(20), 2775-82. (Read full article)
  20. Cheng L, Shen S, Shi S, Yi Y, Wang X, Song G, Yang K, Liu G, Barnhart TE, Cai W, Liu Z (2016). FeSe2-Decorated Bi2Se3 Nanosheets Fabricated via Cation Exchange for Chelator-Free 64Cu-labeling and Multimodal Image-Guided Photothermal-Radiation Therapy. Adv Funct Mater, 26(13), 2185-2197. (Read full article)
  21. Rhode PR, Egan JO, Xu W, Hong H, Webb GM, Chen X, Liu B, Zhu X, Wen J, You L, Kong L, Edwards AC, Han K, Shi S, Alter S, Sacha JB, Jeng EK, Cai W, Wong HC (2015). Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models. Cancer Immunol Res, 4(1), 49-60. (Read full article)
  22. Shi S, Fliss BC, Gu Z, Zhu Y, Hong H, Valdovinos HF, Hernandez R, Goel S, Luo H, Chen F, Barnhart TE, Nickles RJ, Xu ZP, Cai W (2015). Chelator-Free Labeling of Layered Double Hydroxide Nanoparticles for in Vivo PET Imaging. Sci Rep, 5, 16930. (Read full article)
  23. Shi S, Hong H, Orbay H, Graves SA, Yang Y, Ohman JD, Liu B, Nickles RJ, Wong HC, Cai W (2015). ImmunoPET of tissue factor expression in triple-negative breast cancer with a radiolabeled antibody Fab fragment. Eur J Nucl Med Mol Imaging, 42(8), 1295-303. (Read full article)
  24. Shi S, Orbay H, Yang Y, Graves SA, Nayak TR, Hong H, Hernandez R, Luo H, Goel S, Theuer CP, Nickles RJ, Cai W (2015). PET Imaging of Abdominal Aortic Aneurysm with 64Cu-Labeled Anti-CD105 Antibody Fab Fragment. J Nucl Med, 56(6), 927-32. (Read full article)
  25. Luo H, Hong H, Slater MR, Graves SA, Shi S, Yang Y, Nickles RJ, Fan F, Cai W (2015). PET of c-Met in Cancer with ⁶⁴Cu-Labeled Hepatocyte Growth Factor. J Nucl Med, 56(5), 758-63. (Read full article)
  26. Hong H, Yan Y, Shi S, Graves SA, Krasteva LK, Nickles RJ, Yang M, Cai W (2015). PET of follicle-stimulating hormone receptor: broad applicability to cancer imaging. Mol Pharm, 12(2), 403-10. (Read full article)
  27. Liu T, Shi S, Liang C, Shen S, Cheng L, Wang C, Song X, Goel S, Barnhart TE, Cai W, Liu Z (2015). Iron oxide decorated MoS2 nanosheets with double PEGylation for chelator-free radiolabeling and multimodal imaging guided photothermal therapy. ACS Nano, 9(1), 950-60. (Read full article)
  28. Shi S, Yang K, Hong H, Chen F, Valdovinos HF, Goel S, Barnhart TE, Liu Z, Cai W (2014). VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide in vivo. Biomaterials, 39, 39-46. (Read full article)
  29. Chen F, Hong H, Goel S, Graves SA, Orbay H, Ehlerding EB, Shi S, Theuer CP, Nickles RJ, Cai W (2015). In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine. ACS Nano, 9(4), 3926-34. (Read full article)
  30. Guo J, Hong H, Chen G, Shi S, Nayak TR, Theuer CP, Barnhart TE, Cai W, Gong S (2014). Theranostic unimolecular micelles based on brush-shaped amphiphilic block copolymers for tumor-targeted drug delivery and positron emission tomography imaging. ACS Appl Mater Interfaces, 6(24), 21769-79. (Read full article)
  31. Goel S, Chen F, Hong H, Valdovinos HF, Hernandez R, Shi S, Barnhart TE, Cai W (2014). VEGF₁₂₁-conjugated mesoporous silica nanoparticle: a tumor targeted drug delivery system. ACS Appl Mater Interfaces, 6(23), 21677-85. (Read full article)
  32. Hong H, Nayak TR, Shi S, Graves SA, Fliss BC, Barnhart TE, Cai W (2014). Generation and screening of monoclonal antibodies for immunoPET imaging of IGF1R in prostate cancer. Mol Pharm, 11(10), 3624-30. (Read full article)
  33. Zhang Y, Jeon M, Rich LJ, Hong H, Geng J, Zhang Y, Shi S, Barnhart TE, Alexandridis P, Huizinga JD, Seshadri M, Cai W, Kim C, Lovell JF (2014). Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines. Nat Nanotechnol, 9(8), 631-8. (Read full article)
  34. Chen F, Hong H, Shi S, Goel S, Valdovinos HF, Hernandez R, Theuer CP, Barnhart TE, Cai W (2014). Engineering of hollow mesoporous silica nanoparticles for remarkably enhanced tumor active targeting efficacy. Sci Rep, 4, 5080. (Read full article)
  35. Chen F, Ellison PA, Lewis CM, Hong H, Zhang Y, Shi S, Hernandez R, Meyerand ME, Barnhart TE, Cai W (2013). Chelator-free synthesis of a dual-modality PET/MRI agent. Angew Chem Int Ed Engl, 52(50), 13319-23. (Read full article)
  36. Guo J, Hong H, Chen G, Shi S, Zheng Q, Zhang Y, Theuer CP, Barnhart TE, Cai W, Gong S (2013). Image-guided and tumor-targeted drug delivery with radiolabeled unimolecular micelles. Biomaterials, 34(33), 8323-8332. (Read full article)
  37. Chen F, Hong H, Zhang Y, Valdovinos HF, Shi S, Kwon GS, Theuer CP, Barnhart TE, Cai W (2013). In vivo tumor targeting and image-guided drug delivery with antibody-conjugated, radiolabeled mesoporous silica nanoparticles. ACS Nano, 7(10), 9027-39. (Read full article)
  38. Shi S, Yang K, Hong H, Valdovinos HF, Nayak TR, Zhang Y, Theuer CP, Barnhart TE, Liu Z, Cai W (2013). Tumor vasculature targeting and imaging in living mice with reduced graphene oxide. Biomaterials, 34(12), 3002-9. (Read full article)

Review

  1. Li T, Shi S, Goel S, Shen X, Xie X, Chen Z, Zhang H, Li S, Qin X, Yang H, Wu C, Liu Y (2019). Recent advancements in mesoporous silica nanoparticles towards therapeutic applications for cancer. [Review]. Acta Biomater, 89, 1-13. (Read full article)
  2. Shi S, Chen F, Ehlerding EB, Cai W (2014). Surface engineering of graphene-based nanomaterials for biomedical applications. [Review]. Bioconjug Chem, 25(9), 1609-19. (Read full article)
  3. Shi S, Chen F, Cai W (2013). Biomedical applications of functionalized hollow mesoporous silica nanoparticles: focusing on molecular imaging. [Review]. Nanomedicine (Lond), 8(12), 2027-39. (Read full article)

Editorial

  1. Shi S, Goel S, Lan X, Cai W (2022). ImmunoPET of CD38 with a radiolabeled nanobody: promising for clinical translation. Eur J Nucl Med Mol Imaging, 48(9), 2683-2686. (Read full article)