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Shannon M. Buckley, PhD

Languages spoken: English

Academic Information

Departments: Internal Medicine - Associate Professor, Oncological Sciences - Adjunct Associate Professor

Divisions: Hematology/BMT

Academic Office Information

Shannon.Buckley@hci.utah.edu

Education History

Fellowship New York University School of Medicine
Stem Cell Biology
Senior Postdoctoral Fellow
Fellowship New York University School of Medicine
Stem Cell Biology
Postdoctoral Research Fellow
Graduate Training University of Minnesota
Molecular, Cellular, Developmental Biology, & Genetics Program
Ph.D.
Undergraduate University of St. Thomas - Minnesota
Major: Biology; Minors: Psychology and Chemistry
B.A.

Selected Publications

  1. Ma MCJ, Tadros S, Bouska A, Heavican T, Yang H, Deng Q, Moore D, Akhter A, Hartert K, Jain N, Showell J, Ghosh S, Street L, Davidson M, Carey C, Tobin J, Perumal D, Vose JM, Lunning MA, Sohani AR, Chen BJ, Buckley S, Nastoupil LJ, Davis RE, Westin JR, Fowler NH, Parekh S, Gandhi M, Neelapu S, Stewart D, Bhalla K, Iqbal J, Greiner T, Rodig SJ, Mansoor A, Green MR (2022). Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma. Haematologica, 107(3), 690-701.
  2. Caplan M, Wittorf KJ, Weber KK, Swenson SA, Gilbreath TJ, Willow Hynes-Smith R, Amador C, Hyde RK, Buckley SM (2022). Multi-omics reveals mitochondrial metabolism proteins susceptible for drug discovery in AML. Leukemia.
  3. Qiao F, Law HC, Krieger KL, Clement EJ, Xiao Y, Buckley SM, Woods NT (2021). Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs. Biol Open, 10(1).
  4. Hynes-Smith RW, Wittorf KJ, Buckley SM (2020). Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases. [Review]. Trends Immunol, 41(12), 1128-1140.
  5. Swenson SA, Gilbreath TJ, Vahle H, Hynes-Smith RW, Graham JH, Law HC, Amador C, Woods NT, Green MR, Buckley SM (2019). UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells. Blood, 136(3), 299-312.
  6. Gilbreath T, Swenson S, Buckley SM (2019). Role of Ubiquitin E3 Ligase UBR5 in B-Cell Development and Lymphoma [Abstract]. 134(Suppl1), 2794.
  7. Hynes-Smith RW, Swenson SA, Vahle H, Wittorf KJ, Caplan M, Amador C, Hyde RK, Buckley SM (2019). Loss of FBXO9 Enhances Proteasome Activity and Promotes Aggressiveness in Acute Myeloid Leukemia. Cancers (Basel), 11(11).
  8. Quadros RM, Miura H, Harms DW, Akatsuka H, Sato T, Aida T, Redder R, Richardson GP, Inagaki Y, Sakai D, Buckley SM, Seshacharyulu P, Batra SK, Behlke MA, Zeiner SA, Jacobi AM, Izu Y, Thoreson WB, Urness LD, Mansour SL, Ohtsuka M, Gurumurthy CB (2017). Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins. Genome Biol, 18(1), 92.
  9. Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto AL, Yang Y, Ntziachristos P, Rothbart S, Buckley S, Dolgalev I, Stadtfeld M, Strahl BD, Dynlacht BD, Tsirigos A, Aifantis I (2016). Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nat Cell Biol, 18(11), 1127-1138.
  10. Gao J, Buckley SM, Cimmino L, Guillamot M, Strikoudis A, Cang Y, Goff SP, Aifantis I (2015). The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis. Elife, 4.
  11. Khurana S, Margamuljana L, Joseph C, Schouteden S, Buckley SM, Verfaillie CM (2013). Glypican-3-mediated inhibition of CD26 by TFPI: a novel mechanism in hematopoietic stem cell homing and maintenance. Blood, 121(14), 2587-95.
  12. Reavie L, Buckley SM, Loizou E, Takeishi S, Aranda-Orgilles B, Ndiaye-Lobry D, Abdel-Wahab O, Ibrahim S, Nakayama KI, Aifantis I (2011). Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression. Cancer Cell, 23(3), 362-75.
  13. Khurana S, Buckley S, Schouteden S, Ekker S, Petryk A, Delforge M, Zwijsen A, Verfaillie CM (2012). A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression. Blood, 121(5), 781-90.
  14. Buckley SM, Aranda-Orgilles B, Strikoudis A, Apostolou E, Loizou E, Moran-Crusio K, Farnsworth CL, Koller AA, Dasgupta R, Silva JC, Stadtfeld M, Hochedlinger K, Chen EI, Aifantis I (2012). Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell, 11(6), 783-98.
  15. Buckley S, Verfaillie C (2011). Regulation of Hematopoiesis. In Porwit A McCullough J, Erber WN (Eds.), Blood and Bone Marrow Pathology (2nd edition, pp. 63-76). Churchill Livingstone: Elsevier.
  16. Buckley SM, Ulloa-Montoya F, Abts D, Oostendorp RA, Dzierzak E, Ekker SC, Verfaillie CM (2010). Maintenance of HSC by Wnt5a secreting AGM-derived stromal cell line. Exp Hematol, 39(1), 114-123.e1-5.
  17. Reavie L, Della Gatta G, Crusio K, Aranda-Orgilles B, Buckley SM, Thompson B, Lee E, Gao J, Bredemeyer AL, Helmink BA, Zavadil J, Sleckman BP, Palomero T, Ferrando A, Aifantis I (2010). Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol, 11(3), 207-15.
  18. Sahin MB, Schwartz RE, Buckley SM, Heremans Y, Chase L, Hu WS, Verfaillie CM (2008). Isolation and characterization of a novel population of progenitor cells from unmanipulated rat liver. Liver Transpl, 14(3), 333-45.
  19. Serafini M, Dylla SJ, Oki M, Heremans Y, Tolar J, Jiang Y, Buckley SM, Pelacho B, Burns TC, Frommer S, Rossi DJ, Bryder D, Panoskaltsis-Mortari A, OShaughnessy MJ, Nelson-Holte M, Fine GC, Weissman IL, Blazar BR, Verfaillie CM (2007). Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells. J Exp Med, 204(1), 129-39.
  20. Lakshmipathy U, Buckley S, Verfaillie C (2007). Gene transfer via nucleofection into adult and embryonic stem cells. In Vemuri MC (Ed.), Stem Cell Assays, Methods Molecular Biology (pp. 407: 115-26). Humana Press.
  21. Liu B, Buckley SM, Lewis ID, Goldman AI, Wagner JE, van der Loo JC (2003). Homing defect of cultured human hematopoietic cells in the NOD/SCID mouse is mediated by Fas/CD95. Exp Hematol, 31(9), 824-32.
  22. van der Loo JC, Liu BL, Goldman AI, Buckley SM, Chrudimsky KS (2002). Optimization of gene transfer into primitive human hematopoietic cells of granulocyte-colony stimulating factor-mobilized peripheral blood using low-dose cytokines and comparison of a gibbon ape leukemia virus versus an RD114-pseudotyped retroviral vector. Hum Gene Ther, 13(11), 1317-30.