Research Statement
We study how cellular machinery detects, signals, and repairs DNA damage by marrying state-of-the-art chemical biology, biophysical, and genetic techniques.
Education History
| Fellowship |
Johns Hopkins University School of Medicine Biophysics, Chemical Biology |
Postdoctoral Fellow |
|---|---|---|
| Graduate Training |
Emory University Chemistry, Biophysical and Materials Chemistry |
Ph.D. |
| Undergraduate |
Hunan University Chemistry |
B.S. |
Selected Publications
- Roger S Zou, Alberto Marin-Gonzalez, Yang Liu, Hans B Liu, Leo Shen, Rachel K Dveirin, Jay XJ Luo, Reza Kalhor, Taekjip Ha (2022). Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites. Nat Cell Biol, (24), 1433-1444.
- Zou RS, Liu Y, Wu B, Ha T (2021). Cas9 deactivation with photocleavable guide RNAs. Mol Cell, 81(7), 1553-1565.e8.
- Liu Y, Zou RS, He S, Nihongaki Y, Li X, Razavi S, Wu B, Ha T (2019). Very fast CRISPR on demand. Science, 368(6496), 1265-1269.
- Wiegand T, Fratini M, Frey F, Yserentant K, Liu Y, Weber E, Galior K, Ohmes J, Braun F, Herten DP, Boulant S, Schwarz US, Salaita K, Cavalcanti-Adam EA, Spatz JP (2020). Forces during cellular uptake of viruses and nanoparticles at the ventral side. Nat Commun, 11(1), 32.
- Biswas J, Liu Y, Singer RH, Wu B (2019). Fluorescence Imaging Methods to Investigate Translation in Single Cells. [Review]. Cold Spring Harb Perspect Biol, 11(4).
- Liu Y, Blanchfield L, Ma VP, Andargachew R, Galior K, Liu Z, Evavold B, Salaita K (2016). DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity. Proc Natl Acad Sci U S A, 113(20), 5610-5.
- Yehl K, Mugler A, Vivek S, Liu Y, Zhang Y, Fan M, Weeks ER, Salaita K (2015). High-speed DNA-based rolling motors powered by RNase H. Nat Nanotechnol, 11(2), 184-90.
- Liu Z, Liu Y, Chang Y, Seyf HR, Henry A, Mattheyses AL, Yehl K, Zhang Y, Huang Z, Salaita K (2015). Nanoscale optomechanical actuators for controlling mechanotransduction in living cells. Nat Methods, 13(2), 143-6.
- Liu Y, Yehl K, Narui Y, Salaita K (2013). Tension sensing nanoparticles for mechano-imaging at the living/nonliving interface. J Am Chem Soc, 135(14), 5320-3.