Yang Liu

Yang Liu, PhD

Languages spoken: English

Academic Information

Departments Primary - Biochemistry

Lab

Research Statement

We study how cellular machinery detects, signals, and repairs DNA damage by marrying state-of-the-art chemical biology, biophysical, and genetic techniques.

Education History

Undergraduate Hunan University
 BS
Graduate Training Emory University
 PhD

Selected Publications

Journal Article

  1. Zou RS, Liu Y, Wu B, Ha T (2021). Cas9 deactivation with photocleavable guide RNAs. Mol Cell, 81(7), 1553-1565.e8.
  2. Liu Y, Zou RS, He S, Nihongaki Y, Li X, Razavi S, Wu B, Ha T (2020). Very fast CRISPR on demand. Science, 368(6496), 1265-1269.
  3. Liu Y, Blanchfield L, Ma VP, Andargachew R, Galior K, Liu Z, Evavold B, Salaita (2016). DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity. Proceedings of the National Academy of Sciences of the United States of America, 113(20), 5610-5.
  4. Liu Z, Liu Y, Chang Y, Seyf HR, Henry A, Mattheyses AL, Yehl K, Zhang Y, Huang Z, Salaita (2016). Nanoscale optomechanical actuators for controlling mechanotransduction in living cells. Nature methods, 13(2), 143-6.
  5. Liu Y, Yehl K, Narui Y, Salaita (2013). Tension sensing nanoparticles for mechano-imaging at the living/nonliving interface. Journal of the American Chemical Society, 135(14), 5320-3.
  6. Wiegand T, Fratini M, Frey F, Yserentant K, Liu Y, Weber E, Galior K, Ohmes J, Braun F, Herten DP, Boulant S, Schwarz US, Salaita K, Cavalcanti-Adam EA, Spatz J (2020). Forces during cellular uptake of viruses and nanoparticles at the ventral side. Nature communications, 11(1), 32.
  7. Yehl K, Mugler A, Vivek S, Liu Y, Zhang Y, Fan M, Weeks ER, Salaita (2016). High-speed DNA-based rolling motors powered by RNase H. Nature nanotechnology, 11(2), 184-90.
  8. He S, Huang Z, Liu Y, Ha T, Wu (2024). DNA break induces rapid transcription repression mediated by proteasome-dependent RNAPII removal. Cell reports, 43(7), 114420.
  9. Mortenson KL, Dawes C, Wilson ER, Patchen NE, Johnson HE, Gertz J, Bailey SD, Liu Y, Varley KE, Zhang (2024). 3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression. Nature communications, 15(1), 6130.
  10. Blake LA, Watkins L, Liu Y, Inoue T, Wu (2024). A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies. Nature communications, 15(1), 2720.
  11. Zou RS, Liu Y, Gaido OER, Konig MF, Mog BJ, Shen LL, Aviles-Vazquez F, Marin-Gonzalez A, Ha (2023). Improving the sensitivity of in vivo CRISPR off-target detection with DISCOVER-Seq. Nature methods, 20(5), 706-713.
  12. Zou RS, Marin-Gonzalez A, Liu Y, Liu HB, Shen L, Dveirin RK, Luo JXJ, Kalhor R, Ha (2022). Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites. Nature cell biology, 24(9), 1433-1444.

Review

  1. Biswas J, Liu Y, Singer RH, Wu (2019). Fluorescence Imaging Methods to Investigate Translation in Single Cells. Cold Spring Harbor perspectives in biology, 11(4),
  2. Liu Y, Cottle WT, Ha (2023). Mapping cellular responses to DNA double-strand breaks using CRISPR technologies. Trends in genetics, 39(7), 560-574.