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Yang Liu, PhD

Languages spoken: English

Academic Information

Departments: Biochemistry - Assistant Professor

Academic Office Information

(801) 581-7762

Emma Eccles Jones Research Building
15 North Medical Drive East, Room: 3600B
Salt Lake City, UT 84112

Research Interests

  • Single-Molecule Biophysics
  • Cell Dynamics
  • DNA Repair
  • Immunity
  • Nucleic Acids
  • Biotechnology Development
  • Genome Editing

Research Statement

We study how cellular machinery detects, signals, and repairs DNA damage by marrying state-of-the-art chemical biology, biophysical, and genetic techniques.

Education History

Fellowship Johns Hopkins University School of Medicine
Biophysics, Chemical Biology
Postdoctoral Fellow
Graduate Training Emory University
Chemistry, Biophysical and Materials Chemistry
Undergraduate Hunan University

Selected Publications

  1. Roger S Zou, Alberto Marin-Gonzalez, Yang Liu, Hans B Liu, Leo Shen, Rachel K Dveirin, Jay XJ Luo, Reza Kalhor, Taekjip Ha (2022). Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites. Nat Cell Biol, (24), 1433-1444.
  2. Zou RS, Liu Y, Wu B, Ha T (2021). Cas9 deactivation with photocleavable guide RNAs. Mol Cell, 81(7), 1553-1565.e8.
  3. Liu Y, Zou RS, He S, Nihongaki Y, Li X, Razavi S, Wu B, Ha T (2019). Very fast CRISPR on demand. Science, 368(6496), 1265-1269.
  4. Wiegand T, Fratini M, Frey F, Yserentant K, Liu Y, Weber E, Galior K, Ohmes J, Braun F, Herten DP, Boulant S, Schwarz US, Salaita K, Cavalcanti-Adam EA, Spatz JP (2020). Forces during cellular uptake of viruses and nanoparticles at the ventral side. Nat Commun, 11(1), 32.
  5. Biswas J, Liu Y, Singer RH, Wu B (2019). Fluorescence Imaging Methods to Investigate Translation in Single Cells. [Review]. Cold Spring Harb Perspect Biol, 11(4).
  6. Liu Y, Blanchfield L, Ma VP, Andargachew R, Galior K, Liu Z, Evavold B, Salaita K (2016). DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity. Proc Natl Acad Sci U S A, 113(20), 5610-5.
  7. Yehl K, Mugler A, Vivek S, Liu Y, Zhang Y, Fan M, Weeks ER, Salaita K (2015). High-speed DNA-based rolling motors powered by RNase H. Nat Nanotechnol, 11(2), 184-90.
  8. Liu Z, Liu Y, Chang Y, Seyf HR, Henry A, Mattheyses AL, Yehl K, Zhang Y, Huang Z, Salaita K (2015). Nanoscale optomechanical actuators for controlling mechanotransduction in living cells. Nat Methods, 13(2), 143-6.
  9. Liu Y, Yehl K, Narui Y, Salaita K (2013). Tension sensing nanoparticles for mechano-imaging at the living/nonliving interface. J Am Chem Soc, 135(14), 5320-3.