Natalya N. Pavlova, PhD

Languages spoken:

Academic Information

Departments: Oncological Sciences - Assistant Professor

Academic Office Information

Natasha.Pavlova@hci.utah.edu

Education History

Doctoral Training Harvard University Graduate School of Arts & Sciences
Biochemistry and Molecular Pharmacology 		Ph.D.
Undergraduate University of Virginia
Biology 		B.S.
Undergraduate Novosibirsk State University
Natural Sciences

Selected Publications

  1. Ranea-Robles P, Pavlova NN, Bender A, Pereyra AS, Ellis JM, Stauffer B, Yu C, Thompson CB, Argmann C, Puchowicz M, Houten SM (2022). A mitochondrial long-chain fatty acid oxidation defect leads to tRNA uncharging and activation of the integrated stress response in the mouse heart. Cardiovasc Res.
  2. Pavlova NN, Zhu J, Thompson CB (2022). The hallmarks of cancer metabolism: Still emerging. [Review]. Cell Metab, 34(3), 355-377.
  3. Schwrer S, Pavlova NN, Cimino FV, King B, Cai X, Sizemore GM, Thompson CB (2021). Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment. Nat Metab, 3(11), 1484-1499.
  4. Pavlova NN, King B, Josselsohn RH, Violante S, Macera VL, Vardhana SA, Cross JR, Thompson CB (2020). Translation in amino-acid-poor environments is limited by tRNAGln charging. Elife, 9.
  5. Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J (2019). Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. J Biol Chem, 294(49), 18674-18684.
  6. Jiang J, Pavlova NN, Zhang J (2018). Asparagine, a critical limiting metabolite during glutamine starvation. Mol Cell Oncol, 5(3), e1441633.
  7. Zhang J, Pavlova NN, Thompson CB (2017). Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine. [Review]. EMBO J, 36(10), 1302-1315.
  8. Pavlova NN, Thompson CB (2017). Cancer Metabolism. In Bast RC, Croce CM, Hait WN, Hong WK, Kufe DW, Piccart-Gebhart M, Pollock RE, Weichselbaum RR, Wang H, Holland JF (Eds.), Holland-Frei Cancer Medicine 9 (9th Edition). Wiley-Blackwell.
  9. Pavlova NN, Thompson CB (2016). The Emerging Hallmarks of Cancer Metabolism. [Review]. Cell Metab, 23(1), 27-47.
  10. Palm W, Park Y, Wright K, Pavlova NN, Tuveson DA, Thompson CB (2015). The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1. Cell, 162(2), 259-270.
  11. Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ (2013). A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife, 2, e00358.
  12. Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ (2013). Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Nat Biotechnol, 31(4), 331-334.
  13. Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ (2013). STOP gene Phactr4 is a tumor suppressor. Proc Natl Acad Sci U S A, 110(5), E407-14.
  14. Larman HB, Xu GJ, Pavlova NN, Elledge SJ (2012). Construction of a rationally designed antibody platform for sequencing-assisted selection. Proc Natl Acad Sci U S A, 109(45), 18523-8.
  15. Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF (2010). Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell, 144(5), 703-18.
  16. Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y (2008). CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell, 32(5), 718-26.
  17. Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ (2007). SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature, 452(7185), 370-4.
  18. Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR (2007). The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J, 26(21), 4523-34.