Muhammad Zaki Wilmot

Muhammad Zaki Wilmot, PhD

Languages spoken: English

Academic Information

Departments Primary - Oncological Sciences

Education History

Research Fellow University of Utah
 Postdoctoral Research Fellow
Doctoral Training University of Manchester
 PhD
Undergraduate University of Queensland
 BSc (Hons)

Selected Publications

Journal Article

  1. Thambyrajah R, Maqueda M, Fadlullah MZ, Proffitt M, Neo WH, Guilln Y, Casado-Pelaez M, Herrero-Molinero P, Brujas C, Castelluccio N, Gonzlez J, Iglesias A, Marruecos L, Ruiz-Herguido C, Esteller M, Mereu E, Lacaud G, Espinosa L, Bigas A (2024). IκBα controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development. Nat Commun, 15(1), 4673. (Read full article)
  2. Fadlullah MZH, Lin CN, Coleman S, Young A, Naqash AR, Hu-Lieskovan S, Tan AC (2023). Exploring the Landscape of Immune Checkpoint Inhibitor-Induced Adverse Events Through Big Data Mining of Pan-Cancer Clinical Trials. Oncologist, 29(5), 415-421. (Read full article)
  3. Thambyrajah R, Maqueda M, Neo WH, Imbach K, Guilln Y, Grases D, Fadlullah Z, Gambera S, Matteini F, Wang X, Calero-Nieto FJ, Esteller M, Florian MC, Porta E, Benedito R, Gttgens B, Lacaud G, Espinosa L, Bigas A (2024). Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate. Nat Commun, 15(1), 1604. (Read full article)
  4. Kerepesi C, Abushukair HM, Ricciuti B, Nassar AH, Adib E, Alessi JV, Pecci F, Rakaee M, Fadlullah MZH, Tks AM, Rodig SJ, Awad MM, Tan AC, Bakacs T, Naqash AR (2024). Association of Baseline Tumor-Specific Neoantigens and CD8(+) T-Cell Infiltration With Immune-Related Adverse Events Secondary to Immune Checkpoint Inhibitors. JCO Precis Oncol, 8, e2300439. (Read full article)
  5. Hu M, Coleman S, Fadlullah MZH, Spakowicz D, Chung CH, Tan AC (2023). Deciphering the Tumor-Immune-Microbe Interactions in HPV-Negative Head and Neck Cancer. Genes (Basel), 14(8). (Read full article)
  6. Williamson J, Fadlullah MZH, Kovacsovics-Bankowski M, Gibson B, Swami U, Erickson-Wayman A, Jamison D, Sageser D, Jeter J, Bowles T, Cannon DM, Haaland B, Schroeder JD, Nix D, Atkinson A, Hyngstrom J, McPherson J, Tan AC, Hu-Lieskovan S (2023). Response to high dose ipilimumab plus temozolomide after progression on standard or low dose ipilimumab in advanced melanoma: a retrospective analysis. Res Sq. (Read full article)
  7. Saba NF, Steuer CE, Ekpenyong A, McCook-Veal A, Magliocca K, Patel M, Schmitt NC, Stokes W, Bates JE, Rudra S, Remick J, McDonald M, Abousaud M, Tan AC, Fadlullah MZH, Chaudhary R, Muzaffar J, Kirtane K, Liu Y, Chen GZ, Shin DM, Teng Y, Chung CH (2023). Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial. Nat Med, 29(4), 880-887. (Read full article)
  8. Fadlullah MZH, Neo WH, Lie-A-Ling M, Thambyrajah R, Patel R, Mevel R, Aksoy I, Do Khoa N, Savatier P, Fontenille L, Baker SM, Rattray M, Kouskoff V, Lacaud G (2020). Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE. Blood, 139(3), 343-356. (Read full article)
  9. Neo WH, Meng Y, Rodriguez-Meira A, Fadlullah MZH, Booth CAG, Azzoni E, Thongjuea S, de Bruijn MFTR, Jacobsen SEW, Mead AJ, Lacaud G (2021). Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors. Nat Commun, 12(1), 7019. (Read full article)
  10. Mevel R, Steiner I, Mason S, Galbraith LC, Patel R, Fadlullah MZ, Ahmad I, Leung HY, Oliveira P, Blyth K, Baena E, Lacaud G (2020). RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development. Elife, 9. (Read full article)
  11. Sahputra R, Murphy EA, Forman R, Mair I, Fadlullah MZH, Waisman A, Muller W, Else KJ (2020). Investigating the importance of B cells and antibodies during Trichuris muris infection using the IgMi mouse. J Mol Med (Berl), 98(9), 1301-1317. (Read full article)
  12. Lee HM, Kelly GM, Zainal NS, Yee PS, Fadlullah MZH, Lee BKB, Gan CP, Patel V, Cheong SC (2019). The 4717C > G polymorphism in periplakin modulates sensitivity to EGFR inhibitors. Sci Rep, 9(1), 2357. (Read full article)
  13. Tiong KH, Chang JK, Pathmanathan D, Hidayatullah Fadlullah MZ, Yee PS, Liew CS, Abdul Rahman ZA, Beh KL, Cheong SC (2018). QuickCount(®): a novel automated software for rapid cell detection and quantification. Biotechniques, 65(6), 322-330. (Read full article)
  14. Garcia-Alegria E, Menegatti S, Fadlullah MZH, Menendez P, Lacaud G, Kouskoff V (2018). Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro. Stem Cell Reports, 11(5), 1061-1074. (Read full article)
  15. Lee BKB, Gan CP, Chang JK, Tan JL, Fadlullah MZ, Abdul Rahman ZA, Prime SS, Gutkind JS, Liew CS, Khang TF, Tan AC, Cheong SC (2018). GENIPAC: A Genomic Information Portal for Head and Neck Cancer Cell Systems. J Dent Res, 97(8), 909-916. (Read full article)
  16. Thambyrajah R, Fadlullah MZH, Proffitt M, Patel R, Cowley SM, Kouskoff V, Lacaud G (2017). HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition. Stem Cell Reports, 10(4), 1369-1383. (Read full article)
  17. Draper JE, Sroczynska P, Fadlullah MZH, Patel R, Newton G, Breitwieser W, Kouskoff V, Lacaud G (2018). A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects. PLoS Genet, 14(1), e1007127. (Read full article)
  18. Draper JE, Sroczynska P, Leong HS, Fadlullah MZH, Miller C, Kouskoff V, Lacaud G (2017). Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors. Blood, 130(3), 271-284. (Read full article)
  19. Diamantopoulou Z, White G, Fadlullah MZH, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie GS, Kouskoff V, Lacaud G, Murray GI, Sansom OJ, Hurlstone AFL, Malliri A (2017). TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell, 31(5), 621-634.e6. (Read full article)
  20. Lilly AJ, Costa G, Largeot A, Fadlullah MZ, Lie-A-Ling M, Lacaud G, Kouskoff V (2016). Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac. Development, 143(23), 4341-4351. (Read full article)
  21. Ng PS, Wen WX, Fadlullah MZ, Yoon SY, Lee SY, Thong MK, Yip CH, Mohd Taib NA, Teo SH (2016). Identification of germline alterations in breast cancer predisposition genes among Malaysian breast cancer patients using panel testing. Clin Genet, 90(4), 315-23. (Read full article)
  22. Eliades A, Wareing S, Marinopoulou E, Fadlullah MZH, Patel R, Grabarek JB, Plusa B, Lacaud G, Kouskoff V (2016). The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development. Cell Rep, 15(10), 2185-2199. (Read full article)
  23. Fadlullah MZ, Chiang IK, Dionne KR, Yee PS, Gan CP, Sam KK, Tiong KH, Ng AK, Martin D, Lim KP, Kallarakkal TG, Mustafa WM, Lau SH, Abraham MT, Zain RB, Rahman ZA, Molinolo A, Patel V, Gutkind JS, Tan AC, Cheong SC (2015). Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies. Oncotarget, 7(19), 27802-18. (Read full article)
  24. Draper JE, Sroczynska P, Tsoulaki O, Leong HS, Fadlullah MZ, Miller C, Kouskoff V, Lacaud G (2016). RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis. PLoS Genet, 12(1), e1005814. (Read full article)
  25. Waddell N, Pajic M, Patch AM, Chang DK, Kassahn KS, Bailey P, Johns AL, Miller D, Nones K, Quek K, Quinn MC, Robertson AJ, Fadlullah MZ, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, Manning S, Nourse C, Nourbakhsh E, Wani S, Wilson PJ, Markham E, Cloonan N, Anderson MJ, Fink JL, Holmes O, Kazakoff SH, Leonard C, Newell F, Poudel B, Song S, Taylor D, Waddell N, Wood S, Xu Q, Wu J, Pinese M, Cowley MJ, Lee HC, Jones MD, Nagrial AM, Humphris J, Chantrill LA, Chin V, Steinmann AM, Mawson A, Humphrey ES, Colvin EK, Chou A, Scarlett CJ, Pinho AV, Giry-Laterriere M, Rooman I, Samra JS, Kench JG, Pettitt JA, Merrett ND, Toon C, Epari K, Nguyen NQ, Barbour A, Zeps N, Jamieson NB, Graham JS, Niclou SP, Bjerkvig R, Grtzmann R, Aust D, Hruban RH, Maitra A, Iacobuzio-Donahue CA, Wolfgang CL, Morgan RA, Lawlor RT, Corbo V, Bassi C, Falconi M, Zamboni G, Tortora G, Tempero MA, Australian Pancreatic Cancer Genome Initiative, Gill AJ, Eshleman JR, Pilarsky C, Scarpa A, Musgrove EA, Pearson JV, Biankin AV, Grimmond SM (2014). Whole genomes redefine the mutational landscape of pancreatic cancer. Nature, 518(7540), 495-501. (Read full article)
  26. Quek K, Nones K, Patch AM, Fink JL, Newell F, Cloonan N, Miller D, Fadlullah MZ, Kassahn K, Christ AN, Bruxner TJ, Manning S, Harliwong I, Idrisoglu S, Nourse C, Nourbakhsh E, Wani S, Steptoe A, Anderson M, Holmes O, Leonard C, Taylor D, Wood S, Xu Q, Australian Pancreatic Cancer Genome Initiative, Wilson P, Biankin AV, Pearson JV, Waddell N, Grimmond SM (2014). A workflow to increase verification rate of chromosomal structural rearrangements using high-throughput next-generation sequencing. Biotechniques, 57(1), 31-8. (Read full article)

Review

  1. Neo WH, Lie-A-Ling M, Fadlullah MZH, Lacaud G (2021). Contributions of Embryonic HSC-Independent Hematopoiesis to Organogenesis and the Adult Hematopoietic System. [Review]. Front Cell Dev Biol, 9, 631699. (Read full article)