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Qi Chen, MD, PhD

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Academic Information

Departments: Surgery - Associate Professor

Divisions: Urology

Academic Office Information

Qi.Chen@hsc.utah.edu

Education History

Graduate Training Institute of Zoology, Chinese Academy of Sciences
Developmental Biology
Ph.D.
Professional Medical Chongqing Medical University
Medicine
M.D.

Selected Publications

  1. Zhu L, Zhou T, Iyyappan R, Ming H, Dvoran M, Wang Y, Chen Q, Roberts RM, Susor A, Jiang Z (2022). High-resolution ribosome profiling reveals translational selectivity for transcripts in bovine preimplantation embryo development. Development, 149(21).
  2. Shi J, Zhou T, Chen Q (2022). Exploring the expanding universe of small RNAs. [Review]. Nat Cell Biol, 24(4), 415-423.
  3. Zhang L, Li Y, Wang J, Hong C, Lu W, Qu Y, Black SM, Chen Q, Zhou T, Jin W, Duan E, Tang H, Zhang Y (2022). RNA Modification Signature of Peripheral Blood as a Potential Diagnostic Marker for Pulmonary Hypertension. Hypertension, 79(3), e67-e69.
  4. Qu Y, Chen Q, Guo S, Ma C, Lu Y, Shi J, Liu S, Zhou T, Noda T, Qian J, Zhang L, Zhu X, Lei X, Cao Y, Li W, Li W, Plachta N, Matzuk MM, Ikawa M, Duan E, Zhang Y, Wang H (2021). Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization. Protein Cell, 12(10), 810-817.
  5. Chen Q, Zhang X, Shi J, Yan M, Zhou T (2021). Origins and evolving functionalities of tRNA-derived small RNAs. [Review]. Trends Biochem Sci, 46(10), 790-804.
  6. Liu C, Liu H, Zhang H, Wang L, Li M, Cai F, Wang X, Wang L, Zhang R, Yang S, Liu W, Liang Y, Wang L, Song X, Su S, Gao H, Jiang J, Li J, Luo M, Gao F, Chen Q, Li W, Chen ZJ (2021). Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans. EMBO J, 40(13), e106864.
  7. Shi J, Zhang Y, Tan D, Zhang X, Yan M, Zhang Y, Franklin R, Shahbazi M, Mackinlay K, Liu S, Kuhle B, James ER, Zhang L, Qu Y, Zhai Q, Zhao W, Zhao L, Zhou C, Gu W, Murn J, Guo J, Carrell DT, Wang Y, Chen X, Cairns BR, Yang XL, Schimmel P, Zernicka-Goetz M, Cheloufi S, Zhang Y, Zhou T, Chen Q (2021). PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications. Nat Cell Biol, 23(4), 424-436.
  8. Gu W, Shi J, Liu H, Zhang X, Zhou JJ, Li M, Zhou D, Li R, Lv J, Wen G, Zhu S, Qi T, Li W, Wang X, Wang Z, Zhu H, Zhou C, Knox KS, Wang T, Chen Q, Qian Z, Zhou T (2020). Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer. Mol Cancer, 19(1), 159.
  9. Zhang X, Trebak F, Souza LAC, Shi J, Zhou T, Kehoe PG, Chen Q, Feng Earley Y (2020). Small RNA modifications in Alzheimer's disease. Neurobiol Dis, 145, 105058.
  10. Wang J, Xie X, Shi J, He W, Chen Q, Chen L, Gu W, Zhou T (2020). Denoising Autoencoder, A Deep Learning Algorithm, Aids the Identification of A Novel Molecular Signature of Lung Adenocarcinoma. Genomics Proteomics Bioinformatics, 18(4), 468-480.
  11. Zhang X, Chen Q (2020). A Twist between ROS and Sperm-Mediated Intergenerational Epigenetic Inheritance. Mol Cell, 78(3), 371-373.
  12. Sui Y, Meng Z, Park SH, Lu W, Livelo C, Chen Q, Zhou T, Zhou C (2020). Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice. J Lipid Res, 61(5), 696-706.
  13. Zhang Y, Chen Q (2020). Human sperm RNA code senses dietary sugar. Nat Rev Endocrinol, 16(4), 200-201.
  14. Qian J, Chen Q, Ward SM, Duan E, Zhang Y (2019). Impacts of Caffeine during Pregnancy. [Review]. Trends Endocrinol Metab, 31(3), 218-227.
  15. Zhang Y, Shi J, Rassoulzadegan M, Tuorto F, Chen Q (2019). Sperm RNA code programmes the metabolic health of offspring. [Review]. Nat Rev Endocrinol, 15(8), 489-498.
  16. Huang L, Meng TG, Ma XS, Wang ZB, Qi ST, Chen Q, Zhang QH, Liang QX, Wang ZW, Hu MW, Guo L, Ouyang YC, Hou Y, Zhao Y, Sun QY (2018). Rad9a is involved in chromatin decondensation and post-zygotic embryo development in mice. Cell Death Differ, 26(5), 969-980.
  17. Zhang Y, Chen Q (2019). The expanding repertoire of hereditary information carriers. [Review]. Development, 146(6).
  18. Shi J, Zhang Y, Zhou T, Chen Q (2018). tsRNAs: The Swiss Army Knife for Translational Regulation. [Review]. Trends Biochem Sci, 44(3), 185-189.
  19. Durnin L, Kwok B, Kukadia P, McAvera R, Corrigan RD, Ward SM, Zhang Y, Chen Q, Koh SD, Sanders KM, Mutafova-Yambolieva VN (2018). An ex vivo bladder model with detrusor smooth muscle removed to analyse biologically active mediators released from the suburothelium. J Physiol, 597(6), 1467-1485.
  20. Wang J, Wang L, Feng G, Wang Y, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W, Zhou Q (2018). Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell, 175(7), 1887-1901.e18.
  21. Liu Y, Chen Q (2018). 150 years of Darwin's theory of intercellular flow of hereditary information. Nat Rev Mol Cell Biol, 19(12), 749-750.
  22. Qian J, Zhang Y, Qu Y, Zhang L, Shi J, Zhang X, Liu S, Kim BH, Hwang SJ, Zhou T, Chen Q, Ward SM, Duan E, Zhang Y (2018). Caffeine consumption during early pregnancy impairs oviductal embryo transport, embryonic development and uterine receptivity in mice. Biol Reprod, 99(6), 1266-1275.
  23. Zhou T, Xie X, Li M, Shi J, Zhou JJ, Knox KS, Wang T, Chen Q, Gu W (2018). Rat BodyMap transcriptomes reveal unique circular RNA features across tissue types and developmental stages. RNA, 24(11), 1443-1456.
  24. Chen Q, Shi J, Tao Y, Zernicka-Goetz M (2018). Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo. [Review]. Nat Commun, 9(1), 1819.
  25. Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q (2018). Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nat Cell Biol, 20(5), 535-540.
  26. Shi J, Ko EA, Sanders KM, Chen Q, Zhou T (2018). SPORTS1.0: A Tool for Annotating and Profiling Non-coding RNAs Optimized for rRNA- and tRNA-derived Small RNAs. Genomics Proteomics Bioinformatics, 16(2), 144-151.
  27. Zhang Y, Shi J, Chen Q (2017). tsRNAs: new players in mammalian retrotransposon control. Cell Res, 27(11), 1307-1308.
  28. Shi J, Zhang X, Liu Y, Chen Q (2017). Epigenetic information in gametes: Gaming from before fertilization: Comment on "Epigenetic game theory: How to compute the epigenetic control of maternal-to-zygotic transition" by Qian Wang et al. Phys Life Rev, 20, 146-149.
  29. Qiao J, Zhao H, Zhang Y, Peng H, Chen Q, Zhang H, Zheng X, Jin Y, Ni H, Duan E, Guo Y (2016). GPR39 is region-specifically expressed in mouse oviduct correlating with the Zn(2+) distribution. Theriogenology, 88, 98-105.
  30. Chen Q, Yan W, Duan E (2016). Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications. [Review]. Nat Rev Genet, 17(12), 733-743.
  31. Zhang X, Cozen AE, Liu Y, Chen Q, Lowe TM (2016). Small RNA Modifications: Integral to Function and Disease. [Review]. Trends Mol Med, 22(12), 1025-1034.
  32. Shi J, Zhang Y, Chen Q (2016). Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence. Environ Epigenet, 2(2), dvw014.
  33. Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E, Zhai Q, Zhou Q (2015). Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science, 351(6271), 397-400.
  34. Shi J, Chen Q, Li X, Zheng X, Zhang Y, Qiao J, Tang F, Tao Y, Zhou Q, Duan E (2015). Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq. Development, 142(20), 3468-77.
  35. Deng Z, Lei X, Zhang X, Zhang H, Liu S, Chen Q, Hu H, Wang X, Ning L, Cao Y, Zhao T, Zhou J, Chen T, Duan E (2015). mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration. J Mol Cell Biol, 7(1), 62-72.
  36. Zhang Y, Chen Q, Zhang H, Wang Q, Li R, Jin Y, Wang H, Ma T, Qiao J, Duan E (2014). Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation. Cell Res, 25(1), 139-42.
  37. Lei X, Deng Z, Zhang H, Zhao H, Zhou J, Liu S, Chen Q, Ning L, Cao Y, Wang X, Zhang X, Duan E (2014). Rotary suspension culture enhances mesendoderm differentiation of embryonic stem cells through modulation of Wnt/β-catenin pathway. Stem Cell Rev Rep, 10(4), 526-38.
  38. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H (2014). Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res, 24(8), 925-42.
  39. Wang H, Wan H, Li X, Liu W, Chen Q, Wang Y, Yang L, Tang H, Zhang X, Duan E, Zhao X, Gao F, Li W (2014). Atg7 is required for acrosome biogenesis during spermatogenesis in mice. Cell Res, 24(7), 852-69.
  40. Zhang Y, Zhang Y, Shi J, Zhang H, Cao Z, Gao X, Ren W, Ning Y, Ning L, Cao Y, Chen Y, Ji W, Chen ZJ, Chen Q, Duan E (2013). Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection. J Mol Cell Biol, 6(2), 172-4.
  41. Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F, Gao S, Wang H (2014). Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biol Reprod, 90(3), 52.
  42. Chen Q, Zhang Y, Elad D, Jaffa AJ, Cao Y, Ye X, Duan E (2012). Navigating the site for embryo implantation: biomechanical and molecular regulation of intrauterine embryo distribution. [Review]. Mol Aspects Med, 34(5), 1024-42.
  43. Zhang H, Zhang Y, Zhao H, Zhang Y, Chen Q, Peng H, Lei L, Qiao J, Shi J, Cao Z, Duan E, Jin Y (2013). Hormonal regulation of ovarian bursa fluid in mice and involvement of aquaporins. PLoS One, 8(5), e63823.
  44. Zhang Q, Chen Q, Lu X, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y, Wang H (2013). CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis, 4(2), e502.
  45. Wang Q, Lu J, Zhang S, Wang S, Wang W, Wang B, Wang F, Chen Q, Duan E, Leitges M, Kispert A, Wang H (2013). Wnt6 is essential for stromal cell proliferation during decidualization in mice. Biol Reprod, 88(1), 5.
  46. Peng H, Shi J, Zhang Y, Zhang H, Liao S, Li W, Lei L, Han C, Ning L, Cao Y, Zhou Q, Chen Q, Duan E (2012). A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm. Cell Res, 22(11), 1609-12.
  47. Chen Q, Peng H, Lei L, Zhang Y, Kuang H, Cao Y, Shi QX, Ma T, Duan E (2010). Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration. Cell Res, 21(6), 922-33.
  48. Chen Q, Duan EK (2011). Aquaporins in sperm osmoadaptation: an emerging role for volume regulation. Acta Pharmacol Sin, 32(6), 721-4.
  49. Peng H, Zhang Y, Lei L, Chen Q, Yue J, Tan Y, Duan E (2010). Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization. Fertil Steril, 95(4), 1514-7.e1-3.
  50. Chen Q, Zhang Y, Peng H, Lei L, Kuang H, Zhang L, Ning L, Cao Y, Duan E (2010). Transient {beta}2-adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation. J Biol Chem, 286(6), 4349-56.
  51. Kuang H, Zhang L, Peng J, Chen Q (2009). Premature ovarian failure, menopause and ovarian cancer, three nodes on the same string: Pten and other potential genes on the go. Med Hypotheses, 73(6), 961-2.
  52. Kuang H, Chen Q, Zhang Y, Zhang L, Peng H, Ning L, Cao Y, Duan E (2009). The cytokine gene CXCL14 restricts human trophoblast cell invasion by suppressing gelatinase activity. Endocrinology, 150(12), 5596-605.
  53. Zhang L, Guo W, Chen Q, Fan X, Zhang Y, Duan E (2009). Adam12 plays a role during uterine decidualization in mice. Cell Tissue Res, 338(3), 413-21.
  54. Kuang H, Chen Q, Fan X, Zhang Y, Zhang L, Peng H, Cao Y, Duan E (2009). CXCL14 inhibits trophoblast outgrowth via a paracrine/autocrine manner during early pregnancy in mice. J Cell Physiol, 221(2), 448-57.
  55. Peng H, Chen Q, Tan Y (2009). Frequent ejaculation associated free radical and lactic acid accumulation cause noninfectious inflammation and muscle dysfunction: a potential mechanism for symptoms in Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Med Hypotheses, 73(3), 372-3.
  56. Chen Q, Zhang Y, Lu J, Wang Q, Wang S, Cao Y, Wang H, Duan E (2009). Embryo-uterine cross-talk during implantation: the role of Wnt signaling. [Review]. Mol Hum Reprod, 15(4), 215-21.
  57. Zhang Y, Peng S, Kuang H, Chen Q, Liu S, Zhang L, Duan E (2008). Expression and regulation of Dickkopf2 during periimplantation in mice. J Reprod Dev, 55(1), 17-22.
  58. Peng S, Li J, Miao C, Jia L, Hu Z, Zhao P, Li J, Zhang Y, Chen Q, Duan E (2008). Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentation. Reproduction, 135(3), 367-75.