Hongchao Guo

Hongchao Guo, PhD

Languages spoken: English

Academic Information

Departments Primary - Surgery , Adjunct - Human Genetics

Divisions: Cardiothoracic Surgery

Education History

Postdoctoral Fellowship Stanford Cardiovascular Institute
 Postdoctoral Fellow
Research Fellow Institute of Molecular and Cell Biology, A*STAR
 Research Fellow
Doctoral Training College of Life Science, Nankai University
 PhD
Graduate Training College of Life Science, Nankai University
 MS
Undergraduate Tianjin Agricultural University
 BS

Selected Publications

Journal Article

  1. Guo H, Yu X, Liu Y, Paik DT, Justesen JM, Chandy M, Jahng JWS, Zhang T, Wu W, Rwere F, Zhao SR, Pokhrel S, Shivnaraine RV, Mukherjee S, Simon DJ, Manhas A, Zhang A, Chen CH, Rivas MA, Gross ER, Mochly-Rosen D, Wu JC (2023). SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant. Sci Transl Med, 15(680), eabp9952. (Read full article)
  2. Wang YJ, Zhang X, Lam CK, Guo H, Wang C, Zhang S, Wu JC, Snyder M, Li J (2022). Systems analysis of de novo mutations in congenital heart diseases identified a protein network in the hypoplastic left heart syndrome. Cell Syst, 13(11), 895-910.e4. (Read full article)
  3. Guo H, Liu L, Nishiga M, Cong L, Wu JC (2021). Deciphering pathogenicity of variants of uncertain significance with CRISPR-edited iPSCs. Trends Genet, 37(12), 1109-1123. (Read full article)
  4. Wilson KD, Ameen M, Guo H, Abilez OJ, Tian L, Mumbach MR, Diecke S, Qin X, Liu Y, Yang H, Ma N, Gaddam S, Cunningham NJ, Gu M, Neofytou E, Prado M, Hildebrandt TB, Karakikes I, Chang HY, Wu JC (2020). Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates. Dev Cell, 54(6), 694-709.e9. (Read full article)
  5. Ho H, Guo H, Means S, Tang J, Hunter P (2020). Maternal Smoking Induced Cardiovascular Risks in Fetuses: How Can in silico Models Help? Front Bioeng Biotechnol, 8, 97. (Read full article)
  6. Belbachir N, Portero V, Al Sayed ZR, Gourraud JB, Dilasser F, Jesel L, Guo H, Wu H, Gaborit N, Guilluy C, Girardeau A, Bonnaud S, Simonet F, Karakachoff M, Pattier S, Scott C, Burel S, Marionneau C, Chariau C, Gaignerie A, David L, Genin E, Deleuze JF, Dina C, Sauzeau V, Loirand G, Bar I, Schott JJ, Probst V, Wu JC, Redon R, Charpentier F, Le Scouarnec S (2017). RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome. Eur Heart J, 40(37), 3081-3094. (Read full article)
  7. Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC (2018). Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells. J Am Coll Cardiol, 73(21), 2722-2737. (Read full article)
  8. Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC (2019). A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles. Cell Stem Cell, 24(5), 802-811.e5. (Read full article)
  9. Guo H, Tian L, Zhang JZ, Kitani T, Paik DT, Lee WH, Wu JC (2019). Single-Cell RNA Sequencing of Human Embryonic Stem Cell Differentiation Delineates Adverse Effects of Nicotine on Embryonic Development. Stem Cell Reports, 12(4), 772-786. (Read full article)
  10. Zhang JZ, Guo H, Wu JC (2018). Applications of genetically engineered human pluripotent stem cell reporters in cardiac stem cell biology. Curr Opin Biotechnol, 52, 66-73. (Read full article)
  11. Nishiga M, Guo H, Wu JC (2018). Induced pluripotent stem cells as a biopharmaceutical factory for extracellular vesicles. Eur Heart J, 39(20), 1848-1850. (Read full article)
  12. Lee J, Shao NY, Paik DT, Wu H, Guo H, Termglinchan V, Churko JM, Kim Y, Kitani T, Zhao MT, Zhang Y, Wilson KD, Karakikes I, Snyder MP, Wu JC (2017). SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation. Cell Stem Cell, 22(3), 428-444.e5. (Read full article)
  13. Toh CX, Chan JW, Chong ZS, Wang HF, Guo HC, Satapathy S, Ma D, Goh GY, Khattar E, Yang L, Tergaonkar V, Chang YT, Collins JJ, Daley GQ, Wee KB, Farran CA, Li H, Lim YP, Bard FA, Loh YH (2016). RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming. Cell Rep, 15(12), 2597-607. (Read full article)
  14. Zhang W, Ni P, Mou C, Zhang Y, Guo H, Zhao T, Loh YH, Chen L (2016). Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription. Sci Rep, 6, 26804. (Read full article)
  15. Chen H, Guo R, Zhang Q, Guo H, Yang M, Wu Z, Gao S, Liu L, Chen L (2015). Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A, 112(44), E5936-43. (Read full article)
  16. Yang BX, El Farran CA, Guo HC, Yu T, Fang HT, Wang HF, Schlesinger S, Seah YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L, Gunaratne J, Collins JJ, Goff SP, Daley GQ, Li H, Bard FA, Loh YH (2015). Systematic identification of factors for provirus silencing in embryonic stem cells. Cell, 163(1), 230-45. (Read full article)
  17. Wu Z, Yang M, Liu H, Guo H, Wang Y, Cheng H, Chen L (2012). Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance. J Biol Chem, 287(45), 38295-304. (Read full article)

Clinical Trials