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Martin H. Distel, PhD

Languages spoken: English, German

Academic Information

Departments Primary - Pediatrics , Adjunct - Oncological Sciences

Divisions: Hematology/Oncology

Academic Office Information

Martin.Distel@hci.utah.edu

Lab

Education History

Undergraduate Technical University of Munich
 BSc
Graduate Training Technical University of Munich
 MSc
Doctoral Training Institute of Developmental Genetics, Helmholtz Center Munich/Technical University of Munich
 PhD
Fellowship University of California, San Diego
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Sturtzel C, Grissenberger S, Bozatzi P, Scheuringer E, Wenninger-Weinzierl A, Zajec Z, Dernov'ek J, Pascoal S, Gehl V, Kutsch A, Granig A, Rifatbegovic F, Carre M, Lang A, Valtingojer I, Moll J, Lötsch D, Erhart F, Widhalm G, Surdez D, Delattre O, André N, Stampfl J, Toma'i¿ T, Taschner-Mandl S, Distel M (2023). Refined high-content imaging-based phenotypic drug screening in zebrafish xenografts. NPJ Precis Oncol, 7(1), 44.
  2. Grissenberger S, Sturtzel C, Wenninger-Weinzierl A, Radic-Sarikas B, Scheuringer E, Bierbaumer L, Etienne V, Némati F, Pascoal S, Tötzl M, Tomazou EM, Metzelder M, Putz EM, Decaudin D, Delattre O, Surdez D, Kovar H, Halbritter F, Distel M (2023). High-content drug screening in zebrafish xenografts reveals high efficacy of dual MCL-1/BCL-X(L) inhibition against Ewing sarcoma. Cancer Lett, 554, 216028.
  3. Klughammer J, Romanovskaia D, Nemc A, Posautz A, Seid CA, Schuster LC, Keinath MC, Lugo Ramos JS, Kosack L, Evankow A, Printz D, Kirchberger S, Ergüner B, Datlinger P, Fortelny N, Schmidl C, Farlik M, Skjærven K, Bergthaler A, Liedvogel M, Thaller D, Burger PA, Hermann M, Distel M, Distel DL, Kübber-Heiss A, Bock C (2023). Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species. Nat Commun, 14(1), 232.
  4. Eichhoff OM, Stoffel CI, Käsler J, Briker L, Turko P, Karsai G, Zila N, Paulitschke V, Cheng PF, Leitner A, Bileck A, Zamboni N, Irmisch A, Balazs Z, Tastanova A, Pascoal S, Johansen P, Wegmann R, Mena J, Othman A, Viswanathan VS, Wenzina J, Aloia A, Saltari A, Dzung A, TuPro Consortium, Krauthammer M, Schreiber SL, Hornemann T, Distel M, Snijder B, Dummer R, Levesque MP (2023). ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma. Cancer Res, 83(7), 1128-1146.
  5. Schelch K, Eder S, Zitta B, Phimmachanh M, Johnson TG, Emminger D, Wenninger-Weinzierl A, Sturtzel C, Poplimont H, Ries A, Hoetzenecker K, Hoda MA, Berger W, Distel M, Dome B, Reid G, Grusch M (2022). YB-1 regulates mesothelioma cell migration via snail but not EGFR, MMP1, EPHA5 or PARK2.(Epub ahead of print). Mol Oncol.
  6. Andreana M, Sturtzel C, Spielvogel CP, Papp L, Leitgeb R, Drexler W, Distel M, Unterhuber A (2021). Toward Quantitative in vivo Label-Free Tracking of Lipid Distribution in a Zebrafish Cancer Model. Front Cell Dev Biol, 9, 675636.
  7. Pascoal S, Salzer B, Scheuringer E, Wenninger-Weinzierl A, Sturtzel C, Holter W, Taschner-Mandl S, Lehner M, Distel M (2020). A Preclinical Embryonic Zebrafish Xenograft Model to Investigate CAR T Cells In Vivo. Cancers (Basel), 12(3).
  8. Mayr V, Sturtzel C, Stadler M, Grissenberger S, Distel M (2018). Fast Dynamic in vivo Monitoring of Erk Activity at Single Cell Resolution in DREKA Zebrafish. Front Cell Dev Biol, 6, 111.
  9. Li J, Casteels T, Frogne T, Ingvorsen C, Honoré C, Courtney M, Huber KVM, Schmitner N, Kimmel RA, Romanov RA, Sturtzel C, Lardeau CH, Klughammer J, Farlik M, Sdelci S, Vieira A, Avolio F, Briand F, Baburin I, Májek P, Pauler FM, Penz T, Stukalov A, Gridling M, Parapatics K, Barbieux C, Berishvili E, Spittler A, Colinge J, Bennett KL, Hering S, Sulpice T, Bock C, Distel M, Harkany T, Meyer D, Superti-Furga G, Collombat P, Hecksher-Sørensen J, Kubicek S (2017). Artemisinins Target GABA(A) Receptor Signaling and Impair ¿ Cell Identity. Cell, 168(1-2), 86-100.e15.
  10. Alghisi E, Distel M, Malagola M, Anelli V, Santoriello C, Herwig L, Krudewig A, Henkel CV, Russo D, Mione MC (2013). Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the Notch pathway. Leukemia, 27(11), 2229-41.
  11. Distel M, Hocking JC, Volkmann K, Köster RW (2010). The centrosome neither persistently leads migration nor determines the site of axonogenesis in migrating neurons in vivo. J Cell Biol, 191(4), 875-90.
  12. Distel M, Wullimann MF, Köster RW (2009). Optimized Gal4 genetics for permanent gene expression mapping in zebrafish. Proc Natl Acad Sci U S A, 106(32), 13365-70.
  13. Distel M, Köster RW (2007). In vivo time-lapse imaging of zebrafish embryonic development. Cold Spring Harb Protoc, 2007, pdb.prot4816.
  14. Block J, Rashkova C, Castanon I, Zoghi S, Platon J, Ardy RC, Fujiwara M, Chaves B, Schoppmeyer R, van der Made CI, Jimenez Heredia R, Harms FL, Alavi S, Alsina L, Sanchez Moreno P, Ávila Polo R, Cabrera-Pérez R, Kostel Bal S, Pfajfer L, Ransmayr B, Mautner AK, Kondo R, Tinnacher A, Caldera M, Schuster M, Domínguez Conde C, Platzer R, Salzer E, Boyer T, Brunner HG, Nooitgedagt-Frons JE, Iglesias E, Deyà-Martinez A, Camacho-Lovillo M, Menche J, Bock C, Huppa JB, Pickl WF, Distel M, Yoder JA, Traver D, Engelhardt KR, Linden T, Kager L, Hannich JT, Hoischen A, Hambleton S, Illsinger S, Da Costa L, Kutsche K, Chavoshzadeh Z, van Buul JD, Antón J, Calzada-Hernández J, Neth O, Viaud J, Nishikimi A, Dupré L, Boztug (2023). Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency. The New England journal of medicine, 389(6), 527-539.
  15. Zajec ¿, Dernov'ek J, Distel M, Gobec M, Toma'i¿ (2023). Optimisation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as novel Hsp90 C-terminal domain inhibitors against Ewing sarcoma. Bioorganic chemistry, 131, 106311.
  16. Zhang W, Scerbo P, Delagrange M, Candat V, Mayr V, Vriz S, Distel M, Ducos B, Bensimon (2022). Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology, 5(1), 113.
  17. Gabler L, Jaunecker CN, Katz S, van Schoonhoven S, Englinger B, Pirker C, Mohr T, Vician P, Stojanovic M, Woitzuck V, Laemmerer A, Kirchhofer D, Mayr L, LaFranca M, Erhart F, Grissenberger S, Wenninger-Weinzierl A, Sturtzel C, Kiesel B, Lang A, Marian B, Grasl-Kraupp B, Distel M, Schüler J, Gojo J, Grusch M, Spiegl-Kreinecker S, Donoghue DJ, Lötsch D, Berger (2022). Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness. Acta neuropathologica communications, 10(1), 65.
  18. Lichtenegger A, Mukherjee P, Zhu L, Morishita R, Tomita K, Oida D, Leskovar K, Abd El-Sadek I, Makita S, Kirchberger S, Distel M, Baumann B, Yasuno (2022). Non-destructive characterization of adult zebrafish models using Jones matrix optical coherence tomography. Biomedical optics express, 13(4), 2202-2223.
  19. Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, Velasco CD, Taylor JA, Terni B, Weinert T, Standfuss J, Cabernard CC, Llobet A, Steinmetz MO, Bausch AR, Distel M, Thorn-Seshold J, Akhmanova A, Thorn-Seshold (2022). In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M. Journal of the American Chemical Society, 144(12), 5614-5628.
  20. Casteels T, Zhang Y, Frogne T, Sturtzel C, Lardeau CH, Sen I, Liu X, Hong S, Pauler FM, Penz T, Brandstetter M, Barbieux C, Berishvili E, Heuser T, Bock C, Riedel CG, Meyer D, Distel M, Hecksher-Sørensen J, Li J, Kubicek (2021). An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation. Molecular metabolism, 54, 101329.
  21. Fernández A, Straw A, Distel M, Leitgeb R, Baltuska A, Verhoef A (2020). Dynamic real-time subtraction of stray-light and background for multiphoton imaging. Biomedical optics express, 12(1), 288-302.
  22. Wrobel JK, Najafi S, Ayhan S, Gatzweiler C, Krunic D, Ridinger J, Milde T, Westermann F, Peterziel H, Meder B, Distel M, Witt O, Oehme (2020). Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts. Pharmaceuticals (Basel, Switzerland), 13(11),
  23. Lämmle CA, Varady A, Müller TG, Sturtzel C, Riepl M, Mathes B, Eichhorst J, Sporbert A, Lehmann M, Kräusslich HG, Distel M, Broichhagen (2021). Photocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo. Chembiochem, 22(3), 548-556.
  24. Okuda KS, Keyser MS, Gurevich DB, Sturtzel C, Mason EA, Paterson S, Chen H, Scott M, Condon ND, Martin P, Distel M, Hogan B (2021). Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis. eLife, 10,
  25. Haindl R, Duelk M, Gloor S, Dahdah J, Ojeda J, Sturtzel C, Deng S, Joyce Deloria A, Li Q, Liu M, Distel M, Drexler W, Leitgeb (2020). Ultra-high-resolution SD-OCM imaging with a compact polarization-aligned 840 nm broadband combined-SLED source. Biomedical optics express, 11(6), 3395-3406.
  26. Haindl R, Deloria AJ, Sturtzel C, Sattmann H, Rohringer W, Fischer B, Andreana M, Unterhuber A, Schwerte T, Distel M, Drexler W, Leitgeb R, Liu (2020). Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae. Biomedical optics express, 11(4), 2137-2151.
  27. Corallo D, Donadon M, Pantile M, Sidarovich V, Cocchi S, Ori M, De Sarlo M, Candiani S, Frasson C, Distel M, Quattrone A, Zanon C, Basso G, Tonini GP, Aveic (2020). LIN28B increases neural crest cell migration and leads to transformation of trunk sympathoadrenal precursors. Cell death and differentiation, 27(4), 1225-1242.
  28. Shen J, Najafi S, Stäble S, Fabian J, Koeneke E, Kolbinger FR, Wrobel JK, Meder B, Distel M, Heimburg T, Sippl W, Jung M, Peterziel H, Kranz D, Boutros M, Westermann F, Witt O, Oehme (2018). A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment. Cell death and differentiation, 25(12), 2053-2070.
  29. Troll JV, Hamilton MK, Abel ML, Ganz J, Bates JM, Stephens WZ, Melancon E, van der Vaart M, Meijer AH, Distel M, Eisen JS, Guillemin (2018). Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling. Development (Cambridge, England), 145(4),
  30. Aichhorn S, Linhardt A, Halfmann A, Nadlinger M, Kirchberger S, Stadler M, Dillinger B, Distel M, Dohnal A, Teasdale I, Schöfberger (2017). A pH-sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier. Chemistry (Weinheim an der Bergstrasse, Germany), 23(70), 17721-17726.
  31. Haindl R, Preisser S, Andreana M, Rohringer W, Sturtzel C, Distel M, Chen Z, Rank E, Fischer B, Drexler W, Liu (2017). Dual modality reflection mode optical coherence and photoacoustic microscopy using an akinetic sensor. Optics letters, 42(21), 4319-4322.
  32. Fernández A, Grüner-Nielsen L, Andreana M, Stadler M, Kirchberger S, Sturtzel C, Distel M, Zhu L, Kautek W, Leitgeb R, Baltuska A, Jespersen K, Verhoef (2017). Optimizing pulse compressibility in completely all-fibered Ytterbium chirped pulse amplifiers for in vivo two photon laser scanning microscopy. Biomedical optics express, 8(8), 3526-3537.
  33. Kainrath S, Stadler M, Reichhart E, Distel M, Janovjak (2017). Green-Light-Induced Inactivation of Receptor Signaling Using Cobalamin-Binding Domains. Angewandte Chemie (International ed. in English), 56(16), 4608-4611.
  34. Smidak R, Aradska J, Kirchberger S, Distel M, Sialana FJ, Wackerlig J, Mechtcheriakova D, Lubec (2016). A detailed proteomic profiling of plasma membrane from zebrafish brain. Proteomics. Clinical applications, 10(12), 1264-1268.
  35. Matsui H, Dorigo A, Buchberger A, Hocking JC, Distel M, Köster R (2015). Zebrafish jam-b2 Gal4-enhancer trap line recapitulates endogenous jam-b2 expression in extraocular muscles. Developmental dynamics, 244(12), 1574-80.
  36. Butko E, Distel M, Pouget C, Weijts B, Kobayashi I, Ng K, Mosimann C, Poulain FE, McPherson A, Ni CW, Stachura DL, Del Cid N, Espín-Palazón R, Lawson ND, Dorsky R, Clements WK, Traver (2015). Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (Cambridge, England), 142(6), 1050-61.
  37. Kim AD, Melick CH, Clements WK, Stachura DL, Distel M, Panáková D, MacRae C, Mork LA, Crump JG, Traver (2014). Discrete Notch signaling requirements in the specification of hematopoietic stem cells. The EMBO journal, 33(20), 2363-73.
  38. Ma R, Distel M, Deán-Ben XL, Ntziachristos V, Razansky (2012). Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography. Physics in medicine and biology, 57(22), 7227-37.
  39. Xie X, Mathias JR, Smith MA, Walker SL, Teng Y, Distel M, Köster RW, Sirotkin HI, Saxena MT, Mumm J (2012). Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner. BMC biology, 10, 93.
  40. Walker SL, Ariga J, Mathias JR, Coothankandaswamy V, Xie X, Distel M, Köster RW, Parsons MJ, Bhalla KN, Saxena MT, Mumm J (2012). Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish. PloS one, 7(1), e29916.
  41. Hoegler KJ, Distel M, Köster RW, Horne J (2011). Targeting olfactory bulb neurons using combined in vivo electroporation and Gal4-based enhancer trap zebrafish lines. Journal of visualized experiments, (54),
  42. Distel M, Jennifer C H, Köster R (2011). In vivo cell biology using Gal4-mediated multicolor subcellular labeling in zebrafish. Communicative & integrative biology, 4(3), 336-9.
  43. Wullimann MF, Mueller T, Distel M, Babaryka A, Grothe B, Köster R (2011). The long adventurous journey of rhombic lip cells in jawed vertebrates: a comparative developmental analysis. Frontiers in neuroanatomy, 5, 27.
  44. Santoriello C, Gennaro E, Anelli V, Distel M, Kelly A, Köster RW, Hurlstone A, Mione (2010). Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish. PloS one, 5(12), e15170.
  45. Anelli V, Santoriello C, Distel M, Köster RW, Ciccarelli FD, Mione (2009). Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Zebrafish, 6(4), 417-24.
  46. Nikolaou N, Watanabe-Asaka T, Gerety S, Distel M, Köster RW, Wilkinson D (2009). Lunatic fringe promotes the lateral inhibition of neurogenesis. Development (Cambridge, England), 136(15), 2523-33.
  47. Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass (2009). A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. The Journal of clinical investigation, 119(5), 1382-95.
  48. Distel M, Babaryka A, Köster R (2006). Multicolor in vivo time-lapse imaging at cellular resolution by stereomicroscopy. Developmental dynamics, 235(4), 1100-06.
  49. Kirchberger S, Shoeb MR, Lazic D, Wenninger-Weinzierl A, Fischer K, Shaw L, Nogueira F, Rifatbegovic F, Bozasky E, Ladenstein R, Bodenmiller B, Lion T, Traver D, Farlik M, Schofer C, Taschner-Mandl S, Halbritter F, Distel (2024). Comparative transcriptomics coupled to developmental grading via transgenic zebrafish reporter strains identifies conserved features in neutrophil maturation. Nature communications,

Review

  1. Kirchberger S, Sturtzel C, Pascoal S, Distel M (2017). Quo natas, Danio?-Recent Progress in Modeling Cancer in Zebrafish. [Review]. Front Oncol, 7, 186.
  2. Grünewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, Di Pompo G, Distel M, Dorado-Garcia H, Garcia-Castro J, González-González L, Grigoriadis AE, Kasan M, Koelsche C, Krumbholz M, Lecanda F, Lemma S, Longo DL, Madrigal-Esquivel C, Morales-Molina Á, Musa J, Ohmura S, Ory B, Pereira-Silva M, Perut F, Rodriguez R, Seeling C, Al Shaaili N, Shaabani S, Shiavone K, Sinha S, Tomazou EM, Trautmann M, Vela M, Versleijen-Jonkers YM, Visgauss J, Zalacain M, Schober SJ, Lissat A, English WR, Baldini N, Heymann (2020). Sarcoma treatment in the era of molecular medicine. EMBO molecular medicine, 12(11), e11131.
  3. Varady A, Distel (2020). Non-neuromodulatory Optogenetic Tools in Zebrafish. Frontiers in cell and developmental biology, 8, 418.
  4. Hocking JC, Distel M, Köster R (2013). Studying cellular and subcellular dynamics in the developing zebrafish nervous system. Experimental neurology, 242, 1-10.

Book Chapter

  1. Grissenberger S, Salzer B, Pascoal S, Wenninger-Weinzierl A, Lehner M, Distel (2022). Preclinical testing of CAR T cells in zebrafish xenografts. Methods in cell biology, 167, 133-147.
  2. Sturtzel C, Hocking J, Kirchberger S, Distel (2021). Studying the Tumor Microenvironment in Zebrafish. Advances in experimental medicine and biology, 1329, 69-92.
  3. Pascoal S, Grissenberger S, Scheuringer E, Fior R, Ferreira MG, Distel (2021). Using Zebrafish Larvae as a Xenotransplantation Model to Study Ewing Sarcoma. Methods in molecular biology (Clifton, N.J.), 2226, 243-255.