Kaushik Choudhuri

Kaushik Choudhuri, DPhil, MBBS

Languages spoken: English

Academic Information

Departments Primary - Biochemistry

Research Interests

  • T Cell Receptor (TCR) Signal Transduction
  • Cell Biology and Ultrastructure of the T Cell Immunological Synapse
  • Biogenesis and Function of T Cell-Derived Microvesicles
  • ESCRT Proteins in T Cell Function
  • Mechanism-Guided Design of CAR-T Cell Immunotherapies

Education History

Postdoctoral Fellowship New York University Grossman School of Medicine
 Postdoctoral Fellow
Postdoctoral Fellowship University of Oxford Sir William Dunn School of Pathology
 Postdoctoral Fellow
Doctoral Training University of Oxford
 DPhil
Residency National Hospital for Neurology and Neurosurgery
 Senior House Officer
Residency Hammersmith Hospitals NHS Trust
 Senior House Officer
Internship Queen Elizabeth II Hospital
 House Officer
Professional Medical King's College London GKT School of Medical Education
 MBBS
Undergraduate King's College London, University of London
 BSc (Hons)

Selected Publications

Journal Article

  1. Beilin C, Choudhuri K, Bouma G, Malinova D, Llodra J, Stokes DL, Shimaoka M, Springer TA, Dustin ML, Thrasher AJ, Burns SO (2018). Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse. Wellcome Open Res, 3, 84. (Read full article)
  2. Schmid EM, Bakalar MH, Choudhuri K, Weichsel J, Ann H, Geissler PL, Dustin ML, Fletcher DA (2016). Size-dependent protein segregation at membrane interfaces. Nat Phys, 12(7), 704-711. (Read full article)
  3. Choudhuri K, Llodr J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML (2014). Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Nature, 507(7490), 118-23. (Read full article)
  4. Cordoba SP, Choudhuri K, Zhang H, Bridge M, Basat AB, Dustin ML, van der Merwe PA (2013). The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor. Blood, 121(21), 4295-302. (Read full article)
  5. Schubert DA, Gordo S, Sabatino JJ Jr, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW (2012). Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med, 209(2), 335-52. (Read full article)
  6. Vardhana S, Choudhuri K, Varma R, Dustin ML (2009). Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity, 32(4), 531-40. (Read full article)
  7. Choudhuri K, Parker M, Milicic A, Cole DK, Shaw MK, Sewell AK, Stewart-Jones G, Dong T, Gould KG, van der Merwe PA (2009). Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation. J Biol Chem, 284(38), 26096-105. (Read full article)
  8. Palmowski MJ, Parker M, Choudhuri K, Chiu C, Callan MF, van der Merwe PA, Cerundolo V, Gould KG (2009). A single-chain H-2Db molecule presenting an influenza virus nucleoprotein epitope shows enhanced ability at stimulating CD8+ T cell responses in vivo. J Immunol, 182(8), 4565-71. (Read full article)
  9. Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ, van der Merwe PA, Jones EY (2007). Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism. Science, 317(5842), 1217-20. (Read full article)
  10. Choudhuri K, Wiseman D, Brown MH, Gould K, van der Merwe PA (2005). T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature, 436(7050), 578-82. (Read full article)
  11. Gregorio GV, Choudhuri K, Ma Y, Pensati P, Iorio R, Grant P, Garson J, Bogdanos DP, Vegnente A, Mieli-Vergani G, Vergani D (2003). Mimicry between the hepatitis C virus polyprotein and antigenic targets of nuclear and smooth muscle antibodies in chronic hepatitis C virus infection. Clin Exp Immunol, 133(3), 404-13. (Read full article)
  12. Kerkar N, Choudhuri K, Ma Y, Mahmoud A, Bogdanos DP, Muratori L, Bianchi F, Williams R, Mieli-Vergani G, Vergani D (2003). Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease. J Immunol, 170(3), 1481-9. (Read full article)
  13. Gregorio GV, Choudhuri K, Ma Y, Vegnente A, Mieli-Vergani G, Vergani D (1999). Mimicry between the hepatitis B virus DNA polymerase and the antigenic targets of nuclear and smooth muscle antibodies in chronic hepatitis B virus infection. J Immunol, 162(3), 1802-10. (Read full article)
  14. Choudhuri K, Gregorio GV, Mieli-Vergani G, Vergani D (1998). Immunological cross-reactivity to multiple autoantigens in patients with liver kidney microsomal type 1 autoimmune hepatitis. Hepatology, 28(5), 1177-81. (Read full article)
  15. Wright P, Donaldson PT, Underhill JA, Choudhuri K, Doherty DG, Murray RM (1996). Genetic association of the HLA DRB1 gene locus on chromosome 6p21.3 with schizophrenia. Am J Psychiatry, 153(12), 1530-3. (Read full article)
  16. Gregorio GV, Jones H, Choudhuri K, Vegnente A, Bortolotti F, Mieli-Vergani G, Vergani D (1996). Autoantibody prevalence in chronic hepatitis B virus infection: effect in interferon alfa. Hepatology, 24(3), 520-3. (Read full article)

Review

  1. Dustin ML, Choudhuri K (2016). Signaling and Polarized Communication Across the T Cell Immunological Synapse. [Review]. Annu Rev Cell Dev Biol, 32, 303-325. (Read full article)
  2. Choudhuri K, Dustin ML (2010). Signaling microdomains in T cells. [Review]. FEBS Lett, 584(24), 4823-31. (Read full article)
  3. Choudhuri K, van der Merwe PA (2007). Molecular mechanisms involved in T cell receptor triggering. [Review]. Semin Immunol, 19(4), 255-61. (Read full article)
  4. Choudhuri K, Kearney A, Bakker TR, van der Merwe PA (2005). Immunology: how do T cells recognize antigen? [Review]. Curr Biol, 15(10), R382-5. (Read full article)
  5. Vergani D, Choudhuri K, Bogdanos DP, Mieli-Vergani G (2002). Pathogenesis of autoimmune hepatitis. [Review]. Clin Liver Dis, 6(3), 727-37. (Read full article)
  6. Bogdanos DP, Choudhuri K, Vergani D (2001). Molecular mimicry and autoimmune liver disease: virtuous intentions, malign consequences. [Review]. Liver, 21(4), 225-32. (Read full article)
  7. Choudhuri K, Vergani D (1999). MHC restriction to T-cell autoaggression: an emerging understanding of IDDM pathogenesis. [Review]. Diabetes Metab Rev, 14(4), 285-301. (Read full article)
  8. Vergani D, Gregorio GV, Choudhuri K, Ma Y, Vegnente A, Mieli-Vergani G (1998). Hepatitis virus induced autoimmunity. [Review]. Acta Gastroenterol Belg, 61(2), 217-8. (Read full article)

Editorial

  1. Choudhuri K, Mieli-Vergani G, Vergani D (1997). Cytochrome P4502D6: understanding an autoantigen. Clin Exp Immunol, 108(3), 381-3. (Read full article)
  2. Choudhuri K (1995). The immunology of leprosy; unravelling an enigma. Int J Lepr Other Mycobact Dis, 63(3), 430-47. (Read full article)