Jaroslav Zak

Jaroslav Zak, DPhil, PhD

Languages spoken: Czech, English, German

Academic Information

Departments Primary - Radiation Oncology , Adjunct - Internal Medicine

Divisions: Hematology & Hematologic Malignancies

Education History

Postdoctoral Fellowship Scripps Research, Cancer Research Institute (CRI) Irvington
 Postdoctoral Fellow
Postdoctoral Training Scripps Research
 Postdoctoral Associate
Graduate Training St Catharine’s College, University of Cambridge
 MA
Doctoral Training Scripps Research
 PhD
Doctoral Training University of Oxford
 DPhil
Graduate Training St Catharine’s College, University of Cambridge
 MSci
Undergraduate St Catharine’s College, University of Cambridge
 BA

Selected Publications

Journal Article

  1. Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, E Alexander LC, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, OConnell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA (2024). PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections. Sci Transl Med, 16(754), eadi6887. (Read full article)
  2. Zak J, Pratumchai I, Marro BS, Marquardt KL, Zavareh RB, Lairson LL, Oldstone MBA, Varner JA, Hegerova L, Cao Q, Farooq U, Kenkre VP, Bachanova V, Teijaro JR (2024). JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma. Science, 384(6702), eade8520. (Read full article)
  3. Yang Z, Hou Y, Grande G, Cho JH, Wang C, Shi Y, Zak J, Wan Y, Qin K, Liu D, Teijaro JR, Lerner RA, Wu P (2024). Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager. Nat Biomed Eng, 8(5), 499-512. (Read full article)
  4. Pagnamenta AT, Camps C, Giacopuzzi E, Taylor JM, Hashim M, Calpena E, Kaisaki PJ, Hashimoto A, Yu J, Sanders E, Schwessinger R, Hughes JR, Lunter G, Dreau H, Ferla M, Lange L, Kesim Y, Ragoussis V, Vavoulis DV, Allroggen H, Ansorge O, Babbs C, Banka S, Baos-Piero B, Beeson D, Ben-Ami T, Bennett DL, Bento C, Blair E, Brasch-Andersen C, Bull KR, Cario H, Cilliers D, Conti V, Davies EG, Dhalla F, Dacal BD, Dong Y, Dunford JE, Guerrini R, Harris AL, Hartley J, Hollander G, Javaid K, Kane M, Kelly D, Kelly D, Knight SJL, Kreins AY, Kvikstad EM, Langman CB, Lester T, Lines KE, Lord SR, Lu X, Mansour S, Manzur A, Maroofian R, Marsden B, Mason J, McGowan SJ, Mei D, Mlcochova H, Murakami Y, Nmeth AH, Okoli S, Ormondroyd E, Ousager LB, Palace J, Patel SY, Pentony MM, Pugh C, Rad A, Ramesh A, Riva SG, Roberts I, Roy N, Salminen O, Schilling KD, Scott C, Sen A, Smith C, Stevenson M, Thakker RV, Twigg SRF, Uhlig HH, van Wijk R, Vona B, Wall S, Wang J, Watkins H, Zak J, Schuh AH, Kini U, Wilkie AOM, Popitsch N, Taylor JC (2023). Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases. Genome Med, 15(1), 94. (Read full article)
  5. Pratumchai I, Zak J, Huang Z, Min B, Oldstone MBA, Teijaro JR (2021). B cell-derived IL-27 promotes control of persistent LCMV infection. Proc Natl Acad Sci U S A, 119(3). (Read full article)
  6. Huang Z, Kang SG, Li Y, Zak J, Shaabani N, Deng K, Shepherd J, Bhargava R, Teijaro JR, Xiao C (2021). IFNAR1 signaling in NK cells promotes persistent virus infection. Sci Adv, 7(13). (Read full article)
  7. Marro BS, Zak J, Zavareh RB, Teijaro JR, Lairson LL, Oldstone MBA (2019). Discovery of Small Molecules for the Reversal of T Cell Exhaustion. Cell Rep, 29(10), 3293-3302.e3. (Read full article)
  8. Huang Z, Zak J, Pratumchai I, Shaabani N, Vartabedian VF, Nguyen N, Wu T, Xiao C, Teijaro JR (2019). IL-27 promotes the expansion of self-renewing CD8(+) T cells in persistent viral infection. J Exp Med, 216(8), 1791-1808. (Read full article)
  9. ODonnell-Luria AH, Pais LS, Faundes V, Wood JC, Sveden A, Luria V, Abou Jamra R, Accogli A, Amburgey K, Anderlid BM, Azzarello-Burri S, Basinger AA, Bianchini C, Bird LM, Buchert R, Carre W, Ceulemans S, Charles P, Cox H, Culliton L, Curr A, Deciphering Developmental Disorders DDD Study, Demurger F, Dowling JJ, Duban-Bedu B, Dubourg C, Eiset SE, Escobar LF, Ferrarini A, Haack TB, Hashim M, Heide S, Helbig KL, Helbig I, Heredia R, Hron D, Isidor B, Jonasson AR, Joset P, Keren B, Kok F, Kroes HY, Lavillaureix A, Lu X, Maas SM, Maegawa GHB, Marcelis CLM, Mark PR, Masruha MR, McLaughlin HM, McWalter K, Melchinger EU, Mercimek-Andrews S, Nava C, Pendziwiat M, Person R, Ramelli GP, Ramos LLP, Rauch A, Reavey C, Renieri A, Rie A, Sanchez-Valle A, Sattar S, Saunders C, Schwarz N, Smol T, Srour M, Steindl K, Syrbe S, Taylor JC, Telegrafi A, Thiffault I, Trauner DA, van der Linden H Jr, van Koningsbruggen S, Villard L, Vogel I, Vogt J, Weber YG, Wentzensen IM, Widjaja E, Zak J, Baxter S, Banka S, Rodan LH (2019). Heterozygous Variants in KMT2E Cause a Spectrum of Neurodevelopmental Disorders and Epilepsy. Am J Hum Genet, 104(6), 1210-1222. (Read full article)
  10. Marro BS, Ware BC, Zak J, de la Torre JC, Rosen H, Oldstone MB (2017). Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling. Proc Natl Acad Sci U S A, 114(14), 3708-3713. (Read full article)
  11. Zak J, Vives V, Szumska D, Vernet A, Schneider JE, Miller P, Slee EA, Joss S, Lacassie Y, Chen E, Escobar LF, Tucker M, Aylsworth AS, Dubbs HA, Collins AT, Andrieux J, Dieux-Coeslier A, Haberlandt E, Kotzot D, Scott DA, Parker MJ, Zakaria Z, Choy YS, Wieczorek D, Innes AM, Jun KR, Zinner S, Prin F, Lygate CA, Pretorius P, Rosenfeld JA, Mohun TJ, Lu X (2016). ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome. Cell Death Differ, 23(12), 1973-1984. (Read full article)
  12. Zak J, Lu X (2015). Aspp1: A Guardian of Hematopoietic Stem Cell Integrity. Cell Stem Cell, 17(1), 3-5. (Read full article)
  13. Wang Y, Bu F, Royer C, Serres S, Larkin JR, Soto MS, Sibson NR, Salter V, Fritzsche F, Turnquist C, Koch S, Zak J, Zhong S, Wu G, Liang A, Olofsen PA, Moch H, Hancock DC, Downward J, Goldin RD, Zhao J, Tong X, Guo Y, Lu X (2014). ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1. Nat Cell Biol, 16(11), 1092-104. (Read full article)
  14. Royer C, Koch S, Qin X, Zak J, Buti L, Dudziec E, Zhong S, Ratnayaka I, Srinivas S, Lu X (2014). ASPP2 links the apical lateral polarity complex to the regulation of YAP activity in epithelial cells. PLoS One, 9(10), e111384. (Read full article)
  15. Lu M, Zak J, Chen S, Sanchez-Pulido L, Severson DT, Endicott J, Ponting CP, Schofield CJ, Lu X (2013). A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway. Cell, 157(5), 1130-45. (Read full article)
  16. Koblizek V, Chlumsky J, Zindr V, Neumannova K, Zatloukal J, Zak J, Sedlak V, Kocianova J, Zatloukal J, Hejduk K, Pracharova S, Czech Pneumological and Phthisiological Society (2013). Chronic Obstructive Pulmonary Disease: official diagnosis and treatment guidelines of the Czech Pneumological and Phthisiological Society; a novel phenotypic approach to COPD with patient-oriented care. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 157(2), 189-201. (Read full article)
  17. Zak J, Ron D, Riva E, Harding HP, Cross BC, Baxendale IR (2012). Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds. Chemistry—A European Journal, 18(32), 9901-10. (Read full article)
  18. Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D, Harding HP (2012). The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A, 109(15), E869-78. (Read full article)

Editorial

  1. Zak J, Schuster-Boeckler B, Bond G (2016). Cancer Genetics May Aid Diagnostics of Developmental Disorders. Hum Mutat, 37(10), 989. (Read full article)