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Luis Francisco Zirnberger Batista, PhD

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine

Divisions: Hematology & Hematologic Malignancies

Education History

Postdoctoral Training Stanford University
 Postdoctoral Scholar
Doctoral Training University of Sao Paulo (Brazil) and University of Mainz (Germany)
 PhD
Undergraduate University of Sao Paulo
 BSc

Selected Publications

Journal Article

  1. Mendoza-Castrejon J, Yang W, Denby ED, Wang HC, Casey EB, Muthukumar R, Patel RM, Yoon J, Li Y, White JM, Chen R, Batista LFZ, Magee JA (2025). Fetal context conveys heritable protection against MLL-rearranged AML that depends on MLL3. Blood. (Read full article)
  2. Camacho V, Bekendam R, Stone AP, Barrachina MN, Branfield S, Carminita E, Becker IC, Lee DH, Walsey E, Payne C, Kaplan JP, Tilburg J, Pal S, Batista LFZ, Italiano JE Jr, Machlus KR (2025). Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production. Blood Adv. (Read full article)
  3. Collins TB, Laranjeira ABA, Kong T, Fulbright MC, Fisher DAC, Sturgeon CM, Batista LFZ, Oh ST (2024). Altered erythropoiesis via JAK2 and ASXL1 mutations in myeloproliferative neoplasms. Exp Hematol, 132, 104178. (Read full article)
  4. Jeong HC, Shukla S, Fok WC, Huynh TN, Batista LFZ, Parker R Co-Corresponding Author (2023). USB1 is a miRNA deadenylase that regulates hematopoietic development. Science, 379(6635), 901-907. (Read full article)
  5. Vessoni AT, Zhang T, Quinet A, Jeong HC, Munroe M, Wood M, Tedone E, Vindigni A, Shay JW, Greenberg RA, Batista LFZ (2020). Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe. J Cell Biol, 220(6). (Read full article)
  6. Munroe M, Niero EL, Fok WC, Vessoni AT, Jeong HC, Brenner KA, Batista LFZ (2020). Telomere Dysfunction Activates p53 and Represses HNF4α Expression Leading to Impaired Human Hepatocyte Development and Function. Hepatology, 72(4), 1412-1429. (Read full article)
  7. Shukla S, Jeong HC, Sturgeon CM, Parker R, Batista LFZ (2020). Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita. Blood Adv, 4(12), 2717-2722. (Read full article)
  8. Quinet A, Tirman S, Jackson J, vikovi S, Lemaon D, Carvajal-Maldonado D, Gonzlez-Acosta D, Vessoni AT, Cybulla E, Wood M, Tavis S, Batista LFZ, Mndez J, Sale JE, Vindigni A (2019). PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells. Mol Cell, 77(3), 461-474.e9. (Read full article)
  9. Fok WC, Shukla S, Vessoni AT, Brenner KA, Parker R, Sturgeon CM, Batista LFZ (2019). Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita. Blood, 133(12), 1308-1312. (Read full article)
  10. Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ (2018). Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation. Thorax, 73(5), 489-492. (Read full article)
  11. Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S (2017). A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin. Cell Rep, 22(8), 2006-2015. (Read full article)
  12. Fok WC, Niero ELO, Dege C, Brenner KA, Sturgeon CM, Batista LFZ Co-Corresponding Author (2017). p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita. Stem Cell Reports, 9(2), 409-418. (Read full article)
  13. Fok WC, Batista LFZ (2017). Stressed ends: telomere attrition in chronic diseases. Rev Bras Hematol Hemoter, 39(2), 98-99. (Read full article)
  14. Huh CJ, Zhang B, Victor MB, Dahiya S, Batista LF, Horvath S, Yoo AS (2016). Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts. Elife, 5. (Read full article)
  15. Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, OBrien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J, Wernig M (2014). Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis. Cell Stem Cell, 16(1), 39-50. (Read full article)
  16. Zhong FL, Batista LF, Freund A, Pech MF, Venteicher AS, Artandi SE (2012). TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell, 150(3), 481-94. (Read full article)
  17. Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Ramirez CL, Batista LF, Artandi SE, Wernig M, Joung JK (2011). In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells, 29(11), 1717-26. (Read full article)
  18. Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera RA, Artandi SE (2011). Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature, 474(7351), 399-402. (Read full article)
  19. Saffi J, Agnoletto MH, Guecheva TN, Batista LF, Carvalho H, Henriques JA, Stary A, Menck CF, Sarasin A (2009). Effect of the anti-neoplastic drug doxorubicin on XPD-mutated DNA repair-deficient human cells. DNA Repair (Amst), 9(1), 40-7. (Read full article)
  20. Batista LF, Artandi SE (2009). Telomere uncapping, chromosomes, and carcinomas. Cancer Cell, 15(6), 455-7. (Read full article)
  21. Batista LF, Roos WP, Kaina B, Menck CF (2009). p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal. Mol Cancer Res, 7(2), 237-46. (Read full article)
  22. Batista LF, Roos WP, Christmann M, Menck CF, Kaina B (2007). Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks. Cancer Res, 67(24), 11886-95. (Read full article)
  23. Roos WP, Batista LF, Naumann SC, Wick W, Weller M, Menck CF, Kaina B (2006). Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene, 26(2), 186-97. (Read full article)
  24. Batista LF, Chiganas V, Brumatti G, Amarante-Mendes GP, Menck CF (2006). Involvement of DNA replication in ultraviolet-induced apoptosis of mammalian cells. Apoptosis, 11(7), 1139-48. (Read full article)
  25. Chiganas V, Batista LF, Brumatti G, Amarante-Mendes GP, Yasui A, Menck CF (2002). Photorepair of RNA polymerase arrest and apoptosis after ultraviolet irradiation in normal and XPB deficient rodent cells. Cell Death Differ, 9(10), 1099-107. (Read full article)

Review

  1. Chen L, Batista LFZ (2025). Biogenesis and Regulation of Telomerase during Development and Cancer (Epub ahead of print). [Review]. Cold Spring Harb Perspect Biol.
  2. Batista LFZ, Dokal I, Parker R Co-Corresponding Author (2022). Telomere biology disorders: time for moving towards the clinic? [Review]. Trends Mol Med, 28(10), 882-891. (Read full article)
  3. Vessoni AT, Filippi-Chiela EC, Lenz G, Batista LFZ (2019). Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence. [Review]. Oncogene, 39(10), 2055-2068. (Read full article)
  4. Batista LF, Artandi SE (2013). Understanding telomere diseases through analysis of patient-derived iPS cells. [Review]. Curr Opin Genet Dev, 23(5), 526-33. (Read full article)
  5. Batista LFZ, Kaina B, Meneghini R, Menck CFM (2008). How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis. [Review]. Mutat Res, 681(2-3), 197-208. (Read full article)

Letter

  1. Arruda-Neto JD, Friedberg EC, Bittencourt-Oliveira MC, Segreto HR, Moron MM, Maria DA, Batista LF, Schenberg AC (2010). The role played by endogenous and exogenous electric fields in DNA signaling and repair. [Letter to the editor]. DNA Repair (Amst), 9(4), 356-7. (Read full article)