No profile photo available

Luis Francisco Zirnberger Batista, PhD

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine

Divisions: Hematology & Hematologic Malignancies

Education History

Undergraduate University of Sao Paulo
 BSc
Doctoral Training University of Sao Paulo (Brazil) and University of Mainz (Germany)
 PhD
Postdoctoral Training Stanford University
 Postdoctoral Scholar

Selected Publications

Journal Article

  1. Chiganças V, Batista LF, Brumatti G, Amarante-Mendes GP, Yasui A, Menck CF (2002). Photorepair of RNA polymerase arrest and apoptosis after ultraviolet irradiation in normal and XPB deficient rodent cells. Cell Death Differ, 9(10), 1099-107.
  2. Batista LF, Chiganças V, Brumatti G, Amarante-Mendes GP, Menck CF (2006). Involvement of DNA replication in ultraviolet-induced apoptosis of mammalian cells. Apoptosis, 11(7), 1139-48.
  3. Roos WP, Batista LF, Naumann SC, Wick W, Weller M, Menck CF, Kaina B (2007). Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene, 26(2), 186-97.
  4. Batista LF, Roos WP, Christmann M, Menck CF, Kaina B (2007). Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks. Cancer Res, 67(24), 11886-95.
  5. Batista LF, Roos WP, Kaina B, Menck CF (2009). p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal. Mol Cancer Res, 7(2), 237-46.
  6. Saffi J, Agnoletto MH, Guecheva TN, Batista LF, Carvalho H, Henriques JA, Stary A, Menck CF, Sarasin A (2010). Effect of the anti-neoplastic drug doxorubicin on XPD-mutated DNA repair-deficient human cells. DNA Repair (Amst), 9(1), 40-7.
  7. Batista LF, Artandi SE (2009). Telomere uncapping, chromosomes, and carcinomas. Cancer Cell, 15(6), 455-7.
  8. Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera RA, Artandi SE (2011). Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature, 474(7351), 399-402.
  9. Munroe M, Niero EL, Fok WC, Vessoni AT, Jeong HC, Brenner KA, Batista LFZ (2020). Telomere Dysfunction Activates p53 and Represses HNF4¿ Expression Leading to Impaired Human Hepatocyte Development and Function. Hepatology, 72(4), 1412-1429.
  10. Vessoni AT, Zhang T, Quinet A, Jeong HC, Munroe M, Wood M, Tedone E, Vindigni A, Shay JW, Greenberg RA, Batista LFZ (2021). Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe. J Cell Biol, 220(6).
  11. Zhong FL, Batista LF, Freund A, Pech MF, Venteicher AS, Artandi SE (2012). TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell, 150(3), 481-94.
  12. Fok WC, Batista LFZ (2017). Stressed ends: telomere attrition in chronic diseases. Rev Bras Hematol Hemoter, 39(2), 98-99.
  13. Fok WC, Niero ELO, Dege C, Brenner KA, Sturgeon CM*, Batista LFZ* (*Co-Corresponding Author) (2017). p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita. Stem Cell Reports, 9(2), 409-418.
  14. Fok WC, Shukla S, Vessoni AT, Brenner KA, Parker R, Sturgeon CM, Batista LFZ (2019). Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita. Blood, 133(12), 1308-1312.
  15. Shukla S, Jeong HC, Sturgeon CM, Parker R, Batista LFZ (2020). Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita. Blood Adv, 4(12), 2717-2722.
  16. Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Ramirez CL, Batista LF, Artandi SE, Wernig M, Joung JK (2011). In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells, 29(11), 1717-26.
  17. Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O'Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J, Wernig M (2015). Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis. Cell Stem Cell, 16(1), 39-50.
  18. Huh CJ, Zhang B, Victor MB, Dahiya S, Batista LF, Horvath S, Yoo AS (2016). Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts. Elife, 5.
  19. Kreienkamp R, Graziano S, Coll-Bonfill N, Bedia-Diaz G, Cybulla E, Vindigni A, Dorsett D, Kubben N, Batista LFZ, Gonzalo S (2018). A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin. Cell Rep, 22(8), 2006-2015.
  20. Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ (2018). Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation. Thorax, 73(5), 489-492.
  21. Quinet A, Tirman S, Jackson J, ¿vikovi¿ S, Lemaçon D, Carvajal-Maldonado D, González-Acosta D, Vessoni AT, Cybulla E, Wood M, Tavis S, Batista LFZ, Méndez J, Sale JE, Vindigni A (2020). PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells. Mol Cell, 77(3), 461-474.e9.
  22. Jeong HC, Shukla S, Fok WC, Huynh TN, Batista LFZ*, Parker R* (*Co-Corresponding Author) (2023). USB1 is a miRNA deadenylase that regulates hematopoietic development. Science, 379(6635), 901-907.
  23. Collins TB, Laranjeira ABA, Kong T, Fulbright MC, Fisher DAC, Sturgeon CM, Batista LFZ, Oh ST (2024). Altered erythropoiesis via JAK2 and ASXL1 mutations in myeloproliferative neoplasms. Exp Hematol, 132, 104178.
  24. Mendoza-Castrejon J, Yang W, Denby ED, Wang HC, Casey EB, Muthukumar R, Patel RM, Yoon J, Li Y, White JM, Chen R, Batista LFZ, Magee J (2025). Fetal context conveys heritable protection against MLL-rearranged AML that depends on MLL3. Blood,
  25. Camacho V, Bekendam R, Stone AP, Barrachina MN, Branfield S, Carminita E, Becker IC, Lee DH, Walsey E, Payne C, Kaplan JP, Tilburg J, Pal S, Batista LFZ, Italiano JE Jr, Machlus K (2025). Induction of Moderate DNA Damage Enhances Megakaryopoiesis and Platelet Production. Blood advances,

Review

  1. Batista LFZ, Kaina B, Meneghini R, Menck CFM (2009). How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis. [Review]. Mutat Res, 681, (2-3), 197-208.
  2. Batista LF, Artandi SE (2013). Understanding telomere diseases through analysis of patient-derived iPS cells. [Review]. Curr Opin Genet Dev, 23, (5), 526-33.
  3. Batista LFZ*, Dokal I*, Parker R* (*Co-Corresponding Author) (2022). Telomere biology disorders: time for moving towards the clinic? [Review]. Trends Mol Med, 28, (10), 882-891.
  4. Vessoni AT, Filippi-Chiela EC, Lenz G, Batista LFZ (2020). Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence. [Review]. Oncogene, 39, (10), 2055-2068.
  5. Chen L, Batista LF (2025). Biogenesis and Regulation of Telomerase during Development and Cancer (Epub ahead of print). Cold Spring Harbor perspectives in biology,

Letter

  1. Arruda-Neto JD, Friedberg EC, Bittencourt-Oliveira MC, Segreto HR, Moron MM, Maria DA, Batista LF, Schenberg AC (2010). The role played by endogenous and exogenous electric fields in DNA signaling and repair. [Letter to the editor]. DNA Repair (Amst), 9(4), 356-7.