Cancer cells hijack mechanisms of normal development. In a complex milieu of an animal, in which there are many different signals from many different cells, how does a cell parse through this information to know when and where to migrate? Our long term research goal is to identify these signals, how they are communicated, and how they are interpreted into a downstream response to regulate cell motility during development and cancer. We use a combination of animal models (zebrafish and mouse) and cell culture based models, taking advantage of the strengths of each system to answer outstanding questions in cancer cell biology.
Selected Publications
Journal Article
- Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J (2017). Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Dev Cell, 45(6), 738-752.e6. (Read full article)