Natalya N. Pavlova

Natalya N. Pavlova, PhD

Academic Information

Departments Primary - Oncological Sciences

Education History

Doctoral Training Harvard University Graduate School of Arts & Sciences
 PhD
University of Virginia
 BS
Undergraduate Novosibirsk State University

Selected Publications

Journal Article

  1. Ranea-Robles P, Pavlova NN, Bender A, Pereyra AS, Ellis JM, Stauffer B, Yu C, Thompson CB, Argmann C, Puchowicz M, Houten SM (2022). A mitochondrial long-chain fatty acid oxidation defect leads to tRNA uncharging and activation of the integrated stress response in the mouse heart. Cardiovasc Res. (Read full article)
  2. Schwrer S, Pavlova NN, Cimino FV, King B, Cai X, Sizemore GM, Thompson CB (2021). Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment. Nat Metab, 3(11), 1484-1499. (Read full article)
  3. Pavlova NN, King B, Josselsohn RH, Violante S, Macera VL, Vardhana SA, Cross JR, Thompson CB (2020). Translation in amino-acid-poor environments is limited by tRNAGln charging. Elife, 9. (Read full article)
  4. Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J (2019). Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. J Biol Chem, 294(49), 18674-18684. (Read full article)
  5. Jiang J, Pavlova NN, Zhang J (2018). Asparagine, a critical limiting metabolite during glutamine starvation. Mol Cell Oncol, 5(3), e1441633. (Read full article)
  6. Palm W, Park Y, Wright K, Pavlova NN, Tuveson DA, Thompson CB (2015). The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1. Cell, 162(2), 259-270. (Read full article)
  7. Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ (2013). A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife, 2, e00358. (Read full article)
  8. Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ (2013). Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Nat Biotechnol, 31(4), 331-334. (Read full article)
  9. Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ (2013). STOP gene Phactr4 is a tumor suppressor. Proc Natl Acad Sci U S A, 110(5), E407-14. (Read full article)
  10. Larman HB, Xu GJ, Pavlova NN, Elledge SJ (2012). Construction of a rationally designed antibody platform for sequencing-assisted selection. Proc Natl Acad Sci U S A, 109(45), 18523-8. (Read full article)
  11. Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF (2010). Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell, 144(5), 703-18. (Read full article)
  12. Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi Y (2008). CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell, 32(5), 718-26. (Read full article)
  13. Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ (2007). SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature, 452(7185), 370-4. (Read full article)
  14. Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR (2007). The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J, 26(21), 4523-34. (Read full article)

Review

  1. Pavlova NN, Zhu J, Thompson CB (2022). The hallmarks of cancer metabolism: Still emerging. [Review]. Cell Metab, 34(3), 355-377. (Read full article)
  2. Zhang J, Pavlova NN, Thompson CB (2017). Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine. [Review]. EMBO J, 36(10), 1302-1315. (Read full article)
  3. Pavlova NN, Thompson CB (2016). The Emerging Hallmarks of Cancer Metabolism. [Review]. Cell Metab, 23(1), 27-47. (Read full article)

Book Chapter

  1. Pavlova NN, Thompson CB (2017). Cancer Metabolism. In Bast RC, Croce CM, Hait WN, Hong WK, Kufe DW, Piccart-Gebhart M, Pollock RE, Weichselbaum RR, Wang H, Holland JF (Eds.), Holland-Frei Cancer Medicine 9 (9th Edition). Wiley-Blackwell.