Niladri K. Sinha

Niladri K. Sinha, PhD

Languages spoken: English

Academic Information

Departments Primary - Biochemistry

Academic Office Information

niladri.sinha@biochem.utah.edu

Lab

My laboratory studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.

Research Statement

My laboratory studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress. Specifically, we aim to: (1) elucidate how ribosomes detect and respond to ribotoxic stress, and (2) identify and characterize ribosome-mediated quality control and signaling pathways that regulate cellular homeostasis and cell fate decisions in response to translational stress.

Education History

Undergraduate St. Xavier¿s College, University of Calcutta
 BSc (Hons)
Graduate Training University of Calcutta
 MSc
Doctoral Training University of Utah
 PhD

Selected Publications

Journal Article

  1. Sinha NK, McKenney C, Yeow ZY, Li JJ, Nam KH, Yaron-Barir TM, Johnson JL, Huntsman EM, Cantley LC, Ordureau A, Regot S, Green R (2024). The ribotoxic stress response drives UV-mediated cell death. Cell, 187(14), 3652-3670.e40.
  2. McKenney C, Lendner Y, Guerrero Zuniga A, Sinha N, Veresko B, Aikin TJ, Regot S (2024). CDK4/6 activity is required during G(2) arrest to prevent stress-induced endoreplication. Science, 384(6695), eadi2421.
  3. Zhao S, Cordes J, Caban KM, Götz MJ, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R, Stingele J (2023). RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks. Mol Cell, 83(23), 4290-4303.e9.
  4. Livingston NM, Kwon J, Valera O, Saba JA, Sinha NK, Reddy P, Nelson B, Wolfe C, Ha T, Green R, Liu J, Wu B (2023). Bursting translation on single mRNAs in live cells. Mol Cell, 83(13), 2276-2289.e11.
  5. Zinshteyn B, Sinha NK, Enam SU, Koleske B, Green R (2021). Translational repression of NMD targets by GIGYF2 and EIF4E2. PLoS Genet, 17(10), e1009813.
  6. Sinha NK, Ordureau A, Best K, Saba JA, Zinshteyn B, Sundaramoorthy E, Fulzele A, Garshott DM, Denk T, Thoms M, Paulo JA, Harper JW, Bennett EJ, Beckmann R, Green R (2020). EDF1 coordinates cellular responses to ribosome collisions. Elife, 9.
  7. Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK (2020). GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control. Mol Cell, 79(6), 950-962.e6.
  8. D'Orazio KN, Wu CC, Sinha N, Loll-Krippleber R, Brown GW, Green R (2019). The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay. Elife, 8.
  9. Sinha NK, Iwasa J, Shen PS, Bass BL (2018). Dicer uses distinct modules for recognizing dsRNA termini. Science, 359(6373), 329-334.
  10. Trettin KD, Sinha NK, Eckert DM, Apple SE, Bass BL (2017). Loquacious-PD facilitates Drosophila Dicer-2 cleavage through interactions with the helicase domain and dsRNA. Proc Natl Acad Sci U S A, 114(38), E7939-E7948.
  11. Sinha NK, Bass BL (2017). Overexpression and purification of Dicer and accessory proteins for biochemical and structural studies. Methods, 126, 54-65.
  12. Sinha NK, Trettin KD, Aruscavage PJ, Bass BL (2015). Drosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD. Mol Cell, 58(3), 406-17.
  13. Sinha NK, Roy A, Das B, Das S, Basak S (2009). Evolutionary complexities of swine flu H1N1 gene sequences of 2009. Biochem Biophys Res Commun, 390(3), 349-51.
  14. De La Cruz AC, Tisdale G, Nakayama E, Huang Z, Sinha NK, Green R, Wu B (2025). Single-protein/RNA imaging reveals ZNF598 as a limiting factor in resolving collided ribosomes.(Epub ahead of print). EMBO J.