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Sara St. James

Sara St. James, PhD, DABR

Languages spoken: English

Academic Information

Departments Primary - Radiation Oncology

Academic Office Information

Board Certification

  • American Board of Radiology (Therapeutic Medical Physics)

Education History

Certification Harvard Medical School
University of California, Davis
Graduate Training McGill University
Carleton University

Selected Publications

Journal Article

  1. Tranel J, Palm S, Feng FY, St James S, Hope TA (2024). Technical note: Errors introduced when using Dose Voxel Kernels for estimating absorbed dose from radiopharmaceutical therapies involving alpha emitters. Med Phys. (Read full article)
  2. Zhao H, Sarkar V, St James S, Paxton A, Su FF, Price RG, Dial C, Poppe M, Gaffney D, Salter B (2024). Verification of surface-guided radiation therapy (SGRT) alignment for proton breast and chest wall patients by comparison to CT-on-rails and kV-2D alignment. J Appl Clin Med Phys, 25(2), e14263. (Read full article)
  3. Rebolo L, Trigila C, Ellin J, Correia PMM, Silva AL, Veloso J, St James S, Roncali E, Ario-Estrada G (2023). Cherenkov Light Emission in Pure Cherenkov Emitters for Prompt Gamma Imaging. IEEE Trans Radiat Plasma Med Sci, 8(1), 15-20. (Read full article)
  4. Hopfensperger KM, Li X, Paxton A, Sarkar V, Su FF, Price RG, Salter B, St James S (2023). Measurements of fetal dose with Mevion S250i proton therapy system with HYPERSCAN. J Appl Clin Med Phys, 24(5), e13957. (Read full article)
  5. Sgouros G, Dewaraja YK, Escorcia F, Graves SA, Hope TA, Iravani A, Pandit-Taskar N, Saboury B, St James S, Zanzonico PB (2021). Tumor Response to Radiopharmaceutical Therapies: The Knowns and the Unknowns. J Nucl Med, 62(Suppl 3), 12S-22S. (Read full article)
  6. Capala J, Graves SA, Scott A, Sgouros G, St James S, Zanzonico P, Zimmerman BE (2021). Dosimetry for Radiopharmaceutical Therapy: Current Practices and Commercial Resources. J Nucl Med, 62(Suppl 3), 3S-11S. (Read full article)
  7. Laforest R, Khalighi M, Natsuaki Y, Rajagopal A, Chandramohan D, Byrd D, An H, Larson P, St James S, Sunderland JJ, Kinahan PE, Hope TA (2021). Harmonization of PET image reconstruction parameters in simultaneous PET/MRI. EJNMMI Phys, 8(1), 75. (Read full article)
  8. St James S, Bednarz B, Benedict S, Buchsbaum JC, Dewaraja Y, Frey E, Hobbs R, Grudzinski J, Roncali E, Sgouros G, Capala J, Xiao Y (2020). Current Status of Radiopharmaceutical Therapy. Int J Radiat Oncol Biol Phys, 109(4), 891-901. (Read full article)
  9. Tranel J, Feng FY, St James S, Hope TA (2021). Effect of microdistribution of alpha and beta-emitters in targeted radionuclide therapies on delivered absorbed dose in a GATE model of bone marrow. Phys Med Biol, 66(3), 035016. (Read full article)
  10. Roncali E, Capala J, Benedict SH, Akabani G, Bednarz B, Bhadrasain V, Bolch WE, Buchsbaum JC, Coleman NC, Dewaraja YK, Frey E, Ghaly M, Grudzinski J, Hobbs RF, Howell RW, Humm JL, Kunos CL, Larson S, Lin FI, Madsen M, Mirzadeh S, Morse D, Pryma D, Sgouros G, St James S, Wahl RW, Xiao Y, Zanzonico P, Zukotynski K (2021). Overview of the First NRG Oncology–National Cancer Institute Workshop on Dosimetry of Systemic Radiopharmaceutical Therapy. Journal of Nuclear Medicine, 62, 1133-1139.
  11. St James S, Grassberger C, Lu HM (2018). Considerations when treating lung cancer with passive scatter or active scanning proton therapy. Transl Lung Cancer Res, 7(2), 210-215. (Read full article)
  12. Tseng YD, Wootton L, Nyflot M, Apisarnthanarax S, Rengan R, Bloch C, Sandison G, St James S (2018). 4D computed tomography scans for conformal thoracic treatment planning: is a single scan sufficient to capture thoracic tumor motion? Phys Med Biol, 63(2), 02NT03. (Read full article)
  13. Saini J, Maes D, Egan A, Bowen SR, St James S, Janson M, Wong T, Bloch C (2017). Dosimetric evaluation of a commercial proton spot scanning Monte-Carlo dose algorithm: comparisons against measurements and simulations. Phys Med Biol, 62(19), 7659-7681. (Read full article)
  14. Saini J, Bowen SL, St James S, Wong T, Bloch CD (2017). Evaluation of ceramic marker for the treatment of ocular melanoma with proton therapy. Biomed Phys Eng Express, 3(2).
  15. Berman AT, St James S, Rengan R (2015). Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions. Cancers (Basel), 7(3), 1178-90. (Read full article)
  16. Koybasi O, Mishra P, St James S, Lewis JH, Seco J (2014). Simulation of dosimetric consequences of 4D-CT-based motion margin estimation for proton radiotherapy using patient tumor motion data. Phys Med Biol, 59(4), 853-67. (Read full article)
  17. St James S, Seco J, Mishra P, Lewis JH (2013). Simulations using patient data to evaluate systematic errors that may occur in 4D treatment planning: a proof of concept study. Med Phys, 40(9), 091706. (Read full article)
  18. Williams CL, Mishra P, Seco J, St James S, Mak RH, Berbeco RI, Lewis JH (2013). A mass-conserving 4D XCAT phantom for dose calculation and accumulation. Med Phys, 40(7), 071728. (Read full article)
  19. Mishra P, Li R, St James S, Mak RH, Williams CL, Yue Y, Berbeco RI, Lewis JH (2013). Evaluation of 3D fluoroscopic image generation from a single planar treatment image on patient data with a modified XCAT phantom. Phys Med Biol, 58(4), 841-58. (Read full article)
  20. Mishra P, St James S, Segars WP, Berbeco RI, Lewis JH (2012). Adaptation and applications of a realistic digital phantom based on patient lung tumor trajectories. Phys Med Biol, 57(11), 3597-608. (Read full article)
  21. St James S, Mishra P, Hacker F, Berbeco RI, Lewis JH (2012). Quantifying ITV instabilities arising from 4DCT: a simulation study using patient data. Phys Med Biol, 57(5), L1-7. (Read full article)
  22. Yang YSt James S, Wu Y, Du H, Qi J, Farrell R, Dokhale PA, Shah KS, Vaigneur K, Cherry SR (2010). Tapered LSO arrays for small animal PET. Phys Med Biol, 56(1), 139-53. (Read full article)
  23. St James S, Yang Y, Bowen SL, Qi J, Cherry SR (2009). Simulation study of spatial resolution and sensitivity for the tapered depth of interaction PET detectors for small animal imaging. Phys Med Biol, 55(2), N63-74. (Read full article)
  24. St James S, Yang Y, Wu Y, Farrell R, Dokhale P, Shah KS, Cherry SR (2009). Experimental characterization and system simulations of depth of interaction PET detectors using 0.5 mm and 0.7 mm LSO arrays. Phys Med Biol, 54(14), 4605-19. (Read full article)
  25. Yang Y, Qi J, Wu Y, St James S, Farrell R, Dokhale PA, Shah KS, Cherry SR (2008). Depth of interaction calibration for PET detectors with dual-ended readout by PSAPDs. Phys Med Biol, 54(2), 433-45. (Read full article)
  26. Yang Y, Wu Y, Qi J, St James S, Du H, Dokhale PA, Shah KS, Farrell R, Cherry SR (2008). A prototype PET scanner with DOI-encoding detectors. J Nucl Med, 49(7), 1132-40. (Read full article)
  27. St James S, Thompson CJ (2006). Image blurring due to light-sharing in PET block detectors. Med Phys, 33(2), 405-10. (Read full article)


  1. Xiao Y, Roncali E, Hobbs R, St James S, Bednarz B, Benedict S, Dewaraja YK, Frey E, Grudzinski J, Sgouros G, Buchsbaum JC, Capala J (2020). Toward Individualized Voxel-Level Dosimetry for Radiopharmaceutical Therapy. Int J Radiat Oncol Biol Phys, 109(4), 902-904. (Read full article)