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Shami Kanekar

Shami Kanekar, PhD

Languages spoken: English

Academic Information

Departments Primary - Psychiatry

Divisions: Adult Psychiatry

Academic Office Information

Research Interests

  • Depression

Education History

Fellowship University of Utah, Department of Physiology
Postdoctoral Fellow
La Jolla Cancer Research Foundation
Postdoctoral Fellow
Doctoral Training University of Iowa Neuroscience Program
University of Bombay
Undergraduate University of Bombay

Selected Publications

Journal Article

  1. Prescot A, Huber R, Kanekar S, Kondo D, Prisciandaro J, Ongur D, Renshaw PF (2021). Effect of moderate altitude on human cerebral metabolite levels: A preliminary, multi-site, proton magnetic resonance spectroscopy investigation. Psychiatry Res Neuroimaging, 314, 111314.
  2. Kanekar S, Ettaro R, Hoffman MD, Ombach HJ, Brown J, Lynch C, Sheth CS, Renshaw PF (2021). Sex-Based Impact of Creatine Supplementation on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-Resistant Depression. Int J Mol Sci, 22(15).
  3. Kanekar S, Sheth C, Ombach H, Brown J, Hoffman M, Ettaro R, Renshaw P (2021). Sex-based changes in rat brain serotonin and behavior in a model of altitude-related vulnerability to treatment-resistant depression. Psychopharmacology (Berl), 238, 2867-2881.
  4. Ombach HJ, Scholl LS, Bakian AV, Renshaw KT, Sung YH, Renshaw PF, S Kanekar (2019). Association Between Altitude, Prescription Opioid Misuse, and Fatal Overdoses. Addict Behav Rep, 9, 1000167.
  5. Kanekar S, Sheth CS, Olson PR, Bogdanova OV, Ombach H, M Petersen, Renshaw CE, Sung YH, DAnci KE, Renshaw, PF (2018). Hypobaric Hypoxia Exposure in Rats Differentially Alters Antidepressant Efficacy of the Selective Serotonin Reuptake Inhibitors Fluoxetine, Paroxetine, Escitalopram and Sertraline. Pharmacol Biochem Behav, 170, 25-35.
  6. Sheth CS, Ombach HJ, Olson PR, Renshaw PF, Kanekar S (2018). Increased Anxiety And Anhedonia In Female Rats Following Exposure To Altitude. High Alt Med Biol, 19(1), 81-90.
  7. Kanekar S, Bogdanova OV, Olson PR, Sung YH, DAnci KE, Renshaw PF (2015). Hypobaric Hypoxia induces Depression-like Behavior in Female Sprague Dawley Rats, but not in Males. High Alt Med Biol, 16(1), 52-60.
  8. Bogdanova OV, Abdullah O, Kanekar S, Bogdanov VB, Prescot AP, Renshaw PF (2014). Neurochemical Alterations in the Frontal Cortex of the rat after one week of hypobaric hypoxia. Behav Brain Res, 263(263), 203-209.
  9. Hartmann JS, Thompson H, Wang H, Kanekar S, Huang W, Budd SJ, Hartnett ME (2011). Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity. Mol Vis, 17, 1577-87.
  10. Kanekar S, Gandham M, Lucero MT (2010). PACAP protects against TNFalpha-induced cell death in olfactory epithelium and olfactory placodal cell lines. Mol Cell Neurosci, 45(4), 345-54.
  11. Kanekar S, Jia C, Hegg CC (2009). Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices. J Neurosci Res, 87(6), 1424-34.
  12. Sun Y, Kanekar SL, Vetter ML, Gorski S, Jan YN, Glaser T, Brown NL (2003). Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes. Evol Dev, 5(5), 532-41.
  13. Tucker P, Laemle L, Munson A, Kanekar S, Oliver ER, Brown N, Schlecht H, Vetter M, Glaser T (2001). The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene. Genesis, 31(1), 43-53.
  14. Brown NL, Kanekar S, Vetter ML, Tucker PK, Gemza DL, Glaser T (1998). Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis. Development, 125(23), 4821-33.
  15. Perron M, Kanekar S, Vetter ML, Harris WA (1998). The genetic sequence of retinal development in the ciliary margin of the Xenopus eye. Dev Biol, 199(2), 185-200.
  16. Kanekar S, Perron M, Dorsky R, Harris WA, Jan LY, Jan YN, Vetter ML (1997). Xath5 participates in a network of bHLH genes in the developing Xenopus retina. Neuron, 19(5), 981-94.
  17. Kanekar S, Ritchie TC, Coulter JD (1993). Spinal cord afferent systems containing the nerve terminal protein NT75. J Comp Neurol, 332(2), 198-212.


  1. Kanekar S and Renshaw PF (2019). The Impact of Living at Altitude on Depression and Antidepressant Function in Utah Women: The Need for Novel Antidepressants. [Review].
  2. Gould TD, Georgiou P, Brenner LA, Brundin L, Can A, Courtet P, Donaldson Z, Dwivedi Y, Guillaume S, Gottesman II, Kanekar S, Lowry C, Renshaw PF, Rujescu D, Smith E, Turecki G, Zanos P, Zarate CA, Zunszain PA, Postolache TT (04/11/2017). Animal Models to Improve our Understanding and Treatment of Suicidal Behavior. [Review]. Transl Psychiatry, 7(4), 1-22.
  3. Bogdanova OV, Kanekar S, DAnci K, Renshaw PF (2013). Factors influencing behavior in the forced swim test. [Review]. Physiol Behav, 118, 227-239.


  1. Kanekar S (2020). An Animal Model for SSRI-Resistant Depression at Altitude: Brain Serotonin and Antidepressants Based on Bioenergetics. Talk for ACNP Meeting Panel on “Sex Differences in Depression: focus on factors that differentially affect females or males” session [Abstract]. 45, 1-67.
  2. Kanekar S, Sheth CS, Ombach HJ, Olson PR, Bogdanova OV, Petersen M, Renshaw CE, Sung YH, DAnci KE, Renshaw PF (2019). Improving Brain Bioenergetics may Improve Altitude-related Depression: Animal Model Studies. [Abstract]. 44, M139.
  3. CS Sheth, HJ Ombach, J Brown, PF Renshaw, and S Kanekar (2018). Living at Moderate Altitude May Alter Brain Monoamines to Worsen Mood and Substance Use Disorders: A Sex-based Animal Model Study [Abstract]. Neuropsychopharmacology, 43, S69.
  4. HJ Ombach1, LS Scholl, AV Bakian, KT Renshaw, YH Sung, PF Renshaw and S Kanekar (2018). Living at Altitude is an Independent Risk Factor for Increased Prescription Opioid Misuse and Fatal Overdose by Prescription Opioids [Abstract]. Neuropsychopharmacology, 43, S132.
  5. SES Smith, S Kanekar, J Lee, AD Plante, PF Renshaw, MB Scholand (05/14/18). Characterization of shared molecular pathways in depression and idiopathic pulmonary fibrosis [Abstract]. American Thoracic Society, 2018 Meeting.
  6. Kanekar S, Sheth CS, Olson PR, M Petersen, Bogdanova OV, Renshaw CE, Sung YH, DAnci KE, Renshaw, PF (2016). Differential Effects of the SSRIs Fluoxetine, Paroxetine, Escitalopram and Sertraline in a Rodent Model of Hypobaric Hypoxia-related Depression. [Abstract]. Neuropsychopharmacology, 41, S163.
  7. Kanekar S, Bogdanova OV, Olson PR, Renshaw CE, Sung YH, DAnci KE, Renshaw, PF (2015). Antidepressant Efficacy in a Rodent Model of Hypoxia-Related Depression: Do SSRIs Lose Efficacy at Altitude? [Abstract]. Neuropsychopharmacology, 40, S334.
  8. Kanekar S, Bogdanova OV, Olson PR, Nizam H, Ombach HJ, Renshaw CE, Sung Y, DAnci KE, and Renshaw, PF (2015). Methamphetamine preference in female rats in the conditioned place preference test increases at altitude. [Abstract]. Neuropsychopharmacology, 40, S424.
  9. Kanekar S, Bogdanova OV, Olson PR, DAnci KE, Sung YH, Renshaw PF (2014). Hypobaric hypoxia induces DLB and alters SSRI efficacy in female Sprague Dawley rats. [Abstract]. Society for Biological Psychiatry.


  1. S Kanekar, PF Renshaw (2022). Cyclocreatine as a therapeutic for depression and anxiety.
  2. S Kanekar, PF Renshaw (2018). Tianeptine and tianeptine metabolites as atypical antidepressants for hypoxia-related mood disorders and substance abuse.
  3. S Kanekar, PF Renshaw, B Kious, A Prescot, D Kondo (2014). Novel therapeutics for hypoxia-related depression and other forms of treatment-resistant depression.