T. Charles Casper

T. Charles Casper, PhD, MStat

Languages spoken: Italian, Portuguese, Spanish, English

Academic Information

Departments Adjunct - Family & Preventive Medicine , Primary - Pediatrics

Divisions: Public Health , Critical Care

After receiving his Ph.D. in Statistics with an emphasis in Biostatistics from the University of Wisconsin-Madison, Dr. Casper joined the faculty of the University of Utah School of Medicine as Assistant Professor of Pediatric Critical Care. He has collaborated with researchers from a variety of areas including cardiology, oncology, hematology, neurosurgery, nutrition, neurology, and emergency medicine, among others. Dr. Casper also co-authored a graduate level textbook on statistical methods for clinical trials.

Dr. Casper is currently biostatistician for the Pediatric Emergency Care Applied Research Network (PECARN). He is also currently leading the Data Coordinating and Analysis Center for the National Multiple Sclerosis Society's Network of Pediatric Multiple Sclerosis Centers (NPMSC) as principal investigator. Through these efforts, he has supervised study coordination, data collection, and analysis for several multi-center clinical trials and other studies. He also assists investigators at the university through the Study Design and Biostatistics Center of the Center for Clinical and Translational Science (CCTS).

Dr. Casper's research focus is clinical trial design and statistical methods for the analysis of clinical trial data. Statistical methods he is interested in are areas like survival analysis, longitudinal data, gene expression microarray analysis, and classification algorithms.

Education History

Undergraduate University of Utah
 BS
Graduate Training University of Utah
 MStat
Doctoral Training University of Wisconsin
 PhD

Selected Publications

Journal Article

  1. Chitnis T, Ness J, Krupp L, Waubant E, Hunt T, Rodriguez M, Lotze T, Gorman M, Belman A, Weinstock-Guttmann B, Aaen G, Patterson M, Rose J, Casper TC, for the U.S. Network of Pediatric MS Centers of Excellenc (2016). Clinical features of neuromyelitis optica in children: US Network of Pediatric MS Centers report. Neurology, 86(3), 245-52.
  2. King CA, Gipson Allen PY, Ahamed SI, Webb M, Casper TC, Brent D, Grupp-Phelan J, Rogers TA, Arango A, Al-Dajani N, McGuire TC, Bagge C (2023). 24-Hour warning signs for adolescent suicide attempts. Psychological medicine, 1-12. (Read full article)
  3. Tsze DS, Kuppermann N, Casper TC, Barney BJ, Richer LP, Liberman DB, Okada PJ, Morris CR, Myers SR, Soung JK, Mistry RD, Babcock L, Spencer SP, Johnson MD, Klein EJ, Quayle KS, Steele DW, Cruz AT, Rogers AJ, Thomas DG, Grupp-Phelan JM, Johnson TJ, Dayan PS, Pediatric Emergency Care Applied Research Network (PECARN (2023). Stratification of risk for emergent intracranial abnormalities in children with headaches: a Pediatric Emergency Care Applied Research Network (PECARN) study protocol. BMJ open, 13(11), e079040. (Read full article)
  4. Brown KM, Glaser NS, McManemy JK, DePiero A, Nigrovic LE, Quayle KS, Stoner MJ, Schunk JE, Trainor JL, Tzimenatos L, Rewers A, Myers SR, Kwok MY, Ghetti S, Casper TC, Olsen CS, Kuppermann N, Pediatric Emergency Care Applied Research Network Diabetic Ketoacidosis FLUID Study Grou (2023). Rehydration Rates and Outcomes in Overweight Children With Diabetic Ketoacidosis. Pediatrics, 152(6), (Read full article)
  5. Schoeps VA, Zhou X, Horton MK, Zhu F, McCauley KE, Nasr Z, Virupakshaiah A, Gorman MP, Benson LA, Weinstock-Guttman B, Waldman A, Banwell BL, Bar-Or A, Marrie RA, van Domselaar G, O'Mahony J, Mirza AI, Bernstein CN, Yeh EA, Casper TC, Lynch SV, Tremlett H, Baranzini S, Waubant E, US Network of Pediatric MS Center (2024). Short-chain fatty acid producers in the gut are associated with pediatric multiple sclerosis onset. Annals of clinical and translational neurology, 11(1), 169-84. (Read full article)
  6. Cruz AT, Palmer CA, Augustine EM, Casper TC, Dowshen N, Elsholz CL, Mollen CJ, Pickett ML, Schmidt SK, Stukus KS, Goyal MK, Reed J (2024). Concordance of Adolescent Gender, Race, and Ethnicity: Self-report Versus Medical Record Data. Pediatrics, 153(2), (Read full article)
  7. Calhoun ARUL, Lortz A, Casper TC, Carey J (2025). Extended Growth Curves for the Wolf-Hirschhorn Syndrome (4p-). American journal of medical genetics. Part A, 197(8), e64075. (Read full article)
  8. DeBar LL, Mayhew M, Wellman RD, Balderson BH, Dickerson JF, Elder CR, Justice M, Keefe FJ, McMullen CK, Owen-Smith AA, Rini C, Von Korff M, Waring S, Yarava A, Shen Z, Thompson RE, Clark AE, Casper TC, Cook A (2025). Telehealth and Online Cognitive Behavioral Therapy-Based Treatments for High-Impact Chronic Pain: A Randomized Clinical Trial. JAMA, (Read full article)
  9. Goyne C, Fair AE, Yilmaz D, Race J, Schuette A, Caillier SJ, Aaen GS, Abrams AW, Benson LA, Casper TC, Chitnis T, Gorman MP, Lotze TE, Krupp LB, Mar SS, Ness JM, Rensel M, Rodriguez M, Rose JW, Schreiner TL, Tillema JM, Waldman AT, Wheeler YS, Barcellos LF, Waubant E, Graves JS, as the US Network of Pediatric MS Center (2025). Epigenetic Aging in Pediatric-Onset Multiple Sclerosis. Neurology, 104(12), e213673. (Read full article)
  10. Yilmaz D, Adams C, Horton MK, Graves JS, Francisco C, Edwards A, Quach H, Quach D, Aaen G, Lotze T, Mar S, Ness J, Wheeler Y, Gorman MP, Benson L, Weinstock-Guttman B, Waldman A, Schreiner T, Tillema JM, Chitnis T, Rose J, Casper TC, Rensel M, Waubant E, Barcellos LF, Network of Pediatric Multiple Sclerosis Center (2025). Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis. Multiple sclerosis journal - experimental, translational and clinical, 11(2), 20552173251335625. (Read full article)
  11. MacRae R, Race J, Schuette A, Waltz M, Casper TC, Rose J, Abrams A, Rensel M, Waubant E, Virupakshaiah A, Schoeps V, O'Neill K, Ness J, Wheeler Y, Shukla N, Mar S, Rodriguez M, Chitnis T, Gorman M, Benson (2025). Limited early IVIG for the treatment of pediatric myelin oligodendrocyte glycoprotein antibody-associated disease. Multiple sclerosis and related disorders, 97, 106345. (Read full article)
  12. Chang G, Sebastian P, Virupakshaiah A, Schoeps VA, Cherbuin N, Casper TC, Gorman MP, Benson LA, Chitnis T, Rensel M, Abrams AW, Lotze T, Mar SS, Schreiner TL, Wheeler YS, Rose JW, Graves J, Krupp LB, Waldman AT, Lucas R, Waubant E, as the US Network of Pediatric Multiple Sclerosis Center (2025). Association Between Sun Exposure and Risk of Relapse in Pediatric-Onset Multiple Sclerosis. Neurology(R) neuroimmunology & neuroinflammation, 12(2), e200375. (Read full article)
  13. Krysko KM, Waltz M, Chitnis T, Weinstock-Guttman B, Aaen GS, Belman A, Benson LA, Gorman MP, Lotze TE, Mar SS, Moodley M, Ness JM, Rensel M, Rodriguez M, Rose JW, Edwards AR, Schreiner TL, Wheeler YS, Barney BJ, Waubant E, Casper TC, Graves JS, as the US Network of Pediatric MS Center (2025). Study of the Association Between Menarche and Disease Course in Pediatric Multiple Sclerosis. Neurology, 104(4), e210213. (Read full article)
  14. Schoeps VA, Bhargava P, Virupakshaiah A, Ladakis DC, Moseley C, Chong J, Aaen G, Graves JS, Benson L, Gorman MP, Rensel M, Abrams A, Mar S, Lotze TE, Chitnis T, Waldman A, Krupp L, Rodriguez M, Tillema JM, Rose J, Schreiner T, Qureshi F, Peterson S, Barcellos LF, Casper TC, Newman J, Borkowski K, Waubant E, US Network of Pediatric MS Center (2025). Distinct plasma lipids predict axonal injury and multiple sclerosis activity. Journal of neurology, neurosurgery, and psychiatry, 96(2), 150-157. (Read full article)
  15. Virupakshaiah A, Schoeps VA, Race J, Waltz M, Sharayah S, Nasr Z, Moseley CE, Zamvil SS, Gaudioso C, Schuette A, Casper TC, Rose J, Flanagan EP, Rodriguez M, Tillema JM, Chitnis T, Gorman MP, Graves JS, Benson LA, Rensel M, Abrams A, Krupp L, Lotze TE, Aaen G, Wheeler Y, Schreiner T, Waldman A, Chong J, Mar S, Waubant (2024). Predictors of a relapsing course in myelin oligodendrocyte glycoprotein antibody-associated disease. Journal of neurology, neurosurgery, and psychiatry, 96(1), 68-75. (Read full article)
  16. Wilson E, Meeks HD, Barney BJ, Waltz M, Canenguez K, Casper TC, Rose JW, Rodriguez M, Tillema JM, Chitnis T, Gorman MP, Rensel M, Abrams AW, Krupp LB, Lotze TE, Fisher KS, Shukla NM, Schreiner TL, Mar SS, Waubant E, Virupakshaiah A, Wheeler YS, Ness JM, Benson LA, as the United States Network of Pediatric Multiple Sclerosis Center (2024). Epidemiology and Impact of Social Hardships in Children With Multiple Sclerosis in the United States. Neurology, 103(11), e209991. (Read full article)
  17. Bressan S, Tancredi D, Casper TC, Da Dalt L, Kuppermann (2024). Palpable signs of skull fractures on physical examination and depressed skull fractures or traumatic brain injuries on CT in children. European journal of pediatrics, 183(12), 5321-5330. (Read full article)
  18. Huang JX, Casper TC, Pitts C, Myers SR, Lynch R, Loomba L, Ramesh J, Kuppermann N, Ku E, Glaser (2024). Characterizing the relationship between social determinants of health and risk of albuminuria among children with type 1 diabetes. Journal of diabetes and its complications, 38(12), 108880. (Read full article)
  19. O'Donnell E, Schuette A, Waltz M, Aaen G, Benson L, Gorman M, Lotze T, Mar S, Ness J, Rodriguez M, Tillema JM, Schreiner T, Wheeler Y, Casper TC, Chitnis (2024). Patient and family views on research priorities and design of clinical trials and research studies in pediatric multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England), 30(11-12), 1525-1543. (Read full article)
  20. VanBuren JM, Banks RK, Kuppermann N, Gerber JS, Ruddy RM, Casper TC, Florin TA, Pediatric Emergency Care Applied Research Network (PECARN (2025). Evaluating the desirability of outcome ranking and response adjusted for duration of antibiotic risk for clinical trials of antibiotics in pediatric pneumonia. American journal of epidemiology, 194(4), 1090-1096. (Read full article)
  21. King CA, Brent D, Grupp-Phelan J, Page K, Czyz E, McGuire TC, Mahabee-Gittens EM, Block L, Casper T (2024). A Prospective Examination of the Interpersonal-Psychological Theory of Suicidal Behavior in Adolescents. Journal of clinical child and adolescent psychology, 53(6), 922-934. (Read full article)
  22. Jensen SKG, Camposano S, Berens A, Waltz M, Krupp LB, Charvet L, Belman AL, Aaen GS, Benson LA, Candee M, Casper TC, Chitnis T, Graves J, Wheeler YS, Kahn I, Lotze TE, Mar SS, Rensel M, Rodriguez M, Rose JW, Rubin JP, Tillema JM, Waldman AT, Weinstock-Guttman B, Barcellos LF, Waubant E, Gorman MP, US Network of Pediatric Multiple Sclerosis Center (2024). Early Adversity and Socioeconomic Factors in Pediatric Multiple Sclerosis: A Case-Control Study. Neurology(R) neuroimmunology & neuroinflammation, 11(5), e200282. (Read full article)
  23. Krack AT, Eckerle M, Mahajan P, Ramilo O, VanBuren JM, Banks RK, Casper TC, Schnadower D, Kuppermann N, Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN (2024). Leukopenia, neutropenia, and procalcitonin levels in young febrile infants with invasive bacterial infections. Academic emergency medicine, 31(9), 903-914. (Read full article)
  24. Brulotte M, Alvey JS, Casper TC, Cook LJ, Dwyer JP, VanBuren J (2024). A risk-based monitoring approach to source data monitoring and documenting monitoring findings. Contemporary clinical trials, 143, 107581. (Read full article)
  25. Pilloni G, Casper TC, Mar S, Ness J, Schreiner T, Waltz M, Waubant E, Weinstock-Guttman B, Wheeler Y, Krupp L, Charvet (2024). Increased intraindividual variability (IIV) in reaction time is the earliest indicator of cognitive change in MS: A two-year observational study. International journal of clinical and health psychology, 24(3), 100486. (Read full article)
  26. Nasr Z, Casper TC, Waltz M, Virupakshaiah A, Lotze T, Shukla N, Chitnis T, Gorman M, Benson LA, Rodriguez M, Tillema JM, Krupp L, Schreiner T, Mar S, Rensel M, Rose J, Liu C, Guye S, Manlius C, Waubant E, U.S. Network of Pediatric Multiple Sclerosis Center (2024). Clinical and magnetic resonance imaging outcomes in pediatric-onset MS patients on fingolimod and ocrelizumab. Multiple sclerosis and related disorders, 87, 105647. (Read full article)
  27. Nasr Z, Virupakshaiah A, Schoeps VA, Cherbuin N, Casper TC, Waltz M, Hart J, Rodriguez M, Gorman MP, Benson LA, Chitnis T, Rensel M, Abrams A, Krupp L, Waldman AT, Lotze T, Aaen GS, Mar S, Schreiner T, Wheeler Y, Rose J, Shukla NM, Barcellos LF, Lucas R, Waubant (2024). Gene-environment interactions and risk of pediatric-onset multiple sclerosis associated with time spent outdoors. Multiple sclerosis and related disorders, 82, 105351. (Read full article)
  28. Mohan SD, Peterson S, Brenton JN, Carmichael SL, Virupakshaiah A, Rodriguez M, Tillema JM, Mar S, Rensel MR, Abrams A, Chitnis T, Benson L, Gorman M, Lotze T, Shukla N, Graves J, Aaen G, Casper TC, Waubant (2024). Association of nutritional intake with clinical and imaging activity in pediatric multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England), 30(8), 1056-1065. (Read full article)
  29. Canter H, Reed J, Palmer C, Casper TC, Stukus K, Schmidt S, Pickett M, Mollen C, Elsholz C, Cruz AT, Augustine E, Goyal M (2024). Contraception Use and Pregnancy Risk Among Adolescents in Pediatric Emergency Departments. JAMA network open, 7(6), e2418213. (Read full article)
  30. Grupp-Phelan J, Horwitz A, Brent D, Chernick L, Shenoi R, Casper TC, Webb M, King C, Pediatric Emergency Care Applied Research Network (PECARN (2024). Management of suicidal risk in the emergency department: A clinical pathway using the computerized adaptive screen for suicidal youth. Journal of the American College of Emergency Physicians open, 5(2), e13132. (Read full article)
  31. Gambrah-Lyles C, Kannan V, Lotze T, Abrams A, Schreiner T, Rodriguez M, Casper TC, Rose JW, Gorman MP, Chitnis T, Loud S, Wheeler Y, Mar S, US Network of Pediatric MS Center (2024). Assessing Needs and Perceptions of Research Participation in Pediatric-Onset Multiple Sclerosis: A Multistakeholder Survey. Pediatric neurology, 151, 115-120. (Read full article)
  32. Nigrovic LE, Kuppermann N, Ghetti S, Schunk JE, Stoner MJ, Rewers A, McManemy JK, Quayle KS, Trainor JL, Tzimenatos L, Bennett JE, Kwok MY, Myers SR, Brown KM, Casper TC, Olsen CS, Glaser NS, for the Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Grou (2023). Emergency Department Presentations of Diabetic Ketoacidosis in a Large Cohort of Children. Pediatric diabetes, 2023, 6693226. (Read full article)