T. Charles Casper

T. Charles Casper, PhD, MStat

Languages spoken: English, Portuguese, Spanish, Italian

Academic Information

Departments Primary - Pediatrics , Adjunct - Family & Preventive Medicine

Divisions: Critical Care , Public Health

Research Interests

  • Survival Analysis
  • Clinical Trials Methodology
  • Recurrent Events
  • Group Sequential Methods
  • Semi and Nonparametric Methods

After receiving his Ph.D. in Statistics with an emphasis in Biostatistics from the University of Wisconsin-Madison, Dr. Casper joined the faculty of the University of Utah School of Medicine as Assistant Professor of Pediatric Critical Care. He has collaborated with researchers from a variety of areas including cardiology, oncology, hematology, neurosurgery, nutrition, neurology, and emergency medicine, among others. Dr. Casper also co-authored a graduate level textbook on statistical methods for clinical trials.

Dr. Casper is currently biostatistician for the Pediatric Emergency Care Applied Research Network (PECARN). He is also currently leading the Data Coordinating and Analysis Center for the National Multiple Sclerosis Society's Network of Pediatric Multiple Sclerosis Centers (NPMSC) as principal investigator. Through these efforts, he has supervised study coordination, data collection, and analysis for several multi-center clinical trials and other studies. He also assists investigators at the university through the Study Design and Biostatistics Center of the Center for Clinical and Translational Science (CCTS).

Dr. Casper's research focus is clinical trial design and statistical methods for the analysis of clinical trial data. Statistical methods he is interested in are areas like survival analysis, longitudinal data, gene expression microarray analysis, and classification algorithms.

Education History

Doctoral Training University of Wisconsin
 PhD
Graduate Training University of Utah
 MStat
Undergraduate University of Utah
 BS

Selected Publications

Journal Article

  1. Calhoun ARUL, Lortz A, Casper TC, Carey JC (2025). Extended Growth Curves for the Wolf-Hirschhorn Syndrome (4p-). Am J Med Genet A, 197(8), e64075. (Read full article)
  2. DeBar LL, Mayhew M, Wellman RD, Balderson BH, Dickerson JF, Elder CR, Justice M, Keefe FJ, McMullen CK, Owen-Smith AA, Rini C, Von Korff M, Waring S, Yarava A, Shen Z, Thompson RE, Clark AE, Casper TC, Cook AJ (2025). Telehealth and Online Cognitive Behavioral Therapy-Based Treatments for High-Impact Chronic Pain: A Randomized Clinical Trial. JAMA. (Read full article)
  3. Goyne C, Fair AE, Yilmaz D, Race J, Schuette A, Caillier SJ, Aaen GS, Abrams AW, Benson LA, Casper TC, Chitnis T, Gorman MP, Lotze TE, Krupp LB, Mar SS, Ness JM, Rensel M, Rodriguez M, Rose JW, Schreiner TL, Tillema JM, Waldman AT, Wheeler YS, Barcellos LF, Waubant E, Graves JS, as the US Network of Pediatric MS Centers (2025). Epigenetic Aging in Pediatric-Onset Multiple Sclerosis. Neurology, 104(12), e213673. (Read full article)
  4. Yilmaz D, Adams C, Horton MK, Graves JS, Francisco C, Edwards A, Quach H, Quach D, Aaen G, Lotze T, Mar S, Ness J, Wheeler Y, Gorman MP, Benson L, Weinstock-Guttman B, Waldman A, Schreiner T, Tillema JM, Chitnis T, Rose J, Casper TC, Rensel M, Waubant E, Barcellos LF, Network of Pediatric Multiple Sclerosis Centers (2025). Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis. Mult Scler J Exp Transl Clin, 11(2), 20552173251335625. (Read full article)
  5. MacRae R, Race J, Schuette A, Waltz M, Casper TC, Rose J, Abrams A, Rensel M, Waubant E, Virupakshaiah A, Schoeps V, ONeill K, Ness J, Wheeler Y, Shukla N, Mar S, Rodriguez M, Chitnis T, Gorman M, Benson L (2025). Limited early IVIG for the treatment of pediatric myelin oligodendrocyte glycoprotein antibody-associated disease. Mult Scler Relat Disord, 97, 106345. (Read full article)
  6. VanBuren JM, Banks RK, Kuppermann N, Gerber JS, Ruddy RM, Casper TC, Florin TA, Pediatric Emergency Care Applied Research Network PECARN (2023). Evaluating the desirability of outcome ranking and response adjusted for duration of antibiotic risk for clinical trials of antibiotics in pediatric pneumonia. Am J Epidemiol, 194(4), 1090-1096. (Read full article)
  7. Chang G, Sebastian P, Virupakshaiah A, Schoeps VA, Cherbuin N, Casper TC, Gorman MP, Benson LA, Chitnis T, Rensel M, Abrams AW, Lotze T, Mar SS, Schreiner TL, Wheeler YS, Rose JW, Graves J, Krupp LB, Waldman AT, Lucas R, Waubant E, as the US Network of Pediatric Multiple Sclerosis Centers (2025). Association Between Sun Exposure and Risk of Relapse in Pediatric-Onset Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm, 12(2), e200375. (Read full article)
  8. Krysko KM, Waltz M, Chitnis T, Weinstock-Guttman B, Aaen GS, Belman A, Benson LA, Gorman MP, Lotze TE, Mar SS, Moodley M, Ness JM, Rensel M, Rodriguez M, Rose JW, Edwards AR, Schreiner TL, Wheeler YS, Barney BJ, Waubant E, Casper TC, Graves JS, as the US Network of Pediatric MS Centers (2025). Study of the Association Between Menarche and Disease Course in Pediatric Multiple Sclerosis. Neurology, 104(4), e210213. (Read full article)
  9. Schoeps VA, Bhargava P, Virupakshaiah A, Ladakis DC, Moseley C, Chong J, Aaen G, Graves JS, Benson L, Gorman MP, Rensel M, Abrams A, Mar S, Lotze TE, Chitnis T, Waldman A, Krupp L, Rodriguez M, Tillema JM, Rose J, Schreiner T, Qureshi F, Peterson S, Barcellos LF, Casper TC, Newman J, Borkowski K, Waubant E, US Network of Pediatric MS Centers (2025). Distinct plasma lipids predict axonal injury and multiple sclerosis activity. J Neurol Neurosurg Psychiatry, 96(2), 150-157. (Read full article)
  10. Virupakshaiah A, Schoeps VA, Race J, Waltz M, Sharayah S, Nasr Z, Moseley CE, Zamvil SS, Gaudioso C, Schuette A, Casper TC, Rose J, Flanagan EP, Rodriguez M, Tillema JM, Chitnis T, Gorman MP, Graves JS, Benson LA, Rensel M, Abrams A, Krupp L, Lotze TE, Aaen G, Wheeler Y, Schreiner T, Waldman A, Chong J, Mar S, Waubant E (2024). Predictors of a relapsing course in myelin oligodendrocyte glycoprotein antibody-associated disease. J Neurol Neurosurg Psychiatry, 96(1), 68-75. (Read full article)
  11. Wilson E, Meeks HD, Barney BJ, Waltz M, Canenguez K, Casper TC, Rose JW, Rodriguez M, Tillema JM, Chitnis T, Gorman MP, Rensel M, Abrams AW, Krupp LB, Lotze TE, Fisher KS, Shukla NM, Schreiner TL, Mar SS, Waubant E, Virupakshaiah A, Wheeler YS, Ness JM, Benson LA, as the United States Network of Pediatric Multiple Sclerosis Centers (2024). Epidemiology and Impact of Social Hardships in Children With Multiple Sclerosis in the United States. Neurology, 103(11), e209991. (Read full article)
  12. Bressan S, Tancredi D, Casper TC, Da Dalt L, Kuppermann N (2024). Palpable signs of skull fractures on physical examination and depressed skull fractures or traumatic brain injuries on CT in children. Eur J Pediatr, 183(12), 5321-5330. (Read full article)
  13. Huang JX, Casper TC, Pitts C, Myers SR, Lynch R, Loomba L, Ramesh J, Kuppermann N, Ku E, Glaser N (2024). Characterizing the relationship between social determinants of health and risk of albuminuria among children with type 1 diabetes. J Diabetes Complications, 38(12), 108880. (Read full article)
  14. King CA, Brent D, Grupp-Phelan J, Page K, Czyz E, McGuire TC, Mahabee-Gittens EM, Block L, Casper TC (2024). A Prospective Examination of the Interpersonal-Psychological Theory of Suicidal Behavior in Adolescents. J Clin Child Adolesc Psychol, 53(6), 922-934. (Read full article)
  15. ODonnell E, Schuette A, Waltz M, Aaen G, Benson L, Gorman M, Lotze T, Mar S, Ness J, Rodriguez M, Tillema JM, Schreiner T, Wheeler Y, Casper TC, Chitnis T (2024). Patient and family views on research priorities and design of clinical trials and research studies in pediatric multiple sclerosis. Mult Scler, 30(11-12), 1525-1543. (Read full article)
  16. Krack AT, Eckerle M, Mahajan P, Ramilo O, VanBuren JM, Banks RK, Casper TC, Schnadower D, Kuppermann N, Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network PECARN (2024). Leukopenia, neutropenia, and procalcitonin levels in young febrile infants with invasive bacterial infections. Acad Emerg Med, 31(9), 903-914. (Read full article)
  17. Jensen SKG, Camposano S, Berens A, Waltz M, Krupp LB, Charvet L, Belman AL, Aaen GS, Benson LA, Candee M, Casper TC, Chitnis T, Graves J, Wheeler YS, Kahn I, Lotze TE, Mar SS, Rensel M, Rodriguez M, Rose JW, Rubin JP, Tillema JM, Waldman AT, Weinstock-Guttman B, Barcellos LF, Waubant E, Gorman MP, US Network of Pediatric Multiple Sclerosis Centers (2024). Early Adversity and Socioeconomic Factors in Pediatric Multiple Sclerosis: A Case-Control Study. Neurol Neuroimmunol Neuroinflamm, 11(5), e200282. (Read full article)
  18. Brulotte M, Alvey JS, Casper TC, Cook LJ, Dwyer JP, VanBuren JM (2024). A risk-based monitoring approach to source data monitoring and documenting monitoring findings. Contemp Clin Trials, 143, 107581. (Read full article)
  19. Nasr Z, Casper TC, Waltz M, Virupakshaiah A, Lotze T, Shukla N, Chitnis T, Gorman M, Benson LA, Rodriguez M, Tillema JM, Krupp L, Schreiner T, Mar S, Rensel M, Rose J, Liu C, Guye S, Manlius C, Waubant E, US Network of Pediatric Multiple Sclerosis Centers (2024). Clinical and magnetic resonance imaging outcomes in pediatric-onset MS patients on fingolimod and ocrelizumab. Mult Scler Relat Disord, 87, 105647. (Read full article)
  20. Mohan SD, Peterson S, Brenton JN, Carmichael SL, Virupakshaiah A, Rodriguez M, Tillema JM, Mar S, Rensel MR, Abrams A, Chitnis T, Benson L, Gorman M, Lotze T, Shukla N, Graves J, Aaen G, Casper TC, Waubant E (2024). Association of nutritional intake with clinical and imaging activity in pediatric multiple sclerosis. Mult Scler, 30(8), 1056-1065. (Read full article)
  21. Pilloni G, Casper TC, Mar S, Ness J, Schreiner T, Waltz M, Waubant E, Weinstock-Guttman B, Wheeler Y, Krupp L, Charvet L (2024). Increased intraindividual variability (IIV) in reaction time is the earliest indicator of cognitive change in MS: A two-year observational study. Int J Clin Health Psychol, 24(3), 100486. (Read full article)
  22. Canter H, Reed J, Palmer C, Casper TC, Stukus K, Schmidt S, Pickett M, Mollen C, Elsholz C, Cruz AT, Augustine E, Goyal MK (2024). Contraception Use and Pregnancy Risk Among Adolescents in Pediatric Emergency Departments. JAMA Netw Open, 7(6), e2418213. (Read full article)
  23. Grupp-Phelan J, Horwitz A, Brent D, Chernick L, Shenoi R, Casper TC, Webb M, King C, Pediatric Emergency Care Applied Research Network PECARN (2024). Management of suicidal risk in the emergency department: A clinical pathway using the computerized adaptive screen for suicidal youth. J Am Coll Emerg Physicians Open, 5(2), e13132. (Read full article)
  24. Nasr Z, Virupakshaiah A, Schoeps VA, Cherbuin N, Casper TC, Waltz M, Hart J, Rodriguez M, Gorman MP, Benson LA, Chitnis T, Rensel M, Abrams A, Krupp L, Waldman AT, Lotze T, Aaen GS, Mar S, Schreiner T, Wheeler Y, Rose J, Shukla NM, Barcellos LF, Lucas R, Waubant E (2023). Gene-environment interactions and risk of pediatric-onset multiple sclerosis associated with time spent outdoors. Mult Scler Relat Disord, 82, 105351. (Read full article)
  25. Gambrah-Lyles C, Kannan V, Lotze T, Abrams A, Schreiner T, Rodriguez M, Casper TC, Rose JW, Gorman MP, Chitnis T, Loud S, Wheeler Y, Mar S, US Network of Pediatric MS Centers (2023). Assessing Needs and Perceptions of Research Participation in Pediatric-Onset Multiple Sclerosis: A Multistakeholder Survey. Pediatr Neurol, 151, 115-120. (Read full article)
  26. Schoeps VA, Zhou X, Horton MK, Zhu F, McCauley KE, Nasr Z, Virupakshaiah A, Gorman MP, Benson LA, Weinstock-Guttman B, Waldman A, Banwell BL, Bar-Or A, Marrie RA, van Domselaar G, OMahony J, Mirza AI, Bernstein CN, Yeh EA, Casper TC, Lynch SV, Tremlett H, Baranzini S, Waubant E, US Network of Pediatric MS Centers (2023). Short-chain fatty acid producers in the gut are associated with pediatric multiple sclerosis onset. Ann Clin Transl Neurol, 11(1), 169-84. (Read full article)
  27. Cruz AT, Palmer CA, Augustine EM, Casper TC, Dowshen N, Elsholz CL, Mollen CJ, Pickett ML, Schmidt SK, Stukus KS, Goyal MK, Reed JL (2023). Concordance of Adolescent Gender, Race, and Ethnicity: Self-report Versus Medical Record Data. Pediatrics, 153(2). (Read full article)
  28. Brown KM, Glaser NS, McManemy JK, DePiero A, Nigrovic LE, Quayle KS, Stoner MJ, Schunk JE, Trainor JL, Tzimenatos L, Rewers A, Myers SR, Kwok MY, Ghetti S, Casper TC, Olsen CS, Kuppermann N, Pediatric Emergency Care Applied Research Network Diabetic Ketoacidosis FLUID Study Group (2023). Rehydration Rates and Outcomes in Overweight Children With Diabetic Ketoacidosis. Pediatrics, 152(6). (Read full article)
  29. Tsze DS, Kuppermann N, Casper TC, Barney BJ, Richer LP, Liberman DB, Okada PJ, Morris CR, Myers SR, Soung JK, Mistry RD, Babcock L, Spencer SP, Johnson MD, Klein EJ, Quayle KS, Steele DW, Cruz AT, Rogers AJ, Thomas DG, Grupp-Phelan JM, Johnson TJ, Dayan PS, Pediatric Emergency Care Applied Research Network PECARN (2023). Stratification of risk for emergent intracranial abnormalities in children with headaches: a Pediatric Emergency Care Applied Research Network (PECARN) study protocol. BMJ Open, 13(11), e079040. (Read full article)
  30. King CA, Gipson Allen PY, Ahamed SI, Webb M, Casper TC, Brent D, Grupp-Phelan J, Rogers TA, Arango A, Al-Dajani N, McGuire TC, Bagge CL (In Press). 24-Hour warning signs for adolescent suicide attempts. Psychol Med, 1-12. (Read full article)
  31. Nigrovic LE, Kuppermann N, Ghetti S, Schunk JE, Stoner MJ, Rewers A, McManemy JK, Quayle KS, Trainor JL, Tzimenatos L, Bennett JE, Kwok MY, Myers SR, Brown KM, Casper TC, Olsen CS, Glaser NS, for the Pediatric Emergency Care Applied Research Network PECARN DKA FLUID Study Group (2023). Emergency Department Presentations of Diabetic Ketoacidosis in a Large Cohort of Children. Pediatr Diabetes, 2023, 6693226. (Read full article)
  32. Chitnis T, Ness J, Krupp L, Waubant E, Hunt T, Rodriguez M, Lotze T, Gorman M, Belman A, Weinstock-Guttmann B, Aaen G, Patterson M, Rose J, Casper TC, for the US Network of Pediatric MS Centers of Excellence (2016). Clinical features of neuromyelitis optica in children: US Network of Pediatric MS Centers report. Neurology, 86(3), 245-52.