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T. Charles Casper

T. Charles Casper, PhD, MStat

Languages spoken: English, Portuguese, Spanish, Italian

Academic Information

Departments Primary - Pediatrics , Adjunct - Family & Preventive Medicine

Divisions: Critical Care , Public Health

Academic Office Information

Research Interests

  • Survival Analysis
  • Clinical Trials Methodology
  • Recurrent Events
  • Group Sequential Methods
  • Semi and Nonparametric Methods

After receiving his Ph.D. in Statistics with an emphasis in Biostatistics from the University of Wisconsin-Madison, Dr. Casper joined the faculty of the University of Utah School of Medicine as Assistant Professor of Pediatric Critical Care. He has collaborated with researchers from a variety of areas including cardiology, oncology, hematology, neurosurgery, nutrition, neurology, and emergency medicine, among others. Dr. Casper also co-authored a graduate level textbook on statistical methods for clinical trials.

Dr. Casper is currently biostatistician for the Pediatric Emergency Care Applied Research Network (PECARN). He is also currently leading the Data Coordinating and Analysis Center for the National Multiple Sclerosis Society's Network of Pediatric Multiple Sclerosis Centers (NPMSC) as principal investigator. Through these efforts, he has supervised study coordination, data collection, and analysis for several multi-center clinical trials and other studies. He also assists investigators at the university through the Study Design and Biostatistics Center of the Center for Clinical and Translational Science (CCTS).

Dr. Casper's research focus is clinical trial design and statistical methods for the analysis of clinical trial data. Statistical methods he is interested in are areas like survival analysis, longitudinal data, gene expression microarray analysis, and classification algorithms.

Education History

Doctoral Training University of Wisconsin
University of Utah
Undergraduate University of Utah

Selected Publications

Journal Article

  1. Schoeps VA, Zhou X, Horton MK, Zhu F, McCauley KE, Nasr Z, Virupakshaiah A, Gorman MP, Benson LA, Weinstock-Guttman B, Waldman A, Banwell BL, Bar-Or A, Marrie RA, van Domselaar G, OMahony J, Mirza AI, Bernstein CN, Yeh EA, Casper TC, Lynch SV, Tremlett H, Baranzini S, Waubant E, US Network of Pediatric MS Centers (2023). Short-chain fatty acid producers in the gut are associated with pediatric multiple sclerosis onset. Ann Clin Transl Neurol, 11(1), 169-84. (Read full article)
  2. Cruz AT, Palmer CA, Augustine EM, Casper TC, Dowshen N, Elsholz CL, Mollen CJ, Pickett ML, Schmidt SK, Stukus KS, Goyal MK, Reed JL (2023). Concordance of Adolescent Gender, Race, and Ethnicity: Self-report Versus Medical Record Data. Pediatrics, 153(2). (Read full article)
  3. Brown KM, Glaser NS, McManemy JK, DePiero A, Nigrovic LE, Quayle KS, Stoner MJ, Schunk JE, Trainor JL, Tzimenatos L, Rewers A, Myers SR, Kwok MY, Ghetti S, Casper TC, Olsen CS, Kuppermann N, Pediatric Emergency Care Applied Research Network Diabetic Ketoacidosis FLUID Study Group (2023). Rehydration Rates and Outcomes in Overweight Children With Diabetic Ketoacidosis. Pediatrics, 152(6). (Read full article)
  4. Tsze DS, Kuppermann N, Casper TC, Barney BJ, Richer LP, Liberman DB, Okada PJ, Morris CR, Myers SR, Soung JK, Mistry RD, Babcock L, Spencer SP, Johnson MD, Klein EJ, Quayle KS, Steele DW, Cruz AT, Rogers AJ, Thomas DG, Grupp-Phelan JM, Johnson TJ, Dayan PS, Pediatric Emergency Care Applied Research Network PECARN (2023). Stratification of risk for emergent intracranial abnormalities in children with headaches: a Pediatric Emergency Care Applied Research Network (PECARN) study protocol. BMJ Open, 13(11), e079040. (Read full article)
  5. King CA, Gipson Allen PY, Ahamed SI, Webb M, Casper TC, Brent D, Grupp-Phelan J, Rogers TA, Arango A, Al-Dajani N, McGuire TC, Bagge CL (In Press). 24-Hour warning signs for adolescent suicide attempts. Psychol Med, 1-12. (Read full article)
  6. Chitnis T, Ness J, Krupp L, Waubant E, Hunt T, Rodriguez M, Lotze T, Gorman M, Belman A, Weinstock-Guttmann B, Aaen G, Patterson M, Rose J, Casper TC, for the US Network of Pediatric MS Centers of Excellence (2016). Clinical features of neuromyelitis optica in children: US Network of Pediatric MS Centers report. Neurology, 86(3), 245-52.