Vincent Koppelmans

Vincent Koppelmans, PhD

Languages spoken: English, Dutch

Academic Information

Departments Primary - Psychiatry

Divisions: Adult Psychiatry

Vincent Koppelmans, PhD, is a Research Associate Professor in the Department of Psychiatry. He earned a Master of Science degree in Clinical Neuropsychology from the VU University, Amsterdam, the Netherlands, and a Master of Science degree in Health Sciences from the Erasmus University, Rotterdam, the Netherlands. He obtained his PhD in Neuro-epidemiology from the same Erasmus University for his dissertation on The Late Effects of Adjuvant Chemotherapy on Brain Function and Structure.

Dr. Koppelmans completed his postdoctoral training in Neural Control of Movement in the Department of Kinesiology at the University of Michigan in Ann Arbor, MI. He was awarded a fellowship from the National Space Biomedical Research Institute to investigate exercise as a potential countermeasure for brain changes that occur as a result of long-duration bed rest. Following his postdoctoral training he joined the Kinesiology Department of the University of Michigan as an Assistant Research Scientist. He is interested in disease and age related brain structural and functional neuroplasticity and their relation with cognitive function and motor behavior. He is currently funded by an NIH/NIA K01 award to study Neural and Behavioral Motor Profiles as Novel Biomarker for Alzheimer's Disease.

Education History

Graduate Training Vrije Universiteit Amsterdam
 MSc
Graduate Training Erasmus University Rotterdam
 MSc
Doctoral Training Erasmus University Medical Center/Netherlands Cancer Institute
 PhD
Research Fellow University of Michigan School of Kinesiology, Neuromotor Behavior Lab
 Postdoctoral Research Fellow

Selected Publications

Journal Article

  1. Koppelmans V, de Ruiter MB, van der Lijn F, Boogerd W, Seynaeve C, van der Lugt A, Vrooman H, Niessen WJ, Breteler MM, Schagen SB (2012). Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy. Breast Cancer Res Treat, 132(3), 1099-106. (Read full article)
  2. Koppelmans V, van der Willik KD, Aleman BMP, van Leeuwen FE, Kavousi M, Arshi B, Vernooij MW, Ikram MA, Schagen SB (2021). Long-term effects of adjuvant treatment for breast cancer on carotid plaques and brain perfusion. Breast Cancer Res Treat, 186(1), 167-176. (Read full article)
  3. Koppelmans V, Schagen SB, Poels MM, Boogerd W, Seynaeve C, van der Lugt A, Breteler M (2011). Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy. European journal of cancer (Oxford, England, 47(17), 2531-6. (Read full article)
  4. Hupfeld KE, McGregor HR, Koppelmans V, Beltran NE, Kofman IS, De Dios YE, Riascos RF, Reuter-Lorenz PA, Wood SJ, Bloomberg JJ, Mulavara AP, Seidler R (2021). Brain and Behavioral Evidence for Reweighting of Vestibular Inputs with Long-Duration Spaceflight. Cerebral cortex (New York, N.Y., 32, 755-769. (Read full article)
  5. Schoevers RA, Van HL, Koppelmans V, Kool S, Dekker J (2008). Managing the patient with co-morbid depression and an anxiety disorder. Drugs, 68(12), 1621-34. (Read full article)
  6. Yuan P, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Riascos R, Kofman I, Bloomberg J, Mulavara A, Seidler R (2018). Change of cortical foot activation following 70 days of head-down bed rest. Journal of neurophysiology, 119(6), 2145-2152. (Read full article)
  7. Koppelmans V, Breteler MM, Boogerd W, Seynaeve C, Gundy C, Schagen S (2012). Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy. Journal of clinical oncology, 30(10), 1080-6. (Read full article)
  8. Koppelmans V, Vernooij MW, Boogerd W, Seynaeve C, Ikram MA, Breteler MM, Schagen S (2015). Prevalence of cerebral small-vessel disease in long-term breast cancer survivors exposed to both adjuvant radiotherapy and chemotherapy. Journal of clinical oncology, 33(6), 588-93. (Read full article)
  9. Koppelmans V, Schagen S (2011). Effecten van chemotherapie op het cognitief functioneren van kankerpatiënten. Oncologica, 4, 35-7.
  10. Ruitenberg MFL, Koppelmans (2021). Cognition in Motion: Evidence for Intact Action Control With Healthy Aging. The journals of gerontology. Series B, Psychological sciences and social sciences, 76(2), 252-261. (Read full article)
  11. Seidler R, Erdeniz B, Koppelmans V, Hirsiger S, Merillat S, Jancke (2015). Associations between age, motor function, and resting state sensorimotor network connectivity in healthy older adults. NeuroImage, 108, 47-59. (Read full article)
  12. Cassady K, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Wood S, Castenada RR, Kofman I, Bloomberg J, Mulavara A, Seidler (2016). Effects of a spaceflight analog environment on brain connectivity and behavior. NeuroImage, 141, 18-30. (Read full article)
  13. Hoogendam YY, Schagen SB, Ikram MA, Boogerd W, Seynaeve C, Seidler RD, Breteler MM, Van der Geest JN, Koppelmans (2015). Late effects of adjuvant chemotherapy for breast cancer on fine motor function. Psycho-oncology, 24(12), 1799-807. (Read full article)
  14. Koppelmans V, de Groot M, de Ruiter MB, Boogerd W, Seynaeve C, Vernooij MW, Niessen WJ, Schagen SB, Breteler M (2014). Global and focal white matter integrity in breast cancer survivors 20 years after adjuvant chemotherapy. Human brain mapping, 35(3), 889-99. (Read full article)
  15. Koppelmans V, Hirsiger S, Mérillat S, Jäncke L, Seidler R (2015). Cerebellar gray and white matter volume and their relation with age and manual motor performance in healthy older adults. Human brain mapping, 36(6), 2352-63. (Read full article)
  16. Hirsiger S, Koppelmans V, Mérillat S, Liem F, Erdeniz B, Seidler RD, Jäncke (2016). Structural and functional connectivity in healthy aging: Associations for cognition and motor behavior. Human brain mapping, 37(3), 855-67. (Read full article)
  17. Cassady K, Ruitenberg M, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Wood S, Riascos Castenada R, Kofman I, Bloomberg J, Mulavara A, Seidler (2018). Neural predictors of sensorimotor adaptation rate and savings. Human brain mapping, 39(4), 1516-1531. (Read full article)
  18. Yuan P, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Wood S, Riascos R, Kofman I, Bloomberg J, Mulavara A, Seidler (2018). Vestibular brain changes within 70 days of head down bed rest. Human brain mapping, 39(7), 2753-2763. (Read full article)
  19. Duff K, Suhrie KR, Hammers DB, Dixon AM, King JB, Koppelmans V, Hoffman J (2021). Repeatable battery for the assessment of neuropsychological status and its relationship to biomarkers of Alzheimer's disease. The Clinical neuropsychologist, 1-17. (Read full article)
  20. van der Willik KD, Koppelmans V, Hauptmann M, Compter A, Ikram MA, Schagen S (2018). Inflammation markers and cognitive performance in breast cancer survivors 20 years after completion of chemotherapy: a cohort study. Breast cancer research, 20(1), 135. (Read full article)
  21. Koppelmans V, Erdeniz B, De Dios YE, Wood SJ, Reuter-Lorenz PA, Kofman I, Bloomberg JJ, Mulavara AP, Seidler R (2013). Study protocol to examine the effects of spaceflight and a spaceflight analog on neurocognitive performance: extent, longevity, and neural bases. BMC neurology, 13, 205. (Read full article)
  22. Koppelmans V, Schoevers R, van Wijk CG, Mulder W, Hornbach A, Barkhof E, Klaassen A, van Egmond M, van Venrooij J, Bijpost Y, Nusselder H, van Herrewaarden M, Maksimovic I, Achilles A, Dekker (2009). The Amsterdam Studies of Acute Psychiatry - II (ASAP-II): a comparative study of psychiatric intensive care units in the Netherlands. BMC public health, 9, 318. (Read full article)
  23. van der Post L, Schoevers R, Koppelmans V, Visch I, Bernardt C, Mulder N, Beekman A, de Haan L, Dekker (2008). The Amsterdam Studies of Acute Psychiatry I (ASAP-I); a prospective cohort study of determinants and outcome of coercive versus voluntary treatment interventions in a metropolitan area. BMC psychiatry, 8, 35. (Read full article)
  24. Koppelmans V, Bloomberg JJ, De Dios YE, Wood SJ, Reuter-Lorenz PA, Kofman IS, Riascos R, Mulavara AP, Seidler R (2017). Brain plasticity and sensorimotor deterioration as a function of 70 days head down tilt bed rest. PloS one, 12(8), e0182236. (Read full article)
  25. Koppelmans V, Scott JM, Downs ME, Cassady KE, Yuan P, Pasternak O, Wood SJ, De Dios YE, Gadd NE, Kofman I, Riascos R, Reuter-Lorenz PA, Bloomberg JJ, Mulavara AP, Ploutz-Snyder LL, Seidler R (2018). Exercise effects on bed rest-induced brain changes. PloS one, 13(10), e0205515. (Read full article)
  26. Koppelmans V, Hoogendam YY, Hirsiger S, Mérillat S, Jäncke L, Seidler R (2017). Regional cerebellar volumetric correlates of manual motor and cognitive function. Brain structure & function, 222(4), 1929-1944. (Read full article)
  27. Stouten-Kemperman MM, de Ruiter MB, Koppelmans V, Boogerd W, Reneman L, Schagen S (2015). Neurotoxicity in breast cancer survivors >/=10 years post-treatment is dependent on treatment type. Brain imaging and behavior, 9(2), 275-84. (Read full article)
  28. Hirsiger S, Koppelmans V, Mérillat S, Erdin C, Narkhede A, Brickman AM, Jäncke (2017). Executive Functions in Healthy Older Adults Are Differentially Related to Macro- and Microstructural White Matter Characteristics of the Cerebral Lobes. Frontiers in aging neuroscience, 9, 373. (Read full article)
  29. Ruitenberg MFL, Wu T, Averbeck BB, Chou KL, Koppelmans V, Seidler R (2018). Impulsivity in Parkinson's Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks. Frontiers in neurology, 9, 279. (Read full article)
  30. Koppelmans V, Pasternak O, Bloomberg JJ, Dios YE, Wood SJ, Riascos R, Reuter-Lorenz PA, Kofman IS, Mulavara AP, Seidler R (2017). Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog. Scientific reports, 7(1), 3154. (Read full article)
  31. Ruitenberg MFL, Koppelmans V, De Dios YE, Gadd NE, Wood SJ, Reuter-Lorenz PA, Kofman I, Bloomberg JJ, Mulavara AP, Seidler R (2018). Neural correlates of multi-day learning and savings in sensorimotor adaptation. Scientific reports, 8(1), 14286. (Read full article)
  32. Lee JK, Koppelmans V, Riascos RF, Hasan KM, Pasternak O, Mulavara AP, Bloomberg JJ, Seidler R (2019). Spaceflight-Associated Brain White Matter Microstructural Changes and Intracranial Fluid Redistribution. JAMA neurology, 76(4), 412-419. (Read full article)
  33. Menning S, de Ruiter MB, Veltman DJ, Koppelmans V, Kirschbaum C, Boogerd W, Reneman L, Schagen S (2015). Multimodal MRI and cognitive function in patients with breast cancer prior to adjuvant treatment--the role of fatigue. NeuroImage. Clinical, 7, 547-54. (Read full article)
  34. Weisenbach SL, Kim J, Hammers D, Konopacki K, Koppelmans (2019). Linking late life depression and Alzheimer's disease: mechanisms and resilience. Current behavioral neuroscience reports, 6(3), 103-112. (Read full article)
  35. Langenecker SA, Westlund Schreiner M, Thomas LR, Bessette KL, DelDonno SR, Jenkins LM, Easter RE, Stange JP, Pocius SL, Dillahunt A, Love TM, Phan KL, Koppelmans V, Paulus M, Lindquist MA, Caffo B, Mickey BJ, Welsh R (2021). Using Network Parcels and Resting-State Networks to Estimate Correlates of Mood Disorder and Related Research Domain Criteria Constructs of Reward Responsiveness and Inhibitory Control. Biological psychiatry. Cognitive neuroscience and neuroimaging, 7(1), 76-84. (Read full article)
  36. Koppelmans V, Bloomberg JJ, Mulavara AP, Seidler R (2016). Brain structural plasticity with spaceflight. NPJ microgravity, 2, 2. (Read full article)
  37. Lee JK, Koppelmans V, Pasternak O, Beltran NE, Kofman IS, De Dios YE, Mulder ER, Mulavara AP, Bloomberg JJ, Seidler R (2021). Effects of Spaceflight Stressors on Brain Volume, Microstructure, and Intracranial Fluid Distribution. Cerebral cortex communications, 2(2), tgab022. (Read full article)
  38. Koppelmans V, Schagen SB, Breteler MM (2013). Late effecten van adjuvante chemotherapie voor borstkanker op het cognitief functioneren en de structuur van het brein. Neuropraxis, 17(3), 75-79.
  39. Mejia AF, Koppelmans V, Jelsone-Swain L, Kalra S, Welsh R (2022). Longitudinal surface-based spatial Bayesian GLM reveals complex trajectories of motor neurodegeneration in ALS. NeuroImage, 255, 119180. (Read full article)
  40. Ruitenberg MFL, Koppelmans V, Seidler RD, Schomaker (2022). Novelty exposure induces stronger sensorimotor representations during a manual adaptation task. Annals of the New York Academy of Sciences, 1510(1), 68-78. (Read full article)
  41. Waskowiak P, Koppelmans V, Ruitenberg MF (2022). Trait Anxiety as a Risk Factor for Impulse Control Disorders in de novo Parkinson's Disease. Journal of Parkinson's disease, 12(2), 689-697. (Read full article)
  42. Warthen KG, Welsh RC, Sanford B, Koppelmans V, Burmeister M, Mickey B (2021). Neuropeptide Y Variation Is Associated With Altered Static and Dynamic Functional Connectivity of the Salience Network. Frontiers in systems neuroscience, 15, 629488. (Read full article)
  43. Koppelmans V, Mulavara AP, Seidler RD, De Dios YE, Bloomberg JJ, Wood S (2022). Cortical thickness of primary motor and vestibular brain regions predicts recovery from fall and balance directly after spaceflight. Brain structure & function, 227, 2073-2086. (Read full article)
  44. Yuan P, Koppelmans V, Reuter-Lorenz PA, De Dios YE, Gadd NE, Wood SJ, Riascos R, Kofman IS, Bloomberg JJ, Mulavara AP, Seidler R (2016). Increased Brain Activation for Dual Tasking with 70-Days Head-Down Bed Rest. Frontiers in systems neuroscience, 10, 71. (Read full article)
  45. Koppelmans V, Mulavara AP, Yuan P, Cassady KE, Cooke KA, Wood SJ, Reuter-Lorenz PA, De Dios YE, Stepanyan V, Szecsy DL, Gadd NE, Kofman I, Scott JM, Downs ME, Bloomberg JJ, Ploutz-Snyder L, Seidler R (2015). Exercise as potential countermeasure for the effects of 70 days of bed rest on cognitive and sensorimotor performance. Frontiers in systems neuroscience, 9, 121. (Read full article)
  46. Gau R, Noble S, Heuer K, Bottenhorn KL, Bilgin IP, Yang YF, Huntenburg JM, Bayer JMM, Bethlehem RAI, Rhoads SA, Vogelbacher C, Borghesani V, Levitis E, Wang HT, Van Den Bossche S, Kobeleva X, Legarreta JH, Guay S, Atay SM, Varoquaux GP, Huijser DC, Sandström MS, Herholz P, Nastase SA, Badhwar A, Dumas G, Schwab S, Moia S, Dayan M, Bassil Y, Brooks PP, Mancini M, Shine JM, O'Connor D, Xie X, Poggiali D, Friedrich P, Heinsfeld AS, Riedl L, Toro R, Caballero-Gaudes C, Eklund A, Garner KG, Nolan CR, Demeter DV, Barrios FA, Merchant JS, McDevitt EA, Oostenveld R, Craddock RC, Rokem A, Doyle A, Ghosh SS, Nikolaidis A, Stanley OW, Uruñuela E, Brainhack Community (2021). Brainhack: Developing a culture of open, inclusive, community-driven neuroscience. Neuron, 109(11), 1769-1775. (Read full article)
  47. Love T, Shabalin AA, Kember RL, Docherty AR, Zhou H, Koppelmans V, Gelernter J, Baker AK, Hartwell E, Dubroff J, Zubieta JK, Kranzler H (2022). Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function. Neuropsychopharmacology, 47(10), 1784-1790. (Read full article)
  48. Baker AK, Ericksen LC, Koppelmans V, Mickey BJ, Martucci KT, Zubieta JK, Love T (2022). Altered Reward Processing and Sex Differences in Chronic Pain. Frontiers in neuroscience, 16, 889849. (Read full article)
  49. Ruitenberg MFL, Koppelmans V, Wu T, Averbeck BB, Chou KL, Seidler R (2022). Neural correlates of risky decision making in Parkinson's disease patients with impulse control disorders. Experimental brain research, (Read full article)
  50. Kim JU, Bessette KL, Westlund-Schreiner M, Pocius S, Dillahunt AK, Frandsen S, Thomas L, Easter R, Skerrett K, Stange JP, Welsh RC, Langenecker SA, Koppelmans (2022). Relations of gray matter volume to dimensional measures of cognition and affect in mood disorders. Cortex; a journal devoted to the study of the nervous system and behavior, 156, 57-70. (Read full article)
  51. Ruitenberg MFL, Koppelmans V, Seidler RD, Schomaker (2023). Developmental and age differences in visuomotor adaptation across the lifespan. Psychological research, (Read full article)
  52. Malek-Ahmadi M, Duff K, Chen K, Su Y, King JB, Koppelmans V, Schaefer S (2023). Volumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults. Experimental gerontology, 173, 112087. (Read full article)
  53. Koppelmans V, Ruitenberg MFL, Schaefer SY, King JB, Hoffman JM, Mejia AF, Tasdizen T, Duff (2023). Delayed and More Variable Unimanual and Bimanual Finger Tapping in Alzheimer's Disease: Associations with Biomarkers and Applications for Classification. Journal of Alzheimer's disease, 95(3), 1233-1252. (Read full article)
  54. Duff K, Hammers DB, Koppelmans V, King JB, Hoffman J (2024). Short-Term Practice Effects on Cognitive Tests Across the Late Life Cognitive Spectrum and How They Compare to Biomarkers of Alzheimer's Disease. Journal of Alzheimer's disease, 99(1), 321-332. (Read full article)
  55. Armstrong M, Kaufman J, Maciarz J, Sullivan D, Kim J, Koppelmans V, Langenecker S, Weisenbach S (2024). The relationship between personality and cognition in older adults with and without early-onset depression. Frontiers in psychiatry, 15, 1337320. (Read full article)
  56. Koppelmans V, Ruitenberg MFL, Schaefer SY, King JB, Jacobo JM, Silvester BP, Mejia AF, van der Geest J, Hoffman JM, Tasdizen T, Duff (2024). Classification of Mild Cognitive Impairment and Alzheimer's Disease Using Manual Motor Measures. Neuro-degenerative diseases, 24(2), 1-17. (Read full article)
  57. Riis TS, Feldman DA, Kwon SS, Vonesh LC, Koppelmans V, Brown JR, Solzbacher D, Kubanek J, Mickey B (2024). Noninvasive modulation of subcallosal cingulate and depression with focused ultrasonic waves. Biological psychiatry, 97(8), 825-834. (Read full article)
  58. Thurston MD, Ericksen LC, Jacobson MM, Bustamante A, Koppelmans V, Mickey BJ, Love T (2024). Oxytocin differentially modulates reward system responses to social and non-social incentives. Psychopharmacology, 242(3), 449-460. (Read full article)
  59. Whooley E, Koppelmans V, MacDonald HJ, Hall A, Ruitenberg MF (2025). Dopamine genetic risk scores and psychiatric symptoms: Interacting risk factors for impulse control behaviours in de novo Parkinson's disease. Journal of neuropsychology, (Read full article)
  60. Malek-Ahmadi M, Schack K, Duff K, Koppelmans V, King JB, Su Y, Schaefer S (2025). Cortical Thickness Predictors of Performance-Based Functional Task Variability in the Alzheimer Disease Spectrum. Alzheimer disease and associated disorders, (Read full article)
  61. Avila Pérez S, Koppelmans V, Duff KM, Ruitenberg M (2025). One-year practice effects predict long-term cognitive outcomes in Parkinson's disease. Journal of Parkinson's disease, 1877718X251339585. (Read full article)
  62. Nadvar N, Bauer C, Pamir Z, Merabet LB, Koppelmans V, Weiland (2025). Replicability of a resting-state functional connectivity study in profound early blindness. Frontiers in systems neuroscience, 19, 1547276. (Read full article)
  63. Koppelmans V, Duff K, Schaefer S (2025). Using a Functional Upper Limb Motor Task to Predict Cognitive and Functional Decline in Mild Cognitive Impairment and Alzheimer's Disease. Neurorehabilitation and neural repair, 39(3), 226-229. (Read full article)

Review

  1. Koppelmans V, Breteler MM, Boogerd W, Seynaeve C, Schagen SB (2013). Late effects of adjuvant chemotherapy for adult onset non-CNS cancer; cognitive impairment, brain structure and risk of dementia. [Review]. Crit Rev Oncol Hematol, 88, (1), 87-101. (Read full article)
  2. Koppelmans V, Silvester B, Duff (2022). Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review. Journal of Alzheimer's disease reports, 6(1), 307-344. (Read full article)

Book Chapter

  1. Seidler RD, Koppelmans V, Bloomberg JJ, Mulavara A (2017). Sensory and Sensorimotor Changes with Spaceflight: Implications for Functional Performance. 225-251.

Editorial

  1. Koppelmans V, Weisenbach S (2019). Mechanisms Underlying Exercise as a Treatment for Depression. The American journal of geriatric psychiatry, 27(6), 617-618. (Read full article)
  2. Hill CM, Koppelmans V, Manto (2025). Editorial: Reinforcement feedback in motor learning: neural underpinnings of skill refinement. Frontiers in behavioral neuroscience, 19, 1589738. (Read full article)