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Vincent Koppelmans

Vincent Koppelmans, PhD

Languages spoken: English, Dutch

Academic Information

Departments Primary - Psychiatry

Divisions: Adult Psychiatry

Academic Office Information

Vincent Koppelmans, PhD, is a Research Assistant Professor in the Department of Psychiatry. He earned a Master of Science degree in Clinical Neuropsychology from the VU University, Amsterdam, the Netherlands, and a Master of Science degree in Health Sciences from the Erasmus University, Rotterdam, the Netherlands. He obtained his PhD in Neuro-epidemiology from the same Erasmus University for his dissertation on The Late Effects of Adjuvant Chemotherapy on Brain Function and Structure.

Dr. Koppelmans completed his postdoctoral training in Neural Control of Movement in the Department of Kinesiology at the University of Michigan in Ann Arbor, MI. He was awarded a fellowship from the National Space Biomedical Research Institute to investigate exercise as a potential countermeasure for brain changes that occur as a result of long-duration bed rest. Following his postdoctoral training he joined the Kinesiology Department of the University of Michigan as an Assistant Research Scientist. He is interested in disease and age related brain structural and functional neuroplasticity and their relation with cognitive function and motor behavior. He is currently funded by an NIH/NIA K01 award to study Neural and Behavioral Motor Profiles as Novel Biomarker for Alzheimer's Disease.

Education History

Research Fellow University of Michigan School of Kinesiology, Neuromotor Behavior Lab
Postdoctoral Research Fellow
Erasmus University Medical Center/Netherlands Cancer Institute
Graduate Training Erasmus University Rotterdam
Vrije Universiteit Amsterdam

Selected Publications

Journal Article

  1. Koppelmans V, Ruitenberg MFL, Schaefer SY, King JB, Hoffman JM, Mejia AF, Tasdizen T, Duff K (2023). Delayed and More Variable Unimanual and Bimanual Finger Tapping in Alzheimer's Disease: Associations with Biomarkers and Applications for Classification. J Alzheimers Dis.
  2. Malek-Ahmadi M, Duff K, Chen K, Su Y, King JB, Koppelmans V, Schaefer SY (2023). Volumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults. Exp Gerontol, 173, 112087.
  3. Ruitenberg MFL, Koppelmans V, Seidler RD, Schomaker J (2023). Developmental and age differences in visuomotor adaptation across the lifespan. Psychol Res.
  4. Kim JU, Bessette KL, Westlund-Schreiner M, Pocius S, Dillahunt AK, Frandsen S, Thomas L, Easter R, Skerrett K, Stange JP, Welsh RC, Langenecker SA, Koppelmans V (2022). Relations of gray matter volume to dimensional measures of cognition and affect in mood disorders. Cortex, 156, 57-70.
  5. Ruitenberg MFL, Koppelmans V, Wu T, Averbeck BB, Chou KL, Seidler RD (2022). Neural correlates of risky decision making in Parkinson's disease patients with impulse control disorders. Exp Brain Res.
  6. Baker AK, Ericksen LC, Koppelmans V, Mickey BJ, Martucci KT, Zubieta JK, Love TM (2022). Altered Reward Processing and Sex Differences in Chronic Pain. Front Neurosci, 16, 889849.
  7. Love T, Shabalin AA, Kember RL, Docherty AR, Zhou H, Koppelmans V, Gelernter J, Baker AK, Hartwell E, Dubroff J, Zubieta JK, Kranzler HR (2022). Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function. Neuropsychopharmacology, 47(10), 1784-1790.
  8. Koppelmans V, Mulavara AP, Seidler RD, De Dios YE, Bloomberg JJ, Wood SJ (2022). Cortical thickness of primary motor and vestibular brain regions predicts recovery from fall and balance directly after spaceflight. Brain Struct Funct, 227, 2073-2086.
  9. Mejia AF, Koppelmans V, Jelsone-Swain L, Kalra S, Welsh RC (2022). Longitudinal surface-based spatial Bayesian GLM reveals complex trajectories of motor neurodegeneration in ALS. Neuroimage, 255, 119180.
  10. Ruitenberg MFL, Koppelmans V, Seidler RD, Schomaker J (2021). Novelty exposure induces stronger sensorimotor representations during a manual adaptation task. Ann N Y Acad Sci, 1510(1), 68-78.
  11. Waskowiak P, Koppelmans V, Ruitenberg MFL (2021). Trait Anxiety as a Risk Factor for Impulse Control Disorders in de novo Parkinson's Disease. J Parkinsons Dis, 12(2), 689-697.
  12. Warthen KG, Welsh RC, Sanford B, Koppelmans V, Burmeister M, Mickey BJ (2021). Neuropeptide Y Variation Is Associated With Altered Static and Dynamic Functional Connectivity of the Salience Network. Front Syst Neurosci, 15, 629488.
  13. Duff K, Suhrie KR, Hammers DB, Dixon AM, King JB, Koppelmans V, Hoffman JM (2021). Repeatable battery for the assessment of neuropsychological status and its relationship to biomarkers of Alzheimer's disease. Clin Neuropsychol, 1-17.
  14. Hupfeld KE, McGregor HR, Koppelmans V, Beltran NE, Kofman IS, De Dios YE, Riascos RF, Reuter-Lorenz PA, Wood SJ, Bloomberg JJ, Mulavara AP, Seidler RD (2021). Brain and Behavioral Evidence for Reweighting of Vestibular Inputs with Long-Duration Spaceflight. Cereb Cortex, 32, 755-769.
  15. Langenecker SA, Westlund Schreiner M, Thomas LR, Bessette KL, DelDonno SR, Jenkins LM, Easter RE, Stange JP, Pocius SL, Dillahunt A, Love TM, Phan KL, Koppelmans V, Paulus M, Lindquist MA, Caffo B, Mickey BJ, Welsh RC (2021). Using Network Parcels and Resting-State Networks to Estimate Correlates of Mood Disorder and Related Research Domain Criteria Constructs of Reward Responsiveness and Inhibitory Control. Biol Psychiatry Cogn Neurosci Neuroimaging, 7, 76-84.
  16. Gau R, Noble S, Heuer K, Bottenhorn KL, Bilgin IP, Yang YF, Huntenburg JM, Bayer JMM, Bethlehem RAI, Rhoads SA, Vogelbacher C, Borghesani V, Levitis E, Wang HT, Van Den Bossche S, Kobeleva X, Legarreta JH, Guay S, Atay SM, Varoquaux GP, Huijser DC, Sandstrm MS, Herholz P, Nastase SA, Badhwar A, Dumas G, Schwab S, Moia S, Dayan M, Bassil Y, Brooks PP, Mancini M, Shine JM, OConnor D, Xie X, Poggiali D, Friedrich P, Heinsfeld AS, Riedl L, Toro R, Caballero-Gaudes C, Eklund A, Garner KG, Nolan CR, Demeter DV, Barrios FA, Merchant JS, McDevitt EA, Oostenveld R, Craddock RC, Rokem A, Doyle A, Ghosh SS, Nikolaidis A, Stanley OW, Uruuela E, Brainhack Community (2021). Brainhack: Developing a culture of open, inclusive, community-driven neuroscience. Neuron, 109(11), 1769-1775.
  17. Lee JK, Koppelmans V, Pasternak O, Beltran NE, Kofman IS, De Dios YE, Mulder ER, Mulavara AP, Bloomberg JJ, Seidler RD (2021). Effects of Spaceflight Stressors on Brain Volume, Microstructure, and Intracranial Fluid Distribution. Cereb Cortex Commun, 2(2), tgab022.
  18. Koppelmans V, van der Willik KD, Aleman BMP, van Leeuwen FE, Kavousi M, Arshi B, Vernooij MW, Ikram MA, Schagen SB (2020). Long-term effects of adjuvant treatment for breast cancer on carotid plaques and brain perfusion. Breast Cancer Res Treat, 186(1), 167-176.
  19. Ruitenberg MFL, Koppelmans V (2020). Cognition in Motion: Evidence for Intact Action Control With Healthy Aging. J Gerontol B Psychol Sci Soc Sci, 76(2), 252-261.
  20. Lee JK, Koppelmans V, Riascos RF, Hasan KM, Pasternak O, Mulavara AP, Bloomberg JJ, Seidler RD (2019). Spaceflight-Associated Brain White Matter Microstructural Changes and Intracranial Fluid Redistribution. JAMA Neurol, 76(4), 412-419.
  21. Weisenbach SL, Kim J, Hammers D, Konopacki K, Koppelmans V (2019). Linking late life depression and Alzheimer's disease: mechanisms and resilience. Curr Behav Neurosci Rep, 6(3), 103-112.
  22. van der Willik KD, Koppelmans V, Hauptmann M, Compter A, Ikram MA, Schagen SB (2018). Inflammation markers and cognitive performance in breast cancer survivors 20 years after completion of chemotherapy: a cohort study. Breast Cancer Res, 20(1), 135.
  23. Koppelmans V, Scott JM, Downs ME, Cassady KE, Yuan P, Pasternak O, Wood SJ, De Dios YE, Gadd NE, Kofman I, Riascos R, Reuter-Lorenz PA, Bloomberg JJ, Mulavara AP, Ploutz-Snyder LL, Seidler RD (2018). Exercise effects on bed rest-induced brain changes. PLoS One, 13(10), e0205515.
  24. Ruitenberg MFL, Koppelmans V, De Dios YE, Gadd NE, Wood SJ, Reuter-Lorenz PA, Kofman I, Bloomberg JJ, Mulavara AP, Seidler RD (2018). Neural correlates of multi-day learning and savings in sensorimotor adaptation. Sci Rep, 8(1), 14286.
  25. Yuan P, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Wood S, Riascos R, Kofman I, Bloomberg J, Mulavara A, Seidler R (2018). Vestibular brain changes within 70 days of head down bed rest. Hum Brain Mapp, 39(7), 2753-2763.
  26. Yuan P, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Riascos R, Kofman I, Bloomberg J, Mulavara A, Seidler RD (2018). Change of cortical foot activation following 70 days of head-down bed rest. J Neurophysiol, 119(6), 2145-2152.
  27. Ruitenberg MFL, Wu T, Averbeck BB, Chou KL, Koppelmans V, Seidler RD (2018). Impulsivity in Parkinson's Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks. Front Neurol, 9, 279.
  28. Cassady K, Ruitenberg M, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Wood S, Riascos Castenada R, Kofman I, Bloomberg J, Mulavara A, Seidler R (2017). Neural predictors of sensorimotor adaptation rate and savings. Hum Brain Mapp, 39(4), 1516-1531.
  29. Hirsiger S, Koppelmans V, Mrillat S, Erdin C, Narkhede A, Brickman AM, Jncke L (2017). Executive Functions in Healthy Older Adults Are Differentially Related to Macro- and Microstructural White Matter Characteristics of the Cerebral Lobes. Front Aging Neurosci, 9, 373.
  30. Koppelmans V, Bloomberg JJ, De Dios YE, Wood SJ, Reuter-Lorenz PA, Kofman IS, Riascos R, Mulavara AP, Seidler RD (2017). Brain plasticity and sensorimotor deterioration as a function of 70 days head down tilt bed rest. PLoS One, 12(8), e0182236.
  31. Koppelmans V, Pasternak O, Bloomberg JJ, Dios YE, Wood SJ, Riascos R, Reuter-Lorenz PA, Kofman IS, Mulavara AP, Seidler RD (2017). Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog. Sci Rep, 7(1), 3154.
  32. Koppelmans V, Hoogendam YY, Hirsiger S, Mrillat S, Jncke L, Seidler RD (2017). Regional cerebellar volumetric correlates of manual motor and cognitive function. Brain Struct Funct, 222(4), 1929-1944.
  33. Koppelmans V, Bloomberg JJ, Mulavara AP, Seidler RD (2016). Brain structural plasticity with spaceflight. NPJ Microgravity, 2, 2.
  34. Cassady K, Koppelmans V, Reuter-Lorenz P, De Dios Y, Gadd N, Wood S, Castenada RR, Kofman I, Bloomberg J, Mulavara A, Seidler R (2016). Effects of a spaceflight analog environment on brain connectivity and behavior. Neuroimage, 141, 18-30.
  35. Yuan P, Koppelmans V, Reuter-Lorenz PA, De Dios YE, Gadd NE, Wood SJ, Riascos R, Kofman IS, Bloomberg JJ, Mulavara AP, Seidler RD (2016). Increased Brain Activation for Dual Tasking with 70-Days Head-Down Bed Rest. Front Syst Neurosci, 10, 71.
  36. Hirsiger S, Koppelmans V, Mrillat S, Liem F, Erdeniz B, Seidler RD, Jncke L (2016). Structural and functional connectivity in healthy aging: Associations for cognition and motor behavior. Hum Brain Mapp, 37(3), 855-67.
  37. Hoogendam YY, Schagen SB, Ikram MA, Boogerd W, Seynaeve C, Seidler RD, Breteler MM, Van der Geest JN, Koppelmans V (2015). Late effects of adjuvant chemotherapy for breast cancer on fine motor function. Psychooncology, 24(12), 1799-807.
  38. Koppelmans V, Mulavara AP, Yuan P, Cassady KE, Cooke KA, Wood SJ, Reuter-Lorenz PA, De Dios YE, Stepanyan V, Szecsy DL, Gadd NE, Kofman I, Scott JM, Downs ME, Bloomberg JJ, Ploutz-Snyder L, Seidler RD (2015). Exercise as potential countermeasure for the effects of 70 days of bed rest on cognitive and sensorimotor performance. Front Syst Neurosci, 9, 121.
  39. Koppelmans V, Hirsiger S, Mrillat S, Jncke L, Seidler RD (2015). Cerebellar gray and white matter volume and their relation with age and manual motor performance in healthy older adults. Hum Brain Mapp, 36(6), 2352-63.
  40. Stouten-Kemperman MM, de Ruiter MB, Koppelmans V, Boogerd W, Reneman L, Schagen SB (2015). Neurotoxicity in breast cancer survivors >/=10 years post-treatment is dependent on treatment type. Brain Imaging Behav, 9(2), 275-84.
  41. Seidler R, Erdeniz B, Koppelmans V, Hirsiger S, Merillat S, Jancke L (2015). Associations between age, motor function, and resting state sensorimotor network connectivity in healthy older adults. Neuroimage, 108, 47-59.
  42. Menning S, de Ruiter MB, Veltman DJ, Koppelmans V, Kirschbaum C, Boogerd W, Reneman L, Schagen SB (2015). Multimodal MRI and cognitive function in patients with breast cancer prior to adjuvant treatment--the role of fatigue. Neuroimage Clin, 7, 547-54.
  43. Koppelmans V, Vernooij MW, Boogerd W, Seynaeve C, Ikram MA, Breteler MM, Schagen SB (2015). Prevalence of cerebral small-vessel disease in long-term breast cancer survivors exposed to both adjuvant radiotherapy and chemotherapy. J Clin Oncol, 33(6), 588-93.
  44. Koppelmans V, de Groot M, de Ruiter MB, Boogerd W, Seynaeve C, Vernooij MW, Niessen WJ, Schagen SB, Breteler MM (2014). Global and focal white matter integrity in breast cancer survivors 20 years after adjuvant chemotherapy. Hum Brain Mapp, 35(3), 889-99.
  45. Koppelmans V, Erdeniz B, De Dios YE, Wood SJ, Reuter-Lorenz PA, Kofman I, Bloomberg JJ, Mulavara AP, Seidler RD (2013). Study protocol to examine the effects of spaceflight and a spaceflight analog on neurocognitive performance: extent, longevity, and neural bases. BMC Neurol, 13, 205.
  46. Koppelmans V, Schagen SB, Breteler MMB (2013). Late effecten van adjuvante chemotherapie voor borstkanker op het cognitief functioneren en de structuur van het brein. 17(3), 75-79.
  47. Koppelmans V, Breteler MM, Boogerd W, Seynaeve C, Gundy C, Schagen SB (2012). Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy. J Clin Oncol, 30(10), 1080-6.
  48. Koppelmans V, de Ruiter MB, van der Lijn F, Boogerd W, Seynaeve C, van der Lugt A, Vrooman H, Niessen WJ, Breteler MM, Schagen SB (2012). Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy. Breast Cancer Res Treat, 132(3), 1099-106.
  49. Koppelmans V, Schagen SB, Poels MM, Boogerd W, Seynaeve C, van der Lugt A, Breteler MM (2011). Incidental findings on brain Magnetic Resonance Imaging in long-term survivors of breast cancer treated with adjuvant chemotherapy. Eur J Cancer, 47(17), 2531-6.
  50. Koppelmans V, Schagen SB (2011). Effecten van chemotherapie op het cognitief functioneren van kankerpatiënten. Oncologica, 4, 35-7.
  51. Koppelmans V, Schoevers R, van Wijk CG, Mulder W, Hornbach A, Barkhof E, Klaassen A, van Egmond M, van Venrooij J, Bijpost Y, Nusselder H, van Herrewaarden M, Maksimovic I, Achilles A, Dekker J (2009). The Amsterdam Studies of Acute Psychiatry - II (ASAP-II): a comparative study of psychiatric intensive care units in the Netherlands. BMC Public Health, 9, 318.
  52. van der Post L, Schoevers R, Koppelmans V, Visch I, Bernardt C, Mulder N, Beekman A, de Haan L, Dekker J (2008). The Amsterdam Studies of Acute Psychiatry I (ASAP-I); a prospective cohort study of determinants and outcome of coercive versus voluntary treatment interventions in a metropolitan area. BMC Psychiatry, 8, 35.
  53. Schoevers RA, Van HL, Koppelmans V, Kool S, Dekker JJ (2008). Managing the patient with co-morbid depression and an anxiety disorder. Drugs, 68(12), 1621-34.


  1. Koppelmans V, Silvester B, Duff K (2022). Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review. [Review]. J Alzheimers Dis Rep, 6(1), 307-344.
  2. Koppelmans V, Breteler MM, Boogerd W, Seynaeve C, Schagen SB (2013). Late effects of adjuvant chemotherapy for adult onset non-CNS cancer; cognitive impairment, brain structure and risk of dementia. [Review]. Crit Rev Oncol Hematol, 88(1), 87-101.

Book Chapter

  1. Seidler RD, Koppelmans V, Bloomberg JJ, Mulavara AP (2017). Sensory and Sensorimotor Changes with Spaceflight: Implications for Functional Performance. In Macias BR, Liu JHK, Otto C, Hargens AR (Eds.), Intracranial Pressure and its Effect on Vision in Space and on Earth (1st, pp. 225-251). World Scientific.


  1. Koppelmans V, Weisenbach SL (2019). Mechanisms Underlying Exercise as a Treatment for Depression. Am J Geriatr Psychiatry, 27(6), 617-618.