< content="width=device-width, initial-scale=1.0"> W. Zac Stephens | School of Medicine
W. Zac Stephens

W. Zac Stephens, PhD

Languages spoken: English

Academic Information

Departments Primary - Pathology

Academic Office Information

zac.stephens@path.utah.edu

Lab

Research Interests

  • Air Pollution
  • Immunology
  • Host–Microbe Interaction
  • Microbial Ecology
  • Genomics

Education History

Postdoctoral Training University of Utah
 Postdoctoral Training
University of Oregon, Institute of Molecular Biology
 PhD
Undergraduate University of Utah
 BS

Selected Publications

Journal Article

  1. Miljkovic M, Seguin A, Jia X, Cox JE, Catrow JL, Bergonia H, Phillips JD, Stephens WZ, Ward DM (2023). Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4. J Biol Chem, 299(7), 104877. (Read full article)
  2. de Araujo CV, Denorme F, Stephens WZ, Li Q, Cody MJ, Crandell JL, Petrey AC, Queisser KA, Rustad JL, Fulcher JM, Evangelista JL, Kay MS, Schiffman JD, Campbell RA, Yost CC (2023). Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps. Front Immunol, 13, 1046574. (Read full article)
  3. Weinstein SB, Stephens WZ, Greenhalgh R, Round JL, Dearing MD (2022). Wild herbivorous mammals (genus Neotoma) host a diverse but transient assemblage of fungi. Symbiosis, 87, 45-58.
  4. Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, OConnell RM, Round JL (2020). Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell Rep, 37(5), 109916. (Read full article)
  5. Petersen C, Bell R, Klag KA, Lee S, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Crotty S4, Boudina S2, OConnell RM, Cox JE, Villanueva JC, Stephens WZ, Round JL (2019). T cell–mediated regulation of the microbiota protects against obesity. Science, 365(6461), eaat9351.
  6. Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, OConnell R, Jacob V, Scherl E, Crawford C, Stephens WZ, Casjens SR, Longman RS, Round JL (2019). Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Cell Host Microbe, 25(2), 285-299.
  7. Chiaro T, Soto R, Kubinak JL, Stephens WZ, Peterson C, Gogokhia L, Bell R, Delgado J, Cox J, Voth W, Brown J, Stillman D, O Connell RM, Tebo A, Round JL (2017). A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice. Sci Transl Med, 8(9), 380.
  8. Zac Stephens W, Burns AR, Stagaman K, Wong S, Rawls JF, Guillemin K, Bohannan BJ (2016). The composition of the zebrafish intestinal microbial community varies across development. ISME J, 10(3), 644-654. (Read full article)
  9. Kubinak JL, Petersen C, Stephens WZ, Soto R, Bake E, OConnell RM, Round JL (2015). MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health. Cell Host Microbe, 17(2), 153-63. (Read full article)
  10. Stephens WZ, Wiles TJ, Martinez ES, Jemielita M, Burns AR, Parthasarathy R, Bohannan BJ, Guillemin K (2015). Identification of Population Bottlenecks and Colonization Factors during Assembly of Bacterial Communities within the Zebrafish Intestine. mBio, 6(6), e01163-15. (Read full article)
  11. Kubinak JL, Stephens WZ, Soto R, Petersen C, Chiaro T, Gogokhia L, Bell R, Ajami NJ, Petrosino JF, Morrison L, Potts WK, Jensen PE, OConnell RM, Round JL (2015). MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection. Nat Commun, 6, 8642. (Read full article)