Education History
| Fellowship |
University of California, San Francisco |
Postdoctoral Fellow |
|---|---|---|
| Professional Medical |
Washington University School of Medicine in St. Louis |
PhD |
| Fellowship |
Genomic Research Center, Academia Sinica |
Postbaccalaureate Research Fellow |
| Undergraduate |
National Taiwan University School of Medicine |
BPharm |
| Undergraduate |
National Taiwan University School of Medicine |
BS |
Selected Publications
Journal Article
- Li YR, Lee CR, Mohtashami M, Conway K, Lo WL, Ziga-Pflcker JC (2025). Thymus engraftment and developmental progression of adoptively transferred progenitor T cells are affected by host conditioning. J Immunol, 215(4).
- Jang HJ, Jama B, Mills EA, Humphries PA, Marcel N, Lu LF, Lo WL, Morris GP (2025). Dual T cell receptor expression provides intrinsic advantage for agonist selection of thymic FoxP3+ regulatory T cells (Tregs) in the neonatal thymus. J Immunol, 215(2).
- Stadinski BD, Mills EA, Humphries PA, Cleveland SB, Dow P, Murakami K, Li YR, Murakami M, Ono M, Au-Yeung BB, Morris GP, Ziga-Pflcker JC, Campbell RA, Griffiths ER, Huseby ES, Lo WL (2025). Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire. Nat Immunol, 26(12), 2256-2269.
- Fan T, Tai C, Sleiman KC, Cutcliffe MP, Kim H, Liu Y, Li J, Xin G, Grashel M, Baert L, Ekeocha C, Vergenes P, Lima S, Lo WL, Lin J, Hanaoka B, Tankersley TN, Wang M, Zhang X, Tsokos GC, Jarjour W, Longman R, Wu HJ (2025). Aberrant T follicular helper cells generated by T(H)17 cell plasticity in the gut promote extraintestinal autoimmunity. Nat Immunol, 26(5), 790-804.
- van Vlimmeren AE, Voleti R, Chartier CA, Jiang Z, Karandur D, Humphries PA, Lo WL, Shah NH (2024). The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain. Proc Natl Acad Sci U S A, 121(30), e2407159121.
- Bosch M, Kallin N, Donakonda S, Zhang JD, Wintersteller H, Hegenbarth S, Heim K, Ramirez C, Frst A, Lattouf EI, Feuerherd M, Chattopadhyay S, Kumpesa N, Griesser V, Hoflack JC, Siebourg-Polster J, Mogler C, Swadling L, Pallett LJ, Meiser P, Manske K, de Almeida GP, Kosinska AD, Sandu I, Schneider A, Steinbacher V, Teng Y, Schnabel J, Theis F, Gehring AJ, Boonstra A, Janssen HLA, Vandenbosch M, Cuypers E, llinger R, Engleitner T, Rad R, Steiger K, Oxenius A, Lo WL, Klepsch V, Baier G, Holzmann B, Maini MK, Heeren R, Murray PJ, Thimme R, Herrmann C, Protzer U, Bttcher JP, Zehn D, Wohlleber D, Lauer GM, Hofmann M, Luangsay S, Knolle PA (2024). A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection. Nature, 631(8022), 867-875.
- van Vlimmeren AE, Voleti R, Chartier CA, Jiang Z, Karandur D, Humphries PA, Lo WL, Shah NH (2024). The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain. bioRxiv.
- Lo WL, Kuhlmann M, Rizzuto G, Ekiz HA, Kolawole EM, Revelo MP, Andargachew R, Li Z, Tsai YL, Marson A, Evavold BD, Zehn D, Weiss A (2023). A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function. Nat Immunol, 24(4), 676-689.
- Hallumi E, Shalah R, Lo WL, Corso J, Oz I, Beach D, Wittman S, Isenberg A, Sela M, Urlaub H, Weiss A, Yablonski D (2021). Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads. J Immunol, 206(10), 2322-2337.
- Ganti RS, Lo WL, McAffee DB, Groves JT, Weiss A, Chakraborty AK (2020). How the T cell signaling network processes information to discriminate between self and agonist ligands. Proc Natl Acad Sci U S A, 117(42), 26020-26030.
- Lo WL, Shah NH, Rubin SA, Zhang W, Horkova V, Fallahee IR, Stepanek O, Zon LI, Kuriyan J, Weiss A (2019). Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nat Immunol, 20(11), 1481-1493.
- Courtney AH, Shvets AA, Lu W, Griffante G, Mollenauer M, Horkova V, Lo WL, Yu S, Stepanek O, Chakraborty AK, Weiss A (2019). CD45 functions as a signaling gatekeeper in T cells. Sci Signal, 12(604).
- Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A (2018). Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nat Immunol, 19(7), 733-741.
- Ransdell JL, Dranoff E, Lau B, Lo WL, Donermeyer DL, Allen PM, Nerbonne JM (2016). Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance. Cell Rep, 19(3), 532-544.
- Persaud SP, Parker CR, Lo WL, Weber KS, Allen PM (2014). Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol, 15(3), 266-74.
- Lo WL, Solomon BD, Donermeyer DL, Hsieh CS, Allen PM (2014). T cell immunodominance is dictated by the positively selecting self-peptide. Elife, 3, e01457.
- Lo WL, Donermeyer DL, Allen PM (2012). A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells. Nat Immunol, 13(9), 880-7.
- Huang CH, Chuang MH, Lo WL, Wu MS, Wu YH, Wu DC, Chiou SH (2011). Alkylhydroperoxide reductase of Helicobacter pylori as a biomarker for gastric patients with different pathological manifestations. Biochimie, 93(7), 1115-23.
- Morley SC, Wang C, Lo WL, Lio CW, Zinselmeyer BH, Miller MJ, Brown EJ, Allen PM (2010). The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility. J Immunol, 184(7), 3628-38.
- Lo WL, Felix NJ, Walters JJ, Rohrs H, Gross ML, Allen PM (2009). An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells. Nat Immunol, 10(11), 1155-61.
- Lin YC, Kuo MW, Yu J, Kuo HH, Lin RJ, Lo WL, Yu AL (2008). c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development. Mol Biol Evol, 25(10), 2189-98.
- Lin YC, Hsieh LC, Kuo MW, Yu J, Kuo HH, Lo WL, Lin RJ, Yu AL, Li WH (2007). Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. Mol Biol Evol, 24(11), 2525-34.
- Chuang MH, Wu MS, Lo WL, Lin JT, Wong CH, Chiou SH (2006). The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function. Proc Natl Acad Sci U S A, 103(8), 2552-7.
Review
- Lo WL, Yablonski D (2026). Recent progress in CAR T signaling: Maneuvering CARs father along the TCR signaling pathway. [Review]. Crit Rev Oncog, 31(2), 3-21.
- Yoder T, Mills EA, Lo WL (2025). Intrinsically disordered domains expand the CAR T cell toolbox. [Review]. Nat Chem Biol, 22(3), 344-346.
- Lo WL, Huseby ES (2024). The partitioning of TCR repertoires by thymic selection. [Review]. J Exp Med, 221(10).
- Humphries PA, Lo WL (2022). Two CTLA-4 ligands, separate pHates. [Review]. Nat Immunol, 23(9), 1297-1299.
- Ashouri JF, Lo WL, Nguyen TTT, Shen L, Weiss A (2021). ZAP70, too little, too much can lead to autoimmunity. [Review]. Immunol Rev, 307(1), 145-160.
- Alfei F, Ho PC, Lo WL (2021). DCision-making in tumors governs T cell anti-tumor immunity. [Review]. Oncogene, 40(34), 5253-5261.
- Lo WL, Weiss A (2021). Adapting T Cell Receptor Ligand Discrimination Capability via LAT. [Review]. Front Immunol, 12, 673196.
- Courtney AH, Lo WL, Weiss A (2017). TCR Signaling: Mechanisms of Initiation and Propagation. [Review]. Trends Biochem Sci, 43(2), 108-123.
- Lo WL, Allen PM (2013). Self-peptides in TCR repertoire selection and peripheral T cell function. [Review]. Curr Top Microbiol Immunol, 373, 49-67.
- Lo WL, Allen PM (2012). Self-awareness: how self-peptide/MHC complexes are essential in the development of T cells. [Review]. Mol Immunol, 55(2), 186-9.
Book
- Thor Hanson Author Wan-Lin Lo Translator Traditional Chinese (2023). Buzz: The Nature and Necessity of Bees by Thor Hanson. Taiwan: Owl Publishing House.