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Xuan Wang

Xuan Wang, PhD

Academic Information

Departments Primary - Population Health Sciences

Academic Office Information

Research Interests

  • Regression Model and Measurement Error Model
  • Complex Survival Data Analysis
  • Surrogate Evaluation
  • Casual Inference and Missing Data Analysis
  • Electronic Health Record Data Analysis

Education History

Postdoctoral Fellowship Harvard University
Postdoctoral Fellow
University of Washington
Postdoctoral Fellow
Doctoral Training Academy of Mathematics and Systems Science of the Chinese Academy of Sciences
Beijing Jiaotong University

Selected Publications

Journal Article

  1. Wang X, Parast L, Han L, Tian L, Cai T (2022). Robust approach to combining multiple markers to improve surrogacy. Biometrics, 79(2), 788-798. (Read full article)
  2. Hou J, Chan SF, Wang X, Cai T (2021). Risk prediction with imperfect survival outcome information from electronic health records. Biometrics, 79(1), 190-202. (Read full article)
  3. Wang X, Claggett BL, Tian L, Malachias MVB, Pfeffer MA, Wei LJ (2023). Quantifying and Interpreting the Prediction Accuracy of Models for the Time of a Cardiovascular Event-Moving Beyond C Statistic: A Review. JAMA Cardiol, 8(3), 290-295. (Read full article)
  4. Tan ALM, Getzen EJ, Hutch MR, Strasser ZH, Gutirrez-Sacristn A, Le TT, Dagliati A, Morris M, Hanauer DA, Moal B, Bonzel CL, Yuan W, Chiudinelli L, Das P, Zhang HG, Aronow BJ, Avillach P, Brat GA, Cai T, Hong C, La Cava WG, Hooi Will Loh H, Luo Y, Murphy SN, Yuan Hgiam K, Omenn GS, Patel LP, Jebathilagam Samayamuthu M, Shriver ER, Shakeri Hossein Abad Z, Tan BWL, Visweswaran S, Wang X, Weber GM, Xia Z, Verdy B, COVID-19 by EHR 4CE, Long Q, Mowery DL, Holmes JH (2023). Informative missingness: What can we learn from patterns in missing laboratory data in the electronic health record? J Biomed Inform, 139, 104306. (Read full article)
  5. Moal B, Orieux A, Fert T, Neuraz A, Brat GA, Avillach P, Bonzel CL, Cai T, Cho K, Cossin S, Griffier R, Hanauer DA, Haverkamp C, Ho YL, Hong C, Hutch MR, Klann JG, Le TT, Loh NHW, Luo Y, Makoudjou A, Morris M, Mowery DL, Olson KL, Patel LP, Samayamuthu MJ, Sanz Vidorreta FJ, Schriver ER, Schubert P, Verdy G, Visweswaran S, Wang X, Weber GM, Xia Z, Yuan W, Zhang HG, Zller D, Kohane IS, Consortium for Clinical Characterization of COVID-19 by EHR 4CE, Boyer A, Jouhet V (2023). Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium. PLoS One, 18(1), e0266985. (Read full article)
  6. Han L, Wang X, Cai T (2022). Identifying surrogate markers in real-world comparative effectiveness research. Stat Med, 41(26), 5290-5304. (Read full article)
  7. Fan C, Song Y, Wang X, Mao C, Xiong Y (2022). Identification of early derangements of coagulation, hematological and biochemical profiles in patients with acute pancreatitis. Clin Biochem, 109-110, 37-43. (Read full article)
  8. Zhou QM, Wang X, Zheng Y, Cai T (2022). New weighting methods when cases are only a subset of events in a nested case-control study. Biom J, 64(7), 1240-1259. (Read full article)
  9. Wang X, Zhang HG, Xiong X, Hong C, Weber GM, Brat GA, Bonzel CL, Luo Y, Duan R, Palmer NP, Hutch MR, Gutirrez-Sacristn A, Bellazzi R, Chiovato L, Cho K, Dagliati A, Estiri H, Garca-Barrio N, Griffier R, Hanauer DA, Ho YL, Holmes JH, Keller MS, Klann MEng JG, LYi S, Lozano-Zahonero S, Maidlow SE, Makoudjou A, Malovini A, Moal B, Moore JH, Morris M, Mowery DL, Murphy SN, Neuraz A, Yuan Ngiam K, Omenn GS, Patel LP, Pedrera-Jimnez M, Prunotto A, Jebathilagam Samayamuthu M, Sanz Vidorreta FJ, Schriver ER, Schubert P, Serrano-Balazote P, South AM, Tan ALM, Tan BWL, Tibollo V, Tippmann P, Visweswaran S, Xia Z, Yuan W, Zller D, Kohane IS, Avillach P, Guo Z, Cai T, Consortium for Clinical Characterization of COVID-19 by EHR 4CE (2022). SurvMaximin: Robust federated approach to transporting survival risk prediction models. J Biomed Inform, 134, 104176. (Read full article)
  10. Hong C, Zhang HG, LYi S, Weber G, Avillach P, Tan BWQ, Gutirrez-Sacristn A, Bonzel CL, Palmer NP, Malovini A, Tibollo V, Luo Y, Hutch MR, Liu M, Bourgeois F, Bellazzi R, Chiovato L, Sanz Vidorreta FJ, Le TT, Wang X, Yuan W, Neuraz A, Benoit V, Moal B, Morris M, Hanauer DA, Maidlow S, Wagholikar K, Murphy S, Estiri H, Makoudjou A, Tippmann P, Klann J, Follett RW, Gehlenborg N, Omenn GS, Xia Z, Dagliati A, Visweswaran S, Patel LP, Mowery DL, Schriver ER, Samayamuthu MJ, Kavuluru R, Lozano-Zahonero S, Zller D, Tan ALM, Tan BWL, Ngiam KY, Holmes JH, Schubert P, Cho K, Ho YL, Beaulieu-Jones BK, Pedrera-Jimnez M, Garca-Barrio N, Serrano-Balazote P, Kohane I, Consortium for Clinical Characterization of COVID-19 by EHR 4CE, South A, Brat GA, Cai T (2022). Changes in laboratory value improvement and mortality rates over the course of the pandemic: an international retrospective cohort study of hospitalised patients infected with SARS-CoV-2. BMJ Open, 12(6), e057725. (Read full article)
  11. Weber GM, Hong C, Xia Z, Palmer NP, Avillach P, LYi S, Keller MS, Murphy SN, Gutirrez-Sacristn A, Bonzel CL, Serret-Larmande A, Neuraz A, Omenn GS, Visweswaran S, Klann JG, South AM, Loh NHW, Cannataro M, Beaulieu-Jones BK, Bellazzi R, Agapito G, Alessiani M, Aronow BJ, Bell DS, Benoit V, Bourgeois FT, Chiovato L, Cho K, Dagliati A, DuVall SL, Barrio NG, Hanauer DA, Ho YL, Holmes JH, Issitt RW, Liu M, Luo Y, Lynch KE, Maidlow SE, Malovini A, Mandl KD, Mao C, Matheny ME, Moore JH, Morris JS, Morris M, Mowery DL, Ngiam KY, Patel LP, Pedrera-Jimenez M, Ramoni RB, Schriver ER, Schubert P, Balazote PS, Spiridou A, Tan ALM, Tan BWL, Tibollo V, Torti C, Trecarichi EM, Wang X, Consortium for Clinical Characterization of COVID-19 by EHR 4CE, Kohane IS, Cai T, Brat GA (2022). International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality. NPJ Digit Med, 5(1), 74. (Read full article)
  12. Wang X, Cai T, Tian L, Bourgeois F, Parast L (2021). Quantifying the feasibility of shortening clinical trial duration using surrogate markers. Stat Med, 40(28), 6321-6343. (Read full article)
  13. Wang X, Kim DH, Wei LJ (2021). Quantifying and Interpreting Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Cancer Control for Advanced Gastroesophageal Cancer Among an Older Population. JAMA Oncol, 7(11), 1723-1724. (Read full article)
  14. Weber GM, Zhang HG, LYi S, Bonzel CL, Hong C, Avillach P, Gutirrez-Sacristn A, Palmer NP, Tan ALM, Wang X, Yuan W, Gehlenborg N, Alloni A, Amendola DF, Bellasi A, Bellazzi R, Beraghi M, Bucalo M, Chiovato L, Cho K, Dagliati A, Estiri H, Follett RW, Garca Barrio N, Hanauer DA, Henderson DW, Ho YL, Holmes JH, Hutch MR, Kavuluru R, Kirchoff K, Klann JG, Krishnamurthy AK, Le TT, Liu M, Loh NHW, Lozano-Zahonero S, Luo Y, Maidlow S, Makoudjou A, Malovini A, Martins MR, Moal B, Morris M, Mowery DL, Murphy SN, Neuraz A, Ngiam KY, Okoshi MP, Omenn GS, Patel LP, Pedrera Jimnez M, Prudente RA, Samayamuthu MJ, Sanz Vidorreta FJ, Schriver ER, Schubert P, Serrano Balazote P, Tan BW, Tanni SE, Tibollo V, Visweswaran S, Wagholikar KB, Xia Z, Zller D, Consortium For Clinical Characterization Of COVID-19 By EHR 4CE, Kohane IS, Cai T, South AM, Brat GA (2021). International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: Retrospective Cohort Study. J Med Internet Res, 23(10), e31400. (Read full article)
  15. Wang X, Zheng Y, Jensen MK, He Z, Cai T (2021). Biomarker evaluation under imperfect nested case-control design. Stat Med, 40(18), 4035-4052. (Read full article)
  16. Chan S, Wang X, Jazi I, Peskoe S, Zheng Y, Cai T (2020). Developing and evaluating risk prediction models with panel current status data. Biometrics, 77(2), 599-609. (Read full article)
  17. Chepelev LL, Wang X, Gold B, Bonzel CL, Rybicki F Jr, Uyeda JW, Sheikh A, Anderson D, Lindaman J, Mogel G, Mitsouras D, Mahoney MC, Cai T, Rybicki FJ (2021). Improved Appropriateness of Advanced Diagnostic Imaging After Implementation of Clinical Decision Support Mechanism. J Digit Imaging, 34(2), 397-403. (Read full article)
  18. Wang X, Parast L, Tian LU, Cai T (2019). Model-free approach to quantifying the proportion of treatment effect explained by a surrogate marker. Biometrika, 107(1), 107-122. (Read full article)
  19. Tong J, Huang J, Chubak J, Wang X, Moore JH, Hubbard RA, Chen Y (2019). An augmented estimation procedure for EHR-based association studies accounting for differential misclassification. J Am Med Inform Assoc, 27(2), 244-253. (Read full article)
  20. Maier MM, Zhou XH, Chapko M, Leipertz SL, Wang X, Beste LA (2018). Hepatitis C Cure Is Associated with Decreased Healthcare Costs in Cirrhotics in Retrospective Veterans Affairs Cohort. Dig Dis Sci, 63(6), 1454-1462. (Read full article)
  21. Wang X, Beste LA, Maier MM, Zhou XH (2016). Double robust estimator of average causal treatment effect for censored medical cost data. Stat Med, 35(18), 3101-16. (Read full article)


  1. Zhang HG, Honerlaw JP, Maripuri M, Samayamuthu MJ, Beaulieu-Jones BR, Baig HS, LYi S, Ho YL, Morris M, Panickan VA, Wang X, Weber GM, Liao KP, Visweswaran S, Tan BWQ, Yuan W, Gehlenborg N, Muralidhar S, Ramoni RB, Consortium for Clinical Characterization of COVID-19 by EHR 4CE, Kohane IS, Xia Z, Cho K, Cai T, Brat GA (2023). Potential pitfalls in the use of real-world data for studying long COVID. [Letter to the editor]. Nat Med, 29(5), 1040-1043. (Read full article)